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ONTOLOGY REPORT - ANNOTATIONS

Term:fatty acid alpha-oxidation
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Accession:GO:0001561 term browser browse the term
Definition:A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.
Synonyms:xref: MetaCyc:PWY-2501


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fatty acid alpha-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HACL1 2-hydroxyacyl-CoA lyase 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr13:2,786,007...2,840,882
Ensembl chr13:2,766,514...2,840,902 		JBrowse link
G HAO1 hydroxyacid oxidase 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr17:16,746,153...16,802,460
Ensembl chr17:16,744,442...16,802,442 		JBrowse link
G HAO2 hydroxyacid oxidase 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:101,588,510...101,787,818
Ensembl chr 4:101,588,861...101,732,304 		JBrowse link
G ILVBL ilvB acetolactate synthase like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:62,435,368...62,447,030
Ensembl chr 2:62,435,155...62,451,371 		JBrowse link
G PEX13 peroxisomal biogenesis factor 13 acts_upstream_of_or_within ISO (PMID:12897163) MGI PMID:12897163 NCBI chr 3:80,757,470...80,791,107
Ensembl chr 3:80,753,908...80,791,056 		JBrowse link
G PHYH phytanoyl-CoA 2-hydroxylase acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA		 (PMID:12915479), (PMID:9326939) RGD
MGI
GO_Central
InterPro
Ensembl		 PMID:9326939 PMID:10588950 PMID:12915479 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:727286 NCBI chr10:48,404,298...48,423,978
Ensembl chr10:48,404,293...48,423,973 		JBrowse link
G SLC27A2 solute carrier family 27 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:121,530,449...121,578,994
Ensembl chr 1:121,526,295...121,579,120 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17633
    cellular process 16612
      cellular metabolic process 8962
        cellular lipid metabolic process 964
          fatty acid metabolic process 383
            fatty acid oxidation 116
              fatty acid alpha-oxidation 7
Path 2
Term Annotations click to browse term
  biological_process 17633
    metabolic process 10708
      cellular metabolic process 8962
        organic acid metabolic process 896
          oxoacid metabolic process 887
            carboxylic acid metabolic process 871
              monocarboxylic acid metabolic process 603
                fatty acid metabolic process 383
                  fatty acid catabolic process 103
                    fatty acid alpha-oxidation 7
paths to the root