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Term:nuclear MIS12/MIND complex
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Accession:GO:0000818 term browser browse the term
Definition:A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.
Synonyms:exact_synonym: MIND complex;   Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex

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nuclear MIS12/MIND complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BGLAP bone gamma-carboxyglutamate protein IEA InterPro GO_REF:0000002 NCBI chr 7:41,630,092...41,630,976
Ensembl chr 7:41,630,098...41,665,791
JBrowse link
G DSN1 DSN1 component of MIS12 kinetochore complex IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr24:25,506,954...25,523,409
Ensembl chr24:25,507,667...25,523,155
JBrowse link
G LOC102154136 protein MIS12 homolog IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:42,965,045...42,966,881 JBrowse link
G MIS12 MIS12 kinetochore complex component IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:31,314,067...31,319,392 JBrowse link
G SLC25A44 solute carrier family 25 member 44 IBA
(PMID:21873635) GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 7:41,630,868...41,665,894
Ensembl chr 7:41,630,098...41,665,791
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 16531
    protein-containing complex 5149
      MIS12/MIND type complex 6
        nuclear MIS12/MIND complex 5
Path 2
Term Annotations click to browse term
  cellular_component 16531
    cellular anatomical entity 16390
      organelle 11581
        non-membrane-bounded organelle 4333
          intracellular non-membrane-bounded organelle 4314
            chromosome 1265
              chromosomal region 277
                chromosome, centromeric region 181
                  condensed chromosome, centromeric region 78
                    condensed chromosome kinetochore 59
                      MIS12/MIND type complex 6
                        nuclear MIS12/MIND complex 5
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.