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ONTOLOGY REPORT - ANNOTATIONS


Term:fatty acid alpha-oxidation
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Accession:GO:0001561 term browser browse the term
Definition:A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.
Synonyms:xref: MetaCyc:PWY-2501


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fatty acid alpha-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hacl1 2-hydroxyacyl-CoA lyase 1 involved_in IDA
ISO
IBA
PMID:10468558
(MGI:6105330|PMID:28629946)
(PMID:10468558), (PMID:15644336), (PMID:21708296), (PMID:28289220)
PMID:21873635
RGD PMID:10468558 PMID:15644336 PMID:21708296 PMID:28289220 PMID:28629946, PMID:10468558, PMID:21873635 MGI:6105330, RGD:708588, RGD:13792537 NCBI chr16:7,720,047...7,758,119
Ensembl chr16:7,714,465...7,758,189
JBrowse link
G Hao1 hydroxyacid oxidase 1 involved_in IBA
ISO
PMID:21873635
(PMID:18215067)
RGD PMID:18215067, PMID:21873635 RGD:13792537 NCBI chr 3:127,444,900...127,500,709
Ensembl chr 3:127,444,902...127,500,709
JBrowse link
G Ilvbl ilvB acetolactate synthase like involved_in ISO (PMID:28289220) RGD PMID:28289220 NCBI chr 7:14,044,586...14,054,639
Ensembl chr 7:14,044,586...14,054,639
JBrowse link
G Pex13 peroxisomal biogenesis factor 13 acts_upstream_of_or_within ISO MGI:2384515 (MGI:2670243|PMID:12897163) RGD PMID:12897163 MGI:2670243 NCBI chr14:108,394,299...108,411,994
Ensembl chr14:108,394,303...108,412,823
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
(MGI:1097297|PMID:9326939), (MGI:3052413|PMID:12915479)
(PMID:16186124), (PMID:9326939)
PMID:21873635
RGD PMID:9326939 PMID:12915479 PMID:16186124, PMID:10588950, PMID:21873635 MGI:1097297 MGI:3052413, RGD:727286, RGD:13792537 NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530
JBrowse link
G Slc27a2 solute carrier family 27 member 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:10198260)
Ensembl
RGD
PMID:10198260 GO_REF:0000107 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19610
    metabolic process 11878
      cellular metabolic process 10831
        cellular lipid metabolic process 1019
          fatty acid metabolic process 425
            fatty acid catabolic process 104
              fatty acid alpha-oxidation 6
Path 2
Term Annotations click to browse term
  biological_process 19610
    metabolic process 11878
      cellular metabolic process 10831
        organic acid metabolic process 1007
          oxoacid metabolic process 975
            carboxylic acid metabolic process 957
              monocarboxylic acid metabolic process 658
                fatty acid metabolic process 425
                  fatty acid catabolic process 104
                    fatty acid alpha-oxidation 6
paths to the root