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ONTOLOGY REPORT - ANNOTATIONS


Term:nuclear MIS12/MIND complex
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Accession:GO:0000818 term browser browse the term
Definition:A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.
Synonyms:exact_synonym: MIND complex;   Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex


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nuclear MIS12/MIND complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dsn1 DSN1 component of MIS12 kinetochore complex IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:153,101,020...153,115,326
Ensembl chr 3:153,101,036...153,114,520
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G Mis12 MIS12 kinetochore complex component IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:57,653,685...57,661,833
Ensembl chr10:57,660,067...57,660,687
JBrowse link
G Pmf1 polyamine-modulated factor 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:187,751,770...187,771,933
Ensembl chr 2:187,751,776...187,771,865
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20610
    protein-containing complex 6105
      MIS12/MIND type complex 4
        nuclear MIS12/MIND complex 3
Path 2
Term Annotations click to browse term
  cellular_component 20610
    cellular anatomical entity 20359
      organelle 13271
        non-membrane-bounded organelle 5196
          intracellular non-membrane-bounded organelle 5179
            chromosome 1424
              chromosomal region 291
                chromosome, centromeric region 190
                  kinetochore 126
                    condensed chromosome kinetochore 73
                      MIS12/MIND type complex 4
                        nuclear MIS12/MIND complex 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.