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ONTOLOGY REPORT - ANNOTATIONS

Term:radial spoke
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Accession:GO:0001534 term browser browse the term
Definition:Protein complex that links the outer microtubule doublet of a 9+2 type ciliary or flagellar axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules.
Comment:Radial spokes are involved in some types of beating motions of the cilium. The radial spoke is usually a T-shaped structure comprised of a short base that attaches to the A-microtubule of an axonemal outer microtubule doublet (MTD) of a cilium, an elongated stalk, a neck complex, and an orthogonal head structure that extends perpendicularly towards the inner sheath and the central pair (CP) microtubules. Groups of radial spokes (RSs) repeat along the MTD with regular spacing. In most organisms, each group of radial spokes is comprised of a triplet of spokes: RS1, RS2, and RS3. In some organisms (e.g. Chlamydomonas and Sarcophaga bullata), each group contains a doublet of radial spokes: RS1 and RS2, while RS3 is represented only as a stump (referred to as RS3S) attached to the A-microtubule but lacking the rest of the stalk structure and entirely lacking the head structure. {xref="PMID:9450971", xref="GOC:krc", xref="PMID:34871179", xref="PMID:25694453"}
Synonyms:xref: Wikipedia:Radial_spoke


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radial spoke term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfap206 cilia and flagella associated protein 206 part_of ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 5:49,254,399...49,299,145
Ensembl chr 5:49,254,408...49,299,090 		JBrowse link
G Dnajb13 DnaJ heat shock protein family (Hsp40) member B13 part_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 1:154,848,586...154,863,042
Ensembl chr 1:154,848,594...154,862,963 		JBrowse link
G Iqub IQ motif and ubiquitin domain containing part_of ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 4:52,931,768...52,993,795
Ensembl chr 4:52,931,767...52,993,834 		JBrowse link
G Nme5 NME/NM23 family member 5 part_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr18:26,163,558...26,180,742
Ensembl chr18:26,163,555...26,180,794 		JBrowse link
G Ropn1l rhophilin associated tail protein 1-like part_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:82,442,645...82,453,332
Ensembl chr 2:82,441,891...82,453,485 		JBrowse link
radial spoke head term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rsph4a radial spoke head component 4A part_of ISO MGI:5882201 (MGI:5882054|PMID:26506310) RGD PMID:26506310 MGI:5882054 NCBI chr20:30,764,409...30,780,574
Ensembl chr20:30,764,409...30,780,574 		JBrowse link
G Rsph6a radial spoke head 6 homolog A part_of ISO UniProtKB:E9PYQ0|UniProtKB:Q8BYM7|UniProtKB:Q8VIG3|UniProtKB:Q9D9V4 (MGI:6203178|PMID:30185526) RGD PMID:30185526 MGI:6203178 NCBI chr 1:78,700,801...78,720,444
Ensembl chr 1:78,700,814...78,720,431 		JBrowse link
radial spoke head 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rsph1 radial spoke head component 1 part_of ISO (MGI:7447185|PMID:34871179) RGD PMID:34871179 MGI:7447185 NCBI chr20:9,341,910...9,360,640
Ensembl chr20:9,341,913...9,360,640 		JBrowse link
G Rsph4a radial spoke head component 4A part_of ISO (MGI:6404703|PMID:32203505), (MGI:7447185|PMID:34871179) RGD PMID:32203505 PMID:34871179 MGI:6404703 MGI:7447185 NCBI chr20:30,764,409...30,780,574
Ensembl chr20:30,764,409...30,780,574 		JBrowse link
G Rsph9 radial spoke head component 9 part_of ISO (MGI:7447185|PMID:34871179) RGD PMID:34871179 MGI:7447185 NCBI chr 9:14,840,115...14,852,950
Ensembl chr 9:14,840,115...14,860,062 		JBrowse link
radial spoke head 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rsph4a radial spoke head component 4A part_of ISO (MGI:6404703|PMID:32203505) RGD PMID:32203505 MGI:6404703 NCBI chr20:30,764,409...30,780,574
Ensembl chr20:30,764,409...30,780,574 		JBrowse link
radial spoke head 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rsph1 radial spoke head component 1 part_of ISO (MGI:7447185|PMID:34871179) RGD PMID:34871179 MGI:7447185 NCBI chr20:9,341,910...9,360,640
Ensembl chr20:9,341,913...9,360,640 		JBrowse link
G Rsph4a radial spoke head component 4A part_of ISO (MGI:6404703|PMID:32203505), (MGI:7447185|PMID:34871179) RGD PMID:32203505 PMID:34871179 MGI:6404703 MGI:7447185 NCBI chr20:30,764,409...30,780,574
Ensembl chr20:30,764,409...30,780,574 		JBrowse link
G Rsph9 radial spoke head component 9 part_of ISO (MGI:7447185|PMID:34871179) RGD PMID:34871179 MGI:7447185 NCBI chr 9:14,840,115...14,852,950
Ensembl chr 9:14,840,115...14,860,062 		JBrowse link
radial spoke stalk term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfap61 cilia and flagella associated protein 61 part_of ISO PR:B2RY50|PR:Q3UFY4|PR:Q9EQ00|PR:Q9ESG2 (MGI:6832781|PMID:34792097) RGD PMID:34792097 MGI:6832781 NCBI chr 3:133,354,400...133,633,310
Ensembl chr 3:133,354,197...133,633,320 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20140
    protein-containing complex 6480
      radial spoke 10
        radial spoke 1 + 3
        radial spoke 2 + 1
        radial spoke 3 + 3
        radial spoke base + 0
        radial spoke head + 4
        radial spoke neck 0
        radial spoke stalk 1
Path 2
Term Annotations click to browse term
  cellular_component 20140
    cellular anatomical entity 19983
      intracellular anatomical structure 14599
        cytoplasm 11446
          cytoplasmic region 332
            plasma membrane bounded cell projection cytoplasm 289
              ciliary plasm 177
                axoneme 176
                  radial spoke 10
                    radial spoke 1 + 3
                    radial spoke 2 + 1
                    radial spoke 3 + 3
                    radial spoke base + 0
                    radial spoke head + 4
                    radial spoke neck 0
                    radial spoke stalk 1
paths to the root