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ONTOLOGY REPORT - ANNOTATIONS

Term:fatty acid alpha-oxidation
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Accession:GO:0001561 term browser browse the term
Definition:A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.
Synonyms:xref: MetaCyc:PWY-2501


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fatty acid alpha-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAO1 hydroxyacid oxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:14,204,543...14,252,873
Ensembl chr24:14,204,617...14,252,191 		JBrowse link
G ILVBL ilvB acetolactate synthase like involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:47,013,033...47,021,511
Ensembl chr20:47,012,557...47,021,778 		JBrowse link
G LOC119876062 phytanoyl-CoA dioxygenase, peroxisomal-like involved_in IEA InterPro GO_REF:0000002
G LOC119876063 phytanoyl-CoA dioxygenase, peroxisomal-like involved_in IEA InterPro GO_REF:0000002
G LOC119876065 phytanoyl-CoA dioxygenase, peroxisomal-like involved_in IEA InterPro GO_REF:0000002
G LOC119878397 phytanoyl-CoA dioxygenase, peroxisomal-like involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107
G LOC119878398 phytanoyl-CoA dioxygenase, peroxisomal-like involved_in IEA InterPro GO_REF:0000002
G LOC119878493 phytanoyl-CoA dioxygenase, peroxisomal-like involved_in IEA InterPro GO_REF:0000002
G LOC119878928 phytanoyl-CoA dioxygenase, peroxisomal-like involved_in IEA InterPro GO_REF:0000002
G LOC478000 phytanoyl-CoA hydroxylase-like involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:12915479), (PMID:9326939) RGD
InterPro
MGI		 PMID:9326939 PMID:10588950 PMID:12915479 GO_REF:0000002 RGD:727286 NCBI chr 2:23,185,901...23,206,719
Ensembl chr 2:23,185,782...23,253,497 		JBrowse link
G LOC478001 phytanoyl-CoA hydroxylase-like involved_in IEA InterPro GO_REF:0000002 NCBI chr 2:23,235,467...23,253,497 JBrowse link
G LOC608697 2-hydroxyacyl-CoA lyase 1 involved_in ISO (MGI:6105330|PMID:28629946)
(PMID:10468558), (PMID:15644336), (PMID:21708296), (PMID:28289220)		 UniProt
HGNC-UCL		 PMID:10468558 PMID:15644336 PMID:21708296 PMID:28289220 PMID:28629946 MGI:6105330 RGD:708588 NCBI chr23:27,069,676...27,188,247 JBrowse link
G PEX13 peroxisomal biogenesis factor 13 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12897163) Ensembl
MGI		 PMID:12897163 GO_REF:0000107 NCBI chr10:61,113,213...61,130,157
Ensembl chr10:61,123,655...61,193,241 		JBrowse link
G SLC27A2 solute carrier family 27 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:16,155,932...16,196,919
Ensembl chr30:16,156,063...16,196,829 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17067
    cellular process 15924
      cellular metabolic process 9056
        cellular lipid metabolic process 912
          fatty acid metabolic process 361
            fatty acid oxidation 117
              fatty acid alpha-oxidation 14
Path 2
Term Annotations click to browse term
  biological_process 17067
    metabolic process 10852
      cellular metabolic process 9056
        organic acid metabolic process 905
          oxoacid metabolic process 898
            carboxylic acid metabolic process 883
              monocarboxylic acid metabolic process 602
                fatty acid metabolic process 361
                  fatty acid catabolic process 96
                    fatty acid alpha-oxidation 14
paths to the root