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ONTOLOGY REPORT - ANNOTATIONS

Term:fatty acid alpha-oxidation
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Accession:GO:0001561 term browser browse the term
Definition:A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.
Synonyms:xref: MetaCyc:PWY-2501


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fatty acid alpha-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HACL1 2-hydroxyacyl-CoA lyase 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:15,486,897...15,526,552
Ensembl chr 3:15,823,979...15,863,982 		JBrowse link
G HAO1 hydroxyacid oxidase 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:7,856,967...7,914,818
Ensembl chr20:7,633,861...7,695,120 		JBrowse link
G HAO2 hydroxyacid oxidase 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:83,160,326...83,185,688
Ensembl chr 1:118,157,037...118,182,957 		JBrowse link
G ILVBL ilvB acetolactate synthase like involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:14,648,081...14,658,879
Ensembl chr19:15,632,614...15,643,414 		JBrowse link
G PEX13 peroxisomal biogenesis factor 13 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12897163) Ensembl
MGI		 PMID:12897163 GO_REF:0000107 NCBI chr2A:61,108,970...61,143,615
Ensembl chr2A:62,250,887...62,285,151 		JBrowse link
G PHYH phytanoyl-CoA 2-hydroxylase involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:12915479), (PMID:9326939) RGD
Ensembl
InterPro
MGI
TreeGrafter		 PMID:9326939 PMID:10588950 PMID:12915479 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:727286 NCBI chr10:13,277,804...13,300,115
Ensembl chr10:13,251,223...13,636,018 		JBrowse link
G SLC27A2 solute carrier family 27 member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:29,130,262...29,182,752
Ensembl chr15:47,452,227...47,505,066 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16768
    cellular process 15760
      cellular metabolic process 9286
        cellular lipid metabolic process 973
          fatty acid metabolic process 390
            fatty acid oxidation 115
              fatty acid alpha-oxidation 7
Path 2
Term Annotations click to browse term
  biological_process 16768
    metabolic process 11043
      cellular metabolic process 9286
        organic acid metabolic process 922
          oxoacid metabolic process 915
            carboxylic acid metabolic process 895
              monocarboxylic acid metabolic process 627
                fatty acid metabolic process 390
                  fatty acid catabolic process 103
                    fatty acid alpha-oxidation 7
paths to the root