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ONTOLOGY REPORT - ANNOTATIONS

Term:ruffle
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Accession:GO:0001726 term browser browse the term
Definition:Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
Synonyms:related_synonym: membrane ruffle
 never_in_taxon: NCBITaxon:2 ! Bacteria;   NCBITaxon:33090 ! Viridiplantae;   NCBITaxon:4751 ! Fungi;   NCBITaxon:4890 ! Ascomycota


show annotations for term's descendants           Sort by:
ruffle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO RGD PMID:16831423 RGD:1598670 NCBI chr 9:101,834,189...102,005,811
Ensembl chr 9:130,484,333...130,652,941 		JBrowse link
G ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 located_in IEA Ensembl GO_REF:0000107 NCBI chr 3:192,577,813...192,750,435
Ensembl chr 3:202,876,819...203,048,239 		JBrowse link
G ACTN1 actinin alpha 1 located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr14:49,460,390...49,565,986
Ensembl chr14:68,335,694...68,440,836 		JBrowse link
G ACTR3 actin related protein 3 ISO RGD PMID:10209028 RGD:2306208 NCBI chr2B:827,184...900,424
Ensembl chr2B:114,373,392...114,445,729 		JBrowse link
G AIF1 allograft inflammatory factor 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr 6:31,276,215...31,278,051
Ensembl chr 6:32,166,301...32,168,125 		JBrowse link
G ALS2 alsin Rho guanine nucleotide exchange factor ALS2 located_in IEA Ensembl GO_REF:0000107 NCBI chr2B:88,954,167...89,034,764
Ensembl chr2B:207,108,952...207,189,623 		JBrowse link
G AMOT angiomotin located_in IEA Ensembl GO_REF:0000107 NCBI chr  X:101,907,032...101,973,052
Ensembl chr  X:112,362,633...112,428,216 		JBrowse link
G ANXA2 annexin A2 ISO RGD PMID:19193640 RGD:7242275 NCBI chr15:39,322,303...39,371,565
Ensembl chr15:57,625,425...57,674,250 		JBrowse link
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 located_in IEA UniProt
Ensembl		 GO_REF:0000044 GO_REF:0000107 NCBI chr 3:57,161,299...57,206,672
Ensembl chr 3:58,370,430...58,415,258 		JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 located_in IEA Ensembl GO_REF:0000107 NCBI chr12:102,755,388...102,818,686
Ensembl chr12:106,151,969...106,206,879 		JBrowse link
G ARF6 ADP ribosylation factor 6 located_in ISO
IEA		 RGD
TreeGrafter
UniProt
Ensembl		 PMID:11950936 GO_REF:0000044 GO_REF:0000107 GO_REF:0000118 RGD:727254 NCBI chr14:30,482,191...30,486,741
Ensembl chr14:48,789,329...48,789,856 		JBrowse link
G ARFIP2 ADP ribosylation factor interacting protein 2 located_in IEA Ensembl GO_REF:0000107 NCBI chr11:6,608,393...6,613,245
Ensembl chr11:6,290,034...6,296,817 		JBrowse link
G ARHGAP1 Rho GTPase activating protein 1 located_in ISO (PMID:15860730) MGI PMID:15860730 NCBI chr11:46,626,174...46,651,308
Ensembl chr11:47,185,415...47,209,765 		JBrowse link
G ARHGAP18 Rho GTPase activating protein 18 part_of
located_in		 ISO
IEA		 (PMID:28251925) CACAO
Ensembl		 PMID:28251925 GO_REF:0000107 NCBI chr 6:127,368,377...127,558,136
Ensembl chr 6:131,477,383...131,609,221 		JBrowse link
G ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:22,620,812...22,676,755
Ensembl chr 1:23,606,579...23,662,472 		JBrowse link
G ATP6V1B2 ATPase H+ transporting V1 subunit B2 located_in IEA Ensembl GO_REF:0000107 NCBI chr 8:19,422,423...19,446,799
Ensembl chr 8:16,369,937...16,394,284 		JBrowse link
G BAIAP2 BAR/IMD domain containing adaptor protein 2 located_in IEA UniProt GO_REF:0000044 NCBI chr17:75,460,491...75,542,700
Ensembl chr17:81,187,021...81,269,714 		JBrowse link
G BCAR1 BCAR1 scaffold protein, Cas family member located_in IEA Ensembl GO_REF:0000107 NCBI chr16:55,798,578...55,838,448
Ensembl chr16:75,150,122...75,188,775 		JBrowse link
G BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 located_in
is_active_in		 IEA
ISO		 (PMID:19116644) Ensembl
MGI		 PMID:19116644 GO_REF:0000107 NCBI chr15:24,469,225...24,553,163
Ensembl chr15:42,862,112...42,882,316 		JBrowse link
G CARMIL2 capping protein regulator and myosin 1 linker 2 located_in IEA Ensembl GO_REF:0000107 NCBI chr16:47,989,040...48,001,455
Ensembl chr16:67,378,353...67,390,709 		JBrowse link
G CD2AP CD2 associated protein located_in IEA Ensembl GO_REF:0000107 NCBI chr 6:47,065,284...47,210,746
Ensembl chr 6:48,328,863...48,474,163 		JBrowse link
G CDK6 cyclin dependent kinase 6 located_in ISO (PMID:10205165) BHF-UCL PMID:10205165 NCBI chr 7:84,603,419...84,835,082 JBrowse link
G CIT citron rho-interacting serine/threonine kinase located_in ISO (PMID:12781320) MGI PMID:12781320 NCBI chr12:117,264,627...117,456,069
Ensembl chr12:120,641,747...120,832,511 		JBrowse link
G COBL cordon-bleu WH2 repeat protein located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:51,652,318...51,952,256
Ensembl chr 7:51,895,807...52,097,841 		JBrowse link
G CSPG4 chondroitin sulfate proteoglycan 4 located_in IEA Ensembl GO_REF:0000107 NCBI chr15:54,583,010...54,621,240
Ensembl chr15:74,177,909...74,200,498 		JBrowse link
G CTTN cortactin located_in IEA Ensembl GO_REF:0000107 NCBI chr11:65,500,074...65,539,158
Ensembl chr11:68,794,162...68,823,857 		JBrowse link
G CYTH2 cytohesin 2 ISO RGD PMID:12032543 RGD:625544 NCBI chr19:45,471,277...45,481,350
Ensembl chr19:54,063,560...54,073,017 		JBrowse link
G CYTH3 cytohesin 3 located_in IEA Ensembl GO_REF:0000107 NCBI chr 7:7,170,064...7,283,000
Ensembl chr 7:6,357,978...6,386,756 		JBrowse link
G DBNL drebrin like located_in IEA UniProt GO_REF:0000044 NCBI chr 7:44,753,062...44,775,717
Ensembl chr 7:44,824,608...44,845,891 		JBrowse link
G EZR ezrin located_in IEA Ensembl GO_REF:0000107 NCBI chr 6:156,656,146...156,709,986
Ensembl chr 6:161,670,483...161,723,102 		JBrowse link
G FGD1 FYVE, RhoGEF and PH domain containing 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr  X:46,648,765...46,699,444
Ensembl chr  X:54,880,513...54,930,672 		JBrowse link
G FGD2 FYVE, RhoGEF and PH domain containing 2 located_in IEA Ensembl GO_REF:0000107 NCBI chr 6:36,566,942...36,591,044
Ensembl chr 6:37,762,809...37,785,291 		JBrowse link
G FRMD4B FERM domain containing 4B located_in IEA Ensembl GO_REF:0000107 NCBI chr 3:69,105,231...69,478,192
Ensembl chr 3:70,471,897...70,686,895 		JBrowse link
G FSCN1 fascin actin-bundling protein 1 located_in ISO (PMID:3525578) RGD
UniProt		 PMID:3525578 PMID:7657718 RGD:2317778 NCBI chr 7:5,848,902...5,862,756 JBrowse link
G FSCN3 fascin actin-bundling protein 3 located_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:119,589,219...119,597,360
Ensembl chr 7:132,244,268...132,250,913 		JBrowse link
G GAS7 growth arrest specific 7 located_in ISO (PMID:11795944) MGI PMID:11795944 NCBI chr17:41,454,100...41,743,777
Ensembl chr17:46,200,364...46,480,618 		JBrowse link
G GNAS GNAS complex locus ISO Gnas, Alex RGD PMID:11447126 RGD:5509808 NCBI chr20:55,190,607...55,262,245 JBrowse link
G GSN gelsolin ISO RGD PMID:16280379 RGD:1599859 NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831 		JBrowse link
G INPP5E inositol polyphosphate-5-phosphatase E ISO RGD PMID:10405344 RGD:1299274 NCBI chr 9:107,502,838...107,516,325
Ensembl chr 9:136,483,144...136,492,731 		JBrowse link
G INPP5J inositol polyphosphate-5-phosphatase J located_in ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:10593988 GO_REF:0000107 GO_REF:0000118 RGD:633686 NCBI chr22:12,131,746...12,158,481
Ensembl chr22:29,984,096...29,995,256 		JBrowse link
G INPP5K inositol polyphosphate-5-phosphatase K located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:1,477,511...1,499,765
Ensembl chr17:1,377,312...1,399,373 		JBrowse link
G IQGAP1 IQ motif containing GTPase activating protein 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr15:69,076,025...69,190,082
Ensembl chr15:88,276,851...88,388,594 		JBrowse link
G ITGB1BP1 integrin subunit beta 1 binding protein 1 located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr2A:9,396,553...9,413,408
Ensembl chr2A:9,556,857...9,577,155 		JBrowse link
G KIF18A kinesin family member 18A located_in IEA Ensembl GO_REF:0000107 NCBI chr11:27,989,506...28,076,078
Ensembl chr11:27,888,435...27,976,429 		JBrowse link
G KNSTRN kinetochore localized astrin (SPAG5) binding protein located_in ISO (PMID:26242911) ARUK-UCL PMID:26242911 NCBI chr15:19,316,854...19,328,425 JBrowse link
G LCP1 lymphocyte cytosolic protein 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr13:26,820,846...26,906,916 JBrowse link
G LIMA1 LIM domain and actin binding 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr12:38,473,223...38,580,511
Ensembl chr12:39,399,611...39,476,142 		JBrowse link
G LOC100987922 SH2B adapter protein 2 located_in ISO (PMID:15946664) MGI PMID:15946664
G MKLN1 muskelin 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr 7:123,075,319...123,463,509
Ensembl chr 7:135,806,585...135,968,032 		JBrowse link
G MTM1 myotubularin 1 located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr  X:140,218,742...140,323,495
Ensembl chr  X:150,174,758...150,255,381 		JBrowse link
G MTMR14 myotubularin related protein 14 located_in IEA Ensembl GO_REF:0000107 NCBI chr 3:9,600,866...9,653,860
Ensembl chr 3:9,839,821...9,892,055 		JBrowse link
G MTSS2 MTSS I-BAR domain containing 2 located_in IEA Ensembl GO_REF:0000107 NCBI chr16:54,331,300...54,338,656
Ensembl chr16:70,497,625...70,514,716 		JBrowse link
G MYADM myeloid associated differentiation marker located_in IEA Ensembl GO_REF:0000107 NCBI chr19:50,807,615...50,817,196
Ensembl chr19:59,663,790...59,664,758 		JBrowse link
G MYH9 myosin heavy chain 9 located_in IEA Ensembl GO_REF:0000107 NCBI chr22:17,200,623...17,305,826
Ensembl chr22:35,039,101...35,121,618 		JBrowse link
G MYO5A myosin VA located_in IEA Ensembl GO_REF:0000107 NCBI chr15:31,246,192...31,470,040
Ensembl chr15:49,578,491...49,704,319 		JBrowse link
G MYO6 myosin VI located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:73,593,794...73,764,352
Ensembl chr 6:76,951,634...77,048,796 		JBrowse link
G MYO9B myosin IXB ISO RGD PMID:9348541 RGD:1581711 NCBI chr19:16,563,005...16,700,312 JBrowse link
G MYO9B myosin IXB located_in IEA TreeGrafter GO_REF:0000118 Ensembl chr19:17,562,568...17,674,279 JBrowse link
G NCKAP1 NCK associated protein 1 located_in ISO (MGI:5897521|PMID:27927633) BHF-UCL PMID:27927633 MGI:5897521 NCBI chr2B:70,193,950...70,308,442
Ensembl chr2B:188,003,235...188,116,710 		JBrowse link
G NF2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor located_in IEA Ensembl GO_REF:0000107 NCBI chr22:10,648,022...10,738,167
Ensembl chr22:28,454,119...28,544,013 		JBrowse link
G NHERF1 NHERF family PDZ scaffold protein 1 located_in IEA UniProt GO_REF:0000044 NCBI chr17:68,694,468...68,715,157
Ensembl chr17:74,250,406...74,271,234 		JBrowse link
G NME2 NME/NM23 nucleoside diphosphate kinase 2 located_in ISO (PMID:11919189) HGNC-UCL PMID:11919189 NCBI chr17:45,255,982...45,261,541 JBrowse link
G PAK1 p21 (RAC1) activated kinase 1 located_in ISO
IEA		 RGD
Ensembl		 PMID:19574218 GO_REF:0000107 RGD:11533928 NCBI chr11:72,372,577...72,524,817
Ensembl chr11:76,015,998...76,104,197 		JBrowse link
G PALLD palladin, cytoskeletal associated protein ISO RGD PMID:16868024 RGD:2325783 NCBI chr 4:160,718,475...161,140,436 JBrowse link
G PDGFRB platelet derived growth factor receptor beta located_in ISO (PMID:26437238) MGI PMID:26437238 NCBI chr 5:145,538,330...145,580,312
Ensembl chr 5:151,543,891...151,585,530 		JBrowse link
G PDLIM7 PDZ and LIM domain 7 located_in IEA Ensembl GO_REF:0000107 NCBI chr 5:172,784,656...172,798,875
Ensembl chr 5:179,846,476...179,860,619 		JBrowse link
G PDPN podoplanin located_in ISO (MGI:1351508|PMID:10574709) UniProt PMID:10574709 MGI:1351508 NCBI chr 1:12,728,569...12,759,781
Ensembl chr 1:13,728,233...13,759,584 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:9148965 RGD:11541088 NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067 		JBrowse link
G PLCG1 phospholipase C gamma 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr20:37,477,077...37,515,854
Ensembl chr20:38,572,709...38,615,145 		JBrowse link
G PODXL podocalyxin like located_in IEA UniProt GO_REF:0000044 NCBI chr 7:123,467,140...123,523,503
Ensembl chr 7:135,984,592...135,992,815 		JBrowse link
G PTK6 protein tyrosine kinase 6 located_in IEA Ensembl GO_REF:0000107 Ensembl chr20:61,453,386...61,462,951 JBrowse link
G RAB34 RAB34, member RAS oncogene family located_in ISO (PMID:12446704) MGI PMID:12446704 NCBI chr17:28,057,077...28,061,234
Ensembl chr17:28,562,118...28,566,242 		JBrowse link
G RAB5A RAB5A, member RAS oncogene family located_in ISO (PMID:12446704), (PMID:21419809) MGI PMID:12446704 PMID:21419809 NCBI chr 3:19,866,110...19,903,701
Ensembl chr 3:20,197,067...20,234,579 		JBrowse link
G RASA1 RAS p21 protein activator 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr 5:27,980,907...28,104,368
Ensembl chr 5:28,115,159...28,240,321 		JBrowse link
G RDX radixin located_in ISO (PMID:9563848) MGI PMID:9563848 NCBI chr11:105,075,716...105,176,660
Ensembl chr11:108,921,477...109,005,557 		JBrowse link
G RINL Ras and Rab interactor like located_in IEA Ensembl GO_REF:0000107 NCBI chr19:35,971,639...35,984,448
Ensembl chr19:44,524,823...44,532,150 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr18:14,192,293...14,352,357
Ensembl chr18:17,833,047...17,990,086 		JBrowse link
G S100A11 S100 calcium binding protein A11 located_in IEA Ensembl GO_REF:0000107 NCBI chr 1:127,391,695...127,396,231
Ensembl chr 1:131,034,588...131,035,882 		JBrowse link
G S100A6 S100 calcium binding protein A6 located_in IEA Ensembl GO_REF:0000107 NCBI chr 1:128,889,749...128,891,425
Ensembl chr 1:132,518,834...132,520,499 		JBrowse link
G S100B S100 calcium binding protein B located_in ISO (PMID:10913138) UniProt PMID:10913138 NCBI chr21:33,063,845...33,070,073
Ensembl chr21:46,197,750...46,203,953 		JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein located_in IEA Ensembl GO_REF:0000107 NCBI chr17:5,258,376...5,283,747
Ensembl chr17:5,247,307...5,270,817 		JBrowse link
G TESC tescalcin located_in ISO (MGI:3688373|PMID:14661968) HGNC-UCL PMID:14661968 MGI:3688373 NCBI chr12:114,615,155...114,675,932
Ensembl chr12:117,991,047...118,051,346 		JBrowse link
G TLN1 talin 1 located_in IEA InterPro GO_REF:0000002 NCBI chr 9:35,549,328...35,583,376
Ensembl chr 9:36,351,836...36,379,228 		JBrowse link
G TLN2 talin 2 located_in IEA InterPro GO_REF:0000002 NCBI chr15:41,337,084...41,790,949
Ensembl chr15:59,892,920...60,088,414 		JBrowse link
G TLR4 toll like receptor 4 located_in IEA UniProt GO_REF:0000044 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
G TMEM87A transmembrane protein 87A located_in ISO (PMID:32228863) UniProt PMID:32228863 NCBI chr15:21,164,958...21,227,644
Ensembl chr15:39,325,412...39,386,297 		JBrowse link
G TNFRSF12A TNF receptor superfamily member 12A located_in ISO (PMID:14573547) MGI PMID:14573547 NCBI chr16:1,962,179...1,964,223
Ensembl chr16:3,134,577...3,136,581 		JBrowse link
G TRPM7 transient receptor potential cation channel subfamily M member 7 located_in IEA Ensembl GO_REF:0000107 NCBI chr15:29,513,220...29,639,506
Ensembl chr15:47,853,187...47,977,451 		JBrowse link
G VIL1 villin 1 located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr2B:105,677,371...105,711,293
Ensembl chr2B:224,274,548...224,304,550 		JBrowse link
G WASF2 WASP family member 2 located_in ISO (PMID:12446704) MGI PMID:12446704 NCBI chr 1:26,665,853...26,750,618
Ensembl chr 1:27,717,538...27,737,316 		JBrowse link
ruffle membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 located_in ISO (MGI:3662940|PMID:16908670) Alzheimers_University_of_Toronto PMID:16908670 MGI:3662940 NCBI chr19:62,811...77,897
Ensembl chr19:1,018,095...1,042,104 		JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 located_in IEA Ensembl GO_REF:0000107 NCBI chr2A:9,478,080...9,545,363
Ensembl chr2A:9,641,201...9,708,054 		JBrowse link
G AIF1 allograft inflammatory factor 1 located_in IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000044 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:31,276,215...31,278,051
Ensembl chr 6:32,166,301...32,168,125 		JBrowse link
G AIF1L allograft inflammatory factor 1 like located_in IEA UniProt
TreeGrafter		 GO_REF:0000044 GO_REF:0000118 NCBI chr 9:102,218,242...102,244,846
Ensembl chr 9:130,863,031...130,891,744 		JBrowse link
G AKT2 AKT serine/threonine kinase 2 located_in IEA Ensembl GO_REF:0000107 NCBI chr19:37,275,799...37,331,971
Ensembl chr19:45,791,800...45,840,271 		JBrowse link
G APC APC regulator of WNT signaling pathway located_in IEA Ensembl GO_REF:0000107 NCBI chr 5:108,070,697...108,208,273
Ensembl chr 5:113,904,352...114,009,709 		JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 located_in IEA Ensembl GO_REF:0000107 NCBI chr12:102,755,388...102,818,686
Ensembl chr12:106,151,969...106,206,879 		JBrowse link
G ARF4 ADP ribosylation factor 4 located_in IEA Ensembl GO_REF:0000107 NCBI chr 3:57,504,701...57,530,545
Ensembl chr 3:58,710,897...58,736,816 		JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:131,282,514...131,326,535
Ensembl chr 1:135,112,040...135,159,299 		JBrowse link
G ARPC2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:17224451 RGD:2306207 NCBI chr2B:105,478,035...105,513,665
Ensembl chr2B:224,076,356...224,111,643 		JBrowse link
G BMX BMX non-receptor tyrosine kinase located_in IEA Ensembl GO_REF:0000107 NCBI chr  X:8,129,158...8,184,910
Ensembl chr  X:15,410,655...15,466,415 		JBrowse link
G C2CD5 C2 calcium dependent domain containing 5 located_in IEA Ensembl GO_REF:0000107 NCBI chr12:63,769,552...63,865,681
Ensembl chr12:66,377,634...66,472,877 		JBrowse link
G CDC37 cell division cycle 37, HSP90 cochaperone ISO RGD PMID:16335536 RGD:5131523 NCBI chr19:9,942,644...9,955,112
Ensembl chr19:10,606,246...10,618,702 		JBrowse link
G CDKL5 cyclin dependent kinase like 5 located_in ISO PMID:20861382 BHF-UCL PMID:20861382 RGD:8554575 NCBI chr  X:11,047,357...11,261,172
Ensembl chr  X:18,492,329...18,638,735 		JBrowse link
G CFL1 cofilin 1 located_in IEA UniProt GO_REF:0000044 NCBI chr11:61,215,092...61,218,628
Ensembl chr11:64,544,275...64,550,806 		JBrowse link
G CLASP2 cytoplasmic linker associated protein 2 located_in ISO MMO:0000686
(PMID:20937854)		 RGD
UniProt		 PMID:20937854 PMID:22992739 RGD:28912745 NCBI chr 3:33,418,300...33,640,185
Ensembl chr 3:33,721,153...33,938,560 		JBrowse link
G DIAPH1 diaphanous related formin 1 located_in ISO (PMID:9214622) MGI PMID:9214622 NCBI chr 5:136,876,396...136,980,097 JBrowse link
G DLC1 DLC1 Rho GTPase activating protein located_in IEA Ensembl GO_REF:0000107 NCBI chr 8:12,282,190...12,809,770
Ensembl chr 8:9,037,742...9,460,233 		JBrowse link
G DNM2 dynamin 2 ISO RGD PMID:9725914 RGD:9685132 NCBI chr19:10,272,172...10,386,032
Ensembl chr19:10,933,672...11,106,478 		JBrowse link
G EEF1A1 eukaryotic translation elongation factor 1 alpha 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr 6:71,342,291...71,346,033
Ensembl chr 6:74,629,688...74,633,754 		JBrowse link
G EGFR epidermal growth factor receptor is_active_in
located_in		 ISO
IEA		 (PMID:11331309) ARUK-UCL
Ensembl		 PMID:11331309 GO_REF:0000107 NCBI chr 7:55,614,042...55,807,285
Ensembl chr 7:56,046,296...56,111,615 		JBrowse link
G EPB41L5 erythrocyte membrane protein band 4.1 like 5 located_in IEA Ensembl GO_REF:0000107 NCBI chr2B:6,945,289...7,111,595
Ensembl chr2B:120,521,145...120,687,209 		JBrowse link
G EPS8 EGFR pathway substrate 8, signaling adaptor located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr12:15,617,536...15,788,537
Ensembl chr12:16,013,276...16,076,117 		JBrowse link
G EPS8L1 EPS8 signaling adaptor L1 located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:52,114,011...52,125,981
Ensembl chr19:60,803,996...60,819,833 		JBrowse link
G EPS8L2 EPS8 signaling adaptor L2 located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:720,528...741,623
Ensembl chr11:765,689...787,128 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 located_in IEA UniProt GO_REF:0000044 NCBI chr17:17,560,337...17,600,808
Ensembl chr17:17,777,434...17,805,862 		JBrowse link
G EZR ezrin located_in IEA UniProt GO_REF:0000044 NCBI chr 6:156,656,146...156,709,986
Ensembl chr 6:161,670,483...161,723,102 		JBrowse link
G FAM107A family with sequence similarity 107 member A located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr 3:58,494,342...58,557,712
Ensembl chr 3:59,903,602...59,967,013 		JBrowse link
G FGR FGR proto-oncogene, Src family tyrosine kinase located_in IEA Ensembl GO_REF:0000107 NCBI chr 1:26,872,781...26,895,751
Ensembl chr 1:27,918,758...27,941,678 		JBrowse link
G HIP1R huntingtin interacting protein 1 related located_in IEA Ensembl GO_REF:0000107 NCBI chr12:120,438,841...120,467,489
Ensembl chr12:124,685,091...124,700,726 		JBrowse link
G IFIT5 interferon induced protein with tetratricopeptide repeats 5 located_in IEA Ensembl GO_REF:0000107 NCBI chr10:86,139,816...86,146,244
Ensembl chr10:89,678,703...89,685,839 		JBrowse link
G INPP5J inositol polyphosphate-5-phosphatase J located_in ISO PMID:10593988 MGI PMID:10593988 RGD:633686 NCBI chr22:12,131,746...12,158,481
Ensembl chr22:29,984,096...29,995,256 		JBrowse link
G INPP5K inositol polyphosphate-5-phosphatase K located_in IEA Ensembl GO_REF:0000107 NCBI chr17:1,477,511...1,499,765
Ensembl chr17:1,377,312...1,399,373 		JBrowse link
G ITGA5 integrin subunit alpha 5 located_in IEA Ensembl GO_REF:0000107 NCBI chr12:34,326,182...34,350,050
Ensembl chr12:35,052,994...35,075,835 		JBrowse link
G ITGAV integrin subunit alpha V located_in IEA Ensembl GO_REF:0000107 NCBI chr2B:73,880,962...73,972,486
Ensembl chr2B:191,680,655...191,773,028 		JBrowse link
G ITGB1 integrin subunit beta 1 located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr10:33,023,573...33,081,384
Ensembl chr10:33,608,978...33,644,031 		JBrowse link
G ITGB3 integrin subunit beta 3 located_in IEA Ensembl GO_REF:0000107 NCBI chr17:10,134,450...10,194,596
Ensembl chr17:10,353,111...10,392,382 		JBrowse link
G JCAD junctional cadherin 5 associated located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:30,163,932...30,266,266
Ensembl chr10:30,528,772...30,553,865 		JBrowse link
G KANK1 KN motif and ankyrin repeat domains 1 located_in ISO (PMID:19559006) UniProt PMID:19559006 NCBI chr 9:550,713...556,230 JBrowse link
G MACF1 microtubule actin crosslinking factor 1 located_in ISO (PMID:20937854) UniProt PMID:20937854 NCBI chr 1:38,369,021...38,771,911
Ensembl chr 1:39,820,394...40,096,558 		JBrowse link
G MAP2 microtubule associated protein 2 located_in ISO PMID:11029056 CAFA PMID:11029056 RGD:12793013 NCBI chr2B:96,681,268...96,991,650
Ensembl chr2B:215,314,857...215,391,728 		JBrowse link
G MTSS2 MTSS I-BAR domain containing 2 located_in IEA Ensembl GO_REF:0000107 NCBI chr16:54,331,300...54,338,656
Ensembl chr16:70,497,625...70,514,716 		JBrowse link
G MYO1C myosin IC ISO RGD PMID:22918957 RGD:11073622 NCBI chr17:1,446,506...1,475,634
Ensembl chr17:1,345,143...1,375,540 		JBrowse link
G MYO6 myosin VI located_in ISO
IEA		 RGD
UniProt		 PMID:9852149 GO_REF:0000044 RGD:2314969 NCBI chr 6:73,593,794...73,764,352
Ensembl chr 6:76,951,634...77,048,796 		JBrowse link
G NCK2 NCK adaptor protein 2 located_in IEA TreeGrafter GO_REF:0000118 NCBI chr2A:95,939,197...96,089,163
Ensembl chr2A:106,898,547...106,976,363 		JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 located_in ISO (PMID:16814409) UniProt PMID:16814409 NCBI chr17:45,243,588...45,252,135
Ensembl chr17:50,113,622...50,131,636 		JBrowse link
G PACSIN1 protein kinase C and casein kinase substrate in neurons 1 located_in IEA Ensembl
UniProt		 GO_REF:0000044 GO_REF:0000107 NCBI chr 6:34,030,769...34,100,029
Ensembl chr 6:35,180,099...35,201,440 		JBrowse link
G PACSIN2 protein kinase C and casein kinase substrate in neurons 2 located_in IEA UniProt GO_REF:0000044 NCBI chr22:23,757,565...23,900,837
Ensembl chr22:41,908,922...41,999,692 		JBrowse link
G PDPN podoplanin located_in ISO (PMID:17046996) UniProt PMID:17046996 NCBI chr 1:12,728,569...12,759,781
Ensembl chr 1:13,728,233...13,759,584 		JBrowse link
G PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha located_in IEA Ensembl GO_REF:0000107 NCBI chr 1:126,547,793...126,598,618
Ensembl chr 1:130,195,974...130,246,198 		JBrowse link
G PLA2G4F phospholipase A2 group IVF located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:21,095,474...21,110,983
Ensembl chr15:39,253,819...39,271,482 		JBrowse link
G PLCG1 phospholipase C gamma 1 is_active_in
located_in		 ISO
IEA		 (PMID:11331309) ARUK-UCL
Ensembl		 PMID:11331309 GO_REF:0000107 NCBI chr20:37,477,077...37,515,854
Ensembl chr20:38,572,709...38,615,145 		JBrowse link
G PLCG2 phospholipase C gamma 2 is_active_in
located_in		 ISO
IEA		 (PMID:11331309) ARUK-UCL
Ensembl		 PMID:11331309 GO_REF:0000107 NCBI chr16:62,383,270...62,561,579
Ensembl chr16:81,812,565...81,984,064 		JBrowse link
G PLEK pleckstrin located_in IEA Ensembl GO_REF:0000107 NCBI chr2A:68,414,281...68,446,647
Ensembl chr2A:69,537,983...69,570,393 		JBrowse link
G PLEKHA1 pleckstrin homology domain containing A1 located_in IEA Ensembl GO_REF:0000107 NCBI chr10:118,942,896...119,001,185
Ensembl chr10:122,354,765...122,412,588 		JBrowse link
G PLEKHO1 pleckstrin homology domain containing O1 located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:125,494,740...125,504,990
Ensembl chr 1:129,146,459...129,157,401 		JBrowse link
G PPP1R9B protein phosphatase 1 regulatory subunit 9B located_in IEA Ensembl GO_REF:0000107 NCBI chr17:44,224,007...44,240,906
Ensembl chr17:49,098,089...49,126,932 		JBrowse link
G PSD pleckstrin and Sec7 domain containing located_in IEA UniProt
Ensembl		 GO_REF:0000044 GO_REF:0000107 NCBI chr10:99,006,102...99,023,411
Ensembl chr10:102,472,583...102,486,226 		JBrowse link
G PSD2 pleckstrin and Sec7 domain containing 2 located_in IEA UniProt
Ensembl		 GO_REF:0000044 GO_REF:0000107 NCBI chr 5:135,162,701...135,211,389
Ensembl chr 5:141,294,395...141,329,952 		JBrowse link
G PSD3 pleckstrin and Sec7 domain containing 3 located_in IEA UniProt
TreeGrafter		 GO_REF:0000044 GO_REF:0000118 NCBI chr 8:17,758,287...18,308,876
Ensembl chr 8:14,714,575...15,258,823 		JBrowse link
G PSD4 pleckstrin and Sec7 domain containing 4 located_in IEA UniProt
TreeGrafter
Ensembl		 GO_REF:0000044 GO_REF:0000107 GO_REF:0000118 NCBI chr2A:88,921,973...88,968,297
Ensembl chr2A:114,125,643...114,145,103 		JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J located_in IEA Ensembl GO_REF:0000107 NCBI chr11:47,941,134...48,130,538
Ensembl chr11:48,613,761...48,670,494 		JBrowse link
G PTPRZ1 protein tyrosine phosphatase receptor type Z1 ISO RGD PMID:11381105 RGD:9589125 NCBI chr 7:113,882,557...114,073,283
Ensembl chr 7:126,569,630...126,758,155 		JBrowse link
G RAB34 RAB34, member RAS oncogene family NOT|located_in ISO (PMID:17881736) UniProt PMID:17881736 NCBI chr17:28,057,077...28,061,234
Ensembl chr17:28,562,118...28,566,242 		JBrowse link
G RAC1 Rac family small GTPase 1 located_in ISO (PMID:20875796)
(MGI:5315376|PMID:10934045)		 UniProt PMID:10934045 PMID:20875796 MGI:5315376 NCBI chr 7:7,039,379...7,068,866 JBrowse link
G RHOA ras homolog family member A located_in IEA Ensembl GO_REF:0000107 NCBI chr 3:49,282,009...49,339,887 JBrowse link
G RIGI RNA sensor RIG-I located_in IEA Ensembl GO_REF:0000107 NCBI chr 9:32,230,012...32,302,159
Ensembl chr 9:33,040,000...33,110,557 		JBrowse link
G RPS3 ribosomal protein S3 located_in IEA Ensembl GO_REF:0000107 NCBI chr11:70,460,702...70,466,909
Ensembl chr11:73,762,794...73,768,982 		JBrowse link
G SH3BGRL3 SH3 domain binding glutamate rich protein like 3 located_in IEA UniProt GO_REF:0000044 NCBI chr 1:25,540,781...25,542,558 JBrowse link
G SH3YL1 SH3 and SYLF domain containing 1 located_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr2A:211,952...257,266
Ensembl chr2A:208,156...252,938 		JBrowse link
G SNTG1 syntrophin gamma 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr 8:46,358,675...47,223,131
Ensembl chr 8:44,214,273...44,606,891 		JBrowse link
G SPATA13 spermatogenesis associated 13 located_in IEA Ensembl GO_REF:0000107 NCBI chr13:5,298,466...5,626,162
Ensembl chr13:23,837,412...23,921,025 		JBrowse link
G SPRY2 sprouty RTK signaling antagonist 2 located_in IEA UniProt GO_REF:0000044 NCBI chr13:61,569,658...61,574,817
Ensembl chr13:80,596,346...80,597,408 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase located_in IEA Ensembl GO_REF:0000107 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634 		JBrowse link
G SYNJ2 synaptojanin 2 ISO when coexpressed with constitutively GTP-bound Rac1 RGD PMID:11498538 RGD:628465 NCBI chr 6:155,881,818...156,011,416
Ensembl chr 6:157,940,179...158,055,662 		JBrowse link
G TESC tescalcin located_in IEA UniProt GO_REF:0000044 NCBI chr12:114,615,155...114,675,932
Ensembl chr12:117,991,047...118,051,346 		JBrowse link
G THEM4 thioesterase superfamily member 4 located_in IEA UniProt GO_REF:0000044 NCBI chr 1:127,229,378...127,268,884
Ensembl chr 1:130,876,364...130,912,751 		JBrowse link
G TIAM1 TIAM Rac1 associated GEF 1 ISO RGD PMID:12446731 RGD:629540 NCBI chr21:17,483,273...17,925,301
Ensembl chr21:30,868,308...31,016,883 		JBrowse link
G TIRAP TIR domain containing adaptor protein located_in ISO (MGI:4948831|PMID:16751103) BHF-UCL PMID:16751103 MGI:4948831 NCBI chr11:121,100,558...121,112,844
Ensembl chr11:125,018,064...125,022,309 		JBrowse link
G TPM1 tropomyosin 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr15:41,989,239...42,018,520
Ensembl chr15:60,286,587...60,315,530 		JBrowse link
G TRPV4 transient receptor potential cation channel subfamily V member 4 located_in ISO PMID:20657843 BHF-UCL PMID:20657843 RGD:8553293 NCBI chr12:107,359,005...107,409,359
Ensembl chr12:110,754,238...110,786,182 		JBrowse link
G TWF1 twinfilin actin binding protein 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr12:44,925,701...44,938,344
Ensembl chr12:45,794,763...45,807,404 		JBrowse link
G WWC1 WW and C2 domain containing 1 located_in IEA Ensembl GO_REF:0000107 NCBI chr 5:163,654,833...163,835,006
Ensembl chr 5:170,418,414...170,602,373 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 17179
    cellular anatomical entity 16965
      cell leading edge 425
        ruffle 162
          ruffle membrane 83
Path 2
Term Annotations click to browse term
  cellular_component 17179
    cellular anatomical entity 16965
      cell projection 2481
        plasma membrane bounded cell projection 2418
          ruffle 162
            ruffle membrane 83
paths to the root