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ONTOLOGY REPORT - ANNOTATIONS

Term:mitophagy
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Accession:GO:0000423 term browser browse the term
Definition:The selective autophagy process in which a mitochondrion is degraded by macroautophagy.
Comment:Note that this terms refers to the macroautophagy process and is named by common usage. Be aware that there are a separate micromitophagy and mitophagy by induced vacuole formation processes.
Synonyms:exact_synonym: macromitophagy
 xref: Wikipedia:Mitophagy


show annotations for term's descendants           Sort by:
mitophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABI2 abl interactor 2 involved_in ISO (PMID:38081847) UniProt PMID:38081847 NCBI chr37:12,162,815...12,278,505
Ensembl chr37:12,162,392...12,282,395 		JBrowse link
G AMBRA1 autophagy and beclin 1 regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:42,903,815...43,073,918
Ensembl chr18:42,932,513...43,072,827 		JBrowse link
G ARFIP2 ADP ribosylation factor interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:29,793,325...29,798,223
Ensembl chr21:29,791,813...29,798,172 		JBrowse link
G ARHGAP26 Rho GTPase activating protein 26 involved_in ISO (PMID:38081847) UniProt PMID:38081847 NCBI chr 2:37,627,448...38,045,589
Ensembl chr 2:37,626,698...38,040,079 		JBrowse link
G ATG13 autophagy related 13 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr18:42,834,538...42,886,873
Ensembl chr18:42,836,755...42,886,855 		JBrowse link
G ATG14 autophagy related 14 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:31,199,097...31,234,200
Ensembl chr 8:31,201,709...31,234,217 		JBrowse link
G ATG4B autophagy related 4B cysteine peptidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:51,494,316...51,518,683
Ensembl chr25:51,504,537...51,517,659 		JBrowse link
G ATG4D autophagy related 4D cysteine peptidase involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr20:50,618,458...50,623,703
Ensembl chr20:50,618,459...50,624,179 		JBrowse link
G ATG5 autophagy related 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:63,565,859...63,692,383
Ensembl chr12:63,567,568...63,683,485 		JBrowse link
G ATG7 autophagy related 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:6,916,354...7,154,849
Ensembl chr20:6,916,515...7,154,800 		JBrowse link
G BECN1 beclin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:20,204,203...20,215,081
Ensembl chr 9:20,204,220...20,214,236 		JBrowse link
G CTSK cathepsin K involved_in ISO (PMID:24912190) ParkinsonsUK-UCL PMID:24912190 NCBI chr17:59,928,725...59,938,293
Ensembl chr17:59,929,287...59,938,507 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISO (PMID:38340717) UniProt PMID:38340717 NCBI chr 8:41,354,400...41,371,676
Ensembl chr 8:41,351,244...41,371,056 		JBrowse link
G FUNDC1 FUN14 domain containing 1 involved_in ISO (PMID:34244144) FlyBase PMID:34244144 NCBI chr  X:38,492,470...38,505,512
Ensembl chr  X:38,492,720...38,505,424 		JBrowse link
G GBA1 glucosylceramidase beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23707074) Ensembl
MGI		 PMID:23707074 GO_REF:0000107 NCBI chr 7:42,317,704...42,322,285
Ensembl chr 7:42,317,862...42,322,864 		JBrowse link
G LOC119877912 beclin-1 involved_in IEA Ensembl GO_REF:0000107
G LRBA LPS responsive beige-like anchor protein involved_in ISO (PMID:33773106) UniProt PMID:33773106 NCBI chr15:48,273,866...48,996,546
Ensembl chr15:48,274,881...48,995,697 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta involved_in ISO (PMID:28017329)
(PMID:19279012)		 UniProt
ParkinsonsUK-UCL		 PMID:19279012 PMID:28017329 NCBI chr 5:65,669,553...65,683,445 JBrowse link
G NIPSNAP1 nipsnap homolog 1 involved_in ISO (PMID:30982665) UniProt PMID:30982665 NCBI chr26:22,785,902...22,800,241
Ensembl chr26:22,786,987...22,800,206 		JBrowse link
G NIPSNAP2 nipsnap homolog 2 involved_in ISO (PMID:30982665) UniProt PMID:30982665 NCBI chr 6:451,568...485,354
Ensembl chr 6:451,562...484,695 		JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:55,821,227...55,857,597
Ensembl chr  X:55,821,234...55,855,502 		JBrowse link
G PHB2 prohibitin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:38,075,769...38,080,440
Ensembl chr27:38,075,652...38,080,109 		JBrowse link
G PINK1 PTEN induced kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:78,276,091...78,293,761
Ensembl chr 2:78,277,077...78,294,123 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24949970) Ensembl
MGI		 PMID:24949970 GO_REF:0000107 NCBI chr 1:49,886,887...51,201,930
Ensembl chr 1:49,889,005...51,201,764 		JBrowse link
G RETREG1 reticulophagy regulator 1 acts_upstream_of_or_within ISO (PMID:31446166) MGI PMID:31446166 NCBI chr 4:86,817,391...86,921,119 JBrowse link
G RIMOC1 RAB7A interacting MON1-CCZ1 complex subunit 1 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 4:67,668,727...67,688,509
Ensembl chr 4:67,672,923...67,688,451 		JBrowse link
G SQSTM1 sequestosome 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:1,859,776...1,869,289
Ensembl chr11:1,859,465...1,870,755 		JBrowse link
G TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase involved_in ISO (PMID:33096711)
(MGI:6450300|PMID:25919711)		 UniProt PMID:25919711 PMID:33096711 MGI:6450300 NCBI chr  X:122,111,608...122,125,714
Ensembl chr  X:122,111,434...122,125,506 		JBrowse link
G TIGAR TP53 induced glycolysis regulatory phosphatase involved_in
acts_upstream_of		 IEA
ISO		 (PMID:22044588) Ensembl
MGI		 PMID:22044588 GO_REF:0000107 NCBI chr27:40,521,751...40,549,304
Ensembl chr27:40,523,314...40,549,332 		JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:22044588) Ensembl
MGI		 PMID:22044588 GO_REF:0000107 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109 		JBrowse link
G ULK1 unc-51 like autophagy activating kinase 1 involved_in ISO (MGI:5607224|PMID:21855797) ParkinsonsUK-UCL PMID:21855797 MGI:5607224 NCBI chr26:968,714...982,244
Ensembl chr26:970,138...982,229 		JBrowse link
negative regulation of mitophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLEC16A C-type lectin domain containing 16A acts_upstream_of_or_within ISO (PMID:24949970) MGI PMID:24949970 NCBI chr 6:31,560,940...31,757,100
Ensembl chr 6:31,562,834...31,757,678 		JBrowse link
G PINK1 PTEN induced kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:78,276,091...78,293,761
Ensembl chr 2:78,277,077...78,294,123 		JBrowse link
G RNF41 ring finger protein 41 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24949970) Ensembl
MGI		 PMID:24949970 GO_REF:0000107 NCBI chr10:512,650...521,293
Ensembl chr10:514,635...542,395 		JBrowse link
G TIGAR TP53 induced glycolysis regulatory phosphatase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22044588) Ensembl
MGI		 PMID:22044588 GO_REF:0000107 NCBI chr27:40,521,751...40,549,304
Ensembl chr27:40,523,314...40,549,332 		JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22044588) Ensembl
MGI		 PMID:22044588 GO_REF:0000107 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109 		JBrowse link
G TSPO translocator protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:22,388,498...22,399,329
Ensembl chr10:22,274,405...22,399,297 		JBrowse link
G USP30 ubiquitin specific peptidase 30 ISO RGD PMID:24896179 RGD:13208875 NCBI chr26:17,918,852...17,981,947
Ensembl chr26:17,919,512...17,981,846 		JBrowse link
negative regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTRA2 HtrA serine peptidase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:48,610,408...48,613,399
Ensembl chr17:48,610,408...48,613,399 		JBrowse link
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VPS13C vacuolar protein sorting 13 homolog C involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:26,600,181...26,776,347
Ensembl chr30:26,601,513...26,776,763 		JBrowse link
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDAC6 histone deacetylase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:42,004,268...42,024,726
Ensembl chr  X:42,004,591...42,024,427 		JBrowse link
G MFN2 mitofusin 2 involved_in ISO (MGI:5498413|PMID:23620051) ParkinsonsUK-UCL PMID:23620051 MGI:5498413 NCBI chr 2:84,284,719...84,310,715
Ensembl chr 2:84,284,719...84,308,225 		JBrowse link
G OPTN optineurin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:23,356,471...23,390,569
Ensembl chr 2:23,357,237...23,392,511 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:49,886,887...51,201,930
Ensembl chr 1:49,889,005...51,201,764 		JBrowse link
G SMURF1 SMAD specific E3 ubiquitin protein ligase 1 involved_in ISO (MGI:5298125|PMID:22020285) ParkinsonsUK-UCL PMID:22020285 MGI:5298125 NCBI chr 6:10,385,781...10,498,071
Ensembl chr 6:10,385,779...10,494,922 		JBrowse link
positive regulation of mitophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMBRA1 autophagy and beclin 1 regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:42,903,815...43,073,918
Ensembl chr18:42,932,513...43,072,827 		JBrowse link
G CERS1 ceramide synthase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:44,216,568...44,231,820 JBrowse link
G DELE1 DAP3 binding cell death enhancer 1 involved_in ISO (PMID:38340717) UniProt PMID:38340717 NCBI chr 2:36,865,275...36,880,304
Ensembl chr 2:36,865,289...36,879,840 		JBrowse link
G EIF2AK1 eukaryotic translation initiation factor 2 alpha kinase 1 involved_in ISO (PMID:38340717) UniProt PMID:38340717 NCBI chr 6:11,447,225...11,478,611
Ensembl chr 6:11,447,081...11,478,658 		JBrowse link
G FBXO7 F-box protein 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:30,928,059...30,948,858
Ensembl chr10:30,928,329...30,948,977 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692 		JBrowse link
G HTT huntingtin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:61,076,934...61,221,462
Ensembl chr 3:61,079,904...61,330,290 		JBrowse link
G LOC481473 immunity-related GTPase family M protein involved_in ISO (PMID:21102437), (PMID:32939830) UniProt PMID:21102437 PMID:32939830 NCBI chr11:793,416...795,373
Ensembl chr11:793,424...794,617 		JBrowse link
G LOC606863 immunity-related GTPase family M protein-like involved_in ISO (MGI:6705154|PMID:33510463) UniProt PMID:33510463 MGI:6705154 NCBI chr11:506,981...523,338
Ensembl chr11:509,636...510,829 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:64,636,850...64,667,232
Ensembl chr 2:64,635,519...64,667,232 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in ISO
IEA		 RGD
Ensembl		 PMID:28608965 GO_REF:0000107 RGD:13432560 NCBI chr 1:49,886,887...51,201,930
Ensembl chr 1:49,889,005...51,201,764 		JBrowse link
G SLC25A4 solute carrier family 25 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:45,454,660...45,458,606
Ensembl chr16:45,411,810...45,542,162 		JBrowse link
G SLC25A5 solute carrier family 25 member 5 involved_in ISO (MGI:6407583|PMID:31618756) UniProt PMID:31618756 MGI:6407583 NCBI chr  X:91,523,649...91,526,447
Ensembl chr  X:91,523,643...91,526,479 		JBrowse link
G UBE2A ubiquitin conjugating enzyme E2 A involved_in ISO (PMID:23685073) UniProt PMID:23685073 NCBI chr  X:91,608,936...91,617,993
Ensembl chr  X:91,529,855...91,617,086 		JBrowse link
G VPS13D vacuolar protein sorting 13 homolog D involved_in ISO (PMID:29307555) UniProt PMID:29307555 NCBI chr 2:83,898,620...84,132,453
Ensembl chr 2:83,901,018...84,132,529 		JBrowse link
positive regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC37 cell division cycle 37, HSP90 cochaperone involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:50,727,702...50,738,197
Ensembl chr20:50,727,749...50,736,269 		JBrowse link
G HDAC6 histone deacetylase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:42,004,268...42,024,726
Ensembl chr  X:42,004,591...42,024,427 		JBrowse link
G HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:45,234,666...45,409,641
Ensembl chr  X:45,234,322...45,410,043 		JBrowse link
G PINK1 PTEN induced kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:78,276,091...78,293,761
Ensembl chr 2:78,277,077...78,294,123 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:49,886,887...51,201,930
Ensembl chr 1:49,889,005...51,201,764 		JBrowse link
G TOMM7 translocase of outer mitochondrial membrane 7 involved_in ISO (PMID:24270810) ParkinsonsUK-UCL PMID:24270810 NCBI chr14:36,523,707...36,532,180
Ensembl chr14:36,523,707...36,532,291 		JBrowse link
positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VDAC1 voltage dependent anion channel 1 involved_in ISO (PMID:32047033) UniProt PMID:32047033 NCBI chr11:22,197,814...22,212,924
Ensembl chr11:22,197,949...22,212,924 		JBrowse link
regulation of mitophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY10 adenylate cyclase 10 ISO RGD PMID:31172217 RGD:329403053 NCBI chr 7:30,576,445...30,660,926
Ensembl chr 7:30,577,591...30,660,926 		JBrowse link
G BNIP3L BCL2 interacting protein 3 like involved_in ISO (MGI:5616312|PMID:20200478) ParkinsonsUK-UCL PMID:20200478 MGI:5616312 NCBI chr25:31,133,512...31,149,750
Ensembl chr25:31,136,168...31,148,905 		JBrowse link
G CSNK2A2 casein kinase 2 alpha 2 involved_in ISO (PMID:24912190) ParkinsonsUK-UCL PMID:24912190 NCBI chr 2:58,361,328...58,441,701
Ensembl chr 2:58,360,838...58,432,371 		JBrowse link
G CTTN cortactin involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:47,932,367...47,960,732
Ensembl chr18:47,916,632...47,960,674 		JBrowse link
G DNM1L dynamin 1 like involved_in ISO (PMID:19279012) ParkinsonsUK-UCL PMID:19279012 NCBI chr27:16,161,855...16,211,983
Ensembl chr27:16,163,357...16,211,957 		JBrowse link
G FBXW7 F-box and WD repeat domain containing 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:50,187,579...50,417,188
Ensembl chr15:50,189,240...50,417,195 		JBrowse link
G FKBP8 FKBP prolyl isomerase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:44,494,856...44,504,084
Ensembl chr20:44,489,219...44,598,497 		JBrowse link
G FZD5 frizzled class receptor 5 involved_in ISO (PMID:24912190) ParkinsonsUK-UCL PMID:24912190 NCBI chr37:16,123,788...16,126,634
Ensembl chr37:16,123,798...16,125,567 		JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:112,129,116...112,138,714
Ensembl chr 1:112,103,825...112,138,559 		JBrowse link
G PARL presenilin associated rhomboid like involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:16,790,049...16,837,557
Ensembl chr34:16,781,139...16,837,545 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:41,663,809...41,686,764
Ensembl chr 5:41,663,773...41,686,776 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 involved_in ISO (PMID:24912190) ParkinsonsUK-UCL PMID:24912190 NCBI chr10:23,451,923...23,532,765
Ensembl chr10:23,452,561...23,518,689
Ensembl chr10:23,452,561...23,518,689 		JBrowse link
G USP36 ubiquitin specific peptidase 36 involved_in ISO (PMID:24912190) ParkinsonsUK-UCL PMID:24912190 NCBI chr 9:2,547,316...2,587,360
Ensembl chr 9:2,550,452...2,585,108 		JBrowse link
G VDAC1 voltage dependent anion channel 1 involved_in ISO (MGI:5689082|PMID:25470454) ParkinsonsUK-UCL PMID:25470454 MGI:5689082 NCBI chr11:22,197,814...22,212,924
Ensembl chr11:22,197,949...22,212,924 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    cellular process 16926
      process utilizing autophagic mechanism 517
        autophagy 517
          autophagy of mitochondrion 78
            mitophagy 71
              negative regulation of mitophagy 7
              negative regulation of mitophagy in response to mitochondrial depolarization 1
              positive regulation of mitophagy + 16
              positive regulation of mitophagy in response to mitochondrial depolarization + 11
              regulation of mitophagy + 37
Path 2
Term Annotations click to browse term
  biological_process 17917
    cellular process 16926
      cellular component organization or biogenesis 6943
        cellular component organization 6705
          organelle organization 3760
            organelle disassembly 169
              autophagy of mitochondrion 78
                mitophagy 71
                  negative regulation of mitophagy 7
                  negative regulation of mitophagy in response to mitochondrial depolarization 1
                  positive regulation of mitophagy + 16
                  positive regulation of mitophagy in response to mitochondrial depolarization + 11
                  regulation of mitophagy + 37
paths to the root