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ONTOLOGY REPORT - ANNOTATIONS


Term:endodermal cell fate specification
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Accession:GO:0001714 term browser browse the term
Definition:The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
Synonyms:exact_synonym: endoderm cell fate specification


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endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EOMES eomesodermin acts_upstream_of_or_within ISO (MGI:4887279|PMID:21245162) MGI PMID:21245162 MGI:4887279 NCBI chr 3:27,601,829...27,608,701
Ensembl chr 3:27,925,086...27,930,274
JBrowse link
G HNF1B HNF1 homeobox B acts_upstream_of_or_within ISO (MGI:3807614|PMID:18635606) MGI PMID:18635606 MGI:3807614 NCBI chr17:19,333,485...19,392,147
Ensembl chr17:19,633,424...19,691,863
JBrowse link
G NANOG Nanog homeobox involved_in ISO (PMID:20713518) MGI PMID:20713518 NCBI chr12:7,913,037...7,919,715 JBrowse link
G POU5F1 POU class 5 homeobox 1 involved_in ISO (PMID:20713518) MGI PMID:20713518 NCBI chr 6:30,910,421...30,916,465
Ensembl chr 6:31,775,343...31,781,426
JBrowse link
G SOX17 SRY-box transcription factor 17 involved_in ISO (MGI:4946573|PMID:21305474) BHF-UCL PMID:21305474 MGI:4946573 NCBI chr 8:50,883,088...50,885,542
Ensembl chr 8:48,257,287...48,259,808
JBrowse link
G SOX2 SRY-box transcription factor 2 involved_in ISO (PMID:21245162) MGI PMID:21245162 NCBI chr 3:178,744,881...178,747,392
Ensembl chr 3:186,922,705...186,923,662
JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MESP1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:4441249|PMID:18593560) BHF-UCL PMID:18593560 MGI:4441249 NCBI chr15:68,440,626...68,441,935
Ensembl chr15:87,645,768...87,647,210
JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKK1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) BHF-UCL PMID:20559569 NCBI chr10:48,950,704...48,953,815
Ensembl chr10:51,084,027...51,089,776
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12629
    developmental process 5882
      cellular developmental process 3804
        cell fate specification 83
          endodermal cell fate specification 8
            negative regulation of endodermal cell fate specification 1
            regulation of endodermal cell fate specification + 2
            transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification 0
Path 2
Term Annotations click to browse term
  biological_process 12629
    developmental process 5882
      anatomical structure development 5487
        multicellular organism development 5018
          embryo development 1213
            embryonic morphogenesis 646
              gastrulation 182
                formation of primary germ layer 118
                  endoderm formation 51
                    endodermal cell differentiation 45
                      endodermal cell fate commitment 14
                        endodermal cell fate specification 8
                          negative regulation of endodermal cell fate specification 1
                          regulation of endodermal cell fate specification + 2
                          transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification 0
paths to the root