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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA double-strand break processing
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Accession:GO:0000729 term browser browse the term
Definition:The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang.


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DNA double-strand break processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase involved_in ISO (PMID:10802669), (PMID:26240375) RGD PMID:10802669 PMID:26240375 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Blm BLM RecQ like helicase involved_in ISO (PMID:21325134) RGD PMID:21325134 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Dna2 DNA replication helicase/nuclease 2 involved_in ISS
IEA		 GO_REF:0000024
GO_REF:0000107		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Exd2 exonuclease 3'-5' domain containing 2 involved_in ISO (PMID:26807646) RGD PMID:26807646 NCBI chr 6:100,116,867...100,150,452
Ensembl chr 6:100,116,867...100,150,442 		JBrowse link
G Exo1 exonuclease 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in IEA
ISO		 GO_REF:0000107
(PMID:23080121)		 Ensembl
RGD		 PMID:23080121 GO_REF:0000107 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Nbn nibrin involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:16622404)		 Ensembl
UniProt
RGD		 PMID:16622404 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Rad50 RAD50 double strand break repair protein involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:16622404), (PMID:21757780)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:16622404 PMID:21757780 GO_REF:0000024 GO_REF:0000107 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Setmar SET domain and mariner transposase fusion gene involved_in ISO (PMID:21491884) RGD PMID:21491884 NCBI chr 4:141,046,058...141,058,183
Ensembl chr 4:141,046,069...141,058,197 		JBrowse link
G Slc25a16 solute carrier family 25 member 16 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,691,474...25,717,558
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Smarcad1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1` involved_in ISO
ISS		 (PMID:22960744)
GO_REF:0000024		 RGD
UniProt		 PMID:22960744 GO_REF:0000024 NCBI chr 4:94,311,441...94,379,184
Ensembl chr 4:94,311,489...94,372,563 		JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N involved_in ISO (PMID:17349954) RGD PMID:17349954 NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355 		JBrowse link
G Ube2v2 ubiquitin conjugating enzyme E2 V2 involved_in ISO (PMID:17349954) RGD PMID:17349954 NCBI chr11:85,304,528...85,338,430
Ensembl chr11:85,304,526...85,336,369 		JBrowse link
DNA double-strand break processing involved in repair via single-strand annealing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07031480.1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G ENSRNOG00000066166 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr13:62,124,375...62,124,887 JBrowse link
G ENSRNOG00000069305 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr13:18,979,537...18,979,779 JBrowse link
G Helq helicase, POLQ-like involved_in ISO (PMID:34937945) RGD PMID:34937945 NCBI chr14:8,818,582...8,862,926
Ensembl chr14:8,818,592...8,862,960 		JBrowse link
G Rad52 RAD52 homolog, DNA repair protein involved_in
acts_upstream_of_or_within		 ISO (MGI:5619739|PMID:22912580)
(PMID:19506022)		 RGD PMID:19506022 PMID:22912580 MGI:5619739 NCBI chr 4:153,106,062...153,128,598
Ensembl chr 4:153,106,062...153,128,207 		JBrowse link
G Rbbp8 RB binding protein 8, endonuclease involved_in ISO
IBA
IEA		 (PMID:18716619), (PMID:19202191)
GO_REF:0000033
GO_REF:0000118		 RGD
GO_Central
TreeGrafter		 PMID:18716619 PMID:19202191 GO_REF:0000033 GO_REF:0000118 NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846 		JBrowse link
G Rbbp8nl RBBP8 N-terminal like involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 3:167,364,048...167,378,993
Ensembl chr 3:167,364,048...167,379,092 		JBrowse link
G Rnf138 ring finger protein 138 involved_in ISO
ISS
IBA
IEA		 (PMID:26502057)
GO_REF:0000024
GO_REF:0000033
GO_REF:0000118		 RGD
UniProt
GO_Central
TreeGrafter		 PMID:26502057 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr18:12,291,557...12,315,931
Ensembl chr18:12,291,590...12,315,930 		JBrowse link
G Rnf138l1 ring finger protein 138 like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:30,739,541...30,740,614
Ensembl chr  X:30,739,413...30,740,613 		JBrowse link
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit involved_in ISO (PMID:19595721) RGD PMID:19595721 NCBI chr 1:181,286,190...181,291,739
Ensembl chr 1:181,283,921...181,291,775 		JBrowse link
G Slx4 SLX4 structure-specific endonuclease subunit involved_in ISO (PMID:19595721) RGD PMID:19595721 NCBI chr10:11,526,623...11,549,313
Ensembl chr10:11,528,424...11,549,295 		JBrowse link
meiotic DNA double-strand break processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spo11 SPO11 initiator of meiotic double strand breaks involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:161,755,299...161,770,930
Ensembl chr 3:161,757,519...161,770,925 		JBrowse link
meiotic DNA double-strand break processing involved in reciprocal meiotic recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brip1 BRCA1 interacting helicase 1 acts_upstream_of_or_within ISO MGI:4129733 (PMID:26490168) RGD PMID:26490168 NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324 		JBrowse link
G Six6os1 Six6 opposite strand transcript 1 involved_in ISO
IBA		 (MGI:5822939|PMID:27796301)
GO_REF:0000033		 RGD
GO_Central		 PMID:27796301 GO_REF:0000033 MGI:5822939 NCBI chr 6:91,579,185...91,615,183
Ensembl chr 6:91,579,325...91,615,148 		JBrowse link
regulation of DNA double-strand break processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Helb DNA helicase B involved_in ISO (PMID:26774285)
(MGI:5766842|PMID:26774285)		 RGD PMID:26774285 MGI:5766842 NCBI chr 7:55,588,510...55,615,979
Ensembl chr 7:55,588,798...55,615,585 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      primary metabolic process 10352
        nucleobase-containing compound metabolic process 5743
          nucleic acid metabolic process 5144
            DNA metabolic process 991
              DNA double-strand break processing 28
                DNA double-strand break processing involved in repair via single-strand annealing 11
                DNA double-strand break processing involved in repair via synthesis-dependent strand annealing 0
                meiotic DNA double-strand break processing + 3
                regulation of DNA double-strand break processing 1
Path 2
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      organic substance metabolic process 11328
        organic cyclic compound metabolic process 6260
          nucleobase-containing compound metabolic process 5743
            nucleic acid metabolic process 5144
              DNA metabolic process 991
                DNA repair 561
                  double-strand break repair 308
                    DNA double-strand break processing 28
                      DNA double-strand break processing involved in repair via single-strand annealing 11
                      DNA double-strand break processing involved in repair via synthesis-dependent strand annealing 0
                      meiotic DNA double-strand break processing + 3
                      regulation of DNA double-strand break processing 1
paths to the root