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ONTOLOGY REPORT - ANNOTATIONS


Term:endodermal cell fate specification
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Accession:GO:0001714 term browser browse the term
Definition:The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
Synonyms:exact_synonym: endoderm cell fate specification


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endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin involved_in
acts_upstream_of_or_within
IBA
IMP
(MGI:6201960|PMID:21873635)
(MGI:4887279|PMID:21245162)
GO_Central
MGI
PMID:21245162 PMID:21873635 MGI:4887279 MGI:6201960 NCBI chr 9:118,478,186...118,486,132
Ensembl chr 9:118,478,212...118,486,132
JBrowse link
G Hnf1b HNF1 homeobox B acts_upstream_of_or_within IMP (MGI:3807614|PMID:18635606) MGI PMID:18635606 MGI:3807614 NCBI chr11:83,850,209...83,905,917
Ensembl chr11:83,850,063...83,905,819
JBrowse link
G Nanog Nanog homeobox involved_in
acts_upstream_of_or_within
ISO (PMID:20713518)
(MGI:4887279|PMID:21245162)
MGI
MGI
PMID:20713518 PMID:21245162 MGI:4887279 NCBI chr 6:122,707,489...122,714,633
Ensembl chr 6:122,707,489...122,714,633
JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 involved_in
acts_upstream_of_or_within
ISO (PMID:20713518)
(MGI:4887279|PMID:21245162)
MGI
MGI
PMID:20713518 PMID:21245162 MGI:4887279 NCBI chr17:35,506,032...35,510,777
Ensembl chr17:35,506,018...35,510,772
JBrowse link
G Sox17 SRY (sex determining region Y)-box 17 involved_in IMP (MGI:4946573|PMID:21305474) BHF-UCL PMID:21305474 MGI:4946573 NCBI chr 1:4,490,928...4,497,426
Ensembl chr 1:4,490,931...4,497,354
JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 involved_in
acts_upstream_of_or_within
ISO (PMID:21245162)
(MGI:4887279|PMID:21245162)
MGI
MGI
PMID:21245162 MGI:4887279 NCBI chr 3:34,649,995...34,652,461
Ensembl chr 3:34,650,405...34,652,461
JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior 1 involved_in IDA (MGI:4441249|PMID:18593560) BHF-UCL PMID:18593560 MGI:4441249 NCBI chr 7:79,792,241...79,793,590
Ensembl chr 7:79,792,241...79,793,788
JBrowse link
G Nanog Nanog homeobox involved_in TAS (MGI:3690198|PMID:16501172) HGNC-UCL PMID:16501172 MGI:3690198 NCBI chr 6:122,707,489...122,714,633
Ensembl chr 6:122,707,489...122,714,633
JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr19:30,545,876...30,549,496
Ensembl chr19:30,545,863...30,549,665
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23319
    developmental process 7063
      cellular developmental process 4700
        cell fate specification 102
          endodermal cell fate specification 8
            negative regulation of endodermal cell fate specification 2
            regulation of endodermal cell fate specification + 3
            transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification 0
Path 2
Term Annotations click to browse term
  biological_process 23319
    developmental process 7063
      anatomical structure development 6534
        multicellular organism development 5996
          embryo development 1307
            embryonic morphogenesis 681
              gastrulation 203
                formation of primary germ layer 127
                  endoderm formation 56
                    endodermal cell differentiation 46
                      endodermal cell fate commitment 15
                        endodermal cell fate specification 8
                          negative regulation of endodermal cell fate specification 2
                          regulation of endodermal cell fate specification + 3
                          transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification 0
paths to the root