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ONTOLOGY REPORT - ANNOTATIONS

Term:immunological synapse
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Accession:GO:0001772 term browser browse the term
Definition:An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: supramolecular activation cluster
 narrow_synonym: c-SMAC
 xref: Wikipedia:Immunological_synapse

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immunological synapse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alcam activated leukocyte cell adhesion molecule located_in ISO (PMID:15294938) UniProt PMID:15294938 NCBI chrNW_004624731:44,092,505...44,280,022
Ensembl chrNW_004624731:44,091,769...44,280,621 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha located_in ISO (PMID:11728336) MGI PMID:11728336 NCBI chrNW_004624801:10,719,987...10,723,263
Ensembl chrNW_004624801:10,717,133...10,722,840 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 located_in ISO (MGI:6114568|PMID:28827723) UniProt PMID:28827723 MGI:6114568 NCBI chrNW_004624750:16,990,288...17,103,279 JBrowse link
G Bcl10 BCL10 immune signaling adaptor located_in ISO (PMID:14724296) MGI PMID:14724296 NCBI chrNW_004624742:12,210,333...12,222,533
Ensembl chrNW_004624742:12,210,360...12,221,759 		JBrowse link
G Card11 caspase recruitment domain family member 11 located_in ISO (PMID:23793062) MGI PMID:23793062 NCBI chrNW_004624740:29,974,707...30,085,498
Ensembl chrNW_004624740:29,974,689...30,085,981 		JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 located_in ISO (PMID:23793062) MGI PMID:23793062 NCBI chrNW_004624746:18,692,179...18,704,952
Ensembl chrNW_004624746:18,692,225...18,704,476 		JBrowse link
G Cd28 CD28 molecule located_in ISO (PMID:23793062) MGI PMID:23793062 NCBI chrNW_004624765:12,650,092...12,667,168 JBrowse link
G Cd37 CD37 molecule located_in ISO (PMID:21930792) UniProt PMID:21930792 NCBI chrNW_004624832:4,837,247...4,842,126
Ensembl chrNW_004624832:4,837,247...4,841,756 		JBrowse link
G Cd3e CD3e molecule located_in ISO (PMID:14635057), (PMID:15064761) MGI PMID:14635057 PMID:15064761 NCBI chrNW_004624784:13,714,667...13,726,881
Ensembl chrNW_004624784:13,712,920...13,726,950 		JBrowse link
G Cd53 CD53 molecule located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624772:6,630,152...6,660,871
Ensembl chrNW_004624772:6,630,123...6,661,599 		JBrowse link
G Cd6 CD6 molecule located_in ISO (PMID:15294938) UniProt PMID:15294938 NCBI chrNW_004624926:325,327...333,405
Ensembl chrNW_004624926:324,828...333,246 		JBrowse link
G Cd81 CD81 molecule located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624767:15,192,446...15,210,923
Ensembl chrNW_004624767:15,192,452...15,210,922 		JBrowse link
G Coro1a coronin 1A located_in ISO (PMID:24760828)
(PMID:18199416)		 UniProt
MGI		 PMID:18199416 PMID:24760828 NCBI chrNW_004624782:13,106,416...13,111,394
Ensembl chrNW_004624782:13,105,153...13,111,357 		JBrowse link
G Cracr2a calcium release activated channel regulator 2A located_in ISO (PMID:27016526) UniProt PMID:27016526 NCBI chrNW_004624860:846,420...959,600
Ensembl chrNW_004624860:849,278...959,584 		JBrowse link
G Crtam cytotoxic and regulatory T cell molecule located_in ISO (MGI:3834299|PMID:18329370) UniProt PMID:18329370 MGI:3834299 NCBI chrNW_004624880:2,229,201...2,240,068 JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 located_in ISO (PMID:20551903)
(PMID:15699074)		 UniProt
MGI		 PMID:15699074 PMID:20551903 NCBI chrNW_004624730:62,001,547...62,223,098
Ensembl chrNW_004624730:62,002,280...62,223,319 		JBrowse link
G Dusp3 dual specificity phosphatase 3 located_in ISO (PMID:12447358) UniProt PMID:12447358 NCBI chrNW_004624795:994,103...1,001,697 JBrowse link
G Ezr ezrin located_in ISO (PMID:17911601), (PMID:20551903) UniProt PMID:17911601 PMID:20551903 NCBI chrNW_004624929:827,275...873,743
Ensembl chrNW_004624929:826,531...873,572 		JBrowse link
G Fyb2 FYN binding protein 2 located_in ISO (PMID:27335501) UniProt PMID:27335501 NCBI chrNW_004624862:3,323,643...3,463,825 JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 located_in ISO (MGI:5705214|PMID:24337741) UniProt PMID:24337741 MGI:5705214 NCBI chrNW_004624733:32,521,318...32,527,499 JBrowse link
G Icam1 intercellular adhesion molecule 1 located_in ISO (MGI:6838590|PMID:27359298), (PMID:14973438) UniProt PMID:14973438 PMID:27359298 MGI:6838590 NCBI chrNW_004624828:2,432,584...2,451,997
Ensembl chrNW_004624828:2,432,550...2,453,071 		JBrowse link
G Il4i1 interleukin 4 induced 1 located_in ISO (PMID:28891065) UniProt PMID:28891065 NCBI chrNW_004624832:4,404,818...4,444,551
Ensembl chrNW_004624832:4,431,903...4,444,651 		JBrowse link
G Itgal integrin subunit alpha L located_in ISO (PMID:15064761) MGI PMID:15064761 NCBI chrNW_004624782:13,635,217...13,671,401
Ensembl chrNW_004624782:13,640,996...13,669,541 		JBrowse link
G Lat linker for activation of T cells located_in ISO (PMID:12646565)
(PMID:14635057)		 HGNC-UCL
MGI		 PMID:12646565 PMID:14635057 NCBI chrNW_004624782:12,795,104...12,799,496
Ensembl chrNW_004624782:12,795,104...12,799,410 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase located_in ISO (PMID:20007709) MGI PMID:20007709 NCBI chrNW_004624764:15,469,582...15,495,351
Ensembl chrNW_004624764:15,472,685...15,495,351 		JBrowse link
G Lgals3 galectin 3 located_in ISO (MGI:4355752|PMID:19706535)
(PMID:19706535)		 BHF-UCL PMID:19706535 MGI:4355752 NCBI chrNW_004624731:14,300,138...14,307,843
Ensembl chrNW_004624731:14,298,201...14,304,637 		JBrowse link
G LOC101706353 HLA class II histocompatibility antigen, DR alpha chain located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624754:24,079,459...24,086,342
Ensembl chrNW_004624754:24,079,366...24,084,512 		JBrowse link
G LOC101716577 tyrosine-protein kinase ZAP-70 located_in ISO (MGI:3686961|PMID:17028588) UniProt PMID:17028588 MGI:3686961 NCBI chrNW_004624749:2,893,601...2,901,256
Ensembl chrNW_004624749:2,893,601...2,901,035 		JBrowse link
G Myh9 myosin heavy chain 9 located_in ISO (PMID:15064761) MGI PMID:15064761 NCBI chrNW_004624752:11,327,881...11,414,037
Ensembl chrNW_004624752:11,327,877...11,413,669 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 located_in ISO (MGI:6838590|PMID:27359298) UniProt PMID:27359298 MGI:6838590 NCBI chrNW_004624756:14,663,114...14,850,132
Ensembl chrNW_004624756:14,737,054...14,850,708 		JBrowse link
G Nptn neuroplastin located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624781:752,048...818,250
Ensembl chrNW_004624781:751,912...819,847 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein located_in ISO (PMID:19706535) BHF-UCL PMID:19706535 NCBI chrNW_004624788:11,772,268...11,849,040
Ensembl chrNW_004624788:11,772,396...11,845,765 		JBrowse link
G Prf1 perforin 1 is_active_in ISO (PMID:8164737) UniProt PMID:8164737 NCBI chrNW_004624754:4,679,451...4,681,627
Ensembl chrNW_004624754:4,679,521...4,681,627 		JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624870:3,552,608...3,575,461
Ensembl chrNW_004624870:3,552,745...3,574,880 		JBrowse link
G Prkcq protein kinase C theta located_in ISO (PMID:11728336), (PMID:12867038), (PMID:15117976), (PMID:15128768), (PMID:23793062) MGI PMID:11728336 PMID:12867038 PMID:15117976 PMID:15128768 PMID:23793062 NCBI chrNW_004624775:1,419,596...1,543,805
Ensembl chrNW_004624775:1,419,509...1,502,064 		JBrowse link
G Ptprj protein tyrosine phosphatase receptor type J located_in ISO (MGI:4942249|PMID:12913111)
(PMID:12913111)		 UniProt PMID:12913111 MGI:4942249 NCBI chrNW_004624767:942,786...1,051,112
Ensembl chrNW_004624767:945,553...1,051,138 		JBrowse link
G Rhoh ras homolog family member H located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624761:26,717,857...26,721,628
Ensembl chrNW_004624761:26,720,478...26,721,053 		JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein located_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624786:8,975,216...8,982,825
Ensembl chrNW_004624786:8,974,587...9,007,986 		JBrowse link
G Scrib scribble planar cell polarity protein located_in ISO (MGI:3834299|PMID:18329370) UniProt PMID:18329370 MGI:3834299 NCBI chrNW_004624735:12,997,358...13,018,765
Ensembl chrNW_004624735:12,997,408...13,018,533 		JBrowse link
G Skap1 src kinase associated phosphoprotein 1 located_in ISO (PMID:12652296) BHF-UCL PMID:12652296 NCBI chrNW_004624795:4,726,715...4,960,167
Ensembl chrNW_004624795:4,727,149...4,960,082 		JBrowse link
G Snx27 sorting nexin 27 located_in ISO (PMID:17644068) UniProt PMID:17644068 NCBI chrNW_004624772:19,305,355...19,385,298
Ensembl chrNW_004624772:19,305,359...19,385,292 		JBrowse link
G Socs6 suppressor of cytokine signaling 6 located_in ISO (PMID:20007709) MGI PMID:20007709 NCBI chrNW_004624806:10,921,204...10,949,108 JBrowse link
G Stoml2 stomatin like 2 located_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624915:294,781...298,312
Ensembl chrNW_004624915:294,777...298,278 		JBrowse link
G Stx7 syntaxin 7 located_in ISO (PMID:21438968) UniProt PMID:21438968 NCBI chrNW_004624753:6,511,516...6,554,406
Ensembl chrNW_004624753:6,514,056...6,547,480 		JBrowse link
G Vav3 vav guanine nucleotide exchange factor 3 part_of ISO (PMID:15708849) CACAO PMID:15708849 NCBI chrNW_004624772:3,604,553...4,022,986
Ensembl chrNW_004624772:3,604,165...4,022,990 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 15718
    cellular anatomical entity 15620
      immunological synapse 45
Path 2
Term Annotations click to browse term
  cellular_component 15718
    cellular anatomical entity 15620
      membrane 7608
        plasma membrane 4644
          immunological synapse 45
paths to the root