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ONTOLOGY REPORT - ANNOTATIONS


Term:cyclin-dependent protein kinase holoenzyme complex
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Accession:GO:0000307 term browser browse the term
Definition:Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
Synonyms:exact_synonym: CDK holoenzyme



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cyclin-dependent protein kinase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNA1 cyclin A1 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:36,430,488...36,442,870
Ensembl chr13:36,431,520...36,442,870
JBrowse link
G CCNA2 cyclin A2 part_of IBA
IDA
(PMID:21873635)
(PMID:1312467)
GO_Central
UniProt
PMID:1312467 PMID:21873635 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
JBrowse link
G CCNB1 cyclin B1 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCNB2 cyclin B2 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:59,105,146...59,125,045
Ensembl chr15:59,105,126...59,125,045
JBrowse link
G CCNB3 cyclin B3 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:50,202,713...50,351,914
Ensembl chr  X:50,202,713...50,351,914
JBrowse link
G CCND1 cyclin D1 part_of IDA
IBA
(PMID:17420273), (PMID:8114739)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:8114739 PMID:17420273 PMID:21873635 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCND2 cyclin D2 part_of IDA
IBA
(PMID:18827403), (PMID:8114739)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:8114739 PMID:18827403 PMID:21873635 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353
JBrowse link
G CCND3 cyclin D3 part_of IDA
IBA
(PMID:8114739)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:8114739 PMID:21873635 NCBI chr 6:41,934,933...42,048,894
Ensembl chr 6:41,934,934...42,050,357
JBrowse link
G CCNE1 cyclin E1 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CCNE2 cyclin E2 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:94,880,224...94,896,671
Ensembl chr 8:94,879,770...94,896,678
JBrowse link
G CCNF cyclin F part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:2,429,447...2,458,854
Ensembl chr16:2,429,394...2,458,854
JBrowse link
G CCNG1 cyclin G1 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:163,437,571...163,448,199
Ensembl chr 5:163,437,569...163,446,151
JBrowse link
G CCNG2 cyclin G2 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:77,157,207...77,170,060
Ensembl chr 4:77,157,207...77,433,388
JBrowse link
G CCNI cyclin I part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:77,047,155...77,075,989
Ensembl chr 4:77,047,155...77,076,309
JBrowse link
G CCNI2 cyclin I family member 2 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:132,747,426...132,754,403
Ensembl chr 5:132,747,426...132,754,403
JBrowse link
G CCNJ cyclin J part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:96,042,848...96,060,870
Ensembl chr10:96,043,394...96,060,870
JBrowse link
G CCNJL cyclin J like part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:160,249,083...160,339,570
Ensembl chr 5:160,249,083...160,345,396
JBrowse link
G CCNO cyclin O part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:55,231,152...55,233,608
Ensembl chr 5:55,231,152...55,233,608
JBrowse link
G CCNP cyclin P part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:40,222,208...40,227,111
Ensembl chr19:40,222,208...40,226,697
JBrowse link
G CDK1 cyclin dependent kinase 1 part_of IDA (PMID:1312467) UniProt PMID:1312467 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDK12 cyclin dependent kinase 12 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:39,461,486...39,567,560
Ensembl chr17:39,461,486...39,564,907
JBrowse link
G CDK13 cyclin dependent kinase 13 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:39,949,664...40,099,580
Ensembl chr 7:39,950,121...40,099,580
JBrowse link
G CDK2 cyclin dependent kinase 2 part_of IBA
IDA
(PMID:21873635)
(PMID:1312467), (PMID:8692841)
GO_Central
UniProt
PMID:1312467 PMID:8692841 PMID:21873635 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK4 cyclin dependent kinase 4 part_of IDA (PMID:17420273), (PMID:18827403) UniProt PMID:17420273 PMID:18827403 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDK6 cyclin dependent kinase 6 part_of IDA (PMID:17420273) BHF-UCL PMID:17420273 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A part_of IDA (PMID:17420273) BHF-UCL PMID:17420273 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CKS1B CDC28 protein kinase regulatory subunit 1B part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:154,974,681...154,979,251
Ensembl chr 1:154,974,653...154,979,251
JBrowse link
G CKS2 CDC28 protein kinase regulatory subunit 2 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:89,311,195...89,316,703
Ensembl chr 9:89,311,195...89,316,703
JBrowse link
G CNPPD1 cyclin Pas1/PHO80 domain containing 1 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:219,171,897...219,179,272
Ensembl chr 2:219,171,897...219,178,106
JBrowse link
G PCNA proliferating cell nuclear antigen part_of IEA Ensembl GO_REF:0000107 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
cyclin A1-CDK2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNA1 cyclin A1 part_of IEA Ensembl GO_REF:0000107 NCBI chr13:36,430,488...36,442,870
Ensembl chr13:36,431,520...36,442,870
JBrowse link
G CDK2 cyclin dependent kinase 2 part_of IDA (PMID:18305109) UniProt PMID:18305109 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
cyclin A2-CDK2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNA1 cyclin A1 part_of IDA
IBA
(PMID:18305109)
(PMID:21873635)
UniProt
GO_Central
PMID:18305109 PMID:21873635 NCBI chr13:36,430,488...36,442,870
Ensembl chr13:36,431,520...36,442,870
JBrowse link
G CCNA2 cyclin A2 part_of IDA
IBA
(PMID:11746698), (PMID:1312467), (PMID:15024385), (PMID:8684460)
(PMID:21873635)
CAFA
GO_Central
PMID:1312467 PMID:8684460 PMID:11746698 PMID:15024385 PMID:21873635 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
JBrowse link
G CCNO cyclin O part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:55,231,152...55,233,608
Ensembl chr 5:55,231,152...55,233,608
JBrowse link
G CCNP cyclin P part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:40,222,208...40,227,111
Ensembl chr19:40,222,208...40,226,697
JBrowse link
G CDK2 cyclin dependent kinase 2 part_of IDA (PMID:11746698), (PMID:1312467), (PMID:15024385), (PMID:8684460), (PMID:8876165) CAFA PMID:1312467 PMID:8684460 PMID:8876165 PMID:11746698 PMID:15024385 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
cyclin B1-CDK1 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNB1 cyclin B1 part_of IDA
IBA
(PMID:24746669)
(PMID:21873635)
CAFA
GO_Central
PMID:21873635 PMID:24746669 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CDK1 cyclin dependent kinase 1 part_of IMP (PMID:24746669) CAFA PMID:24746669 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
cyclin D2-CDK4 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCND2 cyclin D2 part_of IEA Ensembl GO_REF:0000107 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353
JBrowse link
G CDK4 cyclin dependent kinase 4 part_of IEA Ensembl GO_REF:0000107 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDKN2D cyclin dependent kinase inhibitor 2D part_of IEA Ensembl GO_REF:0000107 NCBI chr19:10,566,460...10,568,979
Ensembl chr19:10,566,460...10,569,059
JBrowse link
cyclin D2-CDK6 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDK6 cyclin dependent kinase 6 part_of ISO (MGI:72259|PMID:7739547) MGI PMID:7739547 MGI:72259 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573
JBrowse link
cyclin E1-CDK2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNE1 cyclin E1 part_of IBA
IDA
(PMID:21873635)
(PMID:18305109)
GO_Central
UniProt
PMID:18305109 PMID:21873635 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CCNE2 cyclin E2 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:94,880,224...94,896,671
Ensembl chr 8:94,879,770...94,896,678
JBrowse link
G CDK2 cyclin dependent kinase 2 part_of IDA (PMID:18305109) UniProt PMID:18305109 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
cyclin E2-CDK2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNE2 cyclin E2 part_of IBA
IDA
(PMID:21873635)
(PMID:18305109)
GO_Central
UniProt
PMID:18305109 PMID:21873635 NCBI chr 8:94,880,224...94,896,671
Ensembl chr 8:94,879,770...94,896,678
JBrowse link
G CDK2 cyclin dependent kinase 2 part_of IDA (PMID:18305109) UniProt PMID:18305109 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
cyclin K-CDK12 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNK cyclin K part_of IPI (PMID:22012619) MGI PMID:22012619 NCBI chr14:99,481,409...99,512,440
Ensembl chr14:99,481,169...99,535,044
JBrowse link
G CDK12 cyclin dependent kinase 12 part_of IPI (PMID:22012619) MGI PMID:22012619 NCBI chr17:39,461,486...39,567,560
Ensembl chr17:39,461,486...39,564,907
JBrowse link
cyclin K-CDK13 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNK cyclin K part_of IPI (PMID:22012619) MGI PMID:22012619 NCBI chr14:99,481,409...99,512,440
Ensembl chr14:99,481,169...99,535,044
JBrowse link
G CDK13 cyclin dependent kinase 13 part_of IPI (PMID:22012619) MGI PMID:22012619 NCBI chr 7:39,949,664...40,099,580
Ensembl chr 7:39,950,121...40,099,580
JBrowse link
cyclin-dependent protein kinase activating kinase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNH cyclin H part_of IMP
IDA
(PMID:23393140)
(PMID:8692841), (PMID:8692842)
CAFA
UniProt
PMID:8692841 PMID:8692842 PMID:23393140 NCBI chr 5:87,311,471...87,412,971
Ensembl chr 5:87,318,416...87,412,930
JBrowse link
G CDK7 cyclin dependent kinase 7 part_of IDA
IMP
(PMID:8692841)
(PMID:23393140)
UniProt
CAFA
PMID:8692841 PMID:23393140 NCBI chr 5:69,234,795...69,277,430
Ensembl chr 5:69,234,795...69,277,430
JBrowse link
G MNAT1 MNAT1 component of CDK activating kinase part_of IDA (PMID:11445587), (PMID:8692841) UniProt PMID:8692841 PMID:11445587 NCBI chr14:60,734,735...60,969,965
Ensembl chr14:60,734,742...60,969,965
JBrowse link
cyclin/CDK positive transcription elongation factor complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD4 bromodomain containing 4 part_of ISO (MGI:5500979|PMID:23752591) MGI PMID:23752591 MGI:5500979 NCBI chr19:15,235,519...15,332,539
Ensembl chr19:15,235,519...15,332,545
JBrowse link
G CCNK cyclin K part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:99,481,409...99,512,440
Ensembl chr14:99,481,169...99,535,044
JBrowse link
G CCNT1 cyclin T1 part_of IBA
IDA
(PMID:21873635)
(PMID:15905409), (PMID:9499409)
GO_Central
UniProt
PMID:9499409 PMID:15905409 PMID:21873635 NCBI chr12:48,688,458...48,716,707
Ensembl chr12:48,688,458...48,716,998
JBrowse link
G CCNT2 cyclin T2 part_of IDA
IBA
(PMID:9499409)
(PMID:21873635)
UniProt
GO_Central
PMID:9499409 PMID:21873635 NCBI chr 2:134,918,810...134,959,342
Ensembl chr 2:134,918,235...134,959,342
JBrowse link
G CDK12 cyclin dependent kinase 12 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:39,461,486...39,567,560
Ensembl chr17:39,461,486...39,564,907
JBrowse link
G CDK13 cyclin dependent kinase 13 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:39,949,664...40,099,580
Ensembl chr 7:39,950,121...40,099,580
JBrowse link
G CDK9 cyclin dependent kinase 9 part_of IDA (PMID:15905409), (PMID:9499409) UniProt PMID:9499409 PMID:15905409 NCBI chr 9:127,786,034...127,790,792
Ensembl chr 9:127,785,679...127,790,792
JBrowse link
G RB1 RB transcriptional corepressor 1 colocalizes_with IDA (PMID:12037672) UniProtKB PMID:12037672 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G SNW1 SNW domain containing 1 colocalizes_with IDA (PMID:15905409) UniProtKB PMID:15905409 NCBI chr14:77,717,599...77,761,156
Ensembl chr14:77,717,599...77,761,207
JBrowse link
cytoplasmic cyclin-dependent protein kinase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNY cyclin Y part_of IDA (PMID:19524571), (PMID:20059949) UniProt PMID:19524571 PMID:20059949 NCBI chr10:35,247,025...35,572,667
Ensembl chr10:35,247,025...35,572,669
JBrowse link
G CDK14 cyclin dependent kinase 14 part_of IDA (PMID:19524571), (PMID:20059949) UniProt PMID:19524571 PMID:20059949 NCBI chr 7:90,596,321...91,210,590
Ensembl chr 7:90,466,424...91,210,590
JBrowse link
nuclear cyclin-dependent protein kinase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCCIP BRCA2 and CDKN1A interacting protein part_of IDA (PMID:10878006) MGI PMID:10878006 NCBI chr10:125,823,546...125,853,695
Ensembl chr10:125,823,546...125,853,695
JBrowse link
G CDK12 cyclin dependent kinase 12 part_of ISS UniProt GO_REF:0000024 NCBI chr17:39,461,486...39,567,560
Ensembl chr17:39,461,486...39,564,907
JBrowse link
G CDK13 cyclin dependent kinase 13 part_of ISS UniProt GO_REF:0000024 NCBI chr 7:39,949,664...40,099,580
Ensembl chr 7:39,950,121...40,099,580
JBrowse link
P-TEFb complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNT1 cyclin T1 part_of IDA (PMID:18483487), (PMID:28431135) FlyBase PMID:18483487 PMID:28431135 NCBI chr12:48,688,458...48,716,707
Ensembl chr12:48,688,458...48,716,998
JBrowse link
G CDK9 cyclin dependent kinase 9 part_of IDA (PMID:18483487) FlyBase PMID:18483487 NCBI chr 9:127,786,034...127,790,792
Ensembl chr 9:127,785,679...127,790,792
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19373
    protein-containing complex 5904
      catalytic complex 1450
        transferase complex 821
          transferase complex, transferring phosphorus-containing groups 267
            protein kinase complex 109
              serine/threonine protein kinase complex 91
                cyclin-dependent protein kinase holoenzyme complex 44
                  MPF complex 0
                  Pho85-Pho80 CDK-cyclin complex 0
                  cyclin A1-CDK1 complex 0
                  cyclin A1-CDK2 complex 2
                  cyclin A2-CDK1 complex 0
                  cyclin A2-CDK2 complex 5
                  cyclin B1-CDK1 complex 2
                  cyclin B2-CDK1 complex 0
                  cyclin B3-CDK2 complex 0
                  cyclin D1-CDK4 complex 0
                  cyclin D1-CDK6 complex 0
                  cyclin D2-CDK4 complex 3
                  cyclin D2-CDK6 complex 1
                  cyclin D3-CDK4 complex 0
                  cyclin D3-CDK6 complex 0
                  cyclin E1-CDK2 complex 3
                  cyclin E2-CDK2 complex 2
                  cyclin K-CDK12 complex 2
                  cyclin K-CDK13 complex 2
                  cytoplasmic cyclin-dependent protein kinase holoenzyme complex 2
                  nuclear cyclin-dependent protein kinase holoenzyme complex + 13
paths to the root