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ONTOLOGY REPORT - ANNOTATIONS

Term:cell fate specification
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Accession:GO:0001708 term browser browse the term
Definition:The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate.


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cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC, WNT signaling pathway regulator involved_in IBA GO_Central GO_REF:0000033 NCBI chr18:34,353,350...34,455,243
Ensembl chr18:34,353,977...34,455,605 		JBrowse link
G Apc2 APC regulator of WNT signaling pathway 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr10:80,131,790...80,154,091
Ensembl chr10:80,131,811...80,154,097 		JBrowse link
G Cdon cell adhesion molecule-related/down-regulated by oncogenes acts_upstream_of_or_within IGI (PMID:16647304) MGI PMID:16647304 NCBI chr 9:35,332,836...35,418,948
Ensembl chr 9:35,332,424...35,418,948 		JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within IMP (PMID:15866163) MGI PMID:15866163 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Dhh desert hedgehog involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:98,779,496...98,796,443
Ensembl chr15:98,789,033...98,796,421 		JBrowse link
G Fkbp8 FK506 binding protein 8 acts_upstream_of_or_within IMP (PMID:18590716) MGI PMID:18590716 NCBI chr 8:70,980,371...70,987,978
Ensembl chr 8:70,980,374...70,987,978 		JBrowse link
G Foxa2 forkhead box A2 acts_upstream_of_or_within IDA (PMID:18076286) MGI PMID:18076286 NCBI chr 2:147,884,797...147,888,889
Ensembl chr 2:147,884,797...147,888,889 		JBrowse link
G Gfi1 growth factor independent 1 transcription repressor acts_upstream_of IMP (PMID:16230531) MGI PMID:16230531 NCBI chr 5:107,864,521...107,873,671
Ensembl chr 5:107,864,523...107,873,902 		JBrowse link
G Ihh Indian hedgehog acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:18582859) MGI
GO_Central		 PMID:18582859 GO_REF:0000033 NCBI chr 1:74,984,474...74,990,831
Ensembl chr 1:74,984,474...74,990,831 		JBrowse link
G Mga MAX gene associated involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:119,702,974...119,800,610
Ensembl chr 2:119,727,709...119,800,062 		JBrowse link
G Nkx2-3 NK2 homeobox 3 acts_upstream_of_or_within IMP (PMID:38311164) MGI PMID:38311164 NCBI chr19:43,600,764...43,604,331
Ensembl chr19:43,600,764...43,604,331 		JBrowse link
G Pou1f1 POU domain, class 1, transcription factor 1 acts_upstream_of_or_within IDA (PMID:10367888) MGI PMID:10367888 NCBI chr16:65,317,398...65,331,904
Ensembl chr16:65,317,397...65,331,183 		JBrowse link
G Prdm14 PR domain containing 14 acts_upstream_of_or_within IMP (PMID:18622394) MGI PMID:18622394 NCBI chr 1:13,183,649...13,197,467
Ensembl chr 1:13,183,681...13,197,387 		JBrowse link
G Psen1 presenilin 1 acts_upstream_of_or_within IGI (PMID:15525534) MGI PMID:15525534 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within IGI (PMID:15525534) MGI PMID:15525534 NCBI chr 1:180,054,569...180,091,030
Ensembl chr 1:180,054,569...180,091,003 		JBrowse link
G Shh sonic hedgehog acts_upstream_of_or_within
involved_in		 IMP
IBA
IDA
IGI		 (PMID:12231626)
(PMID:18076286)
(PMID:16647304)		 MGI
GO_Central		 PMID:12231626 PMID:16647304 PMID:18076286 GO_REF:0000033 NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254 		JBrowse link
G Smo smoothened, frizzled class receptor acts_upstream_of_or_within IMP (PMID:18590716) MGI PMID:18590716 NCBI chr 6:29,735,480...29,761,359
Ensembl chr 6:29,735,502...29,761,364 		JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 acts_upstream_of_or_within IMP (PMID:12514105) MGI PMID:12514105 NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610 		JBrowse link
G T brachyury, T-box transcription factor T involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:8,653,255...8,661,328
Ensembl chr17:8,653,255...8,661,328 		JBrowse link
G Tbr1 T-box brain transcription factor 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:61,633,228...61,644,458
Ensembl chr 2:61,633,274...61,644,458 		JBrowse link
G Tbx1 T-box 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr16:18,399,729...18,409,412
Ensembl chr16:18,399,729...18,409,421 		JBrowse link
G Tbx10 T-box 10 involved_in IBA GO_Central GO_REF:0000033 NCBI chr19:4,042,752...4,049,512
Ensembl chr19:4,042,752...4,049,512 		JBrowse link
G Tbx15 T-box 15 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:99,147,671...99,261,576
Ensembl chr 3:99,147,697...99,261,575 		JBrowse link
G Tbx18 T-box18 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:87,584,853...87,613,313
Ensembl chr 9:87,584,853...87,613,313 		JBrowse link
G Tbx19 T-box 19 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:164,965,403...164,988,342
Ensembl chr 1:164,965,424...164,988,342 		JBrowse link
G Tbx2 T-box 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:85,723,441...85,732,774
Ensembl chr11:85,723,377...85,732,774 		JBrowse link
G Tbx20 T-box 20 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:24,632,108...24,685,580
Ensembl chr 9:24,629,434...24,685,599 		JBrowse link
G Tbx21 T-box 21 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157 		JBrowse link
G Tbx22 T-box 22 involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:106,711,570...106,732,586
Ensembl chr  X:106,711,570...106,732,584 		JBrowse link
G Tbx3 T-box 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 5:119,808,600...119,822,789
Ensembl chr 5:119,808,734...119,822,789 		JBrowse link
G Tbx4 T-box 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:85,777,193...85,806,923
Ensembl chr11:85,777,248...85,806,923 		JBrowse link
G Tbx5 T-box 5 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 5:119,934,581...120,023,285
Ensembl chr 5:119,970,733...120,023,284 		JBrowse link
G Tbx6 T-box 6 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:126,380,655...126,384,720
Ensembl chr 7:126,380,655...126,384,732 		JBrowse link
G Tead4 TEA domain family member 4 acts_upstream_of_or_within IMP (PMID:18083014) MGI PMID:18083014 NCBI chr 6:128,204,106...128,277,776
Ensembl chr 6:128,201,251...128,277,786 		JBrowse link
auditory receptor cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atoh1 atonal bHLH transcription factor 1 acts_upstream_of_or_within IMP (PMID:10364557) MGI PMID:10364557 NCBI chr 6:64,706,109...64,708,229
Ensembl chr 6:64,706,109...64,708,229 		JBrowse link
axial mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nodal nodal growth differentiation factor acts_upstream_of_or_within IMP (PMID:14511481) MGI PMID:14511481 NCBI chr10:61,253,751...61,261,117
Ensembl chr10:61,253,751...61,261,117 		JBrowse link
blood vessel endothelial cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in IGI (PMID:15466160) BHF-UCL PMID:15466160 NCBI chr 5:53,713,121...53,814,787
Ensembl chr 5:53,623,494...53,814,704 		JBrowse link
cardiac cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgb1 integrin beta 1 (fibronectin receptor beta) acts_upstream_of_or_within IMP (PMID:9004034) MGI PMID:9004034 NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681 		JBrowse link
G Tenm4 teneurin transmembrane protein 4 acts_upstream_of_or_within IMP (PMID:17350578) MGI PMID:17350578 NCBI chr 7:95,550,262...96,560,300
Ensembl chr 7:95,820,453...96,560,300 		JBrowse link
endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin acts_upstream_of_or_within
involved_in		 IMP
IBA		 (PMID:21245162) MGI
GO_Central		 PMID:21245162 GO_REF:0000033 NCBI chr 9:118,307,259...118,315,176
Ensembl chr 9:118,307,280...118,315,200 		JBrowse link
G Hnf1b HNF1 homeobox B acts_upstream_of_or_within IMP (PMID:18635606) MGI PMID:18635606 NCBI chr11:83,741,035...83,796,743
Ensembl chr11:83,740,889...83,796,645 		JBrowse link
G Nanog Nanog homeobox acts_upstream_of_or_within ISO (PMID:21245162) MGI PMID:21245162 NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592 		JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 acts_upstream_of_or_within ISO (PMID:21245162) MGI PMID:21245162 NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669 		JBrowse link
G Sox17 SRY (sex determining region Y)-box 17 involved_in IMP (PMID:21305474) BHF-UCL PMID:21305474 NCBI chr 1:4,561,154...4,567,624
Ensembl chr 1:4,561,154...4,567,577 		JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:21245162) MGI
Ensembl		 PMID:21245162 GO_REF:0000107 NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610 		JBrowse link
endothelial cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hoxa13 homeobox A13 acts_upstream_of_or_within IMP (PMID:18483557) MGI PMID:18483557 NCBI chr 6:52,235,833...52,237,865
Ensembl chr 6:52,234,674...52,237,788 		JBrowse link
endothelial tip cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 involved_in IMP (PMID:22282195) UniProt PMID:22282195 NCBI chr17:15,587,616...15,597,275
Ensembl chr17:15,587,616...15,597,134 		JBrowse link
G Flvcr2 feline leukemia virus subgroup C cellular receptor 2 acts_upstream_of_or_within IMP (PMID:32369453) MGI PMID:32369453 NCBI chr12:85,793,313...85,860,359
Ensembl chr12:85,793,313...85,860,359 		JBrowse link
epidermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxi3 forkhead box I3 involved_in IMP (PMID:26450968) UniProt PMID:26450968 NCBI chr 6:70,933,590...70,938,050
Ensembl chr 6:70,933,515...70,938,050 		JBrowse link
G Mir450b microRNA 450b acts_upstream_of_or_within ISO (PMID:22367714) MGI PMID:22367714 NCBI chr  X:52,136,874...52,136,955
Ensembl chr  X:52,136,874...52,136,955 		JBrowse link
G Notch1 notch 1 acts_upstream_of_or_within IMP (PMID:15068794) MGI PMID:15068794 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675 		JBrowse link
G Ptch1 patched 1 acts_upstream_of_or_within IGI (PMID:24492243) MGI PMID:24492243 NCBI chr13:63,656,142...63,721,274
Ensembl chr13:63,656,142...63,721,412 		JBrowse link
G Ptch2 patched 2 acts_upstream_of_or_within IGI (PMID:24492243) MGI PMID:24492243 NCBI chr 4:116,953,253...116,973,298
Ensembl chr 4:116,953,272...116,973,298 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region acts_upstream_of_or_within IMP (PMID:17079689) MGI PMID:17079689 NCBI chr 5:53,713,121...53,814,787
Ensembl chr 5:53,623,494...53,814,704 		JBrowse link
glial cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfia nuclear factor I/A acts_upstream_of_or_within IMP (PMID:31128945) MGI PMID:31128945 NCBI chr 4:97,469,534...98,007,113
Ensembl chr 4:97,660,971...98,007,111 		JBrowse link
G Nfib nuclear factor I/B acts_upstream_of_or_within IMP (PMID:31128945) MGI PMID:31128945 NCBI chr 4:82,208,410...82,424,988
Ensembl chr 4:82,208,410...82,623,987 		JBrowse link
G Nfix nuclear factor I/X acts_upstream_of_or_within IMP (PMID:31128945) MGI PMID:31128945 NCBI chr 8:85,431,341...85,527,086
Ensembl chr 8:85,426,505...85,526,973 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 acts_upstream_of_or_within IMP (PMID:12842915) MGI PMID:12842915 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eya1 EYA transcriptional coactivator and phosphatase 1 involved_in IDA (PMID:17785448) UniProt PMID:17785448 NCBI chr 1:14,239,177...14,381,259
Ensembl chr 1:14,239,178...14,380,459 		JBrowse link
G Hoxa11 homeobox A11 involved_in IDA (PMID:17785448) UniProt PMID:17785448 NCBI chr 6:52,219,086...52,222,784
Ensembl chr 6:52,219,086...52,222,790 		JBrowse link
G Pax2 paired box 2 involved_in IDA (PMID:17785448) UniProt PMID:17785448 NCBI chr19:44,735,040...44,826,708
Ensembl chr19:44,735,057...44,826,310 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of IGI (PMID:17462603) MGI PMID:17462603 NCBI chr 3:83,673,628...83,681,621
Ensembl chr 3:83,673,628...83,681,623 		JBrowse link
G Six2 sine oculis-related homeobox 2 involved_in IDA (PMID:17785448) UniProt PMID:17785448 NCBI chr17:85,970,276...85,995,682
Ensembl chr17:85,991,705...85,995,702 		JBrowse link
G Tbx6 T-box 6 acts_upstream_of_or_within IMP (PMID:9490412) MGI PMID:9490412 NCBI chr 7:126,380,655...126,384,720
Ensembl chr 7:126,380,655...126,384,732 		JBrowse link
muscle cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow involved_in
acts_upstream_of_or_within		 IBA
IMP		 (PMID:1379240) GO_Central
MGI		 PMID:1379240 GO_REF:0000033 NCBI chr 5:122,230,787...122,251,536
Ensembl chr 5:122,239,014...122,251,535 		JBrowse link
myoblast fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgb1 integrin beta 1 (fibronectin receptor beta) acts_upstream_of_or_within IMP (PMID:9004034) MGI PMID:9004034 NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681 		JBrowse link
G Myoparr myogenin promoter-associated myogenic regulatory antisense lncRNA involved_in IDA (PMID:30622218) MGI PMID:30622218 NCBI chr 1:134,216,333...134,217,499 JBrowse link
negative regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfi1 growth factor independent 1 transcription repressor acts_upstream_of_or_within IMP (PMID:16230531) MGI PMID:16230531 NCBI chr 5:107,864,521...107,873,671
Ensembl chr 5:107,864,523...107,873,902 		JBrowse link
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fzd7 frizzled class receptor 7 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 1:59,521,306...59,526,114
Ensembl chr 1:59,521,583...59,526,114 		JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior 1 involved_in IDA (PMID:18593560) BHF-UCL PMID:18593560 NCBI chr 7:79,441,989...79,443,338
Ensembl chr 7:79,441,989...79,443,536 		JBrowse link
G Nanog Nanog homeobox involved_in TAS (PMID:16501172) HGNC-UCL PMID:16501172 NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592 		JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065 		JBrowse link
G Mesp1 mesoderm posterior 1 involved_in IDA (PMID:18593560) BHF-UCL PMID:18593560 NCBI chr 7:79,441,989...79,443,338
Ensembl chr 7:79,441,989...79,443,536 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of_or_within IGI (PMID:17462603) MGI PMID:17462603 NCBI chr 3:83,673,628...83,681,621
Ensembl chr 3:83,673,628...83,681,623 		JBrowse link
neural crest cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsc goosecoid homeobox involved_in ISS
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000119 NCBI chr12:104,437,468...104,439,495
Ensembl chr12:104,437,468...104,439,589 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 involved_in ISS UniProt GO_REF:0000024 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
neuron fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl1 achaete-scute family bHLH transcription factor 1 acts_upstream_of_or_within
involved_in		 IMP
IDA		 (PMID:16469766)
(PMID:24243019)		 MGI
UniProt		 PMID:16469766 PMID:24243019 NCBI chr10:87,326,681...87,329,522
Ensembl chr10:87,326,681...87,329,522 		JBrowse link
G Dll1 delta like canonical Notch ligand 1 involved_in IDA (PMID:18997111) UniProt PMID:18997111 NCBI chr17:15,587,616...15,597,275
Ensembl chr17:15,587,616...15,597,134 		JBrowse link
G Dmrta2 doublesex and mab-3 related transcription factor like family A2 acts_upstream_of_or_within IMP (PMID:21576465) MGI PMID:21576465 NCBI chr 4:109,835,222...109,840,896
Ensembl chr 4:109,835,250...109,840,884 		JBrowse link
G Ehmt2 euchromatic histone lysine N-methyltransferase 2 acts_upstream_of_or_within IMP (PMID:24584053) MGI PMID:24584053 NCBI chr17:35,117,427...35,133,049
Ensembl chr17:35,117,445...35,133,028 		JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 acts_upstream_of_or_within IGI (PMID:22513373) MGI PMID:22513373 NCBI chr 1:14,239,177...14,381,259
Ensembl chr 1:14,239,178...14,380,459 		JBrowse link
G Fev FEV transcription factor, ETS family member acts_upstream_of_or_within IMP (PMID:20818386) MGI PMID:20818386 NCBI chr 1:74,920,660...74,924,632
Ensembl chr 1:74,920,668...74,924,578 		JBrowse link
G Fkbp8 FK506 binding protein 8 acts_upstream_of_or_within IMP (PMID:15105374) MGI PMID:15105374 NCBI chr 8:70,980,371...70,987,978
Ensembl chr 8:70,980,374...70,987,978 		JBrowse link
G Foxa1 forkhead box A1 acts_upstream_of_or_within IGI (PMID:17596284) MGI PMID:17596284 NCBI chr12:57,585,750...57,594,815
Ensembl chr12:57,587,414...57,593,702 		JBrowse link
G Foxa2 forkhead box A2 acts_upstream_of_or_within IGI
IMP		 (PMID:17596284)
(PMID:17922007)		 MGI PMID:17596284 PMID:17922007 NCBI chr 2:147,884,797...147,888,889
Ensembl chr 2:147,884,797...147,888,889 		JBrowse link
G Gsx2 GS homeobox 2 acts_upstream_of_or_within IMP (PMID:15930101) MGI PMID:15930101 NCBI chr 5:75,236,262...75,238,554
Ensembl chr 5:75,236,262...75,238,554 		JBrowse link
G Isl1 ISL1 transcription factor, LIM/homeodomain involved_in IMP
IBA		 (PMID:18849985) BHF-UCL
GO_Central		 PMID:18849985 GO_REF:0000033 NCBI chr13:116,434,806...116,446,224
Ensembl chr13:116,434,817...116,446,225 		JBrowse link
G Isl2 insulin related protein 2 (islet 2) involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:55,445,961...55,454,951
Ensembl chr 9:55,445,956...55,453,464 		JBrowse link
G Mir125a microRNA 125a involved_in ISO (PMID:22357933) BHF-UCL PMID:22357933 NCBI chr17:18,051,074...18,051,141
Ensembl chr17:18,051,074...18,051,141 		JBrowse link
G Myt1l myelin transcription factor 1-like involved_in IDA (PMID:24243019), (PMID:28379941) UniProt PMID:24243019 PMID:28379941 NCBI chr12:29,578,375...29,973,215
Ensembl chr12:29,578,383...29,973,212 		JBrowse link
G Nfia nuclear factor I/A acts_upstream_of_or_within IMP (PMID:31128945) MGI PMID:31128945 NCBI chr 4:97,469,534...98,007,113
Ensembl chr 4:97,660,971...98,007,111 		JBrowse link
G Nfib nuclear factor I/B acts_upstream_of_or_within IMP (PMID:31128945) MGI PMID:31128945 NCBI chr 4:82,208,410...82,424,988
Ensembl chr 4:82,208,410...82,623,987 		JBrowse link
G Nfix nuclear factor I/X acts_upstream_of_or_within IMP (PMID:31128945) MGI PMID:31128945 NCBI chr 8:85,431,341...85,527,086
Ensembl chr 8:85,426,505...85,526,973 		JBrowse link
G Nkx2-2 NK2 homeobox 2 acts_upstream_of_or_within IGI
IMP		 (PMID:16339193)
(PMID:19592574)		 MGI PMID:16339193 PMID:19592574 NCBI chr 2:146,967,909...147,037,270
Ensembl chr 2:147,019,466...147,036,163 		JBrowse link
G Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 involved_in ISO RGD
GO_Central		 PMID:15247919 GO_REF:0000096 RGD:2325628 NCBI chr 7:77,825,711...78,228,865
Ensembl chr 7:77,825,707...78,387,760 		JBrowse link
G Otx2 orthodenticle homeobox 2 acts_upstream_of_or_within IMP (PMID:15888661) MGI PMID:15888661 NCBI chr14:48,894,238...48,905,101
Ensembl chr14:48,895,134...48,911,276 		JBrowse link
G Pou3f2 POU domain, class 3, transcription factor 2 involved_in IDA (PMID:24243019) UniProt PMID:24243019 NCBI chr 4:22,482,095...22,488,366
Ensembl chr 4:22,482,780...22,488,366 		JBrowse link
G Pou4f1 POU domain, class 4, transcription factor 1 involved_in IMP (PMID:19877281), (PMID:20096094) BHF-UCL PMID:19877281 PMID:20096094 NCBI chr14:104,699,111...104,705,554
Ensembl chr14:104,699,112...104,705,435 		JBrowse link
G Six1 sine oculis-related homeobox 1 acts_upstream_of_or_within IGI (PMID:22513373) MGI PMID:22513373 NCBI chr12:73,088,601...73,093,486
Ensembl chr12:73,086,789...73,100,661 		JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 acts_upstream_of_or_within IMP (PMID:12842915) MGI PMID:12842915 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
G Tbx1 T-box 1 acts_upstream_of_or_within IGI
IMP		 (PMID:15064766)
(PMID:15084464)		 MGI PMID:15064766 PMID:15084464 NCBI chr16:18,399,729...18,409,412
Ensembl chr16:18,399,729...18,409,421 		JBrowse link
G Tlx3 T cell leukemia, homeobox 3 acts_upstream_of_or_within IGI
IMP		 (PMID:16234809)
(PMID:15064766)		 MGI PMID:15064766 PMID:16234809 NCBI chr11:33,150,748...33,158,588
Ensembl chr11:33,150,752...33,153,589 		JBrowse link
oligodendrocyte cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pax6 paired box 6 acts_upstream_of_or_within IMP (PMID:9828088) MGI PMID:9828088 NCBI chr 2:105,499,241...105,528,755
Ensembl chr 2:105,499,245...105,527,709 		JBrowse link
G Sox6 SRY (sex determining region Y)-box 6 acts_upstream_of_or_within IMP (PMID:17084361) MGI PMID:17084361 NCBI chr 7:115,070,107...115,639,186
Ensembl chr 7:115,070,107...115,638,031 		JBrowse link
positive regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf2 fibroblast growth factor 2 acts_upstream_of_or_within ISO (PMID:18635606) MGI PMID:18635606 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Gfi1 growth factor independent 1 transcription repressor acts_upstream_of_or_within IMP (PMID:16230531) MGI PMID:16230531 NCBI chr 5:107,864,521...107,873,671
Ensembl chr 5:107,864,523...107,873,902 		JBrowse link
G Pax6 paired box 6 involved_in ISO
IEA		 RGD
GO_Central
Ensembl		 PMID:11880342 GO_REF:0000096 GO_REF:0000107 RGD:729590 NCBI chr 2:105,499,241...105,528,755
Ensembl chr 2:105,499,245...105,527,709 		JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a wingless-type MMTV integration site family, member 3A involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr11:59,138,859...59,181,579
Ensembl chr11:59,138,859...59,181,578 		JBrowse link
regulation of cardiac cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sox17 SRY (sex determining region Y)-box 17 involved_in IMP (PMID:17360443) BHF-UCL PMID:17360443 NCBI chr 1:4,561,154...4,567,624
Ensembl chr 1:4,561,154...4,567,577 		JBrowse link
regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chd4 chromodomain helicase DNA binding protein 4 involved_in NAS (PMID:22560079) ComplexPortal PMID:22560079 NCBI chr 6:125,073,144...125,107,554
Ensembl chr 6:125,072,944...125,107,554 		JBrowse link
G Gatad2a GATA zinc finger domain containing 2A involved_in NAS (PMID:22560079) ComplexPortal PMID:22560079 NCBI chr 8:70,359,719...70,450,093
Ensembl chr 8:70,359,726...70,449,034 		JBrowse link
G Gatad2b GATA zinc finger domain containing 2B involved_in NAS (PMID:22560079) ComplexPortal PMID:22560079 NCBI chr 3:90,200,488...90,270,712
Ensembl chr 3:90,200,485...90,270,714 		JBrowse link
G Hdac1 histone deacetylase 1 involved_in NAS (PMID:22560079) ComplexPortal PMID:22560079 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506 		JBrowse link
G Hdac2 histone deacetylase 2 involved_in NAS (PMID:22560079) ComplexPortal PMID:22560079 NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885 		JBrowse link
G Lmo4 LIM domain only 4 acts_upstream_of_or_within IMP (PMID:19323994) MGI PMID:19323994 NCBI chr 3:143,894,291...143,911,016
Ensembl chr 3:143,894,291...143,910,981 		JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 involved_in NAS (PMID:22560079) ComplexPortal PMID:22560079 NCBI chr10:80,228,373...80,235,365
Ensembl chr10:80,228,373...80,235,384 		JBrowse link
G Mta1 metastasis associated 1 involved_in NAS (PMID:22560079) ComplexPortal PMID:22560079 NCBI chr12:113,061,830...113,100,826
Ensembl chr12:113,061,898...113,100,826 		JBrowse link
G Mta2 metastasis-associated gene family, member 2 involved_in NAS (PMID:22560079) ComplexPortal PMID:22560079 NCBI chr19:8,919,239...8,929,659
Ensembl chr19:8,919,239...8,929,667 		JBrowse link
G Mta3 metastasis associated 3 involved_in NAS (PMID:22560079) ComplexPortal PMID:22560079 NCBI chr17:84,013,483...84,131,144
Ensembl chr17:84,013,592...84,128,945 		JBrowse link
G Rbbp4 retinoblastoma binding protein 4, chromatin remodeling factor involved_in NAS (PMID:22560079) ComplexPortal PMID:22560079 NCBI chr 4:129,200,893...129,229,163
Ensembl chr 4:129,200,893...129,229,163 		JBrowse link
G Rbbp7 retinoblastoma binding protein 7, chromatin remodeling factor involved_in NAS (PMID:22560079) ComplexPortal PMID:22560079 NCBI chr  X:161,543,368...161,562,086
Ensembl chr  X:161,543,398...161,562,088 		JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065 		JBrowse link
regulation of inner ear auditory receptor cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esrp1 epithelial splicing regulatory protein 1 involved_in IMP (PMID:29107558) UniProt PMID:29107558 NCBI chr 4:11,331,933...11,386,783
Ensembl chr 4:11,331,933...11,386,783 		JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor, type 1A acts_upstream_of_or_within IGI (PMID:16943278) MGI PMID:16943278 NCBI chr14:34,133,018...34,225,335
Ensembl chr14:34,132,691...34,225,298 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 acts_upstream_of_or_within IGI (PMID:16943278) MGI PMID:16943278 NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734 		JBrowse link
regulation of neural crest cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor, type 1A NOT|involved_in IMP (PMID:15073157) BHF-UCL PMID:15073157 NCBI chr14:34,133,018...34,225,335
Ensembl chr14:34,132,691...34,225,298 		JBrowse link
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI-Kruppel family member GLI2 acts_upstream_of_or_within IGI (PMID:15215207) MGI PMID:15215207 NCBI chr 1:118,761,791...118,987,578
Ensembl chr 1:118,761,862...118,981,349 		JBrowse link
G Gli3 GLI-Kruppel family member GLI3 acts_upstream_of_or_within IGI (PMID:15215207) MGI PMID:15215207 NCBI chr13:15,638,308...15,904,611
Ensembl chr13:15,637,820...15,904,611 		JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling acts_upstream_of_or_within IMP (PMID:19684112) MGI PMID:19684112 NCBI chr19:46,385,335...46,477,243
Ensembl chr19:46,385,335...46,477,243 		JBrowse link
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI-Kruppel family member GLI2 acts_upstream_of_or_within IGI (PMID:15215207) MGI PMID:15215207 NCBI chr 1:118,761,791...118,987,578
Ensembl chr 1:118,761,862...118,981,349 		JBrowse link
G Gli3 GLI-Kruppel family member GLI3 acts_upstream_of_or_within IGI (PMID:15215207) MGI PMID:15215207 NCBI chr13:15,638,308...15,904,611
Ensembl chr13:15,637,820...15,904,611 		JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling acts_upstream_of_or_within IMP (PMID:19684112) MGI PMID:19684112 NCBI chr19:46,385,335...46,477,243
Ensembl chr19:46,385,335...46,477,243 		JBrowse link
spinal cord motor neuron cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hoxc10 homeobox C10 acts_upstream_of_or_within IGI (PMID:18065432) MGI PMID:18065432 NCBI chr15:102,875,231...102,880,333
Ensembl chr15:102,875,231...102,880,328 		JBrowse link
G Hoxd10 homeobox D10 acts_upstream_of_or_within IGI (PMID:18065432) MGI PMID:18065432 NCBI chr 2:74,514,617...74,525,450
Ensembl chr 2:74,522,268...74,525,449 		JBrowse link
G Isl1 ISL1 transcription factor, LIM/homeodomain acts_upstream_of_or_within IGI (PMID:19666821) MGI PMID:19666821 NCBI chr13:116,434,806...116,446,224
Ensembl chr13:116,434,817...116,446,225 		JBrowse link
G Isl2 insulin related protein 2 (islet 2) acts_upstream_of_or_within IGI (PMID:19666821) MGI PMID:19666821 NCBI chr 9:55,445,961...55,454,951
Ensembl chr 9:55,445,956...55,453,464 		JBrowse link
G Lhx3 LIM homeobox protein 3 acts_upstream_of_or_within IGI (PMID:19666821) MGI PMID:19666821 NCBI chr 2:26,090,224...26,098,261
Ensembl chr 2:26,090,224...26,098,301 		JBrowse link
G Lmo4 LIM domain only 4 involved_in IMP (PMID:18539116) UniProt PMID:18539116 NCBI chr 3:143,894,291...143,911,016
Ensembl chr 3:143,894,291...143,910,981 		JBrowse link
G Mnx1 motor neuron and pancreas homeobox 1 involved_in
acts_upstream_of_or_within		 IBA
IMP		 (PMID:18539116)
(PMID:10482234)		 GO_Central
UniProt
MGI		 PMID:10482234 PMID:18539116 GO_REF:0000033 NCBI chr 5:29,678,821...29,683,468
Ensembl chr 5:29,678,032...29,683,468 		JBrowse link
G Olig3 oligodendrocyte transcription factor 3 acts_upstream_of_or_within IMP (PMID:15769945) MGI PMID:15769945 NCBI chr10:19,232,287...19,234,352
Ensembl chr10:19,232,281...19,234,352 		JBrowse link
spinal cord oligodendrocyte cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl1 achaete-scute family bHLH transcription factor 1 acts_upstream_of_or_within IMP (PMID:18287202) MGI PMID:18287202 NCBI chr10:87,326,681...87,329,522
Ensembl chr10:87,326,681...87,329,522 		JBrowse link
G Nkx2-2 NK2 homeobox 2 acts_upstream_of_or_within IDA (PMID:18287202) MGI PMID:18287202 NCBI chr 2:146,967,909...147,037,270
Ensembl chr 2:147,019,466...147,036,163 		JBrowse link
G Olig2 oligodendrocyte transcription factor 2 acts_upstream_of_or_within IDA (PMID:18287202) MGI PMID:18287202 NCBI chr16:91,016,745...91,025,567
Ensembl chr16:91,022,345...91,025,565 		JBrowse link
stem cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmrta2 doublesex and mab-3 related transcription factor like family A2 acts_upstream_of_or_within IMP (PMID:21576465) MGI PMID:21576465 NCBI chr 4:109,835,222...109,840,896
Ensembl chr 4:109,835,250...109,840,884 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of IGI (PMID:17462603) MGI PMID:17462603 NCBI chr 3:83,673,628...83,681,621
Ensembl chr 3:83,673,628...83,681,623 		JBrowse link
G Sox17 SRY (sex determining region Y)-box 17 acts_upstream_of_or_within IDA (PMID:20228271) MGI PMID:20228271 NCBI chr 1:4,561,154...4,567,624
Ensembl chr 1:4,561,154...4,567,577 		JBrowse link
G Sox18 SRY (sex determining region Y)-box 18 acts_upstream_of_or_within IDA (PMID:20228271) MGI PMID:20228271 NCBI chr 2:181,311,630...181,313,433
Ensembl chr 2:181,311,629...181,313,433 		JBrowse link
ventral spinal cord interneuron specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbx1 developing brain homeobox 1 acts_upstream_of_or_within IMP (PMID:11239429) MGI PMID:11239429 NCBI chr 7:49,281,247...49,286,583
Ensembl chr 7:49,281,247...49,286,597 		JBrowse link
G Dmrt3 doublesex and mab-3 related transcription factor 3 acts_upstream_of_or_within IMP (PMID:22932389) MGI PMID:22932389 NCBI chr19:25,587,609...25,601,285
Ensembl chr19:25,587,665...25,601,285 		JBrowse link
G Lhx3 LIM homeobox protein 3 acts_upstream_of_or_within IDA (PMID:19666821) MGI PMID:19666821 NCBI chr 2:26,090,224...26,098,261
Ensembl chr 2:26,090,224...26,098,301 		JBrowse link
G Shh sonic hedgehog acts_upstream_of_or_within ISO MGI GO_REF:0000008 NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254 		JBrowse link
G Sox1 SRY (sex determining region Y)-box 1 acts_upstream_of_or_within IMP (PMID:20844123) MGI PMID:20844123 NCBI chr 8:12,445,519...12,449,555
Ensembl chr 8:12,445,295...12,450,126 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28635
    cellular process 18389
      cellular developmental process 5146
        cell fate specification 117
          abaxial cell fate specification 0
          anther wall tapetum cell fate specification 0
          bundle sheath cell fate specification 0
          cardiac cell fate specification + 3
          cell fate specification involved in pattern specification + 8
          compound eye cone cell fate specification + 0
          ectodermal cell fate specification + 1
          endodermal cell fate specification + 8
          endothelial cell fate specification + 4
          eosinophil fate specification 0
          epidermal cell fate specification + 6
          epithelial cell type specification, open tracheal system + 0
          glial cell fate specification + 9
          mesodermal cell fate specification + 12
          muscle cell fate specification + 1
          myoblast fate specification + 2
          negative regulation of cell fate specification + 6
          neuroblast fate specification 0
          neuron fate specification + 42
          plant endodermal cell fate specification 0
          plant epidermal cell fate specification + 0
          positive regulation of cell fate specification + 4
          regulation of cell fate specification + 25
          skeletal muscle satellite cell fate specification 0
          stem cell fate specification + 7
          vulval cell fate specification 0
Path 2
Term Annotations click to browse term
  biological_process 28635
    cellular process 18389
      cellular developmental process 5146
        cell differentiation 5145
          cell fate commitment 313
            cell fate specification 117
              abaxial cell fate specification 0
              anther wall tapetum cell fate specification 0
              bundle sheath cell fate specification 0
              cardiac cell fate specification + 3
              cell fate specification involved in pattern specification + 8
              compound eye cone cell fate specification + 0
              ectodermal cell fate specification + 1
              endodermal cell fate specification + 8
              endothelial cell fate specification + 4
              eosinophil fate specification 0
              epidermal cell fate specification + 6
              epithelial cell type specification, open tracheal system + 0
              glial cell fate specification + 9
              mesodermal cell fate specification + 12
              muscle cell fate specification + 1
              myoblast fate specification + 2
              negative regulation of cell fate specification + 6
              neuroblast fate specification 0
              neuron fate specification + 42
              plant endodermal cell fate specification 0
              plant epidermal cell fate specification + 0
              positive regulation of cell fate specification + 4
              regulation of cell fate specification + 25
              skeletal muscle satellite cell fate specification 0
              stem cell fate specification + 7
              vulval cell fate specification 0
paths to the root