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ONTOLOGY REPORT - ANNOTATIONS


Term:nuclear-transcribed mRNA catabolic process, exonucleolytic
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Accession:GO:0000291 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail.
Synonyms:exact_synonym: exonucleolytic degradation of mRNA;   mRNA breakdown, exonucleolytic;   mRNA degradation, exonucleolytic;   nuclear mRNA catabolic process, exonucleolytic



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nuclear-transcribed mRNA catabolic process, exonucleolytic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DIS3L2 DIS3 like 3'-5' exoribonuclease 2 involved_in IEA UniProt
Ensembl
GO_REF:0000104 GO_REF:0000107 NCBI chr15:132,540,784...132,902,943
Ensembl chr15:132,540,829...132,906,232
JBrowse link
G POLR2G RNA polymerase II subunit G involved_in IBA
IEA
GO_Central
TreeGrafter
GO_REF:0000033 GO_REF:0000118 NCBI chr 2:9,004,388...9,008,631
Ensembl chr 2:9,004,390...9,017,779
JBrowse link
exonucleolytic catabolism of deadenylated mRNA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNOT6 CCR4-NOT transcription complex subunit 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:78,131,236...78,202,518
Ensembl chr 2:78,132,939...78,202,492
JBrowse link
G CNOT7 CCR4-NOT transcription complex subunit 7 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr17:4,934,379...4,950,093
Ensembl chr17:4,933,453...4,950,346
JBrowse link
G CNOT8 CCR4-NOT transcription complex subunit 8 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr16:68,329,785...68,352,020
Ensembl chr16:68,329,790...68,350,260
JBrowse link
G EXOSC2 exosome component 2 involved_in IBA
IEA
GO_Central
TreeGrafter
GO_REF:0000033 GO_REF:0000118 NCBI chr 1:270,748,534...270,757,717
Ensembl chr 1:270,748,537...270,758,111
JBrowse link
G EXOSC3 exosome component 3 involved_in IEA
IBA
Ensembl
GO_Central
TreeGrafter
GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:238,536,341...238,541,756
Ensembl chr 1:238,536,345...238,541,333
JBrowse link
G EXOSC5 exosome component 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:49,373,378...49,381,875
Ensembl chr 6:49,373,379...49,382,034
JBrowse link
G EXOSC7 exosome component 7 involved_in IEA
IBA
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr13:28,176,806...28,206,435
Ensembl chr13:28,176,793...28,208,975
JBrowse link
G EXOSC8 exosome component 8 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:12,817,081...12,825,847
Ensembl chr11:12,817,110...12,825,843
JBrowse link
G EXOSC9 exosome component 9 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr 8:102,265,656...102,278,179
Ensembl chr 8:102,264,470...102,278,164
JBrowse link
nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SKIC2 SKI2 subunit of superkiller complex involved_in IEA
IBA
Ensembl
GO_Central
TreeGrafter
GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:24,047,000...24,057,621
Ensembl chr 7:24,047,010...24,057,621
JBrowse link
G SKIC3 SKI3 subunit of superkiller complex involved_in ISO (PMID:32006463), (PMID:35120588) UniProt PMID:32006463 PMID:35120588 NCBI chr 2:102,079,675...102,164,020
Ensembl chr 2:102,079,685...102,163,938
JBrowse link
G SKIC8 SKI8 subunit of superkiller complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:47,641,103...47,661,353
Ensembl chr 7:47,641,162...47,659,866
JBrowse link
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DIS3L2 DIS3 like 3'-5' exoribonuclease 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr15:132,540,784...132,902,943
Ensembl chr15:132,540,829...132,906,232
JBrowse link
G EXOSC2 exosome component 2 involved_in IEA
IBA
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr 1:270,748,534...270,757,717
Ensembl chr 1:270,748,537...270,758,111
JBrowse link
G EXOSC3 exosome component 3 involved_in IEA
IBA
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr 1:238,536,341...238,541,756
Ensembl chr 1:238,536,345...238,541,333
JBrowse link
G EXOSC4 exosome component 4 involved_in IEA
IBA
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr 4:618,993...621,336
Ensembl chr 4:618,990...621,342
JBrowse link
G EXOSC5 exosome component 5 involved_in IEA
IBA
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr 6:49,373,378...49,381,875
Ensembl chr 6:49,373,379...49,382,034
JBrowse link
G EXOSC6 exosome component 6 involved_in IEA
IBA
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr 6:13,295,591...13,296,942
Ensembl chr 6:13,295,125...13,296,914
JBrowse link
G EXOSC7 exosome component 7 involved_in IEA
IBA
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr13:28,176,806...28,206,435
Ensembl chr13:28,176,793...28,208,975
JBrowse link
G EXOSC8 exosome component 8 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:12,817,081...12,825,847
Ensembl chr11:12,817,110...12,825,843
JBrowse link
G EXOSC9 exosome component 9 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:102,265,656...102,278,179
Ensembl chr 8:102,264,470...102,278,164
JBrowse link
G SKIC3 SKI3 subunit of superkiller complex involved_in IBA
IEA
GO_Central
TreeGrafter
GO_REF:0000033 GO_REF:0000118 NCBI chr 2:102,079,675...102,164,020
Ensembl chr 2:102,079,685...102,163,938
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17778
    metabolic process 10327
      organic substance metabolic process 9887
        macromolecule metabolic process 8335
          macromolecule catabolic process 1437
            RNA catabolic process 356
              mRNA catabolic process 312
                nuclear-transcribed mRNA catabolic process 128
                  nuclear-transcribed mRNA catabolic process, exonucleolytic 16
                    exonucleolytic catabolism of deadenylated mRNA + 9
                    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay + 0
                    nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' + 12
                    nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' + 0
Path 2
Term Annotations click to browse term
  biological_process 17778
    biological regulation 12789
      regulation of biological process 12447
        regulation of metabolic process 6167
          regulation of biosynthetic process 5033
            regulation of cellular biosynthetic process 4984
              regulation of macromolecule biosynthetic process 4849
                regulation of gene expression 4734
                  negative regulation of gene expression 1332
                    mRNA catabolic process 312
                      nuclear-transcribed mRNA catabolic process 128
                        nuclear-transcribed mRNA catabolic process, exonucleolytic 16
                          exonucleolytic catabolism of deadenylated mRNA + 9
                          exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay + 0
                          nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' + 12
                          nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' + 0
paths to the root