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ONTOLOGY REPORT - ANNOTATIONS

Term:microglial cell activation
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Accession:GO:0001774 term browser browse the term
Definition:The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.


show annotations for term's descendants           Sort by:
microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in ISO
IEA		 UniProtKB:P05067 (PMID:15457210)
GO_REF:0000107
UniProtKB:P05067 (MGI:5424311|PMID:22406537)		 RGD
Ensembl		 PMID:15457210 PMID:22406537 GO_REF:0000107 MGI:5424311 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G App amyloid beta precursor protein involved_in ISO
IEA		 UniProtKB:Q15109|UniProtKB:Q62151 (PMID:15457210), (PMID:22406537)
GO_REF:0000107
(PMID:18723082)		 RGD
Ensembl		 PMID:15457210 PMID:18723082 PMID:22406537 GO_REF:0000107 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G C1qa complement C1q A chain involved_in ISO
IEA		 UniProtKB:P05067|UniProtKB:P49768 (MGI:3607035|PMID:15269255)
GO_REF:0000107		 RGD
Ensembl		 PMID:15269255 GO_REF:0000107 MGI:3607035 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C5ar1 complement C5a receptor 1 involved_in ISO UniProtKB:P05067 (MGI:4354701|PMID:19561098) RGD PMID:19561098 MGI:4354701 NCBI chr 1:76,948,622...76,959,826 JBrowse link
G Casp1 caspase 1 IMP RGD PMID:15149850 RGD:2315925 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Clu clusterin involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:15857407)		 Alzheimers_University_of_Toronto
Ensembl
RGD		 PMID:15857407 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Csf1r colony stimulating factor 1 receptor IMP RGD PMID:33841088 RGD:151665762 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in IDA PMID:11870871 RGD
ARUK-UCL		 PMID:20018408 PMID:11870871 RGD:9491804, RGD:4892001 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IMP RGD PMID:24447880 RGD:9491776 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Ifng interferon gamma involved_in ISO
IGI		 ComplexPortal:CPX-1062|UniProtKB:P05067|UniProtKB:P10636|UniProtKB:P49768 (PMID:19808651), (PMID:7715705)
ComplexPortal:CPX-1062|UniProtKB:P05067|UniProtKB:P49768 (MGI:4454469|PMID:20368278), (MGI:5776417|PMID:26227742), (MGI:6305053|PMID:7715705)
PMID:27094552		 RGD PMID:7715705 PMID:19808651 PMID:20368278 PMID:26227742 PMID:27094552 MGI:4454469 MGI:5776417 MGI:6305053, RGD:14397550 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO UniProtKB:P05067 (MGI:3697769|PMID:17255335) RGD PMID:17255335 MGI:3697769 NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785 		JBrowse link
G Ifngr2 interferon gamma receptor 2 involved_in IGI PMID:27094552 ARUK-UCL PMID:27094552 RGD:14397550 NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005 		JBrowse link
G Il13 interleukin 13 IMP RGD PMID:19752235 RGD:8549634 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il4 interleukin 4 IDA RGD PMID:23786632 RGD:8142387 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Itgam integrin subunit alpha M involved_in ISO (MGI:3814938|PMID:18981141) RGD PMID:18981141 MGI:3814938 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Jak2 Janus kinase 2 involved_in ISO UniProtKB:P01580 (MGI:5776417|PMID:26227742) RGD PMID:26227742 MGI:5776417 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit acts_upstream_of_or_within ISO MGI:2445420 (PMID:15233917) RGD PMID:15233917 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 acts_upstream_of_or_within ISO MGI:3720053 (PMID:29540778) RGD PMID:29540778 NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase acts_upstream_of_or_within ISO MGI:1934018 (PMID:26607664) RGD PMID:26607664 NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase IMP RGD PMID:28528966 RGD:13781879 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G P2ry1 purinergic receptor P2Y1 NOT|involved_in IMP PMID:11245682 ARUK-UCL PMID:11245682 RGD:13673788 NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457 		JBrowse link
G P2ry2 purinergic receptor P2Y2 NOT|involved_in IMP PMID:11245682 ARUK-UCL PMID:11245682 RGD:13673788 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632 		JBrowse link
G Snca synuclein alpha acts_upstream_of_or_within ISO MGI:2389489 (PMID:17035541) RGD PMID:17035541 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Tlr1 toll-like receptor 1 IDA RGD PMID:16973131 RGD:1643119 NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125 		JBrowse link
G Tlr2 toll-like receptor 2 IDA RGD PMID:16973131 RGD:1643119 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr3 toll-like receptor 3 IDA RGD PMID:16973131 RGD:1643119 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tlr4 toll-like receptor 4 IDA RGD PMID:16973131 RGD:1643119 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr6 toll-like receptor 6 IDA RGD PMID:16973131 RGD:1643119 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685 		JBrowse link
G Tlr9 toll-like receptor 9 IDA RGD PMID:16973131 RGD:1643119 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO (MGI:6274957|PMID:22950459) RGD PMID:22950459 MGI:6274957 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO ComplexPortal:CPX-1120|UniProtKB:P10636 (MGI:5906931|PMID:28802038), (MGI:6095556|PMID:29073081), (MGI:6150565|PMID:29518356), (MGI:6294162|PMID:28592261), (MGI:6695683|PMID:29663649) RGD PMID:28592261 PMID:28802038 PMID:29073081 PMID:29518356 PMID:29663649 MGI:5906931 MGI:6095556 MGI:6150565 MGI:6294162 MGI:6695683 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:19385063 RGD:2316194 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
microglial cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cx3cr1 C-X3-C motif chemokine receptor 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Grn granulin precursor involved_in ISS
ISO		 GO_REF:0000024
(MGI:4421471|PMID:20026663)		 UniProt
RGD		 PMID:20026663 GO_REF:0000024 MGI:4421471 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Il33 interleukin 33 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5008219|PMID:21349253)		 Ensembl
RGD		 PMID:21349253 GO_REF:0000107 MGI:5008219 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6201658|PMID:30232263) RGD PMID:30232263 MGI:6201658 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in ISO
IBA		 (MGI:5638298|PMID:25690660)
GO_REF:0000033		 RGD
GO_Central		 PMID:25690660 GO_REF:0000033 MGI:5638298 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848 		JBrowse link
negative regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cst7 cystatin F involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:5910746 (PMID:28251676)		 GO_Central
RGD		 PMID:28251676 GO_REF:0000033 NCBI chr 3:139,396,830...139,405,557
Ensembl chr 3:139,396,850...139,405,557 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in IDA PMID:19627440 ARUK-UCL PMID:19627440 RGD:13673772 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Grn granulin precursor involved_in ISS
ISO		 GO_REF:0000024
(MGI:5440302|PMID:23041626)		 UniProt
RGD		 PMID:23041626 GO_REF:0000024 MGI:5440302 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in ISO
IEA		 UniProtKB:P05067|UniProtKB:P49768 (MGI:4415751|PMID:20005821)
GO_REF:0000107		 RGD
Ensembl		 PMID:20005821 GO_REF:0000107 MGI:4415751 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:6283959|PMID:30792350)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:30792350 GO_REF:0000024 GO_REF:0000107 MGI:6283959 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO RNAcentral:URS000024A59E_10090 (MGI:6270781|PMID:30412727) RGD PMID:30412727 MGI:6270781 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Syt11 synaptotagmin 11 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5913303|PMID:28686317)		 UniProt
Ensembl
RGD		 PMID:28686317 GO_REF:0000024 GO_REF:0000107 MGI:5913303 NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964 		JBrowse link
G Tafa3 TAFA chemokine like family member 3 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:25595455)		 GO_Central
RGD		 PMID:25595455 GO_REF:0000033 NCBI chr 2:192,264,153...192,280,356
Ensembl chr 2:192,267,093...192,274,019 		JBrowse link
positive regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsc cathepsin C acts_upstream_of_or_within ISO (PMID:28251676) RGD PMID:28251676 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 IMP RGD PMID:21750563 RGD:329955444 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 IMP RGD PMID:22302802 RGD:13462052 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
(MGI:6201889|PMID:25049354)		 Ensembl
RGD		 PMID:25049354 GO_REF:0000107 MGI:6201889 NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520 		JBrowse link
G Stap1 signal transducing adaptor family member 1 involved_in ISO (MGI:3831067|PMID:19100238) RGD PMID:19100238 MGI:3831067 NCBI chr14:21,950,466...21,981,395
Ensembl chr14:21,952,496...21,981,245 		JBrowse link
G Tafa3 TAFA chemokine like family member 3 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:25595455)		 GO_Central
RGD		 PMID:25595455 GO_REF:0000033 NCBI chr 2:192,264,153...192,280,356
Ensembl chr 2:192,267,093...192,274,019 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO
IBA		 (PMID:24990881)
(MGI:5606096|PMID:24990881), (MGI:6284411|PMID:29752066), (MGI:6304666|PMID:25631124), (MGI:6313424|PMID:30617257), (MGI:6391511|PMID:31370707)
GO_REF:0000033		 RGD
GO_Central		 PMID:24990881 PMID:25631124 PMID:29752066 PMID:30617257 PMID:31370707 GO_REF:0000033 MGI:5606096 MGI:6284411 MGI:6304666 MGI:6313424 MGI:6391511 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Ttbk1 tau tubulin kinase 1 involved_in ISO (PMID:19118186) RGD PMID:19118186 NCBI chr 9:14,493,166...14,538,372
Ensembl chr 9:14,493,389...14,535,774 		JBrowse link
regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP RGD PMID:28007901 RGD:12879399 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Calhm2 calcium homeostasis modulator family member 2 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:246,022,324...246,028,050
Ensembl chr 1:246,022,324...246,028,218 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 IMP rat gene in mouse model RGD PMID:17473852 RGD:5688754 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6158194|PMID:29662056)		 UniProt
RGD		 PMID:29662056 GO_REF:0000024 MGI:6158194 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    cellular process 18812
      cell activation 1204
        glial cell activation 63
          microglial cell activation 51
            microglial cell activation involved in immune response 5
            negative regulation of microglial cell activation 8
            positive regulation of microglial cell activation 8
            regulation of microglial cell activation + 19
Path 2
Term Annotations click to browse term
  biological_process 20413
    response to stimulus 10920
      response to stress 4281
        defense response 1894
          inflammatory response 854
            neuroinflammatory response 89
              glial cell activation 63
                microglial cell activation 51
                  microglial cell activation involved in immune response 5
                  negative regulation of microglial cell activation 8
                  positive regulation of microglial cell activation 8
                  regulation of microglial cell activation + 19
paths to the root