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ONTOLOGY REPORT - ANNOTATIONS

Term:fatty acid alpha-oxidation
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Accession:GO:0001561 term browser browse the term
Definition:A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.
Synonyms:xref: MetaCyc:PWY-2501


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fatty acid alpha-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hacl1 2-hydroxyacyl-CoA lyase 1 involved_in IDA
ISO
IEA
IBA		 PMID:10468558
(PMID:10468558), (PMID:15644336), (PMID:21708296), (PMID:28289220)
(MGI:6105330|PMID:28629946)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:10468558 PMID:15644336 PMID:21708296 PMID:28289220 PMID:28629946 More... GO_REF:0000033 GO_REF:0000107 MGI:6105330, RGD:708588 NCBI chr16:6,826,881...6,863,027
Ensembl chr16:6,824,906...6,863,027 		JBrowse link
G Hao1 hydroxyacid oxidase 1 involved_in ISO
IBA		 (PMID:18215067)
GO_REF:0000033		 RGD
GO_Central		 PMID:18215067 GO_REF:0000033 NCBI chr 3:121,757,400...121,828,721
Ensembl chr 3:121,771,836...121,828,721 		JBrowse link
G Hao2 hydroxyacid oxidase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425 		JBrowse link
G Ilvbl ilvB acetolactate synthase like involved_in ISO (PMID:28289220) RGD PMID:28289220 NCBI chr 7:11,039,870...11,049,924
Ensembl chr 7:11,039,871...11,049,924 		JBrowse link
G Pex13 peroxisomal biogenesis factor 13 acts_upstream_of_or_within ISO MGI:2384515 (PMID:12897163) RGD PMID:12897163 NCBI chr14:97,602,829...97,621,233
Ensembl chr14:97,603,539...97,621,262 		JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase involved_in
acts_upstream_of_or_within		 IDA
ISO
IBA		 (PMID:16186124), (PMID:9326939)
GO_REF:0000033
(PMID:12915479), (PMID:9326939)		 RGD
GO_Central		 PMID:9326939 PMID:12915479 PMID:16186124 PMID:10588950 GO_REF:0000033, RGD:727286 NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409 		JBrowse link
G Slc27a2 solute carrier family 27 member 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:10198260)		 Ensembl
RGD		 PMID:10198260 GO_REF:0000107 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    cellular process 18524
      cellular metabolic process 10293
        cellular lipid metabolic process 1068
          fatty acid metabolic process 454
            fatty acid oxidation 120
              fatty acid alpha-oxidation 7
Path 2
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12289
      cellular metabolic process 10293
        organic acid metabolic process 1033
          oxoacid metabolic process 1022
            carboxylic acid metabolic process 1007
              monocarboxylic acid metabolic process 730
                fatty acid metabolic process 454
                  fatty acid catabolic process 115
                    fatty acid alpha-oxidation 7
paths to the root