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ONTOLOGY REPORT - ANNOTATIONS


Term:cyclin-dependent protein kinase holoenzyme complex
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Accession:GO:0000307 term browser browse the term
Definition:Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
Synonyms:exact_synonym: CDK holoenzyme


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cyclin-dependent protein kinase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07049223.1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G AC112018.1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 4:144,220,751...144,220,990 JBrowse link
G Ccna1 cyclin A1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
JBrowse link
G Ccna2 cyclin A2 part_of IBA
ISO
PMID:21873635
(PMID:1312467)
RGD PMID:1312467 PMID:21873635 RGD:13792537 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnb3 cyclin B3 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:15,478,050...15,543,292
Ensembl chr  X:15,478,065...15,542,885
JBrowse link
G Ccnd1 cyclin D1 part_of ISS
ISO
IBA
GO_REF:0000024
PR:P30285|UniProtKB:P30285 (MGI:2677082|PMID:12970760), (MGI:4820703|PMID:19767775)
PMID:21873635
(PMID:17420273), (PMID:8114739)
UniProt
RGD
PMID:8114739 PMID:12970760 PMID:17420273 PMID:19767775 PMID:21873635 GO_REF:0000024 MGI:2677082 MGI:4820703, RGD:13792537 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 part_of IBA
ISO
PMID:21873635
(PMID:18827403), (PMID:8114739)
RGD PMID:8114739 PMID:18827403 PMID:21873635 RGD:13792537 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccnd3 cyclin D3 part_of ISO
IBA
IEA
(PMID:8114739)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:8114739 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 part_of IBA
ISO
PMID:21873635
PR:P97377 (MGI:2677082|PMID:12970760)
RGD PMID:12970760 PMID:21873635 MGI:2677082, RGD:13792537 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccne2 cyclin E2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Ccnf cyclin F part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
JBrowse link
G Ccng1 cyclin G1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Ccng2 cyclin G2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Ccni cyclin I part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:14,879,698...14,902,510
Ensembl chr14:14,879,717...14,902,510
JBrowse link
G Ccnj cyclin J part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:239,659,588...239,677,367 JBrowse link
G Ccnjl cyclin J-like part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:27,995,682...28,053,428
Ensembl chr10:27,995,679...28,053,426
JBrowse link
G Ccno cyclin O part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:44,630,640...44,633,914
Ensembl chr 2:44,626,369...44,633,914
JBrowse link
G Cdk1 cyclin-dependent kinase 1 part_of ISO (PMID:1312467) RGD PMID:1312467 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk12 cyclin-dependent kinase 12 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:83,201,177...83,256,906
Ensembl chr10:83,201,211...83,280,888
JBrowse link
G Cdk13 cyclin-dependent kinase 13 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721
JBrowse link
G Cdk2 cyclin dependent kinase 2 part_of ISO
IBA
(PMID:1312467), (PMID:8692841)
PR:P17918|PR:P39689|PR:Q61457 (MGI:2677082|PMID:12970760)
PMID:21873635
RGD PMID:1312467 PMID:8692841 PMID:12970760 PMID:21873635 MGI:2677082, RGD:13792537 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 part_of ISO (PMID:17420273), (PMID:18827403)
PR:P17918|PR:P25322|PR:P39689 (MGI:2677082|PMID:12970760)
RGD PMID:12970760 PMID:17420273 PMID:18827403 MGI:2677082 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 part_of ISO (PMID:17420273) RGD PMID:17420273 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdk7 cyclin-dependent kinase 7 TAS RGD PMID:8906616 RGD:1302419 NCBI chr 2:31,840,545...31,865,447
Ensembl chr 2:31,840,558...31,865,383
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A part_of ISO (PMID:17420273)
PR:P30285|PR:P97377 (MGI:2677082|PMID:12970760)
RGD PMID:12970760 PMID:17420273 MGI:2677082 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636
JBrowse link
G Cks1l CDC28 protein kinase regulatory subunit 1-like part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:106,982,447...106,983,199
Ensembl chr 5:106,982,882...106,983,121
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Cnppd1 cyclin Pas1/PHO80 domain containing 1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:76,633,475...76,640,164
Ensembl chr 9:76,633,477...76,640,188
JBrowse link
G Pcna proliferating cell nuclear antigen part_of ISO PR:P30285|PR:P97377 (MGI:2677082|PMID:12970760) RGD PMID:12970760 MGI:2677082 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
cyclin A1-CDK2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccna1 cyclin A1 part_of ISO (MGI:72259|PMID:7739547) RGD PMID:7739547 MGI:72259 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
JBrowse link
G Cdk2 cyclin dependent kinase 2 part_of IEA
ISO
GO_REF:0000107
(MGI:72259|PMID:7739547)
(PMID:18305109)
Ensembl
RGD
PMID:7739547 PMID:18305109 GO_REF:0000107 MGI:72259 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
cyclin A2-CDK2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccna1 cyclin A1 part_of ISO
IBA
(PMID:18305109)
PMID:21873635
RGD PMID:18305109 PMID:21873635 RGD:13792537 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
JBrowse link
G Ccna2 cyclin A2 part_of IBA
ISO
PMID:21873635
(MGI:72259|PMID:7739547)
(PMID:11746698), (PMID:1312467), (PMID:15024385), (PMID:8684460)
RGD PMID:1312467 PMID:7739547 PMID:8684460 PMID:11746698 PMID:15024385 More... MGI:72259, RGD:13792537 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccno cyclin O part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:44,630,640...44,633,914
Ensembl chr 2:44,626,369...44,633,914
JBrowse link
G Cdk2 cyclin dependent kinase 2 part_of IEA
ISO
GO_REF:0000107
(MGI:72259|PMID:7739547)
(PMID:11746698), (PMID:1312467), (PMID:15024385), (PMID:8684460), (PMID:8876165)
Ensembl
RGD
PMID:1312467 PMID:7739547 PMID:8684460 PMID:8876165 PMID:11746698 More... GO_REF:0000107 MGI:72259 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
cyclin B1-CDK1 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 part_of IBA
ISO
PMID:21873635
(PMID:24746669)
RGD PMID:24746669 PMID:21873635 RGD:13792537 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cdk1 cyclin-dependent kinase 1 part_of ISO (PMID:24746669) RGD PMID:24746669 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
cyclin D2-CDK4 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd2 cyclin D2 part_of IEA
ISO
GO_REF:0000107
(MGI:72259|PMID:7739547), (MGI:78049|PMID:8543804)
Ensembl
RGD
PMID:7739547 PMID:8543804 GO_REF:0000107 MGI:72259 MGI:78049 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Cdk4 cyclin-dependent kinase 4 part_of ISO (MGI:72259|PMID:7739547), (MGI:78049|PMID:8543804) RGD PMID:7739547 PMID:8543804 MGI:72259 MGI:78049 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D part_of ISO (MGI:72259|PMID:7739547) RGD PMID:7739547 MGI:72259 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674
JBrowse link
cyclin D2-CDK6 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk6 cyclin-dependent kinase 6 part_of ISO (MGI:72259|PMID:7739547) RGD PMID:7739547 MGI:72259 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
cyclin E1-CDK2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccne1 cyclin E1 part_of IEA
ISO
IBA
GO_REF:0000107
(MGI:72259|PMID:7739547)
PMID:21873635
(PMID:18305109)
Ensembl
RGD
PMID:7739547 PMID:18305109 PMID:21873635 GO_REF:0000107 MGI:72259, RGD:13792537 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccne2 cyclin E2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Cdk2 cyclin dependent kinase 2 part_of IEA
ISO
GO_REF:0000107
(MGI:72259|PMID:7739547)
(PMID:18305109)
Ensembl
RGD
PMID:7739547 PMID:18305109 GO_REF:0000107 MGI:72259 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
cyclin E2-CDK2 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccne2 cyclin E2 part_of ISO
IBA
(PMID:18305109)
PMID:21873635
(MGI:72259|PMID:7739547)
RGD PMID:7739547 PMID:18305109 PMID:21873635 MGI:72259, RGD:13792537 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Cdk2 cyclin dependent kinase 2 part_of ISO
IEA
(PMID:18305109)
(MGI:72259|PMID:7739547)
GO_REF:0000107
RGD
Ensembl
PMID:7739547 PMID:18305109 GO_REF:0000107 MGI:72259 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
cyclin K-CDK12 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnk cyclin K part_of ISO UniProtKB:Q9NYV4 (PMID:22012619) RGD PMID:22012619 NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191
JBrowse link
G Cdk12 cyclin-dependent kinase 12 part_of ISO UniProtKB:O75909 (PMID:22012619) RGD PMID:22012619 NCBI chr10:83,201,177...83,256,906
Ensembl chr10:83,201,211...83,280,888
JBrowse link
cyclin K-CDK13 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnk cyclin K part_of ISO UniProtKB:Q14004 (PMID:22012619) RGD PMID:22012619 NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191
JBrowse link
G Cdk13 cyclin-dependent kinase 13 part_of ISO UniProtKB:O75909 (PMID:22012619) RGD PMID:22012619 NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721
JBrowse link
cyclin-dependent protein kinase activating kinase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnh cyclin H part_of ISO (PMID:23393140), (PMID:8692841), (PMID:8692842) RGD PMID:8692841 PMID:8692842 PMID:23393140 NCBI chr 2:15,834,833...15,855,643
Ensembl chr 2:15,834,833...15,855,819
JBrowse link
G Cdk7 cyclin-dependent kinase 7 part_of ISO
IEA
(PMID:23393140), (PMID:8692841)
GO_REF:0000107
RGD
Ensembl
PMID:8692841 PMID:23393140 GO_REF:0000107 NCBI chr 2:31,840,545...31,865,447
Ensembl chr 2:31,840,558...31,865,383
JBrowse link
G Mnat1 MNAT1 component of CDK activating kinase part_of ISO (PMID:11445587), (PMID:8692841) RGD PMID:8692841 PMID:11445587 NCBI chr 6:91,814,703...91,971,945
Ensembl chr 6:91,814,749...91,970,744
JBrowse link
cyclin/CDK positive transcription elongation factor complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd4 bromodomain containing 4 part_of ISO (MGI:5500979|PMID:23752591) RGD PMID:23752591 MGI:5500979 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
JBrowse link
G Ccnk cyclin K part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191
JBrowse link
G Ccnt1 cyclin T1 part_of ISO
IBA
(PMID:15905409), (PMID:9499409)
PMID:21873635
RGD PMID:9499409 PMID:15905409 PMID:21873635 RGD:13792537 NCBI chr 7:129,687,146...129,718,082
Ensembl chr 7:129,691,209...129,717,871
JBrowse link
G Ccnt2 cyclin T2 part_of ISO
IBA
(PMID:9499409)
PMID:21873635
RGD PMID:9499409 PMID:21873635 RGD:13792537 NCBI chr13:39,251,573...39,293,172
Ensembl chr13:39,251,573...39,292,019
JBrowse link
G Cdk12 cyclin-dependent kinase 12 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:83,201,177...83,256,906
Ensembl chr10:83,201,211...83,280,888
JBrowse link
G Cdk13 cyclin-dependent kinase 13 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721
JBrowse link
G Cdk9 cyclin-dependent kinase 9 part_of ISO
ISS
(PMID:15905409), (PMID:9499409)
(MGI:5500979|PMID:23752591)
GO_REF:0000024
RGD
UniProt
PMID:9499409 PMID:15905409 PMID:23752591 GO_REF:0000024 MGI:5500979 NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
JBrowse link
G Rb1 RB transcriptional corepressor 1 colocalizes_with
part_of
ISO
IEA
ISS
(PMID:12037672)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:12037672 GO_REF:0000024 GO_REF:0000107 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Snw1 SNW domain containing 1 colocalizes_with
part_of
ISO
IEA
(PMID:15905409)
GO_REF:0000107
RGD
Ensembl
PMID:15905409 GO_REF:0000107 NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536
JBrowse link
cytoplasmic cyclin-dependent protein kinase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccny cyclin Y part_of ISO (PMID:19524571), (PMID:20059949) RGD PMID:19524571 PMID:20059949 NCBI chr17:57,385,002...57,512,860
Ensembl chr17:57,384,176...57,522,378
JBrowse link
G Cdk14 cyclin-dependent kinase 14 part_of ISO (PMID:19524571), (PMID:20059949) RGD PMID:19524571 PMID:20059949 NCBI chr 4:28,666,688...29,258,865
Ensembl chr 4:28,666,843...29,258,861
JBrowse link
nuclear cyclin-dependent protein kinase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bccip BRCA2 and CDKN1A interacting protein part_of ISO (PMID:10878006) RGD PMID:10878006 NCBI chr 1:188,512,544...188,524,957
Ensembl chr 1:188,512,367...188,524,958
JBrowse link
G Cdk12 cyclin-dependent kinase 12 part_of IDA PMID:16537916 UniProt PMID:16537916 RGD:8553775 NCBI chr10:83,201,177...83,256,906
Ensembl chr10:83,201,211...83,280,888
JBrowse link
G Cdk13 cyclin-dependent kinase 13 part_of ISO (MGI:3699439|PMID:17261272) RGD PMID:17261272 MGI:3699439 NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721
JBrowse link
P-TEFb complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnt1 cyclin T1 part_of ISO (PMID:18483487), (PMID:28431135) RGD PMID:18483487 PMID:28431135 NCBI chr 7:129,687,146...129,718,082
Ensembl chr 7:129,691,209...129,717,871
JBrowse link
G Cdk9 cyclin-dependent kinase 9 part_of ISO (PMID:18483487) RGD PMID:18483487 NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20010
    protein-containing complex 6011
      catalytic complex 1464
        transferase complex 801
          transferase complex, transferring phosphorus-containing groups 259
            protein kinase complex 104
              serine/threonine protein kinase complex 86
                cyclin-dependent protein kinase holoenzyme complex 44
                  MPF complex 0
                  Pho85-Pho80 CDK-cyclin complex 0
                  cyclin A1-CDK1 complex 0
                  cyclin A1-CDK2 complex 2
                  cyclin A2-CDK1 complex 0
                  cyclin A2-CDK2 complex 4
                  cyclin B1-CDK1 complex 2
                  cyclin B2-CDK1 complex 0
                  cyclin B3-CDK2 complex 0
                  cyclin D1-CDK4 complex 0
                  cyclin D1-CDK6 complex 0
                  cyclin D2-CDK4 complex 3
                  cyclin D2-CDK6 complex 1
                  cyclin D3-CDK4 complex 0
                  cyclin D3-CDK6 complex 0
                  cyclin E1-CDK2 complex 3
                  cyclin E2-CDK2 complex 2
                  cyclin K-CDK12 complex 2
                  cyclin K-CDK13 complex 2
                  cytoplasmic cyclin-dependent protein kinase holoenzyme complex 2
                  nuclear cyclin-dependent protein kinase holoenzyme complex + 13
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