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Term:nuclear MIS12/MIND complex
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Accession:GO:0000818 term browser browse the term
Definition:A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.
Synonyms:exact_synonym: MIND complex;   Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex

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nuclear MIS12/MIND complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DSN1 DSN1 component of MIS12 kinetochore complex IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:39,992,769...40,017,388
Ensembl chr17:39,990,623...40,017,500
JBrowse link
G MIS12 MIS12 kinetochore complex component IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:51,505,376...51,508,337
Ensembl chr12:51,505,381...51,507,943
JBrowse link
G PMF1 polyamine modulated factor 1 IEA InterPro GO_REF:0000002 NCBI chr 4:93,810,863...93,836,786
Ensembl chr 4:93,811,744...93,857,117
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 16944
    protein-containing complex 4975
      MIS12/MIND type complex 4
        nuclear MIS12/MIND complex 3
Path 2
Term Annotations click to browse term
  cellular_component 16944
    cellular anatomical entity 16805
      organelle 11475
        non-membrane-bounded organelle 4238
          intracellular non-membrane-bounded organelle 4219
            chromosome 1245
              chromosomal region 274
                chromosome, centromeric region 177
                  condensed chromosome, centromeric region 70
                    condensed chromosome kinetochore 52
                      MIS12/MIND type complex 4
                        nuclear MIS12/MIND complex 3
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.