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ONTOLOGY REPORT - ANNOTATIONS


Term:immunological synapse formation
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Accession:GO:0001771 term browser browse the term
Definition:The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
Synonyms:exact_synonym: formation of immunological synapse



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immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
JBrowse link
G Cd6 Cd6 molecule involved_in ISO (PMID:15294938) RGD PMID:15294938 NCBI chr 1:207,442,873...207,481,703
Ensembl chr 1:207,442,877...207,481,634
JBrowse link
G Cd81 Cd81 molecule involved_in ISS
ISO
GO_REF:0000024
(PMID:23858057)
UniProt
RGD
PMID:23858057 GO_REF:0000024 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660
JBrowse link
G Coro1a coronin 1A NOT|involved_in ISO (PMID:24760828) RGD PMID:24760828 NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3528803|PMID:15699074)
Ensembl
RGD
PMID:15699074 GO_REF:0000107 MGI:3528803 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within ISO MGI:2152031 (MGI:2668308|PMID:12871644) RGD PMID:12871644 MGI:2668308 NCBI chr10:18,827,237...19,244,823
Ensembl chr10:18,827,239...19,244,808
JBrowse link
G Dock8 dedicator of cytokinesis 8 acts_upstream_of_or_within ISO MGI:3835421 (MGI:5300105|PMID:22006977) RGD PMID:22006977 MGI:5300105 NCBI chr 1:222,649,309...222,842,474
Ensembl chr 1:222,649,309...222,842,474
JBrowse link
G Ephb1 Eph receptor B1 acts_upstream_of_or_within IGI PMID:17310244 MGI PMID:17310244 PMID:17310244 RGD:10047256, RGD:10047256 NCBI chr 8:102,507,549...102,944,839
Ensembl chr 8:102,507,549...102,944,839
JBrowse link
G Git1 GIT ArfGAP 1 acts_upstream_of_or_within IGI PMID:17310244 MGI PMID:17310244 PMID:17310244 RGD:10047256, RGD:10047256 NCBI chr10:62,342,082...62,356,379
Ensembl chr10:62,342,299...62,356,373
JBrowse link
G Msn moesin involved_in ISO
ISS
(PMID:27405666)
GO_REF:0000024
RGD
UniProt
PMID:27405666 GO_REF:0000024 NCBI chr  X:60,996,043...61,064,011
Ensembl chr  X:60,995,951...61,065,628
JBrowse link
G Nck2 NCK adaptor protein 2 acts_upstream_of_or_within IGI PMID:17310244 MGI PMID:17310244 PMID:17310244 RGD:10047256, RGD:10047256 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307
JBrowse link
G Prf1 perforin 1 involved_in ISO
IBA
(PMID:21438968)
PMID:21873635
RGD PMID:21438968 PMID:21873635 RGD:13792537 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
JBrowse link
negative regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:5705214|PMID:24337741) RGD PMID:24337741 MGI:5705214 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137
JBrowse link
G Lgals3 galectin 3 involved_in ISO (MGI:4355752|PMID:19706535) RGD PMID:19706535 MGI:4355752 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
positive regulation of immunological synapse formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 involved_in ISO (MGI:6838590|PMID:27359298) RGD PMID:27359298 MGI:6838590 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19876
    cellular process 18552
      cell recognition 199
        cell-cell recognition 80
          immunological synapse formation 17
            negative regulation of immunological synapse formation 2
            positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
            positive regulation of immunological synapse formation 2
            regulation of immunological synapse formation + 4
Path 2
Term Annotations click to browse term
  biological_process 19876
    cellular process 18552
      cell activation 1196
        leukocyte activation 1042
          lymphocyte activation 853
            immunological synapse formation 17
              negative regulation of immunological synapse formation 2
              positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation 1
              positive regulation of immunological synapse formation 2
              regulation of immunological synapse formation + 4
paths to the root