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ONTOLOGY REPORT - ANNOTATIONS

Term:Prp19 complex
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Accession:GO:0000974 term browser browse the term
Definition:A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.
Synonyms:narrow_synonym: MOS4-Associated Complex;   Prp19/CDC5 complex;   nineteen complex
 related_synonym: NTC


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Prp19 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcas2 BCAS2, pre-mRNA processing factor part_of IBA
ISO		 GO_REF:0000033
(PMID:20176811)		 GO_Central
RGD		 PMID:20176811 GO_REF:0000033 NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389 		JBrowse link
G Cdc5l cell division cycle 5-like part_of ISO
ISS
IEA
IBA		 (PMID:20176811)
GO_REF:0000024
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033		 RGD
UniProt
InterPro
Ensembl
GO_Central		 PMID:20176811 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450 		JBrowse link
G Crnkl1 crooked neck pre-mRNA splicing factor 1 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:133,338,593...133,354,329
Ensembl chr 3:133,337,039...133,354,302
Ensembl chr 6:133,337,039...133,354,302 		JBrowse link
G Ctnnbl1 catenin, beta like 1 part_of ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:15175653), (PMID:20176811)		 UniProt
Ensembl
RGD		 PMID:15175653 PMID:20176811 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:146,387,940...146,548,987
Ensembl chr 3:146,387,889...146,548,987 		JBrowse link
G Cwc15 CWC15 spliceosome-associated protein part_of ISO (PMID:20176811) RGD PMID:20176811 NCBI chr 8:11,305,401...11,316,326
Ensembl chr 8:11,305,424...11,316,325 		JBrowse link
G Haus8l2 HAUS augmin-like complex, subunit 8 like 2 part_of IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr11:5,628,432...5,630,535
Ensembl chr11:5,628,427...5,630,533 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 part_of ISS
ISO
IEA		 GO_REF:0000024
(PMID:20176811)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:20176811 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Isy1 ISY1 splicing factor homolog part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:120,276,535...120,297,227
Ensembl chr 4:120,276,292...120,297,188 		JBrowse link
G Plrg1 pleiotropic regulator 1 part_of IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:20176811)		 Ensembl
GO_Central
RGD		 PMID:20176811 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:168,408,139...168,424,470
Ensembl chr 2:168,408,124...168,424,522 		JBrowse link
G Polr2a RNA polymerase II subunit A located_in ISO (PMID:21536736) RGD PMID:21536736 NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455 		JBrowse link
G Prpf19 pre-mRNA processing factor 19 part_of ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:20176811)
GO_REF:0000104
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:20176811 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662 		JBrowse link
G Rbm22 RNA binding motif protein 22 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:54,013,374...54,024,182
Ensembl chr18:54,013,351...54,024,569 		JBrowse link
G Syf2 SYF2 pre-mRNA-splicing factor part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:147,156,492...147,164,416
Ensembl chr 5:147,156,480...147,164,414 		JBrowse link
G U2af2 U2 small nuclear RNA auxiliary factor 2 located_in ISO (PMID:21536736) RGD PMID:21536736 NCBI chr 1:68,760,911...68,779,730
Ensembl chr 1:68,760,924...68,778,492 		JBrowse link
G Xab2 XPA binding protein 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:1,667,672...1,679,702
Ensembl chr12:1,667,672...1,679,692 		JBrowse link
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  cellular_component 20813
    protein-containing complex 6433
      Prp19 complex 15
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