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ONTOLOGY REPORT - ANNOTATIONS

Term:fatty acid alpha-oxidation
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Accession:GO:0001561 term browser browse the term
Definition:A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.
Synonyms:xref: MetaCyc:PWY-2501


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fatty acid alpha-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hacl1 2-hydroxyacyl-CoA lyase 1 involved_in IMP
ISO
IBA		 (MGI:6105330|PMID:28629946) UniProt
MGI
GO_Central		 PMID:28629946 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 MGI:6105330 NCBI chr14:31,329,183...31,364,201
Ensembl chr14:31,320,687...31,363,243 		JBrowse link
G Hao1 hydroxyacid oxidase 1, liver involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:134,339,281...134,396,272
Ensembl chr 2:134,339,281...134,396,288 		JBrowse link
G Hao2 hydroxyacid oxidase 2, kidney involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:98,781,835...98,802,692
Ensembl chr 3:98,781,837...98,800,555 		JBrowse link
G Ilvbl ilvB (bacterial acetolactate synthase)-like involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:78,410,178...78,420,336
Ensembl chr10:78,410,180...78,420,336 		JBrowse link
G Pex13 peroxisomal biogenesis factor 13 acts_upstream_of_or_within IMP (PMID:12897163) MGI PMID:12897163 NCBI chr11:23,597,283...23,615,883
Ensembl chr11:23,596,479...23,615,959 		JBrowse link
G Phyh phytanoyl-CoA hydroxylase involved_in
acts_upstream_of_or_within		 ISO
IDA
IBA		 (PMID:12915479), (PMID:9326939) RGD
MGI
GO_Central		 PMID:9326939 PMID:10588950 PMID:12915479 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:727286 NCBI chr 2:4,923,807...4,943,554
Ensembl chr 2:4,923,830...4,943,541 		JBrowse link
G Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:126,394,944...126,430,163
Ensembl chr 2:126,394,327...126,430,163 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28697
    cellular process 17623
      cellular metabolic process 9818
        cellular lipid metabolic process 1091
          fatty acid metabolic process 486
            fatty acid oxidation 120
              fatty acid alpha-oxidation 7
Path 2
Term Annotations click to browse term
  biological_process 28697
    metabolic process 11702
      cellular metabolic process 9818
        organic acid metabolic process 1037
          oxoacid metabolic process 1030
            carboxylic acid metabolic process 1008
              monocarboxylic acid metabolic process 740
                fatty acid metabolic process 486
                  fatty acid catabolic process 108
                    fatty acid alpha-oxidation 7
paths to the root