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ONTOLOGY REPORT - ANNOTATIONS


Term:THO complex
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Accession:GO:0000347 term browser browse the term
Definition:The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.


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THO complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Da2-19 uncharacterized LOC302729 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:48,196,789...48,213,506
Ensembl chr  X:48,196,916...48,213,505
JBrowse link
G Thoc1 THO complex 1 ISO (PMID:15998806) RGD PMID:15998806 NCBI chr18:1,142,540...1,177,084
Ensembl chr18:1,142,782...1,176,974
JBrowse link
G Thoc2 THO complex 2 ISO (PMID:15998806) RGD PMID:15998806 NCBI chr  X:128,153,824...128,268,327
Ensembl chr  X:128,161,895...128,268,322
JBrowse link
G Thoc5 THO complex 5 ISO (PMID:15998806) RGD PMID:15998806 NCBI chr14:85,138,219...85,171,729
Ensembl chr14:85,142,279...85,171,726
JBrowse link
G Thoc6 THO complex 6 ISO (PMID:15998806) RGD PMID:15998806 NCBI chr10:12,989,135...12,994,495
Ensembl chr10:12,989,135...12,994,495
JBrowse link
G Thoc7 THO complex 7 ISO (PMID:15998806) RGD PMID:15998806 NCBI chr15:12,569,235...12,584,101
Ensembl chr15:12,569,235...12,584,094
JBrowse link
THO complex part of transcription export complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Da2-19 uncharacterized LOC302729 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:48,196,789...48,213,506
Ensembl chr  X:48,196,916...48,213,505
JBrowse link
G LOC679894 similar to THO complex subunit 2 (Tho2) IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:6,561,962...6,601,906
Ensembl chr14:6,581,983...6,587,141
JBrowse link
G Thoc1 THO complex 1 ISO (PMID:15998806) RGD PMID:15998806 NCBI chr18:1,142,540...1,177,084
Ensembl chr18:1,142,782...1,176,974
JBrowse link
G Thoc2 THO complex 2 ISO
IBA
(PMID:15998806)
PMID:21873635
RGD PMID:15998806, PMID:21873635 RGD:13792537 NCBI chr  X:128,153,824...128,268,327
Ensembl chr  X:128,161,895...128,268,322
JBrowse link
G Thoc3 THO complex 3 ISO
IBA
(PMID:23222130)
PMID:21873635
RGD PMID:23222130, PMID:21873635 RGD:13792537 NCBI chr17:10,676,943...10,686,134
Ensembl chr17:10,676,943...10,686,134
JBrowse link
G Thoc5 THO complex 5 ISO
IBA
(PMID:15998806)
PMID:21873635
RGD PMID:15998806, PMID:21873635 RGD:13792537 NCBI chr14:85,138,219...85,171,729
Ensembl chr14:85,142,279...85,171,726
JBrowse link
G Thoc6 THO complex 6 ISO (PMID:15998806) RGD PMID:15998806 NCBI chr10:12,989,135...12,994,495
Ensembl chr10:12,989,135...12,994,495
JBrowse link
G Thoc7 THO complex 7 ISO
IBA
(PMID:15998806)
PMID:21873635
RGD PMID:15998806, PMID:21873635 RGD:13792537 NCBI chr15:12,569,235...12,584,101
Ensembl chr15:12,569,235...12,584,094
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6092
      THO complex 8
        THO complex part of transcription export complex 8
        nucleoplasmic THO complex 0
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      organelle 13257
        membrane-bounded organelle 11448
          intracellular membrane-bounded organelle 10704
            nucleus 7183
              THO complex 8
                THO complex part of transcription export complex 8
                nucleoplasmic THO complex 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.