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ONTOLOGY REPORT - ANNOTATIONS


Term:double-strand break repair via homologous recombination
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Accession:GO:0000724 term browser browse the term
Definition:The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
Synonyms:exact_synonym: HDR;   HRR;   Rad51-dependent recombinational repair;   Rhp51-dependent recombinational repair;   homologous recombinational repair;   homology-directed repair
 alt_id: GO:0016924


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double-strand break repair via homologous recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ap5s1 adaptor related protein complex 5 subunit sigma 1 JBrowse link 3 123,754,035 123,757,349 RGD:1624291
RGD:1600115
G Ap5z1 adaptor related protein complex 5 subunit zeta 1 JBrowse link 12 14,161,998 14,175,997 RGD:1624291
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1624291
RGD:1600115
G Aunip aurora kinase A and ninein interacting protein JBrowse link 5 152,721,799 152,734,577 RGD:1624291
RGD:1600115
G Blm BLM RecQ like helicase JBrowse link 1 142,246,773 142,332,616 RGD:13792537
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:1624291
RGD:13792537
RGD:1600115
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:1624291
RGD:13792537
RGD:1600115
G Ccdc155 coiled-coil domain containing 155 JBrowse link 1 101,180,497 101,203,048 RGD:1624291
RGD:1600115
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit JBrowse link 10 2,010,140 2,037,953 RGD:1624291
G Exd2 exonuclease 3'-5' domain containing 2 JBrowse link 6 104,017,620 104,051,442 RGD:1624291
RGD:1600115
G Fan1 FANCD2 and FANCI associated nuclease 1 JBrowse link 1 125,182,117 125,209,772 RGD:1624291
RGD:1600115
G Fbh1 F-box DNA helicase 1 JBrowse link 17 70,399,093 70,437,151 RGD:13792537
G Gen1 GEN1 Holliday junction 5' flap endonuclease JBrowse link 6 36,910,064 36,940,868 RGD:1624291
RGD:1600115
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:1624291
RGD:1600115
G Helq helicase, POLQ-like JBrowse link 14 10,446,981 10,491,042 RGD:1624291
RGD:1600115
G Hus1 HUS1 checkpoint clamp component JBrowse link 14 89,194,086 89,208,825 RGD:1624291
RGD:13792537
G Ino80 INO80 complex ATPase subunit JBrowse link 3 111,186,371 111,266,542 RGD:1624291
RGD:1600115
G Kdm4d lysine demethylase 4D JBrowse link 8 12,968,192 12,993,651 RGD:1624291
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor JBrowse link 3 125,470,499 125,500,795 RGD:1624291
RGD:13792537
RGD:1600115
G Mcm9 minichromosome maintenance 9 homologous recombination repair factor JBrowse link 20 34,818,093 34,930,157 RGD:1624291
RGD:13792537
G Mcmdc1 minichromosome maintenance deficient domain containing 1 RGD:1600115
RGD:13792537
G Meiob meiosis specific with OB-fold JBrowse link 10 14,174,645 14,206,026 RGD:1600115
RGD:1624291
G Mms22l MMS22-like, DNA repair protein JBrowse link 5 38,844,502 38,960,989 RGD:1624291
RGD:13792537
G Morf4l1 mortality factor 4 like 1 JBrowse link 8 97,473,454 97,494,974 RGD:1624291
RGD:1600115
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:1600115
RGD:1624291
RGD:13792537
G Nabp1 nucleic acid binding protein 1 JBrowse link 9 55,049,893 55,057,784 RGD:1624291
RGD:13792537
RGD:1600115
G Nabp2 nucleic acid binding protein 2 JBrowse link 7 2,820,006 2,825,627 RGD:1600115
RGD:13792537
RGD:1624291
G Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:13792537
G Nsmce1 NSE1 homolog, SMC5-SMC6 complex component JBrowse link 1 196,857,490 196,883,907 RGD:13792537
G Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase JBrowse link 7 99,677,295 99,900,765 RGD:1600115
RGD:1624291
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 JBrowse link 13 48,679,726 48,709,663 RGD:1624291
RGD:1600115
G Palb2 partner and localizer of BRCA2 JBrowse link 1 192,064,586 192,088,547 RGD:1624291
RGD:1600115
G Poll DNA polymerase lambda JBrowse link 1 265,290,337 265,298,847 RGD:1624291
RGD:1600115
G Poln DNA polymerase nu JBrowse link 14 81,837,764 82,037,999 RGD:1624291
RGD:1600115
G Psmd14 proteasome 26S subunit, non-ATPase 14 JBrowse link 3 47,578,449 47,673,330 RGD:1624291
RGD:1600115
G Rad21l1 RAD21 cohesin complex component like 1 JBrowse link 3 147,163,335 147,191,008 RGD:1624291
RGD:1600115
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:9831188
RGD:1624291
G Rad51ap1 RAD51 associated protein 1 JBrowse link 4 159,469,803 159,482,869 RGD:1624291
RGD:1600115
G Rad51b RAD51 paralog B JBrowse link 6 102,473,978 103,018,185 RGD:1624291
RGD:13792537
G Rad51c RAD51 paralog C JBrowse link 10 74,697,713 74,724,004 RGD:1624291
RGD:1600115
G Rad51d RAD51 paralog D JBrowse link 10 70,222,703 70,241,352 RGD:1624291
RGD:13792537
G Rad52 RAD52 homolog, DNA repair protein JBrowse link 4 152,429,826 152,451,875 RGD:1624291
RGD:13792537
G Rad54b RAD54 homolog B JBrowse link 5 25,140,531 25,214,469 RGD:1624291
RGD:13792537
G Rad54l RAD54 like JBrowse link 5 134,948,511 134,978,125 RGD:1624291
RGD:1600115
G Rbbp8 RB binding protein 8, endonuclease JBrowse link 18 3,134,630 3,227,702 RGD:1600115
RGD:13792537
G Rec8 REC8 meiotic recombination protein JBrowse link 15 34,296,922 34,304,387 RGD:1624291
RGD:1600115
G Recql RecQ like helicase JBrowse link 4 176,581,892 176,606,520 RGD:13792537
G Recql4 RecQ like helicase 4 JBrowse link 7 117,765,892 117,773,128 RGD:13792537
G Recql5 RecQ like helicase 5 JBrowse link 10 104,443,735 104,482,889 RGD:13792537
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit JBrowse link 20 44,803,664 44,961,362 RGD:13792537
G Rfwd3 ring finger and WD repeat domain 3 JBrowse link 19 42,960,597 42,971,894 RGD:1624291
G RGD1565844 similar to RIKEN cDNA 1700045I19 JBrowse link X 32,495,573 32,496,646 RGD:13792537
G Rmi1 RecQ mediated genome instability 1 JBrowse link 17 6,658,285 6,665,618 RGD:13792537
G Rnf138 ring finger protein 138 JBrowse link 18 15,146,925 15,167,361 RGD:1600115
RGD:13792537
RGD:1624291
G Rpa1 replication protein A1 JBrowse link 10 62,140,419 62,191,518 RGD:1624291
RGD:13792537
G Rpa2 replication protein A2 JBrowse link 5 150,957,041 150,967,597 RGD:1624291
RGD:13792537
RGD:1600115
G Rpa3 replication protein A3 JBrowse link 4 34,279,320 34,282,351 RGD:1624291
RGD:13792537
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 JBrowse link 3 153,210,829 153,250,705 RGD:1624291
RGD:1600115
G Sem1 SEM1, 26S proteasome complex subunit JBrowse link 4 32,067,444 32,087,600 RGD:1624291
RGD:13792537
G Sfpq splicing factor proline and glutamine rich JBrowse link 5 145,079,803 145,088,517 RGD:1624291
RGD:1600115
G Sfr1 SWI5-dependent homologous recombination repair protein 1 JBrowse link 1 267,505,336 267,509,350 RGD:1600115
RGD:13792537
RGD:1624291
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit JBrowse link 1 198,114,514 198,120,061 RGD:1624291
RGD:13792537
G Slx4 SLX4 structure-specific endonuclease subunit JBrowse link 10 11,787,756 11,808,326 RGD:1624291
RGD:1600115
G Smc5 structural maintenance of chromosomes 5 JBrowse link 1 240,977,898 241,046,273 RGD:1624291
RGD:1600115
G Spidr scaffold protein involved in DNA repair JBrowse link 11 89,009,931 89,260,361 RGD:1624291
RGD:13792537
G Stn1 STN1 subunit of CST complex JBrowse link 1 267,281,786 267,315,714 RGD:13792537
G Swi5 SWI5 homologous recombination repair protein JBrowse link 3 11,307,981 11,317,049 RGD:1624291
RGD:1600115
G Swsap1 SWIM-type zinc finger 7 associated protein 1 JBrowse link 8 22,966,752 22,969,280 RGD:1624291
RGD:1600115
G Tonsl tonsoku-like, DNA repair protein JBrowse link 7 117,688,397 117,703,139 RGD:1600115
RGD:1624291
G Ube2n ubiquitin-conjugating enzyme E2N JBrowse link 7 36,610,147 36,640,190 RGD:1624291
RGD:1600115
G Wdr48 WD repeat domain 48 JBrowse link 8 128,577,080 128,610,287 RGD:1624291
RGD:1600115
G Wrn WRN RecQ like helicase JBrowse link 16 62,483,773 62,619,018 RGD:13792537
G Xrcc2 X-ray repair cross complementing 2 JBrowse link 4 5,842,013 5,860,516 RGD:1624291
RGD:13792537
G Xrcc3 X-ray repair cross complementing 3 JBrowse link 6 136,366,917 136,380,751 RGD:1624291
G Yy1 YY1 transcription factor JBrowse link 6 132,702,443 132,726,848 RGD:1624291
RGD:1600115
G Zfyve26 zinc finger FYVE-type containing 26 JBrowse link 6 102,409,235 102,472,962 RGD:1600115
RGD:1624291
G Zswim7 zinc finger, SWIM-type containing 7 JBrowse link 10 48,587,117 48,599,208 RGD:1624291
RGD:13792537
DNA recombinase assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dmc1 DNA meiotic recombinase 1 JBrowse link 7 120,796,217 120,840,524 RGD:13792537
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:1624291
RGD:13792537
G Rad52 RAD52 homolog, DNA repair protein JBrowse link 4 152,429,826 152,451,875 RGD:1600115
G Swi5 SWI5 homologous recombination repair protein JBrowse link 3 11,307,981 11,317,049 RGD:13792537
double-strand break repair via break-induced replication term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc45 cell division cycle 45 JBrowse link 11 86,328,785 86,354,099 RGD:13792537
G Cdc7 cell division cycle 7 JBrowse link 14 3,826,658 3,846,891 RGD:13792537
G Gins2 GINS complex subunit 2 JBrowse link 19 54,151,048 54,163,701 RGD:13792537
G Gins4 GINS complex subunit 4 JBrowse link 16 73,584,412 73,596,808 RGD:13792537
G Mcm2 minichromosome maintenance complex component 2 JBrowse link 4 120,825,699 120,840,221 RGD:13792537
G Mcm3 minichromosome maintenance complex component 3 JBrowse link 9 26,914,057 26,932,201 RGD:13792537
G Mcm4 minichromosome maintenance complex component 4 JBrowse link 11 89,511,191 89,524,892 RGD:13792537
G Mcm5 minichromosome maintenance complex component 5 JBrowse link 19 14,523,482 14,561,281 RGD:13792537
G Mcm6 minichromosome maintenance complex component 6 JBrowse link 13 45,042,882 45,068,073 RGD:13792537
G Mcm7 minichromosome maintenance complex component 7 JBrowse link 12 19,306,615 19,313,877 RGD:13792537
G Mus81 MUS81 structure-specific endonuclease subunit JBrowse link 1 220,862,474 220,867,973 RGD:13792537
double-strand break repair via synthesis-dependent strand annealing term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Xrcc3 X-ray repair cross complementing 3 JBrowse link 6 136,366,917 136,380,751 RGD:13792537
late meiotic recombination nodule assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mcmdc2 minichromosome maintenance domain containing 2 JBrowse link 5 8,973,861 9,039,616 RGD:1624291
RGD:1600115
meiotic recombination nodule assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mcmdc2 minichromosome maintenance domain containing 2 JBrowse link 5 8,973,861 9,039,616 RGD:1624291
negative regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cgas cyclic GMP-AMP synthase JBrowse link 8 85,789,515 85,804,008 RGD:1624291
RGD:13792537
G Fancb FA complementation group B JBrowse link X 31,124,018 31,140,790 RGD:1624291
RGD:13792537
G Fbh1 F-box DNA helicase 1 JBrowse link 17 70,399,093 70,437,151 RGD:1624291
RGD:1600115
G Helb DNA helicase B JBrowse link 7 64,860,641 64,888,146 RGD:1624291
RGD:13792537
G Klhl15 kelch-like family member 15 JBrowse link X 63,342,277 63,390,915 RGD:1624291
RGD:1600115
G Mad2l2 mitotic arrest deficient 2 like 2 JBrowse link 5 164,943,183 164,956,255 RGD:1600115
RGD:1624291
G Parpbp PARP1 binding protein JBrowse link 7 28,654,707 28,724,412 RGD:1624291
RGD:1600115
G Polq DNA polymerase theta JBrowse link 11 66,585,860 66,695,369 RGD:1624291
RGD:1600115
G Radx RPA1 related single stranded DNA binding protein, X-linked JBrowse link X 110,670,037 110,782,420 RGD:1624291
RGD:1600115
G Recql5 RecQ like helicase 5 JBrowse link 10 104,443,735 104,482,889 RGD:1624291
RGD:1600115
G Rif1 replication timing regulatory factor 1 JBrowse link 3 37,599,540 37,648,818 RGD:1624291
RGD:1600115
G Rmi2 RecQ mediated genome instability 2 JBrowse link 10 4,904,458 4,910,339 RGD:13792537
G Shld1 shieldin complex subunit 1 JBrowse link 3 125,318,682 125,396,705 RGD:1600115
RGD:1624291
G Shld2 shieldin complex subunit 2 JBrowse link 16 10,570,307 10,661,528 RGD:1624291
RGD:1600115
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 JBrowse link 9 119,675,750 119,818,620 RGD:1600115
RGD:1624291
G Tp53bp1 tumor protein p53 binding protein 1 JBrowse link 3 113,160,030 113,259,701 RGD:1624291
RGD:1600115
G Ubqln4 ubiquilin 4 JBrowse link 2 187,915,701 187,931,035 RGD:1600115
RGD:1624291
positive regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actr2 actin related protein 2 JBrowse link 14 104,338,486 104,375,840 RGD:1600115
RGD:1624291
G Blm BLM RecQ like helicase JBrowse link 1 142,246,773 142,332,616 RGD:1624291
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 16 8,734,028 8,804,610 RGD:1624291
RGD:1600115
G Fancb FA complementation group B JBrowse link X 31,124,018 31,140,790 RGD:1624291
RGD:13792537
G Fus FUS RNA binding protein JBrowse link 1 199,412,805 199,426,705 RGD:1600115
RGD:1624291
G Mms19 MMS19 homolog, cytosolic iron-sulfur assembly component JBrowse link 1 261,191,646 261,229,070 RGD:1624291
RGD:13792537
G Mrnip MRN complex interacting protein JBrowse link 10 35,680,687 35,704,685 RGD:1624291
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:1600115
RGD:1624291
G Timeless timeless circadian regulator JBrowse link 7 2,643,288 2,667,329 RGD:1600115
RGD:1624291
G Was WASP actin nucleation promoting factor JBrowse link X 15,155,246 15,164,099 RGD:1600115
RGD:1624291
G Wrap53 WD repeat containing, antisense to TP53 JBrowse link 10 56,169,024 56,185,800 RGD:1600115
RGD:1624291
regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:1624291
RGD:1600115
G Fign fidgetin, microtubule severing factor JBrowse link 3 49,992,250 50,120,601 RGD:13792537
G Fignl1 fidgetin-like 1 JBrowse link 14 91,895,902 91,904,474 RGD:1624291
RGD:13792537
RGD:1600115
G Kdm1a lysine demethylase 1A JBrowse link 5 154,909,003 154,965,171 RGD:1624291
RGD:1600115
G Ppp4c protein phosphatase 4, catalytic subunit JBrowse link 1 198,219,012 198,225,775 RGD:1600115
RGD:1624291
G Ppp4r2 protein phosphatase 4, regulatory subunit 2 JBrowse link 4 133,285,552 133,323,755 RGD:1624291
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:1624291
RGD:1600115
G Rad51ap1 RAD51 associated protein 1 JBrowse link 4 159,469,803 159,482,869 RGD:1624291
RGD:1600115
G Rpa2 replication protein A2 JBrowse link 5 150,957,041 150,967,597 RGD:1624291
RGD:1600115
G Rtel1 regulator of telomere elongation helicase 1 JBrowse link 3 176,818,012 176,856,531 RGD:1624291
RGD:13792537
RGD:1600115
G Setd2 SET domain containing 2, histone lysine methyltransferase JBrowse link 8 118,802,478 118,888,224 RGD:1624291
RGD:1600115
G Sirt6 sirtuin 6 JBrowse link 7 10,937,622 10,943,048 RGD:1624291
RGD:1600115
G Spidr scaffold protein involved in DNA repair JBrowse link 11 89,009,931 89,260,361 RGD:1624291
RGD:1600115
G Terf2ip TERF2 interacting protein JBrowse link 19 44,231,317 44,238,406 RGD:1624291
RGD:1600115
G Tex15 testis expressed 15, meiosis and synapsis associated JBrowse link 16 62,313,284 62,373,288 RGD:1624291
RGD:1600115
G Usp51 ubiquitin specific peptidase 51 JBrowse link X 19,268,352 19,273,753 RGD:1624291
RGD:1600115
G Zfp365 zinc finger protein 365 JBrowse link 20 22,060,160 22,083,766 RGD:1624291
RGD:1600115
replication-born double-strand break repair via sister chromatid exchange term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Blm BLM RecQ like helicase JBrowse link 1 142,246,773 142,332,616 RGD:1624291
G Fancb FA complementation group B JBrowse link X 31,124,018 31,140,790 RGD:1624291
RGD:13792537
G Nipbl NIPBL, cohesin loading factor JBrowse link 2 57,508,830 57,676,197 RGD:13792537
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:1624291
RGD:1600115
G Recql5 RecQ like helicase 5 JBrowse link 10 104,443,735 104,482,889 RGD:1624291
RGD:1600115
G Xrcc1 X-ray repair cross complementing 1 JBrowse link 1 81,412,635 81,441,680 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18166
    metabolic process 10845
      cellular metabolic process 9907
        cellular macromolecule metabolic process 7595
          DNA metabolic process 831
            DNA repair 444
              recombinational repair 130
                double-strand break repair via homologous recombination 129
                  DNA synthesis involved in double-strand break repair via homologous recombination 0
                  double-strand break repair via break-induced replication + 11
                  double-strand break repair via synthesis-dependent strand annealing + 6
                  negative regulation of double-strand break repair via homologous recombination + 17
                  positive regulation of double-strand break repair via homologous recombination 11
                  regulation of double-strand break repair via homologous recombination + 44
                  replication-born double-strand break repair via sister chromatid exchange 6
Path 2
Term Annotations click to browse term
  biological_process 18166
    cellular process 16266
      cellular metabolic process 9907
        cellular nitrogen compound metabolic process 5768
          nucleobase-containing compound metabolic process 4953
            nucleic acid metabolic process 4502
              DNA metabolic process 831
                DNA repair 444
                  double-strand break repair 226
                    double-strand break repair via homologous recombination 129
                      DNA synthesis involved in double-strand break repair via homologous recombination 0
                      double-strand break repair via break-induced replication + 11
                      double-strand break repair via synthesis-dependent strand annealing + 6
                      negative regulation of double-strand break repair via homologous recombination + 17
                      positive regulation of double-strand break repair via homologous recombination 11
                      regulation of double-strand break repair via homologous recombination + 44
                      replication-born double-strand break repair via sister chromatid exchange 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.