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ONTOLOGY REPORT - ANNOTATIONS


Term:Prp19 complex
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Accession:GO:0000974 term browser browse the term
Definition:A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.
Synonyms:narrow_synonym: Prp19/CDC5 complex;   nineteen complex
 related_synonym: NTC


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Prp19 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcas2 BCAS2, pre-mRNA processing factor part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389
JBrowse link
G Cdc5l cell division cycle 5-like part_of ISO
ISS
IBA
(PMID:20176811)
GO_REF:0000024
PMID:21873635
RGD
UniProt
PMID:20176811 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450
JBrowse link
G Crnkl1 crooked neck pre-mRNA splicing factor 1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:133,338,593...133,354,329
Ensembl chr 6:1,140,615...1,142,918
Ensembl chr 3:1,140,615...1,142,918
JBrowse link
G Ctnnbl1 catenin, beta like 1 part_of ISO
ISS
(PMID:15175653)
GO_REF:0000024
RGD
UniProt
PMID:15175653 GO_REF:0000024 NCBI chr 3:146,387,940...146,548,987
Ensembl chr 3:146,387,889...146,548,987
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 part_of ISS
ISO
GO_REF:0000024
(PMID:20176811)
UniProt
RGD
PMID:20176811 GO_REF:0000024 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Isy1 ISY1 splicing factor homolog part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:120,276,535...120,297,227
Ensembl chr 4:120,276,292...120,297,188
JBrowse link
G LOC102548514 crooked neck-like protein 1-like part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Plrg1 pleiotropic regulator 1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:168,408,139...168,424,470
Ensembl chr 2:168,408,124...168,424,522
JBrowse link
G Polr2a RNA polymerase II subunit A colocalizes_with ISO (PMID:21536736) RGD PMID:21536736 NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455
JBrowse link
G Prpf19 pre-mRNA processing factor 19 part_of ISS
ISO
IBA
GO_REF:0000024
(PMID:20176811)
PMID:21873635
UniProt
RGD
PMID:20176811 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662
JBrowse link
G Rbm22 RNA binding motif protein 22 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:54,013,374...54,024,182
Ensembl chr18:54,013,351...54,024,569
JBrowse link
G Syf2 SYF2 pre-mRNA-splicing factor part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:147,156,492...147,164,416
Ensembl chr 5:147,156,480...147,164,414
JBrowse link
G U2af2 U2 small nuclear RNA auxiliary factor 2 colocalizes_with
part_of
ISO
IEA
(PMID:21536736)
GO_REF:0000107
RGD
Ensembl
PMID:21536736 GO_REF:0000107 NCBI chr 1:68,760,911...68,779,730
Ensembl chr 1:68,760,924...68,778,492
JBrowse link
G Xab2 XPA binding protein 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:1,667,672...1,679,702
Ensembl chr12:1,667,672...1,679,692
JBrowse link

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  cellular_component 20010
    protein-containing complex 6011
      Prp19 complex 14
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