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ONTOLOGY REPORT - ANNOTATIONS


Term:alternative mRNA splicing, via spliceosome
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Accession:GO:0000380 term browser browse the term
Definition:The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
Comment:Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals.
Synonyms:exact_synonym: alternative nuclear mRNA splicing, via spliceosome
 broad_synonym: splice site selection


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alternative mRNA splicing, via spliceosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCAS2 BCAS2 pre-mRNA processing factor acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:34972250) MGI
Ensembl
PMID:34972250 GO_REF:0000107 NCBI chr20:19,084,908...19,099,204
Ensembl chr20:19,084,954...19,099,590
JBrowse link
G CDK13 cyclin dependent kinase 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:18,551,273...18,688,889
Ensembl chr21:18,553,446...18,688,525
JBrowse link
G CELF4 CUGBP Elav-like family member 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:19720736) MGI
Ensembl
PMID:19720736 GO_REF:0000107 NCBI chr18:43,314,960...43,635,301
Ensembl chr18:43,603,021...43,624,537
JBrowse link
G DDX17 DEAD-box helicase 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:21,145,576...21,167,091
Ensembl chr19:21,145,417...21,167,543
JBrowse link
G DDX5 DEAD-box helicase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:56,766,669...56,773,767
Ensembl chr16:56,767,186...56,773,464
JBrowse link
G DHX9 DExH-box helicase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:46,485,602...46,534,046
Ensembl chr25:46,485,427...46,518,406
JBrowse link
G ESRP1 epithelial splicing regulatory protein 1 acts_upstream_of_or_within ISO (PMID:26371508) MGI PMID:26371508 NCBI chr 8:89,609,723...89,679,035
Ensembl chr 8:89,608,014...89,679,037
JBrowse link
G ESRP2 epithelial splicing regulatory protein 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:26371508) MGI
Ensembl
PMID:26371508 GO_REF:0000107 NCBI chr 5:59,184,624...59,192,842
Ensembl chr 5:59,186,167...59,197,003
JBrowse link
G HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 acts_upstream_of_or_within ISO (PMID:15798186) MGI PMID:15798186 NCBI chr11:50,397,173...50,403,192
Ensembl chr11:50,396,888...50,400,802
JBrowse link
G HNRNPM heterogeneous nuclear ribonucleoprotein M involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:7,795,996...7,839,506
Ensembl chr 6:7,796,045...7,839,244
JBrowse link
G HNRNPU heterogeneous nuclear ribonucleoprotein U involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr25:81,879,532...81,890,684
Ensembl chr25:81,878,111...81,890,701
JBrowse link
G HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:35,580,856...35,628,263
Ensembl chr 6:35,582,849...35,627,195
JBrowse link
G HNRNPUL2 heterogeneous nuclear ribonucleoprotein U like 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:11,179,711...11,194,995
Ensembl chr 1:11,179,728...11,195,178
JBrowse link
G MBNL1 muscleblind like splicing regulator 1 acts_upstream_of_or_within ISO (PMID:19720736)
(PMID:19075228)
MGI PMID:19075228 PMID:19720736 NCBI chr15:38,208,694...38,427,867
Ensembl chr15:38,208,038...38,375,273
JBrowse link
G PQBP1 polyglutamine binding protein 1 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr  X:46,014,664...46,020,204
Ensembl chr  X:46,015,250...46,023,988
JBrowse link
G PUF60 poly(U) binding splicing factor 60 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:138,034,526...138,047,485
Ensembl chr 8:138,034,395...138,042,468
JBrowse link
G RBM17 RNA binding motif protein 17 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr 9:6,213,477...6,240,945
Ensembl chr 9:6,221,570...6,239,678
JBrowse link
G RSRC1 arginine and serine rich coiled-coil 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:15798186) InterPro
TreeGrafter
MGI
Ensembl
PMID:15798186 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr15:32,283,999...32,684,786
Ensembl chr15:32,280,514...32,680,618
JBrowse link
G SFPQ splicing factor proline and glutamine rich involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:97,698,953...97,715,762
Ensembl chr20:97,698,411...97,711,294
JBrowse link
G SFSWAP splicing factor SWAP involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:8940107) Ensembl
MGI
PMID:8940107 GO_REF:0000107 NCBI chr11:127,086,690...127,177,327
Ensembl chr11:127,086,668...127,177,324
JBrowse link
G SLU7 SLU7 homolog, splicing factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:62,761,466...62,778,613
Ensembl chr23:62,764,335...62,778,910
JBrowse link
G SRSF1 serine and arginine rich splicing factor 1 involved_in ISO
IEA
RGD
Ensembl
PMID:23462647 GO_REF:0000107 RGD:11038736 NCBI chr16:35,392,573...35,396,815
Ensembl chr16:35,392,873...35,394,982
JBrowse link
G SRSF6 serine and arginine rich splicing factor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:20,340,163...20,345,873
Ensembl chr 2:20,342,681...20,346,122
JBrowse link
G STRAP serine/threonine kinase receptor associated protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:15,790,449...15,812,964
Ensembl chr11:15,790,798...15,813,585
JBrowse link
regulation of alternative mRNA splicing, via spliceosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARB2A ARB2 cotranscriptional regulator A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:87,499,061...87,978,159 JBrowse link
G ARGLU1 arginine and glutamate rich 1 involved_in ISO (PMID:30698747) UniProt PMID:30698747 NCBI chr 3:84,958,279...84,983,102 JBrowse link
G ARGLU1 arginine and glutamate rich 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 3:84,972,187...84,983,106 JBrowse link
G CELF1 CUGBP Elav-like family member 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:32109384) MGI
Ensembl
PMID:32109384 GO_REF:0000107 NCBI chr 1:17,764,915...17,852,974
Ensembl chr 1:17,817,422...17,853,783
JBrowse link
G CELF3 CUGBP Elav-like family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:11,973,531...11,988,560
Ensembl chr20:11,981,181...11,992,302
JBrowse link
G CELF4 CUGBP Elav-like family member 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:19720736) MGI
Ensembl
PMID:19720736 GO_REF:0000107 NCBI chr18:43,314,960...43,635,301
Ensembl chr18:43,603,021...43,624,537
JBrowse link
G CELF5 CUGBP Elav-like family member 5 involved_in ISO (PMID:11158314) UniProt PMID:11158314 NCBI chr 6:2,988,764...3,065,099 JBrowse link
G CELF5 CUGBP Elav-like family member 5 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 6:3,041,933...3,055,376 JBrowse link
G CELF6 CUGBP Elav-like family member 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:11,135,021...11,169,351
Ensembl chr26:11,135,088...11,166,493
JBrowse link
G DDX17 DEAD-box helicase 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:21,145,576...21,167,091
Ensembl chr19:21,145,417...21,167,543
JBrowse link
G DDX5 DEAD-box helicase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:56,766,669...56,773,767
Ensembl chr16:56,767,186...56,773,464
JBrowse link
G DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A involved_in ISO PMID:22767602 UniProt PMID:22767602 RGD:8554210 NCBI chr 2:81,318,509...81,467,227
Ensembl chr 2:81,425,902...81,467,677
JBrowse link
G FMR1 Fragile X messenger ribonucleoprotein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:122,635,383...122,674,298
Ensembl chr  X:122,635,439...122,674,355
JBrowse link
G HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:50,397,173...50,403,192
Ensembl chr11:50,396,888...50,400,802
JBrowse link
G HNRNPL heterogeneous nuclear ribonucleoprotein L involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:33,452,705...33,469,070
Ensembl chr 6:33,452,852...33,466,284
JBrowse link
G HNRNPU heterogeneous nuclear ribonucleoprotein U involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:81,879,532...81,890,684
Ensembl chr25:81,878,111...81,890,701
JBrowse link
G KHDRBS1 KH RNA binding domain containing, signal transduction associated 1 involved_in IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chr20:100,831,307...100,859,609
Ensembl chr20:100,832,461...100,859,630
JBrowse link
G KHDRBS2 KH RNA binding domain containing, signal transduction associated 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:12,522,386...13,150,784
Ensembl chr17:12,522,531...12,898,201
JBrowse link
G KHDRBS3 KH RNA binding domain containing, signal transduction associated 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:129,814,228...130,044,479
Ensembl chr 8:129,911,686...130,035,258
JBrowse link
G LOC103221203 RNA-binding protein 4 involved_in
acts_upstream_of_or_within
ISO (PMID:12628928), (PMID:16260624), (PMID:16777844), (PMID:16934801), (PMID:21518792)
(PMID:23129807)
UniProt
MGI
PMID:12628928 PMID:16260624 PMID:16777844 PMID:16934801 PMID:21518792 More... NCBI chr 1:7,604,440...7,638,536 JBrowse link
G LOC103239432 myoblast determination protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:9525963) Ensembl
MGI
PMID:9525963 GO_REF:0000107 NCBI chr 1:47,250,927...47,254,572
Ensembl chr 1:47,251,551...47,253,284
JBrowse link
G LOC103245886 heterogeneous nuclear ribonucleoprotein A1-like involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:47,513,308...47,515,651 JBrowse link
G LOC119622192 heterogeneous nuclear ribonucleoprotein A1-like involved_in IEA Ensembl GO_REF:0000107
G MAGOH mago homolog, exon junction complex subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:79,685,884...79,697,583
Ensembl chr20:79,685,950...79,698,129
JBrowse link
G MBNL1 muscleblind like splicing regulator 1 involved_in ISO PMID:31283468 UniProt PMID:31283468 RGD:243049249 NCBI chr15:38,208,694...38,427,867
Ensembl chr15:38,208,038...38,375,273
JBrowse link
G MBNL2 muscleblind like splicing regulator 2 involved_in
acts_upstream_of_or_within
ISO PMID:31283468
(PMID:19720736)
UniProt
MGI
PMID:19720736 PMID:31283468 RGD:243049249 NCBI chr 3:75,936,438...76,108,163
Ensembl chr 3:75,987,751...76,109,519
JBrowse link
G NOVA1 NOVA alternative splicing regulator 1 involved_in ISO (PMID:17065982)
(PMID:14615540), (PMID:27223325)
UniProt PMID:14615540 PMID:17065982 PMID:27223325 NCBI chr24:3,363,652...3,513,901
Ensembl chr24:3,360,831...3,514,435
JBrowse link
G NOVA2 NOVA alternative splicing regulator 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:39,390,384...39,428,290
Ensembl chr 6:39,393,868...39,428,272
JBrowse link
G NSRP1 nuclear speckle splicing regulatory protein 1 involved_in IEA Ensembl
InterPro
GO_REF:0000002 GO_REF:0000107 NCBI chr16:23,852,744...23,919,101
Ensembl chr16:23,852,981...23,918,783
JBrowse link
G PTBP1 polypyrimidine tract binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:546,010...560,086
Ensembl chr 6:545,964...562,630
JBrowse link
G PUF60 poly(U) binding splicing factor 60 involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chr 8:138,034,526...138,047,485
Ensembl chr 8:138,034,395...138,042,468
JBrowse link
G RBFOX1 RNA binding fox-1 homolog 1 acts_upstream_of_or_within ISO (PMID:23300487) MGI PMID:23300487 NCBI chr 5:4,896,225...7,365,137 JBrowse link
G RBFOX1 RNA binding fox-1 homolog 1 involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 Ensembl chr 5:7,163,079...7,365,171 JBrowse link
G RBFOX2 RNA binding fox-1 homolog 2 involved_in
acts_upstream_of_or_within
ISO
IEA
Atp2b1, Mef2a
(PMID:22357600)
Cacna1c
Fxr1, Mef2a, Mtmr3
Mcl1
RGD
TreeGrafter
Ensembl
MGI
InterPro
PMID:22357600 PMID:27239029 PMID:28993448 PMID:31778749 PMID:35641779 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:329845872 RGD:329845873 RGD:329845874 RGD:329848961 NCBI chr19:18,507,184...18,801,535 JBrowse link
G RBFOX3 RNA binding fox-1 homolog 3 involved_in IEA InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000118 NCBI chr16:71,058,257...71,673,053
Ensembl chr16:71,058,131...71,276,475
JBrowse link
G RBM11 RNA binding motif protein 11 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:21984414) MGI
TreeGrafter
PMID:21984414 GO_REF:0000118 NCBI chr 2:78,390,304...78,395,739 JBrowse link
G RBM15 RNA binding motif protein 15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:23,191,916...23,200,626
Ensembl chr20:23,193,349...23,199,524
JBrowse link
G RBM15B RNA binding motif protein 15B involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:12,732,260...12,735,401
Ensembl chr22:12,732,396...12,735,068
JBrowse link
G RBM20 RNA binding motif protein 20 involved_in ISO PMID:33805770
PMID:27289039
UniProt PMID:27289039 PMID:33805770 RGD:152995553 RGD:152995577 NCBI chr 9:103,583,722...103,775,391
Ensembl chr 9:103,703,569...103,777,934
JBrowse link
G RBM24 RNA binding motif protein 24 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr17:54,853,761...54,865,742
Ensembl chr17:54,853,761...54,866,058
JBrowse link
G RBM25 RNA binding motif protein 25 involved_in IEA TreeGrafter
Ensembl
GO_REF:0000107 GO_REF:0000118 NCBI chr24:50,307,718...50,384,087
Ensembl chr24:50,307,790...50,382,521
JBrowse link
G RBM47 RNA binding motif protein 47 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:9,683,026...9,888,245
Ensembl chr27:9,873,138...9,888,239
JBrowse link
G RBM5 RNA binding motif protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:11,473,623...11,505,251
Ensembl chr22:11,473,494...11,507,096
JBrowse link
G RBM7 RNA binding motif protein 7 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:105,806,156...105,815,518
Ensembl chr 1:105,806,228...105,816,356
JBrowse link
G RBM8A RNA binding motif protein 8A involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:12,819,891...12,821,656
Ensembl chr20:12,819,956...12,821,629
JBrowse link
G RBMX RNA binding motif protein X-linked involved_in ISO (PMID:12165565), (PMID:12761049) UniProt PMID:12165565 PMID:12761049 NCBI chr  X:111,880,859...111,892,660 JBrowse link
G RBMXL1 RBMX like 1 involved_in ISO PMID:19282290 UniProt PMID:19282290 RGD:2316827 NCBI chr20:44,416,179...44,428,807 JBrowse link
G RBPMS RNA binding protein, mRNA processing factor involved_in ISO PMID:37548402 UniProt PMID:37548402 RGD:401901235 NCBI chr 8:28,496,583...28,684,487
Ensembl chr 8:28,496,075...28,659,907
JBrowse link
G RBPMS2 RNA binding protein, mRNA processing factor 2 involved_in ISO PMID:31283468 UniProt PMID:31283468 RGD:243049249 NCBI chr26:18,810,371...18,847,642 JBrowse link
G REST RE1 silencing transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:11,749,312...11,776,103
Ensembl chr 7:11,749,168...11,773,340
JBrowse link
G RNPS1 RNA binding protein with serine rich domain 1 involved_in ISO (PMID:22203037) UniProt PMID:22203037 NCBI chr 5:2,148,929...2,163,810 JBrowse link
G SAP18 Sin3A associated protein 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:63,736...72,521
Ensembl chr 3:61,957...72,524
JBrowse link
G SF3A1 splicing factor 3a subunit 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:13,213,059...13,237,200
Ensembl chr19:13,211,275...13,237,257
JBrowse link
G SMNDC1 survival motor neuron domain containing 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:103,217,216...103,229,422
Ensembl chr 9:103,218,308...103,228,053
JBrowse link
G SRRM4 serine/arginine repetitive matrix 4 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23055939) Ensembl
MGI
PMID:23055939 GO_REF:0000107 NCBI chr11:114,329,529...114,506,944
Ensembl chr11:114,329,733...114,500,732
JBrowse link
G SRSF12 serine and arginine rich splicing factor 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:13,864,683...13,884,424
Ensembl chr13:13,864,870...13,884,334
JBrowse link
G SRSF2 serine and arginine rich splicing factor 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:21470964) Ensembl
MGI
PMID:21470964 GO_REF:0000107 NCBI chr16:44,945,193...44,948,496
Ensembl chr16:44,945,200...44,946,438
JBrowse link
G SRSF6 serine and arginine rich splicing factor 6 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:23132731) MGI
Ensembl
PMID:23132731 GO_REF:0000107 NCBI chr 2:20,340,163...20,345,873
Ensembl chr 2:20,342,681...20,346,122
JBrowse link
G THRAP3 thyroid hormone receptor associated protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:96,552,233...96,631,220
Ensembl chr20:96,552,077...96,599,904
JBrowse link
G TIA1 TIA1 cytotoxic granule associated RNA binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:36,866,379...36,902,683
Ensembl chr14:36,866,414...36,903,246
JBrowse link
G TRA2B transformer 2 beta homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:3,493,287...3,514,421
Ensembl chr15:3,493,541...3,513,994
JBrowse link
G WTAP WT1 associated protein involved_in IEA InterPro
Ensembl
TreeGrafter
GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr13:87,328,228...87,357,868 JBrowse link
G YTHDC1 YTH N6-methyladenosine RNA binding protein C1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:29799838) MGI
TreeGrafter
PMID:29799838 GO_REF:0000118 NCBI chr 7:633,158...670,000
Ensembl chr 7:633,172...671,030
JBrowse link
G ZBTB7A zinc finger and BTB domain containing 7A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:3,802,171...3,824,552
Ensembl chr 6:3,801,046...3,812,884
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17043
    cellular process 16562
      metabolic process 10934
        primary metabolic process 9703
          RNA processing 886
            mRNA processing 427
              mRNA splicing, via spliceosome 302
                alternative mRNA splicing, via spliceosome 80
                  mRNA alternative trans-splicing 0
                  regulation of alternative mRNA splicing, via spliceosome 64
Path 2
Term Annotations click to browse term
  biological_process 17043
    cellular process 16562
      metabolic process 10934
        primary metabolic process 9703
          nucleobase-containing compound metabolic process 5446
            nucleobase-containing compound biosynthetic process 4540
              nucleic acid biosynthetic process 4283
                RNA biosynthetic process 4178
                  RNA processing 886
                    RNA splicing 393
                      RNA splicing, via transesterification reactions 302
                        RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 302
                          mRNA splicing, via spliceosome 302
                            alternative mRNA splicing, via spliceosome 80
                              mRNA alternative trans-splicing 0
                              regulation of alternative mRNA splicing, via spliceosome 64
paths to the root