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ONTOLOGY REPORT - ANNOTATIONS


Term:endodermal cell fate specification
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Accession:GO:0001714 term browser browse the term
Definition:The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
Synonyms:exact_synonym: endoderm cell fate specification


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endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EOMES eomesodermin involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:4887279|PMID:21245162)
GO_Central
MGI
PMID:21245162 PMID:21873635 MGI:4887279 NCBI chr13:14,209,590...14,216,184
Ensembl chr13:14,210,083...14,215,797
JBrowse link
G HNF1B HNF1 homeobox B involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3807614|PMID:18635606) Ensembl
MGI
PMID:18635606 GO_REF:0000107 MGI:3807614 NCBI chr12:39,143,119...39,201,631
Ensembl chr12:39,143,121...39,313,511
JBrowse link
G NANOG Nanog homeobox involved_in ISO (PMID:20713518) MGI PMID:20713518 NCBI chr 5:62,931,642...62,939,086
Ensembl chr 5:62,932,382...62,939,082
JBrowse link
G POU5F1 POU class 5 homeobox 1 involved_in ISO (PMID:20713518) MGI PMID:20713518 NCBI chr 7:23,564,654...23,570,691 JBrowse link
G SOX17 SRY-box transcription factor 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:76,854,218...76,857,143
Ensembl chr 4:76,852,230...76,857,139
JBrowse link
G SOX2 SRY-box transcription factor 2 involved_in ISO (PMID:21245162) MGI PMID:21245162 NCBI chr13:119,668,476...119,669,435 JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MESP1 mesoderm posterior bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:55,322,016...55,327,600
Ensembl chr 7:55,322,010...55,325,732
JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKK1 dickkopf WNT signaling pathway inhibitor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:97,487,854...97,490,118
Ensembl chr14:97,487,226...97,490,450
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16538
    developmental process 6329
      cellular developmental process 4168
        cell fate specification 99
          endodermal cell fate specification 8
            negative regulation of endodermal cell fate specification 1
            regulation of endodermal cell fate specification + 2
            transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification 0
Path 2
Term Annotations click to browse term
  biological_process 16538
    developmental process 6329
      anatomical structure development 5869
        multicellular organism development 5365
          embryo development 1264
            embryonic morphogenesis 670
              gastrulation 196
                formation of primary germ layer 128
                  endoderm formation 56
                    endodermal cell differentiation 46
                      endodermal cell fate commitment 15
                        endodermal cell fate specification 8
                          negative regulation of endodermal cell fate specification 1
                          regulation of endodermal cell fate specification + 2
                          transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification 0
paths to the root