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ONTOLOGY REPORT - ANNOTATIONS

Term:endodermal cell fate specification
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Accession:GO:0001714 term browser browse the term
Definition:The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
Synonyms:exact_synonym: endoderm cell fate specification

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endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EOMES eomesodermin involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:21873635)
(MGI:4887279|PMID:21245162)		 GO_Central
MGI		 PMID:21245162 PMID:21873635 MGI:4887279 NCBI chr 3:27,715,953...27,722,713
Ensembl chr 3:27,715,949...27,722,711 		JBrowse link
G HNF1B HNF1 homeobox B acts_upstream_of_or_within ISO (MGI:3807614|PMID:18635606) MGI PMID:18635606 MGI:3807614 NCBI chr17:37,686,431...37,745,059
Ensembl chr17:37,686,431...37,745,105 		JBrowse link
G NANOG Nanog homeobox involved_in IDA (PMID:20713518) MGI PMID:20713518 NCBI chr12:7,789,402...7,799,146
Ensembl chr12:7,787,794...7,799,146 		JBrowse link
G POU5F1 POU class 5 homeobox 1 involved_in IDA (PMID:20713518) MGI PMID:20713518 NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731 		JBrowse link
G SOX17 SRY-box transcription factor 17 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 8:54,457,935...54,460,892
Ensembl chr 8:54,457,935...54,460,892 		JBrowse link
G SOX2 SRY-box transcription factor 2 involved_in IDA (PMID:21245162) MGI PMID:21245162 NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436 		JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MESP1 mesoderm posterior bHLH transcription factor 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr15:89,734,772...89,751,309
Ensembl chr15:89,748,661...89,751,310 		JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKK1 dickkopf WNT signaling pathway inhibitor 1 involved_in IDA (PMID:20559569) BHF-UCL PMID:20559569 NCBI chr10:52,314,281...52,317,657
Ensembl chr10:52,314,281...52,318,042 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18680
    developmental process 7486
      cellular developmental process 5028
        cell fate specification 104
          endodermal cell fate specification 8
            negative regulation of endodermal cell fate specification 1
            regulation of endodermal cell fate specification + 2
            transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification 0
Path 2
Term Annotations click to browse term
  biological_process 18680
    developmental process 7486
      anatomical structure development 6911
        multicellular organism development 6389
          embryo development 1328
            embryonic morphogenesis 703
              gastrulation 209
                formation of primary germ layer 132
                  endoderm formation 57
                    endodermal cell differentiation 46
                      endodermal cell fate commitment 15
                        endodermal cell fate specification 8
                          negative regulation of endodermal cell fate specification 1
                          regulation of endodermal cell fate specification + 2
                          transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification 0
paths to the root