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ONTOLOGY REPORT - ANNOTATIONS


Term:cyclin-dependent protein kinase holoenzyme complex
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Accession:GO:0000307 term browser browse the term
Definition:Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
Synonyms:exact_synonym: CDK holoenzyme



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cyclin-dependent protein kinase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNA2 cyclin A2 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:18,317,866...18,324,592
Ensembl chr19:18,318,004...18,323,691
JBrowse link
G CCNB1 cyclin B1 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:54,256,957...54,264,749 JBrowse link
G CCNB2 cyclin B2 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr30:24,040,859...24,063,084
Ensembl chr30:24,040,859...24,063,084
JBrowse link
G CCND1 cyclin D1 part_of IBA
ISS
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000024 NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005
JBrowse link
G CCND2 cyclin D2 part_of ISO (PMID:18827403), (PMID:8114739) BHF-UCL PMID:8114739 PMID:18827403 NCBI chr27:40,563,306...40,593,362
Ensembl chr27:40,564,921...40,594,255
JBrowse link
G CCND3 cyclin D3 part_of ISO (PMID:8114739) BHF-UCL PMID:8114739 NCBI chr12:10,593,786...10,688,304
Ensembl chr12:10,594,712...10,600,891
JBrowse link
G CCNE1 cyclin E1 part_of ISO (MGI:2677082|PMID:12970760) MGI PMID:12970760 MGI:2677082 NCBI chr 1:121,688,622...121,697,533
Ensembl chr 1:121,688,796...121,697,649
JBrowse link
G CCNG1 cyclin G1 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:47,800,697...47,808,259
Ensembl chr 4:47,801,575...47,808,211
JBrowse link
G CCNG2 cyclin G2 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr32:1,719,325...1,727,769
Ensembl chr32:1,720,156...1,726,842
JBrowse link
G CDK1 cyclin dependent kinase 1 part_of ISO (PMID:1312467) UniProt PMID:1312467 NCBI chr 4:12,884,106...12,899,203
Ensembl chr 4:12,883,385...12,899,197
JBrowse link
G CDK2 cyclin dependent kinase 2 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:300,863...306,546
Ensembl chr10:300,903...305,438
JBrowse link
G CDK4 cyclin dependent kinase 4 part_of ISO (PMID:17420273), (PMID:18827403)
(MGI:2677082|PMID:12970760)
UniProt
MGI
PMID:12970760 PMID:17420273 PMID:18827403 MGI:2677082 NCBI chr10:1,812,864...1,815,815
Ensembl chr10:1,812,886...1,815,789
JBrowse link
G CDK6 cyclin dependent kinase 6 part_of ISO (PMID:17420273) BHF-UCL PMID:17420273 NCBI chr14:18,178,352...18,413,869
Ensembl chr14:18,188,429...18,419,869
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A part_of ISO (PMID:17420273)
(MGI:2677082|PMID:12970760)
BHF-UCL
MGI
PMID:12970760 PMID:17420273 MGI:2677082 NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281
JBrowse link
G CKS2 CDC28 protein kinase regulatory subunit 2 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:96,928,690...96,934,154
Ensembl chr 1:96,880,369...96,933,862
JBrowse link
G CNPPD1 cyclin Pas1/PHO80 domain containing 1 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr37:25,729,196...25,734,724
Ensembl chr37:25,729,180...25,737,627
JBrowse link
G PCNA proliferating cell nuclear antigen part_of IEA Ensembl GO_REF:0000107 NCBI chr24:16,478,774...16,485,992
Ensembl chr24:16,478,769...16,484,992
JBrowse link
cyclin A1-CDK2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNA1 cyclin A1 part_of ISO (MGI:72259|PMID:7739547) MGI PMID:7739547 MGI:72259 NCBI chr25:4,189,457...4,198,170
Ensembl chr25:4,189,457...4,198,373
JBrowse link
G CDK2 cyclin dependent kinase 2 part_of ISO (MGI:72259|PMID:7739547)
(PMID:18305109)
MGI
UniProt
PMID:7739547 PMID:18305109 MGI:72259 NCBI chr10:300,863...306,546
Ensembl chr10:300,903...305,438
JBrowse link
cyclin A2-CDK2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNA1 cyclin A1 part_of ISO (PMID:18305109) UniProt PMID:18305109 NCBI chr25:4,189,457...4,198,170
Ensembl chr25:4,189,457...4,198,373
JBrowse link
G CCNA2 cyclin A2 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:18,317,866...18,324,592
Ensembl chr19:18,318,004...18,323,691
JBrowse link
G CDK2 cyclin dependent kinase 2 part_of ISO (PMID:11746698), (PMID:1312467), (PMID:15024385), (PMID:8684460), (PMID:8876165)
(MGI:72259|PMID:7739547)
CAFA
MGI
PMID:1312467 PMID:7739547 PMID:8684460 PMID:8876165 PMID:11746698 More... MGI:72259 NCBI chr10:300,863...306,546
Ensembl chr10:300,903...305,438
JBrowse link
cyclin B1-CDK1 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNB1 cyclin B1 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:54,256,957...54,264,749 JBrowse link
G CDK1 cyclin dependent kinase 1 part_of IEA Ensembl GO_REF:0000107 NCBI chr 4:12,884,106...12,899,203
Ensembl chr 4:12,883,385...12,899,197
JBrowse link
cyclin D2-CDK4 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCND2 cyclin D2 part_of ISO (MGI:72259|PMID:7739547), (MGI:78049|PMID:8543804) MGI PMID:7739547 PMID:8543804 MGI:72259 MGI:78049 NCBI chr27:40,563,306...40,593,362
Ensembl chr27:40,564,921...40,594,255
JBrowse link
G CDK4 cyclin dependent kinase 4 part_of ISO (MGI:72259|PMID:7739547), (MGI:78049|PMID:8543804) MGI PMID:7739547 PMID:8543804 MGI:72259 MGI:78049 NCBI chr10:1,812,864...1,815,815
Ensembl chr10:1,812,886...1,815,789
JBrowse link
G CDKN2D cyclin dependent kinase inhibitor 2D part_of ISO (MGI:72259|PMID:7739547) MGI PMID:7739547 MGI:72259 NCBI chr20:50,607,382...50,609,929
Ensembl chr20:50,607,674...50,609,482
JBrowse link
cyclin D2-CDK6 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDK6 cyclin dependent kinase 6 part_of ISO (MGI:72259|PMID:7739547) MGI PMID:7739547 MGI:72259 NCBI chr14:18,178,352...18,413,869
Ensembl chr14:18,188,429...18,419,869
JBrowse link
cyclin E1-CDK2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNE1 cyclin E1 part_of ISO (PMID:18305109)
(MGI:72259|PMID:7739547)
UniProt
MGI
PMID:7739547 PMID:18305109 MGI:72259 NCBI chr 1:121,688,622...121,697,533
Ensembl chr 1:121,688,796...121,697,649
JBrowse link
G CDK2 cyclin dependent kinase 2 part_of ISO (PMID:18305109)
(MGI:72259|PMID:7739547)
UniProt
MGI
PMID:7739547 PMID:18305109 MGI:72259 NCBI chr10:300,863...306,546
Ensembl chr10:300,903...305,438
JBrowse link
cyclin E2-CDK2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNE2 cyclin E2 part_of ISO (MGI:72259|PMID:7739547)
(PMID:18305109)
MGI
UniProt
PMID:7739547 PMID:18305109 MGI:72259 NCBI chr29:39,534,872...39,551,141
Ensembl chr29:39,534,968...39,546,566
JBrowse link
G CDK2 cyclin dependent kinase 2 part_of ISO (PMID:18305109)
(MGI:72259|PMID:7739547)
UniProt
MGI
PMID:7739547 PMID:18305109 MGI:72259 NCBI chr10:300,863...306,546
Ensembl chr10:300,903...305,438
JBrowse link
cyclin K-CDK12 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNK cyclin K part_of ISO (PMID:22012619) MGI PMID:22012619 NCBI chr 8:67,910,772...67,927,216
Ensembl chr 8:67,901,426...67,945,214
JBrowse link
G CDK12 cyclin dependent kinase 12 part_of ISO (PMID:22012619) MGI PMID:22012619 NCBI chr 9:22,900,170...22,979,353
Ensembl chr 9:22,917,979...22,979,019
JBrowse link
cyclin K-CDK13 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNK cyclin K part_of ISO (PMID:22012619) MGI PMID:22012619 NCBI chr 8:67,910,772...67,927,216
Ensembl chr 8:67,901,426...67,945,214
JBrowse link
G CDK13 cyclin dependent kinase 13 part_of ISO (PMID:22012619) MGI PMID:22012619 NCBI chr18:9,801,350...9,920,401
Ensembl chr18:9,803,535...9,920,281
JBrowse link
cyclin-dependent protein kinase activating kinase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNH cyclin H part_of IEA Ensembl GO_REF:0000107 NCBI chr 3:21,046,477...21,067,305
Ensembl chr 3:21,046,472...21,178,315
JBrowse link
G CDK7 cyclin dependent kinase 7 part_of ISO (PMID:8692841)
(PMID:23393140)
UniProt
CAFA
PMID:8692841 PMID:23393140 NCBI chr 2:54,317,472...54,350,633
Ensembl chr 2:54,317,534...54,350,742
JBrowse link
G MNAT1 MNAT1 component of CDK activating kinase part_of IEA Ensembl GO_REF:0000107 NCBI chr 8:35,747,883...35,946,353
Ensembl chr 8:35,756,933...35,946,353
JBrowse link
cyclin/CDK positive transcription elongation factor complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD4 bromodomain containing 4 part_of ISO (MGI:5500979|PMID:23752591) MGI PMID:23752591 MGI:5500979 NCBI chr20:46,844,795...46,927,620
Ensembl chr20:46,891,514...46,927,608
JBrowse link
G CCNT1 cyclin T1 part_of ISO (PMID:15905409), (PMID:9499409) UniProt PMID:9499409 PMID:15905409 NCBI chr27:5,788,426...5,817,518
Ensembl chr27:5,788,785...5,817,043
JBrowse link
G CCNT2 cyclin T2 part_of IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:37,743,442...37,787,875
Ensembl chr19:37,743,235...37,783,220
JBrowse link
G CDK9 cyclin dependent kinase 9 part_of ISO (PMID:15905409), (PMID:9499409)
(MGI:5500979|PMID:23752591)
UniProt
MGI
PMID:9499409 PMID:15905409 PMID:23752591 MGI:5500979 NCBI chr 9:55,615,271...55,619,493
Ensembl chr 9:55,615,827...55,620,236
JBrowse link
G RB1 RB transcriptional corepressor 1 colocalizes_with ISO (PMID:12037672) UniProtKB PMID:12037672 NCBI chr22:3,061,621...3,204,625
Ensembl chr22:3,063,239...3,257,726
JBrowse link
G SNW1 SNW domain containing 1 colocalizes_with ISO (PMID:15905409) UniProtKB PMID:15905409 NCBI chr 8:50,478,924...50,512,360
Ensembl chr 8:50,479,338...50,512,243
JBrowse link
cytoplasmic cyclin-dependent protein kinase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNY cyclin Y part_of IEA Ensembl GO_REF:0000107 NCBI chr 2:1,387,962...1,720,497
Ensembl chr 2:1,390,082...1,720,357
JBrowse link
G CDK14 cyclin dependent kinase 14 part_of IEA Ensembl GO_REF:0000107 NCBI chr14:16,286,052...17,007,482
Ensembl chr14:16,440,383...17,005,727
JBrowse link
nuclear cyclin-dependent protein kinase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCCIP BRCA2 and CDKN1A interacting protein part_of IEA Ensembl GO_REF:0000107 NCBI chr28:34,983,827...34,999,180
Ensembl chr28:34,983,858...34,999,118
JBrowse link
G CDK12 cyclin dependent kinase 12 part_of ISO PMID:16537916 UniProt PMID:16537916 RGD:8553775 NCBI chr 9:22,900,170...22,979,353
Ensembl chr 9:22,917,979...22,979,019
JBrowse link
G CDK13 cyclin dependent kinase 13 part_of ISO (MGI:3699439|PMID:17261272) UniProt PMID:17261272 MGI:3699439 NCBI chr18:9,801,350...9,920,401
Ensembl chr18:9,803,535...9,920,281
JBrowse link
P-TEFb complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNT1 cyclin T1 part_of ISO (PMID:18483487), (PMID:28431135) FlyBase PMID:18483487 PMID:28431135 NCBI chr27:5,788,426...5,817,518
Ensembl chr27:5,788,785...5,817,043
JBrowse link
G CDK9 cyclin dependent kinase 9 part_of ISO (PMID:18483487) FlyBase PMID:18483487 NCBI chr 9:55,615,271...55,619,493
Ensembl chr 9:55,615,827...55,620,236
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 13999
    protein-containing complex 4466
      catalytic complex 1199
        transferase complex 661
          transferase complex, transferring phosphorus-containing groups 206
            protein kinase complex 87
              serine/threonine protein kinase complex 70
                cyclin-dependent protein kinase holoenzyme complex 35
                  MPF complex 0
                  Pho85-Pho80 CDK-cyclin complex 0
                  cyclin A1-CDK1 complex 0
                  cyclin A1-CDK2 complex 2
                  cyclin A2-CDK1 complex 0
                  cyclin A2-CDK2 complex 3
                  cyclin B1-CDK1 complex 2
                  cyclin B2-CDK1 complex 0
                  cyclin B3-CDK2 complex 0
                  cyclin D1-CDK4 complex 0
                  cyclin D1-CDK6 complex 0
                  cyclin D2-CDK4 complex 3
                  cyclin D2-CDK6 complex 1
                  cyclin D3-CDK4 complex 0
                  cyclin D3-CDK6 complex 0
                  cyclin E1-CDK2 complex 2
                  cyclin E2-CDK2 complex 2
                  cyclin K-CDK12 complex 2
                  cyclin K-CDK13 complex 2
                  cytoplasmic cyclin-dependent protein kinase holoenzyme complex 2
                  nuclear cyclin-dependent protein kinase holoenzyme complex + 12
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