ONTOLOGY REPORT - ANNOTATIONS
Term: alternative mRNA splicing, via spliceosome
Accession: GO:0000380
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Definition: The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
Comment: Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals.
Synonyms: exact_synonym: alternative nuclear mRNA splicing, via spliceosome
broad_synonym: splice site selection
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BCAS2
BCAS2 pre-mRNA processing factor
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:34972250)
MGI Ensembl
PMID:34972250
GO_REF:0000107
NCBI chr20:19,084,908...19,099,204
Ensembl chr20:19,084,954...19,099,590
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CDK13
cyclin dependent kinase 13
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr21:18,551,273...18,688,889
Ensembl chr21:18,553,446...18,688,525
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CELF4
CUGBP Elav-like family member 4
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:19720736)
MGI Ensembl
PMID:19720736
GO_REF:0000107
NCBI chr18:43,314,960...43,635,301
Ensembl chr18:43,603,021...43,624,537
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DDX17
DEAD-box helicase 17
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr19:21,145,576...21,167,091
Ensembl chr19:21,145,417...21,167,543
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DDX5
DEAD-box helicase 5
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:56,766,669...56,773,767
Ensembl chr16:56,767,186...56,773,464
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DHX9
DExH-box helicase 9
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr25:46,485,602...46,534,046
Ensembl chr25:46,485,427...46,518,406
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ESRP1
epithelial splicing regulatory protein 1
acts_upstream_of_or_within
ISO
(PMID:26371508)
MGI
PMID:26371508
NCBI chr 8:89,609,723...89,679,035
Ensembl chr 8:89,608,014...89,679,037
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ESRP2
epithelial splicing regulatory protein 2
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:26371508)
MGI Ensembl
PMID:26371508
GO_REF:0000107
NCBI chr 5:59,184,624...59,192,842
Ensembl chr 5:59,186,167...59,197,003
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HNRNPA1
heterogeneous nuclear ribonucleoprotein A1
acts_upstream_of_or_within
ISO
(PMID:15798186)
MGI
PMID:15798186
NCBI chr11:50,397,173...50,403,192
Ensembl chr11:50,396,888...50,400,802
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HNRNPM
heterogeneous nuclear ribonucleoprotein M
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:7,795,996...7,839,506
Ensembl chr 6:7,796,045...7,839,244
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HNRNPU
heterogeneous nuclear ribonucleoprotein U
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr25:81,879,532...81,890,684
Ensembl chr25:81,878,111...81,890,701
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HNRNPUL1
heterogeneous nuclear ribonucleoprotein U like 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 6:35,580,856...35,628,263
Ensembl chr 6:35,582,849...35,627,195
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HNRNPUL2
heterogeneous nuclear ribonucleoprotein U like 2
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 1:11,179,711...11,194,995
Ensembl chr 1:11,179,728...11,195,178
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MBNL1
muscleblind like splicing regulator 1
acts_upstream_of_or_within
ISO
(PMID:19720736) (PMID:19075228)
MGI
PMID:19075228 PMID:19720736
NCBI chr15:38,208,694...38,427,867
Ensembl chr15:38,208,038...38,375,273
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PQBP1
polyglutamine binding protein 1
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr X:46,014,664...46,020,204
Ensembl chr X:46,015,250...46,023,988
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PUF60
poly(U) binding splicing factor 60
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 8:138,034,526...138,047,485
Ensembl chr 8:138,034,395...138,042,468
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RBM17
RNA binding motif protein 17
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 9:6,213,477...6,240,945
Ensembl chr 9:6,221,570...6,239,678
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RSRC1
arginine and serine rich coiled-coil 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:15798186)
InterPro TreeGrafter MGI Ensembl
PMID:15798186
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr15:32,283,999...32,684,786
Ensembl chr15:32,280,514...32,680,618
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SFPQ
splicing factor proline and glutamine rich
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:97,698,953...97,715,762
Ensembl chr20:97,698,411...97,711,294
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SFSWAP
splicing factor SWAP
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:8940107)
Ensembl MGI
PMID:8940107
GO_REF:0000107
NCBI chr11:127,086,690...127,177,327
Ensembl chr11:127,086,668...127,177,324
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SLU7
SLU7 homolog, splicing factor
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr23:62,761,466...62,778,613
Ensembl chr23:62,764,335...62,778,910
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SRSF1
serine and arginine rich splicing factor 1
involved_in
ISO IEA
RGD Ensembl
PMID:23462647
GO_REF:0000107 RGD:11038736
NCBI chr16:35,392,573...35,396,815
Ensembl chr16:35,392,873...35,394,982
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SRSF6
serine and arginine rich splicing factor 6
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 2:20,340,163...20,345,873
Ensembl chr 2:20,342,681...20,346,122
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STRAP
serine/threonine kinase receptor associated protein
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr11:15,790,449...15,812,964
Ensembl chr11:15,790,798...15,813,585
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ARB2A
ARB2 cotranscriptional regulator A
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 4:87,499,061...87,978,159
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ARGLU1
arginine and glutamate rich 1
involved_in
ISO
(PMID:30698747)
UniProt
PMID:30698747
NCBI chr 3:84,958,279...84,983,102
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ARGLU1
arginine and glutamate rich 1
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr 3:84,972,187...84,983,106
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CELF1
CUGBP Elav-like family member 1
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:32109384)
MGI Ensembl
PMID:32109384
GO_REF:0000107
NCBI chr 1:17,764,915...17,852,974
Ensembl chr 1:17,817,422...17,853,783
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CELF3
CUGBP Elav-like family member 3
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:11,973,531...11,988,560
Ensembl chr20:11,981,181...11,992,302
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CELF4
CUGBP Elav-like family member 4
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:19720736)
MGI Ensembl
PMID:19720736
GO_REF:0000107
NCBI chr18:43,314,960...43,635,301
Ensembl chr18:43,603,021...43,624,537
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CELF5
CUGBP Elav-like family member 5
involved_in
ISO
(PMID:11158314)
UniProt
PMID:11158314
NCBI chr 6:2,988,764...3,065,099
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CELF5
CUGBP Elav-like family member 5
involved_in
IEA
Ensembl
GO_REF:0000107
Ensembl chr 6:3,041,933...3,055,376
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CELF6
CUGBP Elav-like family member 6
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr26:11,135,021...11,169,351
Ensembl chr26:11,135,088...11,166,493
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DDX17
DEAD-box helicase 17
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr19:21,145,576...21,167,091
Ensembl chr19:21,145,417...21,167,543
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DDX5
DEAD-box helicase 5
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:56,766,669...56,773,767
Ensembl chr16:56,767,186...56,773,464
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DYRK1A
dual specificity tyrosine phosphorylation regulated kinase 1A
involved_in
ISO
PMID:22767602
UniProt
PMID:22767602
RGD:8554210
NCBI chr 2:81,318,509...81,467,227
Ensembl chr 2:81,425,902...81,467,677
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FMR1
Fragile X messenger ribonucleoprotein 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr X:122,635,383...122,674,298
Ensembl chr X:122,635,439...122,674,355
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HNRNPA1
heterogeneous nuclear ribonucleoprotein A1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr11:50,397,173...50,403,192
Ensembl chr11:50,396,888...50,400,802
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HNRNPL
heterogeneous nuclear ribonucleoprotein L
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:33,452,705...33,469,070
Ensembl chr 6:33,452,852...33,466,284
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HNRNPU
heterogeneous nuclear ribonucleoprotein U
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr25:81,879,532...81,890,684
Ensembl chr25:81,878,111...81,890,701
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KHDRBS1
KH RNA binding domain containing, signal transduction associated 1
involved_in
IEA
TreeGrafter Ensembl
GO_REF:0000107 GO_REF:0000118
NCBI chr20:100,831,307...100,859,609
Ensembl chr20:100,832,461...100,859,630
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KHDRBS2
KH RNA binding domain containing, signal transduction associated 2
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr17:12,522,386...13,150,784
Ensembl chr17:12,522,531...12,898,201
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KHDRBS3
KH RNA binding domain containing, signal transduction associated 3
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 8:129,814,228...130,044,479
Ensembl chr 8:129,911,686...130,035,258
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LOC103221203
RNA-binding protein 4
involved_in acts_upstream_of_or_within
ISO
(PMID:12628928), (PMID:16260624), (PMID:16777844), (PMID:16934801), (PMID:21518792) (PMID:23129807)
UniProt MGI
PMID:12628928 PMID:16260624 PMID:16777844 PMID:16934801 PMID:21518792 PMID:23129807 More...
NCBI chr 1:7,604,440...7,638,536
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LOC103239432
myoblast determination protein 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:9525963)
Ensembl MGI
PMID:9525963
GO_REF:0000107
NCBI chr 1:47,250,927...47,254,572
Ensembl chr 1:47,251,551...47,253,284
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LOC103245886
heterogeneous nuclear ribonucleoprotein A1-like
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr26:47,513,308...47,515,651
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LOC119622192
heterogeneous nuclear ribonucleoprotein A1-like
involved_in
IEA
Ensembl
GO_REF:0000107
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MAGOH
mago homolog, exon junction complex subunit
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:79,685,884...79,697,583
Ensembl chr20:79,685,950...79,698,129
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MBNL1
muscleblind like splicing regulator 1
involved_in
ISO
PMID:31283468
UniProt
PMID:31283468
RGD:243049249
NCBI chr15:38,208,694...38,427,867
Ensembl chr15:38,208,038...38,375,273
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MBNL2
muscleblind like splicing regulator 2
involved_in acts_upstream_of_or_within
ISO
PMID:31283468 (PMID:19720736)
UniProt MGI
PMID:19720736 PMID:31283468
RGD:243049249
NCBI chr 3:75,936,438...76,108,163
Ensembl chr 3:75,987,751...76,109,519
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NOVA1
NOVA alternative splicing regulator 1
involved_in
ISO
(PMID:17065982) (PMID:14615540), (PMID:27223325)
UniProt
PMID:14615540 PMID:17065982 PMID:27223325
NCBI chr24:3,363,652...3,513,901
Ensembl chr24:3,360,831...3,514,435
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NOVA2
NOVA alternative splicing regulator 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:39,390,384...39,428,290
Ensembl chr 6:39,393,868...39,428,272
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NSRP1
nuclear speckle splicing regulatory protein 1
involved_in
IEA
Ensembl InterPro
GO_REF:0000002 GO_REF:0000107
NCBI chr16:23,852,744...23,919,101
Ensembl chr16:23,852,981...23,918,783
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PTBP1
polypyrimidine tract binding protein 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:546,010...560,086
Ensembl chr 6:545,964...562,630
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PUF60
poly(U) binding splicing factor 60
involved_in
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr 8:138,034,526...138,047,485
Ensembl chr 8:138,034,395...138,042,468
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RBFOX1
RNA binding fox-1 homolog 1
acts_upstream_of_or_within
ISO
(PMID:23300487)
MGI
PMID:23300487
NCBI chr 5:4,896,225...7,365,137
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RBFOX1
RNA binding fox-1 homolog 1
involved_in
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
Ensembl chr 5:7,163,079...7,365,171
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RBFOX2
RNA binding fox-1 homolog 2
involved_in acts_upstream_of_or_within
ISO IEA
Atp2b1, Mef2a (PMID:22357600) Cacna1c Fxr1, Mef2a, Mtmr3 Mcl1
RGD TreeGrafter Ensembl MGI InterPro
PMID:22357600 PMID:27239029 PMID:28993448 PMID:31778749 PMID:35641779
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:329845872 RGD:329845873 RGD:329845874 RGD:329848961
NCBI chr19:18,507,184...18,801,535
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RBFOX3
RNA binding fox-1 homolog 3
involved_in
IEA
InterPro TreeGrafter
GO_REF:0000002 GO_REF:0000118
NCBI chr16:71,058,257...71,673,053
Ensembl chr16:71,058,131...71,276,475
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RBM11
RNA binding motif protein 11
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:21984414)
MGI TreeGrafter
PMID:21984414
GO_REF:0000118
NCBI chr 2:78,390,304...78,395,739
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RBM15
RNA binding motif protein 15
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:23,191,916...23,200,626
Ensembl chr20:23,193,349...23,199,524
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RBM15B
RNA binding motif protein 15B
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr22:12,732,260...12,735,401
Ensembl chr22:12,732,396...12,735,068
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RBM20
RNA binding motif protein 20
involved_in
ISO
PMID:33805770 PMID:27289039
UniProt
PMID:27289039 PMID:33805770
RGD:152995553 RGD:152995577
NCBI chr 9:103,583,722...103,775,391
Ensembl chr 9:103,703,569...103,777,934
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RBM24
RNA binding motif protein 24
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr17:54,853,761...54,865,742
Ensembl chr17:54,853,761...54,866,058
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RBM25
RNA binding motif protein 25
involved_in
IEA
TreeGrafter Ensembl
GO_REF:0000107 GO_REF:0000118
NCBI chr24:50,307,718...50,384,087
Ensembl chr24:50,307,790...50,382,521
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RBM47
RNA binding motif protein 47
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr27:9,683,026...9,888,245
Ensembl chr27:9,873,138...9,888,239
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RBM5
RNA binding motif protein 5
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr22:11,473,623...11,505,251
Ensembl chr22:11,473,494...11,507,096
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RBM7
RNA binding motif protein 7
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 1:105,806,156...105,815,518
Ensembl chr 1:105,806,228...105,816,356
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RBM8A
RNA binding motif protein 8A
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:12,819,891...12,821,656
Ensembl chr20:12,819,956...12,821,629
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RBMX
RNA binding motif protein X-linked
involved_in
ISO
(PMID:12165565), (PMID:12761049)
UniProt
PMID:12165565 PMID:12761049
NCBI chr X:111,880,859...111,892,660
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RBMXL1
RBMX like 1
involved_in
ISO
PMID:19282290
UniProt
PMID:19282290
RGD:2316827
NCBI chr20:44,416,179...44,428,807
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RBPMS
RNA binding protein, mRNA processing factor
involved_in
ISO
PMID:37548402
UniProt
PMID:37548402
RGD:401901235
NCBI chr 8:28,496,583...28,684,487
Ensembl chr 8:28,496,075...28,659,907
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RBPMS2
RNA binding protein, mRNA processing factor 2
involved_in
ISO
PMID:31283468
UniProt
PMID:31283468
RGD:243049249
NCBI chr26:18,810,371...18,847,642
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REST
RE1 silencing transcription factor
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:11,749,312...11,776,103
Ensembl chr 7:11,749,168...11,773,340
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RNPS1
RNA binding protein with serine rich domain 1
involved_in
ISO
(PMID:22203037)
UniProt
PMID:22203037
NCBI chr 5:2,148,929...2,163,810
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SAP18
Sin3A associated protein 18
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 3:63,736...72,521
Ensembl chr 3:61,957...72,524
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SF3A1
splicing factor 3a subunit 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr19:13,213,059...13,237,200
Ensembl chr19:13,211,275...13,237,257
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SMNDC1
survival motor neuron domain containing 1
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 9:103,217,216...103,229,422
Ensembl chr 9:103,218,308...103,228,053
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SRRM4
serine/arginine repetitive matrix 4
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:23055939)
Ensembl MGI
PMID:23055939
GO_REF:0000107
NCBI chr11:114,329,529...114,506,944
Ensembl chr11:114,329,733...114,500,732
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SRSF12
serine and arginine rich splicing factor 12
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr13:13,864,683...13,884,424
Ensembl chr13:13,864,870...13,884,334
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SRSF2
serine and arginine rich splicing factor 2
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:21470964)
Ensembl MGI
PMID:21470964
GO_REF:0000107
NCBI chr16:44,945,193...44,948,496
Ensembl chr16:44,945,200...44,946,438
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SRSF6
serine and arginine rich splicing factor 6
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:23132731)
MGI Ensembl
PMID:23132731
GO_REF:0000107
NCBI chr 2:20,340,163...20,345,873
Ensembl chr 2:20,342,681...20,346,122
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THRAP3
thyroid hormone receptor associated protein 3
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr20:96,552,233...96,631,220
Ensembl chr20:96,552,077...96,599,904
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TIA1
TIA1 cytotoxic granule associated RNA binding protein
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr14:36,866,379...36,902,683
Ensembl chr14:36,866,414...36,903,246
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TRA2B
transformer 2 beta homolog
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr15:3,493,287...3,514,421
Ensembl chr15:3,493,541...3,513,994
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WTAP
WT1 associated protein
involved_in
IEA
InterPro Ensembl TreeGrafter
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118
NCBI chr13:87,328,228...87,357,868
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YTHDC1
YTH N6-methyladenosine RNA binding protein C1
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:29799838)
MGI TreeGrafter
PMID:29799838
GO_REF:0000118
NCBI chr 7:633,158...670,000
Ensembl chr 7:633,172...671,030
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ZBTB7A
zinc finger and BTB domain containing 7A
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:3,802,171...3,824,552
Ensembl chr 6:3,801,046...3,812,884
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