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ONTOLOGY REPORT - ANNOTATIONS

Term:fatty acid alpha-oxidation
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Accession:GO:0001561 term browser browse the term
Definition:A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.
Synonyms:xref: MetaCyc:PWY-2501


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fatty acid alpha-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HACL1 2-hydroxyacyl-CoA lyase 1 involved_in IDA
IEA
IBA		 (PMID:10468558), (PMID:15644336), (PMID:21708296), (PMID:28289220) UniProt
Ensembl
TreeGrafter
GO_Central		 PMID:10468558 PMID:15644336 PMID:21708296 PMID:28289220 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:15,560,699...15,601,569
Ensembl chr 3:15,560,699...15,601,852 		JBrowse link
G HAO1 hydroxyacid oxidase 1 involved_in IDA
IEA
IBA		 (PMID:18215067) UniProt
TreeGrafter
GO_Central		 PMID:18215067 GO_REF:0000033 GO_REF:0000118 NCBI chr20:7,882,985...7,940,458
Ensembl chr20:7,882,985...7,940,458 		JBrowse link
G HAO2 hydroxyacid oxidase 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:119,368,785...119,394,130
Ensembl chr 1:119,368,779...119,394,130 		JBrowse link
G ILVBL ilvB acetolactate synthase like involved_in IDA (PMID:28289220) UniProt PMID:28289220 NCBI chr19:15,114,987...15,125,786
Ensembl chr19:15,114,984...15,125,786 		JBrowse link
G PEX13 peroxisomal biogenesis factor 13 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 (PMID:12897163) UniProt
MGI
Ensembl		 PMID:12897163 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:61,017,720...61,051,990
Ensembl chr 2:61,017,225...61,051,990 		JBrowse link
G PHYH phytanoyl-CoA 2-hydroxylase acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA
IDA		 (PMID:12915479), (PMID:9326939)
(PMID:16186124), (PMID:9326939)		 RGD
MGI
TreeGrafter
GO_Central
InterPro
CAFA
Ensembl		 PMID:9326939 PMID:10588950 PMID:12915479 PMID:16186124 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 RGD:727286 NCBI chr10:13,277,799...13,300,064
Ensembl chr10:13,277,796...13,302,412 		JBrowse link
G SLC25A17 solute carrier family 25 member 17 involved_in TAS Reactome Reactome:R-HSA-389599 NCBI chr22:40,769,630...40,819,346
Ensembl chr22:40,769,630...40,819,399 		JBrowse link
G SLC27A2 solute carrier family 27 member 2 involved_in TAS
IDA		 (PMID:10198260) Reactome
UniProt		 PMID:10198260 Reactome:R-HSA-389599 NCBI chr15:50,182,196...50,236,385
Ensembl chr15:50,182,196...50,236,385 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      cellular metabolic process 10651
        cellular lipid metabolic process 1120
          fatty acid metabolic process 456
            fatty acid catabolic process 116
              fatty acid alpha-oxidation 8
Path 2
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      cellular metabolic process 10651
        organic acid metabolic process 1051
          oxoacid metabolic process 1042
            carboxylic acid metabolic process 1017
              monocarboxylic acid metabolic process 716
                fatty acid metabolic process 456
                  fatty acid catabolic process 116
                    fatty acid alpha-oxidation 8
paths to the root