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ONTOLOGY REPORT - ANNOTATIONS


Term:fatty acid alpha-oxidation
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Accession:GO:0001561 term browser browse the term
Definition:A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.
Synonyms:xref: MetaCyc:PWY-2501



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fatty acid alpha-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hacl1 2-hydroxyacyl-CoA lyase 1 involved_in IDA
ISO
IBA
PMID:10468558
(MGI:6105330|PMID:28629946)
(PMID:10468558), (PMID:15644336), (PMID:21708296), (PMID:28289220)
PMID:21873635
RGD PMID:10468558 PMID:15644336 PMID:21708296 PMID:28289220 PMID:28629946 More... MGI:6105330, RGD:708588, RGD:13792537 NCBI chr16:6,826,881...6,863,027
Ensembl chr16:6,824,906...6,863,027
JBrowse link
G Hao1 hydroxyacid oxidase 1 involved_in IBA
ISO
PMID:21873635
(PMID:18215067)
RGD PMID:18215067 PMID:21873635 RGD:13792537 NCBI chr 3:121,757,400...121,828,721
Ensembl chr 3:121,771,836...121,828,721
JBrowse link
G Ilvbl ilvB acetolactate synthase like involved_in ISO (PMID:28289220) RGD PMID:28289220 NCBI chr 7:11,039,870...11,049,924
Ensembl chr 7:11,039,871...11,049,924
JBrowse link
G Pex13 peroxisomal biogenesis factor 13 acts_upstream_of_or_within ISO MGI:2384515 (MGI:2670243|PMID:12897163) RGD PMID:12897163 MGI:2670243 NCBI chr14:97,602,829...97,621,233
Ensembl chr14:97,603,539...97,621,262
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
(MGI:1097297|PMID:9326939), (MGI:3052413|PMID:12915479)
(PMID:16186124), (PMID:9326939)
PMID:21873635
RGD PMID:9326939 PMID:12915479 PMID:16186124 PMID:10588950 PMID:21873635 MGI:1097297 MGI:3052413, RGD:727286, RGD:13792537 NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409
JBrowse link
G Slc27a2 solute carrier family 27 member 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:10198260)
Ensembl
RGD
PMID:10198260 GO_REF:0000107 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    metabolic process 12359
      cellular metabolic process 10396
        cellular lipid metabolic process 1062
          fatty acid metabolic process 449
            fatty acid catabolic process 111
              fatty acid alpha-oxidation 6
Path 2
Term Annotations click to browse term
  biological_process 20091
    metabolic process 12359
      cellular metabolic process 10396
        organic acid metabolic process 1045
          oxoacid metabolic process 1030
            carboxylic acid metabolic process 1015
              monocarboxylic acid metabolic process 699
                fatty acid metabolic process 449
                  fatty acid catabolic process 111
                    fatty acid alpha-oxidation 6
paths to the root