ONTOLOGY REPORT - ANNOTATIONS
Term: nuclear-transcribed mRNA catabolic process, exonucleolytic
Accession: GO:0000291
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Definition: The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail.
Synonyms: exact_synonym: exonucleolytic degradation of mRNA; mRNA breakdown, exonucleolytic; mRNA degradation, exonucleolytic; nuclear mRNA catabolic process, exonucleolytic
G
DIS3L2
DIS3 like 3'-5' exoribonuclease 2
involved_in
IEA
UniProt Ensembl
GO_REF:0000104 GO_REF:0000107
NCBI chr15:132,540,784...132,902,943
Ensembl chr15:132,540,829...132,906,232
G
POLR2G
RNA polymerase II subunit G
involved_in
IBA IEA
GO_Central TreeGrafter
GO_REF:0000033 GO_REF:0000118
NCBI chr 2:9,004,388...9,008,631
Ensembl chr 2:9,004,390...9,017,779
G
CNOT6
CCR4-NOT transcription complex subunit 6
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 2:78,131,236...78,202,518
Ensembl chr 2:78,132,939...78,202,492
G
CNOT7
CCR4-NOT transcription complex subunit 7
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr17:4,934,379...4,950,093
Ensembl chr17:4,933,453...4,950,346
G
CNOT8
CCR4-NOT transcription complex subunit 8
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr16:68,329,785...68,352,020
Ensembl chr16:68,329,790...68,350,260
G
EXOSC2
exosome component 2
involved_in
IBA IEA
GO_Central TreeGrafter
GO_REF:0000033 GO_REF:0000118
NCBI chr 1:270,748,534...270,757,717
Ensembl chr 1:270,748,537...270,758,111
G
EXOSC3
exosome component 3
involved_in
IEA IBA
Ensembl GO_Central TreeGrafter
GO_REF:0000033 GO_REF:0000107 GO_REF:0000118
NCBI chr 1:238,536,341...238,541,756
Ensembl chr 1:238,536,345...238,541,333
G
EXOSC5
exosome component 5
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:49,373,378...49,381,875
Ensembl chr 6:49,373,379...49,382,034
G
EXOSC7
exosome component 7
involved_in
IEA IBA
TreeGrafter GO_Central
GO_REF:0000033 GO_REF:0000118
NCBI chr13:28,176,806...28,206,435
Ensembl chr13:28,176,793...28,208,975
G
EXOSC8
exosome component 8
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr11:12,817,081...12,825,847
Ensembl chr11:12,817,110...12,825,843
G
EXOSC9
exosome component 9
involved_in
IEA
Ensembl TreeGrafter
GO_REF:0000107 GO_REF:0000118
NCBI chr 8:102,265,656...102,278,179
Ensembl chr 8:102,264,470...102,278,164
G
SKIC2
SKI2 subunit of superkiller complex
involved_in
IEA IBA
Ensembl GO_Central TreeGrafter
GO_REF:0000033 GO_REF:0000107 GO_REF:0000118
NCBI chr 7:24,047,000...24,057,621
Ensembl chr 7:24,047,010...24,057,621
G
SKIC3
SKI3 subunit of superkiller complex
involved_in
ISO
(PMID:32006463), (PMID:35120588)
UniProt
PMID:32006463 PMID:35120588
NCBI chr 2:102,079,675...102,164,020
Ensembl chr 2:102,079,685...102,163,938
G
SKIC8
SKI8 subunit of superkiller complex
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:47,641,103...47,661,353
Ensembl chr 7:47,641,162...47,659,866
G
DIS3L2
DIS3 like 3'-5' exoribonuclease 2
involved_in
IEA
InterPro
GO_REF:0000002
NCBI chr15:132,540,784...132,902,943
Ensembl chr15:132,540,829...132,906,232
G
EXOSC2
exosome component 2
involved_in
IEA IBA
TreeGrafter GO_Central
GO_REF:0000033 GO_REF:0000118
NCBI chr 1:270,748,534...270,757,717
Ensembl chr 1:270,748,537...270,758,111
G
EXOSC3
exosome component 3
involved_in
IEA IBA
TreeGrafter GO_Central
GO_REF:0000033 GO_REF:0000118
NCBI chr 1:238,536,341...238,541,756
Ensembl chr 1:238,536,345...238,541,333
G
EXOSC4
exosome component 4
involved_in
IEA IBA
TreeGrafter GO_Central
GO_REF:0000033 GO_REF:0000118
NCBI chr 4:618,993...621,336
Ensembl chr 4:618,990...621,342
G
EXOSC5
exosome component 5
involved_in
IEA IBA
TreeGrafter GO_Central
GO_REF:0000033 GO_REF:0000118
NCBI chr 6:49,373,378...49,381,875
Ensembl chr 6:49,373,379...49,382,034
G
EXOSC6
exosome component 6
involved_in
IEA IBA
TreeGrafter GO_Central
GO_REF:0000033 GO_REF:0000118
NCBI chr 6:13,295,591...13,296,942
Ensembl chr 6:13,295,125...13,296,914
G
EXOSC7
exosome component 7
involved_in
IEA IBA
TreeGrafter GO_Central
GO_REF:0000033 GO_REF:0000118
NCBI chr13:28,176,806...28,206,435
Ensembl chr13:28,176,793...28,208,975
G
EXOSC8
exosome component 8
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr11:12,817,081...12,825,847
Ensembl chr11:12,817,110...12,825,843
G
EXOSC9
exosome component 9
involved_in
IEA
TreeGrafter
GO_REF:0000118
NCBI chr 8:102,265,656...102,278,179
Ensembl chr 8:102,264,470...102,278,164
G
SKIC3
SKI3 subunit of superkiller complex
involved_in
IBA IEA
GO_Central TreeGrafter
GO_REF:0000033 GO_REF:0000118
NCBI chr 2:102,079,675...102,164,020
Ensembl chr 2:102,079,685...102,163,938
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
biological_process
17778
metabolic process
10327
organic substance metabolic process
9887
macromolecule metabolic process
8335
macromolecule catabolic process
1437
RNA catabolic process
356
mRNA catabolic process
312
nuclear-transcribed mRNA catabolic process
128
nuclear-transcribed mRNA catabolic process, exonucleolytic
16
exonucleolytic catabolism of deadenylated mRNA +
9
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay +
0
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' +
12
nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' +
0
Path 2
biological_process
17778
biological regulation
12789
regulation of biological process
12447
regulation of metabolic process
6167
regulation of biosynthetic process
5033
regulation of cellular biosynthetic process
4984
regulation of macromolecule biosynthetic process
4849
regulation of gene expression
4734
negative regulation of gene expression
1332
mRNA catabolic process
312
nuclear-transcribed mRNA catabolic process
128
nuclear-transcribed mRNA catabolic process, exonucleolytic
16
exonucleolytic catabolism of deadenylated mRNA +
9
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay +
0
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' +
12
nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' +
0