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ONTOLOGY REPORT - ANNOTATIONS


Term:formation of primary germ layer
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Accession:GO:0001704 term browser browse the term
Definition:The formation of the ectoderm, mesoderm and endoderm during gastrulation.


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formation of primary germ layer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARID1A AT-rich interaction domain 1A acts_upstream_of_or_within ISO (MGI:3789431|PMID:18448678) MGI PMID:18448678 MGI:3789431 NCBI chr 2:73,331,606...73,401,151
Ensembl chr 2:73,324,852...73,401,102
JBrowse link
G ATOH8 atonal bHLH transcription factor 8 involved_in ISO (MGI:3798332|PMID:18560595) UniProt PMID:18560595 MGI:3798332 NCBI chr17:39,255,725...39,280,022 JBrowse link
G KIF16B kinesin family member 16B involved_in ISO (MGI:4889011|PMID:21238925) UniProt PMID:21238925 MGI:4889011 NCBI chr24:6,260,558...6,576,544
Ensembl chr24:6,261,553...6,575,845
JBrowse link
axial mesoderm formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AXIN1 axin 1 acts_upstream_of_or_within ISO (MGI:894149|PMID:9230313) MGI PMID:9230313 MGI:894149 NCBI chr 6:40,155,797...40,218,330
Ensembl chr 6:40,158,244...40,218,343
JBrowse link
G EPHA2 EPH receptor A2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1934524|PMID:11287184) Ensembl
MGI
PMID:11287184 GO_REF:0000107 MGI:1934524 NCBI chr 2:81,534,130...81,561,722
Ensembl chr 2:81,534,125...81,561,725
JBrowse link
axial mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NODAL nodal growth differentiation factor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2677178|PMID:14511481) Ensembl
MGI
PMID:14511481 GO_REF:0000107 MGI:2677178 NCBI chr 4:21,366,828...21,374,623
Ensembl chr 4:21,367,583...21,375,151
JBrowse link
BMP signaling pathway involved in mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ETV2 ETS variant transcription factor 2 acts_upstream_of_or_within ISO (MGI:4415813|PMID:18462699) MGI PMID:18462699 MGI:4415813 NCBI chr 1:116,971,238...116,974,831
Ensembl chr 1:116,971,365...116,985,796
JBrowse link
ectoderm formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXA2 forkhead box A2 acts_upstream_of_or_within ISO (MGI:1344734|PMID:10498685) MGI PMID:10498685 MGI:1344734 NCBI chr24:1,010,370...1,013,791
Ensembl chr24:1,010,651...1,013,072
JBrowse link
G LHX1 LIM homeobox 1 involved_in
acts_upstream_of_or_within
ISS
ISO
(MGI:1344734|PMID:10498685) UniProt
MGI
PMID:10498685 GO_REF:0000024 MGI:1344734 NCBI chr 9:36,760,890...36,768,345
Ensembl chr 9:36,761,826...36,768,164
JBrowse link
ectodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ELF5 E74 like ETS transcription factor 5 acts_upstream_of_or_within ISO (MGI:5616945|PMID:25446535) MGI PMID:25446535 MGI:5616945 NCBI chr18:33,342,962...33,376,012
Ensembl chr18:33,332,324...33,374,828
JBrowse link
G ETS2 ETS proto-oncogene 2, transcription factor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5616945|PMID:25446535) Ensembl
MGI
PMID:25446535 GO_REF:0000107 MGI:5616945 NCBI chr31:33,846,821...33,861,394
Ensembl chr31:33,839,010...33,860,330
JBrowse link
G LOC481709 POU domain, class 5, transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:860,702...866,099 JBrowse link
endoderm formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTNNB1 catenin beta 1 acts_upstream_of_or_within ISO (MGI:5498579|PMID:23824574)
(MGI:3625553|PMID:12194849)
MGI PMID:12194849 PMID:23824574 MGI:3625553 MGI:5498579 NCBI chr23:10,559,722...10,572,933
Ensembl chr23:10,559,718...10,572,927
JBrowse link
G DKK1 dickkopf WNT signaling pathway inhibitor 1 acts_upstream_of_or_within ISO (MGI:4415813|PMID:18462699) MGI PMID:18462699 MGI:4415813 NCBI chr26:35,697,428...35,701,596
Ensembl chr26:35,697,618...35,701,496
JBrowse link
G DUSP1 dual specificity phosphatase 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:39,588,833...39,591,065
Ensembl chr 4:39,588,339...39,590,514
JBrowse link
G DUSP2 dual specificity phosphatase 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:34,586,635...34,589,076
Ensembl chr17:34,586,716...34,588,453
JBrowse link
G DUSP4 dual specificity phosphatase 4 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 Ensembl chr16:34,801,869...34,814,111 JBrowse link
G DUSP5 dual specificity phosphatase 5 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr28:21,829,891...21,844,590
Ensembl chr28:21,829,921...21,841,454
JBrowse link
G EOMES eomesodermin involved_in
acts_upstream_of_or_within
ISO (MGI:3772748|PMID:18171685)
(MGI:4887279|PMID:21245162), (MGI:5293253|PMID:21822279)
UniProt
MGI
PMID:18171685 PMID:21245162 PMID:21822279 MGI:3772748 MGI:4887279 MGI:5293253 NCBI chr23:16,476,498...16,512,406
Ensembl chr23:16,506,032...16,511,527
JBrowse link
G GATA4 GATA binding protein 4 acts_upstream_of_or_within ISO (MGI:77407|PMID:8582296) MGI PMID:8582296 MGI:77407 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989
JBrowse link
G LHX1 LIM homeobox 1 involved_in
acts_upstream_of_or_within
ISS
ISO
(MGI:3487194|PMID:15355796) UniProt
MGI
PMID:15355796 GO_REF:0000024 MGI:3487194 NCBI chr 9:36,760,890...36,768,345
Ensembl chr 9:36,761,826...36,768,164
JBrowse link
G MIXL1 Mix paired-like homeobox acts_upstream_of_or_within ISO (MGI:3695524|PMID:17151016) MGI PMID:17151016 MGI:3695524 NCBI chr 7:38,651,481...38,652,560 JBrowse link
G NOG noggin acts_upstream_of_or_within ISO (MGI:4415813|PMID:18462699) MGI PMID:18462699 MGI:4415813 NCBI chr 9:31,453,604...31,456,060 JBrowse link
G SMAD2 SMAD family member 2 acts_upstream_of_or_within ISO (MGI:5293253|PMID:21822279) MGI PMID:21822279 MGI:5293253 NCBI chr 7:43,696,883...43,778,063
Ensembl chr 7:43,700,445...43,769,983
JBrowse link
G SOX17 SRY-box transcription factor 17 involved_in ISO (PMID:18682240) UniProt PMID:18682240 NCBI chr29:5,979,092...5,981,504
Ensembl chr29:5,979,261...5,981,124
JBrowse link
G SOX7 SRY-box transcription factor 7 involved_in ISO (PMID:18682240) UniProt PMID:18682240 NCBI chr25:27,216,111...27,222,142
Ensembl chr25:27,215,528...27,220,227
JBrowse link
G TNRC6C trinucleotide repeat containing adaptor 6C acts_upstream_of_or_within ISO (MGI:5315650|PMID:22187428) MGI PMID:22187428 MGI:5315650 NCBI chr 9:3,018,599...3,122,664
Ensembl chr 9:3,020,533...3,171,471
JBrowse link
endodermal cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CMSS1 cms1 ribosomal small subunit homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:6,442,721...6,818,394
Ensembl chr33:6,443,035...6,818,171
JBrowse link
G COL11A1 collagen type XI alpha 1 chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:47,425,387...47,622,189
Ensembl chr 6:47,425,307...47,621,012
JBrowse link
G COL12A1 collagen type XII alpha 1 chain involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr12:36,720,686...36,838,321
Ensembl chr12:36,646,408...36,838,622
JBrowse link
G COL4A2 collagen type IV alpha 2 chain involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chr22:58,656,579...58,820,560
Ensembl chr22:58,697,175...58,773,297
JBrowse link
G COL6A1 collagen type VI alpha 1 chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr31:39,301,718...39,319,895
Ensembl chr31:39,301,748...39,448,062
JBrowse link
G COL7A1 collagen type VII alpha 1 chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:40,519,121...40,550,305
Ensembl chr20:40,519,378...40,552,935
JBrowse link
G COL8A1 collagen type VIII alpha 1 chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:6,285,742...6,428,172
Ensembl chr33:6,285,415...6,425,414
JBrowse link
G FN1 fibronectin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:22,456,854...22,522,410
Ensembl chr37:22,420,428...22,523,123
JBrowse link
G GATA6 GATA binding protein 6 acts_upstream_of_or_within ISO (MGI:1315079|PMID:9832509) MGI PMID:9832509 MGI:1315079 NCBI chr 7:65,932,114...65,962,574 JBrowse link
G HMGA2 high mobility group AT-hook 2 involved_in ISO (PMID:17624332) UniProt PMID:17624332 NCBI chr10:8,348,101...8,491,435 JBrowse link
G HSBP1 heat shock factor binding protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5553204|PMID:24380799) Ensembl
MGI
PMID:24380799 GO_REF:0000107 MGI:5553204 NCBI chr 5:68,474,960...68,479,206
Ensembl chr 5:68,475,948...68,479,145
JBrowse link
G INHBA inhibin subunit beta A involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:8,272,978...8,288,432
Ensembl chr18:8,272,872...8,283,794
JBrowse link
G ITGA4 integrin subunit alpha 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:24,670,464...24,686,719
Ensembl chr36:24,653,408...24,729,057
JBrowse link
G ITGA5 integrin subunit alpha 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:904,892...924,757
Ensembl chr27:904,102...924,084
JBrowse link
G ITGA7 integrin subunit alpha 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:91,782...110,839
Ensembl chr10:91,391...110,817
JBrowse link
G ITGAV integrin subunit alpha V involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:28,815,215...28,890,569
Ensembl chr36:28,804,013...28,887,430
JBrowse link
G ITGB2 integrin subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr31:38,520,733...38,547,003
Ensembl chr31:38,521,103...38,547,018
JBrowse link
G ITGB5 integrin subunit beta 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:27,797,204...27,912,558
Ensembl chr33:27,797,667...27,912,584
JBrowse link
G LAMA3 laminin subunit alpha 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:64,405,719...64,654,910
Ensembl chr 7:64,406,082...64,655,268
JBrowse link
G LAMB1 laminin subunit beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:12,634,640...12,700,311
Ensembl chr18:12,630,554...12,700,308
JBrowse link
G LAMB3 laminin subunit beta 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:8,272,326...8,313,322
Ensembl chr 7:8,272,736...8,310,474
JBrowse link
G MIXL1 Mix paired-like homeobox involved_in ISO (MGI:5447921|PMID:19038793) BHF-UCL PMID:19038793 MGI:5447921 NCBI chr 7:38,651,481...38,652,560 JBrowse link
G MMP14 matrix metallopeptidase 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:3,183,419...3,193,079
Ensembl chr 8:3,183,606...3,194,122
JBrowse link
G MMP15 matrix metallopeptidase 15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:58,501,783...58,512,507
Ensembl chr 2:58,504,848...58,512,371
JBrowse link
G MMP2 matrix metallopeptidase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113
JBrowse link
G MMP8 matrix metallopeptidase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:29,036,381...29,047,180
Ensembl chr 5:29,035,820...29,046,808
JBrowse link
G MMP9 matrix metallopeptidase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
JBrowse link
G NODAL nodal growth differentiation factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:21,366,828...21,374,623
Ensembl chr 4:21,367,583...21,375,151
JBrowse link
G SETD2 SET domain containing 2, histone lysine methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:41,675,539...41,800,697
Ensembl chr20:41,675,599...41,800,612
JBrowse link
G VTN vitronectin involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chr 9:42,617,860...42,620,825
Ensembl chr 9:42,614,941...42,630,864
JBrowse link
endodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC73 cell division cycle 73 involved_in ISO (MGI:3849235|PMID:19345177) UniProt PMID:19345177 MGI:3849235 NCBI chr38:5,826,209...5,937,930
Ensembl chr38:5,805,916...5,938,111
JBrowse link
G CTNNB1 catenin beta 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3625553|PMID:12194849) Ensembl
MGI
PMID:12194849 GO_REF:0000107 MGI:3625553 NCBI chr23:10,559,722...10,572,933
Ensembl chr23:10,559,718...10,572,927
JBrowse link
G CTR9 CTR9 homolog, Paf1/RNA polymerase II complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:33,915,804...33,949,597
Ensembl chr21:33,915,772...33,949,103
JBrowse link
G LEO1 LEO1 homolog, Paf1/RNA polymerase II complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:17,614,502...17,651,715
Ensembl chr30:17,598,076...17,651,290
JBrowse link
G LOC481709 POU domain, class 5, transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:860,702...866,099 JBrowse link
G PAF1 PAF1 homolog, Paf1/RNA polymerase II complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:113,828,219...113,832,747
Ensembl chr 1:113,828,007...113,832,735
JBrowse link
G RTF1 RTF1 homolog, Paf1/RNA polymerase II complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:8,468,001...8,524,712
Ensembl chr30:8,467,761...8,522,874
JBrowse link
endodermal cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA6 GATA binding protein 6 acts_upstream_of_or_within ISO (MGI:4442295|PMID:20308546) MGI PMID:20308546 MGI:4442295 NCBI chr 7:65,932,114...65,962,574 JBrowse link
G SOX17 SRY-box transcription factor 17 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4442295|PMID:20308546) Ensembl
MGI
PMID:20308546 GO_REF:0000107 MGI:4442295 NCBI chr29:5,979,092...5,981,504
Ensembl chr29:5,979,261...5,981,124
JBrowse link
endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EOMES eomesodermin involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:4887279|PMID:21245162)
GO_Central
MGI
PMID:21245162 PMID:21873635 MGI:4887279 NCBI chr23:16,476,498...16,512,406
Ensembl chr23:16,506,032...16,511,527
JBrowse link
G HNF1B HNF1 homeobox B involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3807614|PMID:18635606) Ensembl
MGI
PMID:18635606 GO_REF:0000107 MGI:3807614 NCBI chr 9:37,437,992...37,493,200
Ensembl chr 9:37,438,583...37,492,993
JBrowse link
G NANOG Nanog homeobox involved_in ISO (PMID:20713518) MGI PMID:20713518 NCBI chr27:37,262,558...37,266,449 JBrowse link
G SOX17 SRY-box transcription factor 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:5,979,092...5,981,504
Ensembl chr29:5,979,261...5,981,124
JBrowse link
G SOX2 SRY-box transcription factor 2 involved_in ISO (PMID:21245162) MGI PMID:21245162 NCBI chr34:14,853,000...14,855,153 JBrowse link
hemangioblast cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TAL1 TAL bHLH transcription factor 1, erythroid differentiation factor acts_upstream_of_or_within ISO (MGI:3838687|PMID:19182774)
(MGI:3580923|PMID:15677567), (MGI:3807430|PMID:18550854)
MGI PMID:15677567 PMID:18550854 PMID:19182774 MGI:3580923 MGI:3807430 MGI:3838687 NCBI chr15:13,446,752...13,462,038
Ensembl chr15:13,449,481...13,462,047
JBrowse link
intermediate mesodermal cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:29,997,563...30,254,307
Ensembl chr 8:29,997,569...30,004,557
JBrowse link
lateral mesodermal cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXF1 forkhead box F1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1928688|PMID:11124112) Ensembl
MGI
PMID:11124112 GO_REF:0000107 MGI:1928688 NCBI chr 5:66,343,776...66,347,785
Ensembl chr 5:66,345,150...66,347,935
JBrowse link
mesoderm formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1 activin A receptor type 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1345529|PMID:10479450)
(MGI:3695845|PMID:17117439)
Ensembl
MGI
PMID:10479450 PMID:17117439 GO_REF:0000107 MGI:1345529 MGI:3695845 NCBI chr36:3,743,257...3,818,659
Ensembl chr36:3,744,163...3,818,652
JBrowse link
G ARMC5 armadillo repeat containing 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5913685|PMID:28911199) Ensembl
MGI
PMID:28911199 GO_REF:0000107 MGI:5913685 NCBI chr 6:16,782,732...16,789,490
Ensembl chr 6:16,781,860...16,788,878
JBrowse link
G BMP4 bone morphogenetic protein 4 acts_upstream_of_or_within ISO (MGI:4415813|PMID:18462699), (MGI:70235|PMID:7799920) MGI PMID:7799920 PMID:18462699 MGI:4415813 MGI:70235 NCBI chr 8:29,997,563...30,254,307
Ensembl chr 8:29,997,569...30,004,557
JBrowse link
G BMP7 bone morphogenetic protein 7 acts_upstream_of_or_within ISO (MGI:3578079|PMID:15843411) MGI PMID:15843411 MGI:3578079 NCBI chr24:42,203,183...42,294,105
Ensembl chr24:42,204,823...42,294,653
JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3722226|PMID:17699604) Ensembl
MGI
PMID:17699604 GO_REF:0000107 MGI:3722226 NCBI chr 4:34,499,898...34,582,481
Ensembl chr 4:34,517,492...34,578,923
JBrowse link
G BMPR2 bone morphogenetic protein receptor type 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1855789|PMID:10772805) Ensembl
MGI
PMID:10772805 GO_REF:0000107 MGI:1855789 NCBI chr37:11,342,292...11,540,199
Ensembl chr37:11,342,384...11,533,024
JBrowse link
G CHRD chordin acts_upstream_of_or_within ISO (MGI:2662951|PMID:12810603) MGI PMID:12810603 MGI:2662951 NCBI chr34:17,255,770...17,264,776
Ensembl chr34:17,255,562...17,271,713
JBrowse link
G CRB2 crumbs cell polarity complex component 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:59,427,661...59,450,436
Ensembl chr 9:59,427,569...59,450,434
JBrowse link
G DKK1 dickkopf WNT signaling pathway inhibitor 1 acts_upstream_of_or_within ISO (MGI:4415813|PMID:18462699) MGI PMID:18462699 MGI:4415813 NCBI chr26:35,697,428...35,701,596
Ensembl chr26:35,697,618...35,701,496
JBrowse link
G ECSIT ECSIT signaling integrator acts_upstream_of_or_within ISO (MGI:2682456|PMID:14633973) MGI PMID:14633973 MGI:2682456 NCBI chr20:49,848,848...49,867,075
Ensembl chr20:49,848,912...49,867,066
JBrowse link
G EOMES eomesodermin involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:1354065|PMID:10716450)
GO_Central
MGI
PMID:10716450 PMID:21873635 MGI:1354065 NCBI chr23:16,476,498...16,512,406
Ensembl chr23:16,506,032...16,511,527
JBrowse link
G ETV2 ETS variant transcription factor 2 acts_upstream_of_or_within ISO (MGI:4415813|PMID:18462699) MGI PMID:18462699 MGI:4415813 NCBI chr 1:116,971,238...116,974,831
Ensembl chr 1:116,971,365...116,985,796
JBrowse link
G EXT2 exostosin glycosyltransferase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3608483|PMID:16236767) Ensembl
MGI
PMID:16236767 GO_REF:0000107 MGI:3608483 NCBI chr18:44,987,310...45,122,339
Ensembl chr18:44,987,748...45,129,974
JBrowse link
G GPI glucose-6-phosphate isomerase acts_upstream_of_or_within ISO (MGI:84014|PMID:8922529) MGI PMID:8922529 MGI:84014 NCBI chr 1:117,922,380...117,948,325
Ensembl chr 1:117,922,635...117,948,316
JBrowse link
G HAND1 heart and neural crest derivatives expressed 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1197801|PMID:9500550) Ensembl
MGI
PMID:9500550 GO_REF:0000107 MGI:1197801 NCBI chr 4:55,231,061...55,234,640
Ensembl chr 4:55,231,481...55,234,265
JBrowse link
G INHBA inhibin subunit beta A acts_upstream_of_or_within ISO (MGI:70235|PMID:7799920) MGI PMID:7799920 MGI:70235 NCBI chr18:8,272,978...8,288,432
Ensembl chr18:8,272,872...8,283,794
JBrowse link
G MACF1 microtubule actin crosslinking factor 1 acts_upstream_of_or_within ISO (MGI:3640889|PMID:16815997) MGI PMID:16815997 MGI:3640889 NCBI chr15:3,361,887...3,703,891
Ensembl chr15:3,362,867...3,573,325
JBrowse link
G MESP1 mesoderm posterior bHLH transcription factor 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:52,738,333...52,739,962
Ensembl chr 3:52,738,366...52,739,755
JBrowse link
G MESP2 mesoderm posterior bHLH transcription factor 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:52,757,581...52,759,987
Ensembl chr 3:52,756,836...52,760,004
JBrowse link
G MSGN1 mesogenin 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:13,266,674...13,267,968
Ensembl chr17:13,266,674...13,267,240
JBrowse link
G NF2 neurofibromin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:707944|PMID:9171370) Ensembl
MGI
PMID:9171370 GO_REF:0000107 MGI:707944 NCBI chr26:22,816,869...22,896,103
Ensembl chr26:22,816,551...22,894,196
JBrowse link
G NODAL nodal growth differentiation factor acts_upstream_of_or_within ISO (MGI:2155575|PMID:11311163) MGI PMID:11311163 MGI:2155575 NCBI chr 4:21,366,828...21,374,623
Ensembl chr 4:21,367,583...21,375,151
JBrowse link
G NOG noggin acts_upstream_of_or_within ISO (MGI:4415813|PMID:18462699) MGI PMID:18462699 MGI:4415813 NCBI chr 9:31,453,604...31,456,060 JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 acts_upstream_of_or_within ISO (MGI:3042044|PMID:13129926) MGI PMID:13129926 MGI:3042044 NCBI chr11:56,806,506...56,846,997
Ensembl chr11:56,812,804...56,847,689
JBrowse link
G POFUT2 protein O-fucosyltransferase 2 acts_upstream_of_or_within ISO (MGI:4838381|PMID:20637190) MGI PMID:20637190 MGI:4838381 NCBI chr31:38,813,252...38,821,656
Ensembl chr31:38,813,255...38,818,734
JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2183097|PMID:12004056) Ensembl
MGI
PMID:12004056 GO_REF:0000107 MGI:2183097 NCBI chr20:48,416,730...48,425,237
Ensembl chr20:48,409,045...48,426,669
JBrowse link
G PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2183097|PMID:12004056) Ensembl
MGI
PMID:12004056 GO_REF:0000107 MGI:2183097 NCBI chr 9:15,180,940...15,203,035
Ensembl chr 9:15,181,393...15,200,683
JBrowse link
G SCX scleraxis bHLH transcription factor involved_in ISS UniProt GO_REF:0000024 NCBI chr13:37,701,781...37,704,949
Ensembl chr13:37,703,232...37,704,657
JBrowse link
G SMAD2 SMAD family member 2 acts_upstream_of_or_within ISO (MGI:3039049|PMID:15084457) MGI PMID:15084457 MGI:3039049 NCBI chr 7:43,696,883...43,778,063
Ensembl chr 7:43,700,445...43,769,983
JBrowse link
G SMAD3 SMAD family member 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3039049|PMID:15084457) Ensembl
MGI
PMID:15084457 GO_REF:0000107 MGI:3039049 NCBI chr30:31,246,313...31,360,098
Ensembl chr30:31,245,657...31,363,337
JBrowse link
G SNAI1 snail family transcriptional repressor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:36,498,343...36,503,623
Ensembl chr24:36,498,062...36,503,628
JBrowse link
G SRF serum response factor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1312998|PMID:9799237), (MGI:1927031|PMID:11060034) Ensembl
MGI
PMID:9799237 PMID:11060034 GO_REF:0000107 MGI:1312998 MGI:1927031 NCBI chr12:11,664,441...11,673,846
Ensembl chr12:11,664,527...11,671,533
JBrowse link
G TBX19 T-box transcription factor 19 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:30,198,912...30,248,410
Ensembl chr 7:30,185,850...30,365,512
JBrowse link
G TBX6 T-box transcription factor 6 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3577662|PMID:15755804)
(MGI:2447720|PMID:9490412)
Ensembl
MGI
PMID:9490412 PMID:15755804 GO_REF:0000107 MGI:2447720 MGI:3577662 NCBI chr 6:18,093,201...18,098,592
Ensembl chr 6:18,093,189...18,097,636
JBrowse link
G TBXT T-box transcription factor T involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:54,183,495...54,192,331
Ensembl chr 1:54,183,153...54,192,352
JBrowse link
G TLX2 T cell leukemia homeobox 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1267265|PMID:9550720) Ensembl
MGI
PMID:9550720 GO_REF:0000107 MGI:1267265 NCBI chr17:48,625,008...48,627,085
Ensembl chr17:48,625,632...48,627,052
JBrowse link
G TWSG1 twisted gastrulation BMP signaling modulator 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3578079|PMID:15843411) Ensembl
MGI
PMID:15843411 GO_REF:0000107 MGI:3578079 NCBI chr 7:75,337,347...75,397,485
Ensembl chr 7:75,335,235...75,398,325
JBrowse link
G TXNRD1 thioredoxin reductase 1 acts_upstream_of_or_within ISO (MGI:3721365|PMID:17697936) MGI PMID:17697936 MGI:3721365 NCBI chr10:33,904,065...34,021,549
Ensembl chr10:33,886,343...34,021,696
JBrowse link
G WLS Wnt ligand secretion mediator involved_in ISO (MGI:4397730|PMID:19841259) UniProt PMID:19841259 MGI:4397730 NCBI chr 6:77,053,242...77,146,549
Ensembl chr 6:77,053,237...77,317,761
JBrowse link
G WNT3 Wnt family member 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1341483|PMID:10431240) Ensembl
MGI
PMID:10431240 GO_REF:0000107 MGI:1341483 NCBI chr 9:10,073,019...10,124,454
Ensembl chr 9:10,077,567...10,124,508
JBrowse link
mesoderm migration involved in gastrulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EPB41L5 erythrocyte membrane protein band 4.1 like 5 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3821807|PMID:18794329) Ensembl
MGI
PMID:18794329 GO_REF:0000107 MGI:3821807 NCBI chr19:29,916,994...30,063,243
Ensembl chr19:29,921,636...30,063,216
JBrowse link
G TBXT T-box transcription factor T involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:71468|PMID:7720590) Ensembl
MGI
PMID:7720590 GO_REF:0000107 MGI:71468 NCBI chr 1:54,183,495...54,192,331
Ensembl chr 1:54,183,153...54,192,352
JBrowse link
mesodermal cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 acts_upstream_of_or_within ISO (MGI:70235|PMID:7799920) MGI PMID:7799920 MGI:70235 NCBI chr 8:29,997,563...30,254,307
Ensembl chr 8:29,997,569...30,004,557
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 ISO RGD PMID:7803853 RGD:632663 NCBI chr28:31,303,882...31,411,015
Ensembl chr28:31,303,894...31,411,621
JBrowse link
G HMGA2 high mobility group AT-hook 2 involved_in ISO (PMID:17624332) UniProt PMID:17624332 NCBI chr10:8,348,101...8,491,435 JBrowse link
G INHBA inhibin subunit beta A involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:70235|PMID:7799920) Ensembl
MGI
PMID:7799920 GO_REF:0000107 MGI:70235 NCBI chr18:8,272,978...8,288,432
Ensembl chr18:8,272,872...8,283,794
JBrowse link
G ITGA2 integrin subunit alpha 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:62,170,137...62,268,962
Ensembl chr 4:62,170,452...62,268,983
JBrowse link
G ITGA3 integrin subunit alpha 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:26,065,792...26,095,649
Ensembl chr 9:26,062,393...26,094,422
JBrowse link
G ITGA8 integrin subunit alpha 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:21,034,630...21,244,304
Ensembl chr 2:21,075,653...21,241,951
JBrowse link
G ITGB1 integrin subunit beta 1 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chr 2:3,728,472...3,757,696
Ensembl chr 2:3,670,596...3,756,961
JBrowse link
G ITGB3 integrin subunit beta 3 involved_in ISO (PMID:23154389) UniProt PMID:23154389 NCBI chr 9:9,179,667...9,231,061
Ensembl chr 9:9,182,562...9,231,451
JBrowse link
G ITGB4 integrin subunit beta 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:4,825,148...4,855,266
Ensembl chr 9:4,825,292...4,855,820
JBrowse link
G KDM6A lysine demethylase 6A involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5448135|PMID:22949634) Ensembl
MGI
PMID:22949634 GO_REF:0000107 MGI:5448135 NCBI chr  X:38,745,854...38,964,029
Ensembl chr  X:38,745,854...38,959,842
JBrowse link
G KDM6B lysine demethylase 6B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:32,689,000...32,711,026
Ensembl chr 5:32,696,211...32,710,666
JBrowse link
mesodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC481709 POU domain, class 5, transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:860,702...866,099 JBrowse link
G NANOG Nanog homeobox acts_upstream_of_or_within ISO (MGI:3654744|PMID:16801560) MGI PMID:16801560 MGI:3654744 NCBI chr27:37,262,558...37,266,449 JBrowse link
G SMAD1 SMAD family member 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3654744|PMID:16801560) Ensembl
MGI
PMID:16801560 GO_REF:0000107 MGI:3654744 NCBI chr15:44,093,491...44,171,177
Ensembl chr15:44,095,497...44,170,098
JBrowse link
mesodermal cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:76261|PMID:7657163) Ensembl
MGI
PMID:7657163 GO_REF:0000107 MGI:76261 NCBI chr 8:29,997,563...30,254,307
Ensembl chr 8:29,997,569...30,004,557
JBrowse link
mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EYA1 EYA transcriptional coactivator and phosphatase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:20,176,306...20,595,131
Ensembl chr29:20,177,014...20,525,653
JBrowse link
G HOXA11 homeobox A11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:40,355,907...40,360,120
Ensembl chr14:40,357,478...40,359,919
JBrowse link
G PAX2 paired box 2 involved_in ISO (MGI:3768605|PMID:17785448) UniProt PMID:17785448 MGI:3768605 NCBI chr28:13,442,894...13,519,853
Ensembl chr28:13,442,893...13,532,094
JBrowse link
G SIX2 SIX homeobox 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:47,399,152...47,403,503
Ensembl chr10:47,400,034...47,403,509
JBrowse link
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FZD7 frizzled class receptor 7 involved_in ISO (PMID:18681827) BHF-UCL PMID:18681827 NCBI chr37:11,054,572...11,061,173
Ensembl chr37:11,053,521...11,060,821
JBrowse link
negative regulation of endodermal cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL5A1 collagen type V alpha 1 chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:50,706,852...50,856,691
Ensembl chr 9:50,770,277...50,854,728
JBrowse link
G COL5A2 collagen type V alpha 2 chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:30,538,863...30,677,450
Ensembl chr36:30,540,229...30,691,564
JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MESP1 mesoderm posterior bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:52,738,333...52,739,962
Ensembl chr 3:52,738,366...52,739,755
JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKK1 dickkopf WNT signaling pathway inhibitor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:35,697,428...35,701,596
Ensembl chr26:35,697,618...35,701,496
JBrowse link
G MESP1 mesoderm posterior bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:52,738,333...52,739,962
Ensembl chr 3:52,738,366...52,739,755
JBrowse link
G SFRP2 secreted frizzled related protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3711603|PMID:17462603) Ensembl
MGI
PMID:17462603 GO_REF:0000107 MGI:3711603 NCBI chr15:51,541,197...51,548,765
Ensembl chr15:51,540,500...51,548,765
JBrowse link
paraxial mesoderm formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EXOC4 exocyst complex component 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1195048|PMID:9441674) Ensembl
MGI
PMID:9441674 GO_REF:0000107 MGI:1195048 NCBI chr14:3,334,286...4,077,478
Ensembl chr14:3,334,220...4,077,411
JBrowse link
G FOXC1 forkhead box C1 involved_in
acts_upstream_of_or_within
ISO (MGI:3047050|PMID:15196959)
(MGI:2150572|PMID:11562355)
UniProt
MGI
PMID:11562355 PMID:15196959 MGI:2150572 MGI:3047050
G FOXC2 forkhead box C2 acts_upstream_of_or_within ISO (MGI:2150572|PMID:11562355) MGI PMID:11562355 MGI:2150572 NCBI chr 5:66,234,336...66,296,007
Ensembl chr 5:66,294,176...66,295,693
JBrowse link
G HNF1A HNF1 homeobox A involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1334099|PMID:10090727) Ensembl
MGI
PMID:10090727 GO_REF:0000107 MGI:1334099 NCBI chr26:16,805,690...16,826,065
Ensembl chr26:16,805,690...16,824,790
JBrowse link
G HTT huntingtin acts_upstream_of_or_within ISO (MGI:3609520|PMID:16109169) MGI PMID:16109169 MGI:3609520 NCBI chr 3:61,076,934...61,221,462
Ensembl chr 3:61,079,904...61,330,290
JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1334099|PMID:10090727) Ensembl
MGI
PMID:10090727 GO_REF:0000107 MGI:1334099 NCBI chr32:28,516,002...28,633,759
Ensembl chr32:28,517,108...28,634,019
JBrowse link
G WNT11 Wnt family member 11 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5634837|PMID:25813538) Ensembl
MGI
PMID:25813538 GO_REF:0000107 MGI:5634837 NCBI chr21:22,442,496...22,463,040
Ensembl chr21:22,446,051...22,463,173
JBrowse link
G WNT5A Wnt family member 5A involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5634837|PMID:25813538) Ensembl
MGI
PMID:25813538 GO_REF:0000107 MGI:5634837 NCBI chr20:34,756,430...34,790,937
Ensembl chr20:34,769,930...34,786,673
JBrowse link
paraxial mesodermal cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXC2 forkhead box C2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:86990|PMID:9106663) Ensembl
MGI
PMID:9106663 GO_REF:0000107 MGI:86990 NCBI chr 5:66,234,336...66,296,007
Ensembl chr 5:66,294,176...66,295,693
JBrowse link
G LOC119863920 forkhead box C2 involved_in IEA Ensembl GO_REF:0000107
G WNT3A Wnt family member 3A involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:86727|PMID:9126297) Ensembl
MGI
PMID:9126297 GO_REF:0000107 MGI:86727 NCBI chr14:864,393...899,698
Ensembl chr14:863,424...896,412
JBrowse link
positive regulation of endodermal cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MACROH2A1 macroH2A.1 histone involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:23,369,957...23,448,235
Ensembl chr11:23,370,300...23,438,219
JBrowse link
positive regulation of mesodermal cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 involved_in ISO (PMID:30599359) ARUK-UCL PMID:30599359 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936
JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT3A Wnt family member 3A involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:864,393...899,698
Ensembl chr14:863,424...896,412
JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKK1 dickkopf WNT signaling pathway inhibitor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:35,697,428...35,701,596
Ensembl chr26:35,697,618...35,701,496
JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR1A bone morphogenetic protein receptor type 1A involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3702797|PMID:16943278) Ensembl
MGI
PMID:16943278 GO_REF:0000107 MGI:3702797 NCBI chr 4:34,499,898...34,582,481
Ensembl chr 4:34,517,492...34,578,923
JBrowse link
G FGFR1 fibroblast growth factor receptor 1 acts_upstream_of_or_within ISO (MGI:3702797|PMID:16943278) MGI PMID:16943278 MGI:3702797 NCBI chr16:27,029,902...27,080,514
Ensembl chr16:27,031,588...27,078,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16213
    developmental process 6402
      anatomical structure formation involved in morphogenesis 1195
        formation of primary germ layer 129
          cell fate commitment involved in formation of primary germ layer + 32
          ectoderm formation + 6
          endoderm formation + 57
          mesoderm formation + 75
Path 2
Term Annotations click to browse term
  biological_process 16213
    developmental process 6402
      anatomical structure development 5947
        multicellular organism development 5432
          embryo development 1272
            embryonic morphogenesis 671
              gastrulation 195
                formation of primary germ layer 129
                  cell fate commitment involved in formation of primary germ layer + 32
                  ectoderm formation + 6
                  endoderm formation + 57
                  mesoderm formation + 75
paths to the root