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ONTOLOGY REPORT - ANNOTATIONS


Term:immunological synapse formation
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Accession:GO:0001771 term browser browse the term
Definition:The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: formation of immunological synapse


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immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr 5:58,197,678...58,198,782
Ensembl chr 5:58,197,680...58,198,782
JBrowse link
G Cd6 Cd6 molecule involved_in ISO (PMID:15294938) RGD PMID:15294938 NCBI chr 1:226,848,399...226,887,259
Ensembl chr 1:226,848,403...226,887,156
JBrowse link
G Cd81 Cd81 molecule involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:23858057)
UniProt
Ensembl
RGD
PMID:23858057 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311
JBrowse link
G Coro1a coronin 1A NOT|involved_in ISO (PMID:24760828) RGD PMID:24760828 NCBI chr 1:198,123,883...198,128,890
Ensembl chr 1:198,123,884...198,128,857
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3528803|PMID:15699074)
Ensembl
RGD
PMID:15699074 GO_REF:0000107 MGI:3528803 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895
JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within ISO MGI:2152031 (MGI:2668308|PMID:12871644) RGD PMID:12871644 MGI:2668308 NCBI chr10:19,181,512...19,603,171 JBrowse link
G Dock8 dedicator of cytokinesis 8 acts_upstream_of_or_within ISO MGI:3835421 (MGI:5300105|PMID:22006977) RGD PMID:22006977 MGI:5300105 NCBI chr 1:242,934,685...243,153,472
Ensembl chr 1:242,959,488...243,153,465
JBrowse link
G Msn moesin involved_in ISO
ISS
IEA
(PMID:27405666)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:27405666 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:65,226,834...65,294,192
Ensembl chr  X:65,226,748...65,295,810
JBrowse link
G Prf1 perforin 1 involved_in ISO
IEA
(PMID:21438968)
GO_REF:0000107
RGD
Ensembl
PMID:21438968 GO_REF:0000107 NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382
JBrowse link
negative regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:5705214|PMID:24337741) RGD PMID:24337741 MGI:5705214 NCBI chr10:31,561,838...31,590,624
Ensembl chr10:31,561,895...31,588,943
JBrowse link
G Lgals3 galectin 3 involved_in ISO (MGI:4355752|PMID:19706535) RGD PMID:19706535 MGI:4355752 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
positive regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19599
    cellular process 18451
      cell recognition 266
        cell-cell recognition 72
          immunological synapse formation 13
            negative regulation of immunological synapse formation 2
            positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
            positive regulation of immunological synapse formation 1
            regulation of immunological synapse formation + 3
Path 2
Term Annotations click to browse term
  biological_process 19599
    cellular process 18451
      cell activation 1208
        leukocyte activation 1069
          lymphocyte activation 883
            immunological synapse formation 13
              negative regulation of immunological synapse formation 2
              positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
              positive regulation of immunological synapse formation 1
              regulation of immunological synapse formation + 3
paths to the root