Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:natural killer cell differentiation
go back to main search page
Accession:GO:0001779 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: NK cell differentiation
 related_synonym: natural killer cell development



show annotations for term's descendants           Sort by:
 
natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl Axl receptor tyrosine kinase involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:104294|MGI:96965 (MGI:3662985|PMID:16751775)
RGD PMID:16751775 PMID:21873635 MGI:3662985, RGD:13792537 NCBI chr 1:81,265,656...81,296,278
Ensembl chr 1:81,265,088...81,296,265
JBrowse link
G Hectd1 HECT domain E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO MGI:2137552 (MGI:5604339|PMID:24855001) RGD PMID:24855001 MGI:5604339 NCBI chr 6:69,181,429...69,267,803
Ensembl chr 6:69,181,436...69,268,053
JBrowse link
G Id2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO MGI:2384134|MGI:98510 (MGI:3759740|PMID:17452521) RGD PMID:17452521 MGI:3759740 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Ikzf1 IKAROS family zinc finger 1 acts_upstream_of_or_within ISO MGI:2158738 (MGI:68746|PMID:7923373) RGD PMID:7923373 MGI:68746 NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416
JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 acts_upstream_of_or_within ISO MGI:2177774 (MGI:3505799|PMID:15499555) RGD PMID:15499555 MGI:3505799 NCBI chr 5:56,931,824...56,941,408
Ensembl chr 5:56,935,516...56,941,408
JBrowse link
G Kat7 lysine acetyltransferase 7 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:6393224|PMID:27733580)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:27733580 GO_REF:0000024 GO_REF:0000107 MGI:6393224 NCBI chr10:80,221,519...80,255,590
Ensembl chr10:80,221,524...80,255,567
JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase acts_upstream_of_or_within ISO MGI:104294|MGI:1347244 (MGI:3662985|PMID:16751775) RGD PMID:16751775 MGI:3662985 NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554
JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated involved_in ISS
ISO
GO_REF:0000024
(MGI:6460593|PMID:32190943)
UniProt
RGD
PMID:32190943 GO_REF:0000024 MGI:6460593 NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858
JBrowse link
G Pbx1 PBX homeobox 1 involved_in ISO (MGI:6460593|PMID:32190943) RGD PMID:32190943 MGI:6460593 NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C involved_in ISO (MGI:3521537|PMID:15557316) RGD PMID:15557316 MGI:3521537 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G Rabl3 RAB, member of RAS oncogene family-like 3 involved_in ISO (MGI:6405642|PMID:32220963) RGD PMID:32220963 MGI:6405642 NCBI chr11:63,153,281...63,182,240
Ensembl chr11:63,152,792...63,182,671
JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 involved_in ISO (MGI:3763993|PMID:18031695) RGD PMID:18031695 MGI:3763993 NCBI chr13:84,270,316...84,305,497
Ensembl chr13:84,270,316...84,305,497
JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (MGI:3763993|PMID:18031695) RGD PMID:18031695 MGI:3763993 NCBI chr13:84,384,561...84,405,300
Ensembl chr13:84,383,742...84,405,300
JBrowse link
G Sp3 Sp3 transcription factor acts_upstream_of_or_within ISO MGI:2182438 (MGI:2670314|PMID:12676787) RGD PMID:12676787 MGI:2670314 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:103035 (MGI:1332382|PMID:10072077) RGD PMID:10072077 MGI:1332382 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:103036 (MGI:1332382|PMID:10072077)
Ensembl
RGD
PMID:10072077 GO_REF:0000107 MGI:1332382 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Tcf3 transcription factor 3 acts_upstream_of_or_within ISO MGI:96397 (MGI:3759740|PMID:17452521) RGD PMID:17452521 MGI:3759740 NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314
JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in ISO (PMID:21126536) RGD PMID:21126536 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272
JBrowse link
G Tusc2 tumor suppressor 2, mitochondrial calcium regulator acts_upstream_of_or_within ISO MGI:103014|MGI:3706236 (MGI:3703651|PMID:17318811) RGD PMID:17318811 MGI:3703651 NCBI chr 8:108,236,838...108,240,056
Ensembl chr 8:108,236,838...108,240,056
JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1347244|MGI:96965 (MGI:3662985|PMID:16751775)
Ensembl
RGD
PMID:16751775 GO_REF:0000107 MGI:3662985 NCBI chr 3:106,777,686...106,797,154
Ensembl chr 3:106,777,635...106,797,142
JBrowse link
G Zfp683 zinc finger protein 683 acts_upstream_of_or_within ISO MGI:4276801 (MGI:5437828|PMID:22885984) RGD PMID:22885984 MGI:5437828 NCBI chr 5:146,277,972...146,285,856 JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pglyrp1 peptidoglycan recognition protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2670590 (MGI:5297102|PMID:20709292)
Ensembl
RGD
PMID:20709292 GO_REF:0000107 MGI:5297102 NCBI chr 1:78,531,815...78,537,001
Ensembl chr 1:78,531,815...78,537,001
JBrowse link
G Pglyrp2 peptidoglycan recognition protein 2 acts_upstream_of_or_within ISO MGI:5297105 (MGI:5297102|PMID:20709292) RGD PMID:20709292 MGI:5297102 NCBI chr 7:11,418,674...11,432,162
Ensembl chr 7:11,418,880...11,427,773
JBrowse link
G Pglyrp3 peptidoglycan recognition protein 3 acts_upstream_of_or_within ISO MGI:5297106 (MGI:5297102|PMID:20709292) RGD PMID:20709292 MGI:5297102 NCBI chr 2:177,479,693...177,490,867
Ensembl chr 2:176,855,732...176,874,162
Ensembl chr 2:176,855,732...176,874,162
JBrowse link
G Pglyrp4 peptidoglycan recognition protein 4 acts_upstream_of_or_within ISO MGI:5297107 (MGI:5297102|PMID:20709292) RGD PMID:20709292 MGI:5297102 NCBI chr 2:176,202,654...176,322,859
Ensembl chr 2:176,218,519...176,242,251
JBrowse link
positive regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axl Axl receptor tyrosine kinase involved_in ISO (PMID:18840707) RGD PMID:18840707 NCBI chr 1:81,265,656...81,296,278
Ensembl chr 1:81,265,088...81,296,265
JBrowse link
G Flt3lg Fms related receptor tyrosine kinase 3 ligand acts_upstream_of_or_within ISO MGI:2158499 (MGI:3701546|PMID:14607906) RGD PMID:14607906 MGI:3701546 NCBI chr 1:95,615,056...95,620,463 JBrowse link
G Gas6 growth arrest specific 6 involved_in ISS
ISO
GO_REF:0000024
(PMID:18840707)
UniProt
RGD
PMID:18840707 GO_REF:0000024 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
JBrowse link
G Il15 interleukin 15 acts_upstream_of_or_within ISO MGI:1931086|MGI:2136897 (MGI:3701546|PMID:14607906), (MGI:3703651|PMID:17318811) RGD PMID:14607906 PMID:17318811 MGI:3701546 MGI:3703651 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il15ra interleukin 15 receptor subunit alpha acts_upstream_of_or_within ISO MGI:1934016 (MGI:3701546|PMID:14607906) RGD PMID:14607906 MGI:3701546 NCBI chr17:66,802,300...66,831,973
Ensembl chr17:66,802,334...66,832,278
JBrowse link
G Il21 interleukin 21 acts_upstream_of_or_within ISO (MGI:3028812|PMID:14764669) RGD PMID:14764669 MGI:3028812 NCBI chr 2:120,119,598...120,126,941
Ensembl chr 2:120,119,444...120,126,996
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in ISO (MGI:5302428|PMID:21957144) RGD PMID:21957144 MGI:5302428 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056
JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:1857249 (MGI:3655409|PMID:9841920) RGD PMID:9841920 MGI:3655409 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2181592 (MGI:3655409|PMID:9841920)
Ensembl
RGD
PMID:9841920 GO_REF:0000107 MGI:3655409 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Tox thymocyte selection-associated high mobility group box acts_upstream_of_or_within ISO MGI:3773716 (MGI:4834966|PMID:20818394) RGD PMID:20818394 MGI:4834966 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272
JBrowse link
G Zbtb1 zinc finger and BTB domain containing 1 involved_in ISO (MGI:5446979|PMID:22753936) RGD PMID:22753936 MGI:5446979 NCBI chr 6:95,096,838...95,125,811
Ensembl chr 6:95,096,387...95,118,996
JBrowse link
regulation of natural killer cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (MGI:5491117|PMID:23408620) RGD PMID:23408620 MGI:5491117 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Prdm1 PR/SET domain 1 involved_in ISO (MGI:5779429|PMID:27102484) RGD PMID:27102484 MGI:5779429 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
JBrowse link
G Zfp683 zinc finger protein 683 involved_in ISO (MGI:5779429|PMID:27102484) RGD PMID:27102484 MGI:5779429 NCBI chr 5:146,277,972...146,285,856 JBrowse link
regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zfp683 zinc finger protein 683 involved_in ISO (MGI:5437828|PMID:22885984) RGD PMID:22885984 MGI:5437828 NCBI chr 5:146,277,972...146,285,856 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19504
    immune system process 2805
      leukocyte activation 1070
        lymphocyte activation 885
          lymphocyte differentiation 424
            natural killer cell differentiation 34
              natural killer cell differentiation involved in immune response + 5
              negative regulation of natural killer cell differentiation + 4
              positive regulation of natural killer cell differentiation + 11
              regulation of natural killer cell differentiation + 18
Path 2
Term Annotations click to browse term
  biological_process 19504
    developmental process 6778
      anatomical structure development 6203
        multicellular organism development 5642
          system development 5310
            animal organ development 4069
              hematopoietic or lymphoid organ development 1029
                hemopoiesis 977
                  leukocyte differentiation 611
                    mononuclear cell differentiation 476
                      lymphocyte differentiation 424
                        natural killer cell differentiation 34
                          natural killer cell differentiation involved in immune response + 5
                          negative regulation of natural killer cell differentiation + 4
                          positive regulation of natural killer cell differentiation + 11
                          regulation of natural killer cell differentiation + 18
paths to the root