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ONTOLOGY REPORT - ANNOTATIONS

Term:fatty acid alpha-oxidation
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Accession:GO:0001561 term browser browse the term
Definition:A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.
Synonyms:xref: MetaCyc:PWY-2501

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fatty acid alpha-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HACL1 2-hydroxyacyl-CoA lyase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:60,360,380...60,433,528
Ensembl chr15:60,322,722...60,433,647 		JBrowse link
G HAO1 hydroxyacid oxidase 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:30,183,031...30,238,663
Ensembl chr 2:30,183,705...30,240,231 		JBrowse link
G HAO2 hydroxyacid oxidase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:14,376,096...14,408,753
Ensembl chr20:14,374,543...14,407,992 		JBrowse link
G ILVBL ilvB acetolactate synthase like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:13,717,252...13,728,880
Ensembl chr 6:13,715,767...13,728,855 		JBrowse link
G PEX13 peroxisomal biogenesis factor 13 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12897163) Ensembl
MGI		 PMID:12897163 GO_REF:0000107 NCBI chr14:45,939,181...45,973,049
Ensembl chr14:45,938,940...45,973,125 		JBrowse link
G PHYH phytanoyl-CoA 2-hydroxylase involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:12915479), (PMID:9326939) RGD
TreeGrafter
MGI
InterPro		 PMID:9326939 PMID:10588950 PMID:12915479 GO_REF:0000002 GO_REF:0000118 RGD:727286 NCBI chr 9:13,309,059...13,331,606
Ensembl chr 9:13,308,951...13,331,504 		JBrowse link
G SLC27A2 solute carrier family 27 member 2 involved_in ISO (PMID:10198260) UniProt PMID:10198260 NCBI chr26:33,080,844...33,134,467
Ensembl chr26:33,083,317...33,134,433 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17079
    cellular process 15998
      cellular metabolic process 9346
        cellular lipid metabolic process 983
          fatty acid metabolic process 386
            fatty acid oxidation 114
              fatty acid alpha-oxidation 7
Path 2
Term Annotations click to browse term
  biological_process 17079
    metabolic process 11164
      cellular metabolic process 9346
        organic acid metabolic process 913
          oxoacid metabolic process 906
            carboxylic acid metabolic process 890
              monocarboxylic acid metabolic process 617
                fatty acid metabolic process 386
                  fatty acid catabolic process 105
                    fatty acid alpha-oxidation 7
paths to the root