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ONTOLOGY REPORT - ANNOTATIONS

Term:fatty acid alpha-oxidation
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Accession:GO:0001561 term browser browse the term
Definition:A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.
Synonyms:xref: MetaCyc:PWY-2501

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fatty acid alpha-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hacl1 2-hydroxyacyl-CoA lyase 1 involved_in ISO (PMID:10468558), (PMID:15644336), (PMID:21708296), (PMID:28289220)
(MGI:6105330|PMID:28629946)		 HGNC-UCL
UniProt		 PMID:10468558 PMID:15644336 PMID:21708296 PMID:28289220 PMID:28629946 MGI:6105330 RGD:708588 NCBI chrNW_004955430:2,055,774...2,096,260
Ensembl chrNW_004955430:2,053,640...2,096,432 		JBrowse link
G Hao1 hydroxyacid oxidase 1 involved_in ISO (PMID:18215067) UniProt PMID:18215067 NCBI chrNW_004955415:17,981,791...18,035,151
Ensembl chrNW_004955415:17,981,791...18,035,224 		JBrowse link
G Ilvbl ilvB acetolactate synthase like involved_in ISO (PMID:28289220) UniProt PMID:28289220 NCBI chrNW_004955495:8,130,875...8,140,152
Ensembl chrNW_004955495:8,130,875...8,140,146 		JBrowse link
G Pex13 peroxisomal biogenesis factor 13 acts_upstream_of_or_within ISO (PMID:12897163) MGI PMID:12897163 NCBI chrNW_004955424:22,799,568...22,830,718
Ensembl chrNW_004955424:22,799,568...22,830,718 		JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase involved_in
acts_upstream_of_or_within		 ISO (PMID:16186124), (PMID:9326939)
(PMID:12915479), (PMID:9326939)		 RGD
UniProt
MGI		 PMID:9326939 PMID:10588950 PMID:12915479 PMID:16186124 RGD:727286 NCBI chrNW_004955462:1,238,622...1,250,731
Ensembl chrNW_004955462:1,238,622...1,250,736 		JBrowse link
G Slc27a2 solute carrier family 27 member 2 involved_in ISO (PMID:10198260) UniProt PMID:10198260 NCBI chrNW_004955409:4,077,685...4,112,828
Ensembl chrNW_004955409:4,077,149...4,112,828 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12483
    cellular process 11573
      cellular metabolic process 6696
        cellular lipid metabolic process 747
          fatty acid metabolic process 285
            fatty acid oxidation 92
              fatty acid alpha-oxidation 6
Path 2
Term Annotations click to browse term
  biological_process 12483
    metabolic process 7922
      cellular metabolic process 6696
        organic acid metabolic process 676
          oxoacid metabolic process 672
            carboxylic acid metabolic process 664
              monocarboxylic acid metabolic process 465
                fatty acid metabolic process 285
                  fatty acid catabolic process 72
                    fatty acid alpha-oxidation 6
paths to the root