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ONTOLOGY REPORT - ANNOTATIONS


Term:mitochondrial fission
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Accession:GO:0000266 term browser browse the term
Definition:The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
Synonyms:exact_synonym: mitochondrial division
 related_synonym: mitochondrial proliferation



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mitochondrial fission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 acts_upstream_of_or_within ISO MGI:1931135|MGI:3605782 (MGI:3604933|PMID:16103131) RGD PMID:16103131 MGI:3604933 NCBI chr10:48,630,993...48,742,835
Ensembl chr10:48,630,676...48,746,667
JBrowse link
G Dnm1l dynamin 1-like involved_in
acts_upstream_of_or_within
ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:23349293)
(PMID:23530241), (PMID:23921378), (PMID:26992161), (PMID:27145208)
(MGI:4421613|PMID:20038678), (MGI:5319417|PMID:22493254)
(MGI:5508698|PMID:23283981)
UniProt
RGD
PMID:20038678 PMID:22493254 PMID:23283981 PMID:23349293 PMID:23530241 More... GO_REF:0000024 MGI:4421613 MGI:5319417 MGI:5508698, RGD:13792537 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Fis1 fission, mitochondrial 1 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:5508698|PMID:23283981)
GO_REF:0000024
(PMID:16118244), (PMID:18845145), (PMID:19864424)
RGD
UniProt
PMID:16118244 PMID:18845145 PMID:19864424 PMID:23283981 PMID:21873635 GO_REF:0000024 MGI:5508698, RGD:13792537 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Gdap1 ganglioside-induced differentiation-associated-protein 1 involved_in ISO
IBA
ISS
(PMID:15772096)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:15772096 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 5:1,932,613...1,951,691
Ensembl chr 5:1,932,613...2,030,061
JBrowse link
G Ggnbp1 gametogenetin binding protein 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3848864|PMID:19208545)
UniProt
RGD
PMID:19208545 GO_REF:0000024 MGI:3848864 NCBI chr20:5,109,849...5,116,185
Ensembl chr20:5,099,311...5,116,183
JBrowse link
G Lpin1 lipin 1 involved_in ISO (MGI:4943609|PMID:21397848) RGD PMID:21397848 MGI:4943609 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
JBrowse link
G Mff mitochondrial fission factor involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000104
(MGI:5508698|PMID:23283981), (MGI:6200588|PMID:30059978)
UniProt
RGD
PMID:23283981 PMID:30059978 GO_REF:0000024 GO_REF:0000104 MGI:5508698 MGI:6200588 NCBI chr 9:84,007,798...84,036,039
Ensembl chr 9:84,007,798...84,036,039
JBrowse link
G Mief1 mitochondrial elongation factor 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:21701560)
UniProt
RGD
PMID:21701560 GO_REF:0000024 NCBI chr 7:111,786,630...111,802,220
Ensembl chr 7:111,786,709...111,802,220
JBrowse link
G Mtfp1 mitochondrial fission process 1 involved_in IBA
ISO
PMID:21873635
(PMID:15985469)
RGD PMID:15985469 PMID:21873635 RGD:13792537 NCBI chr14:78,968,434...78,972,274
Ensembl chr14:78,968,442...78,972,274
JBrowse link
G Mtfr1 mitochondrial fission regulator 1 involved_in ISS
IBA
GO_REF:0000024
PMID:21873635
UniProt PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 2:101,678,331...101,713,547
Ensembl chr 2:101,679,265...101,713,544
JBrowse link
G Mtfr1l mitochondrial fission regulator 1-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:146,736,927...146,746,891
Ensembl chr 5:146,736,927...146,746,784
JBrowse link
G Mtfr2 mitochondrial fission regulator 2 involved_in IBA
ISO
PMID:21873635
(MGI:5320275|PMID:20568109)
RGD PMID:20568109 PMID:21873635 MGI:5320275, RGD:13792537 NCBI chr 1:15,123,232...15,138,632
Ensembl chr 1:15,070,894...15,148,832
JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO (PMID:18207745) RGD PMID:18207745 NCBI chr 5:150,652,812...150,661,863
Ensembl chr 5:150,652,812...150,661,863
JBrowse link
G Pink1 PTEN induced kinase 1 HMP RGD PMID:25421206 RGD:11560775 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta IDA RGD PMID:18940801 RGD:2314538 NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISS GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Slc25a46 solute carrier family 25, member 46 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:23,215,954...23,244,917
Ensembl chr18:23,215,962...23,244,314
JBrowse link
establishment of protein localization to mitochondrial membrane involved in mitochondrial fission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap3b1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within ISO (MGI:1928195|PMID:11058094) RGD PMID:11058094 MGI:1928195 NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935
JBrowse link
G Mtch2 mitochondrial carrier 2 acts_upstream_of_or_within ISO MGI:2449949|MGI:5566664 (MGI:5662300|PMID:26219591) RGD PMID:26219591 MGI:5662300 NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189
JBrowse link
mitochondrial membrane fission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnm1l dynamin 1-like involved_in ISO (PMID:11514614), (PMID:21822277), (PMID:27301544), (PMID:27328748) RGD PMID:11514614 PMID:21822277 PMID:27301544 PMID:27328748 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Slc25a46 solute carrier family 25, member 46 involved_in ISS
ISO
GO_REF:0000024
(PMID:26168012), (PMID:27543974)
UniProt
RGD
PMID:26168012 PMID:27543974 GO_REF:0000024 NCBI chr18:23,215,954...23,244,917
Ensembl chr18:23,215,962...23,244,314
JBrowse link
negative regulation of mitochondrial fission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapt microtubule-associated protein tau involved_in ISO (PMID:22920254) RGD PMID:22920254 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mfn1 mitofusin 1 IMP RGD PMID:18832378 RGD:12738368 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:28478070 RGD:12910733 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:19279012) RGD PMID:19279012 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO (PMID:29182484) RGD PMID:29182484 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IMP RGD PMID:23449689 RGD:10059694 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase IMP RGD PMID:24096089 RGD:10413842 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G RGD1311251 similar to RIKEN cDNA 4930550C14 involved_in ISS
ISO
GO_REF:0000024
(MGI:6200588|PMID:30059978)
UniProt
RGD
PMID:30059978 GO_REF:0000024 MGI:6200588 NCBI chr 8:53,796,033...53,825,277
Ensembl chr 8:53,796,366...53,824,748
JBrowse link
positive regulation of mitochondrial fission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurka aurora kinase A involved_in ISO (PMID:21822277) RGD PMID:21822277 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO (PMID:20436456) RGD PMID:20436456 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Dcn decorin acts_upstream_of_or_within ISO UniProtKB:P35968 (PMID:23798385) RGD PMID:23798385 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Ddhd1 DDHD domain containing 1 acts_upstream_of_or_within ISO (PMID:24599962) RGD PMID:24599962 NCBI chr15:18,824,389...18,891,036
Ensembl chr15:18,824,394...18,890,952
JBrowse link
G Ddhd2 DDHD domain containing 2 acts_upstream_of_or_within ISO (MGI:5581382|PMID:24599962) RGD PMID:24599962 MGI:5581382 NCBI chr16:66,319,469...66,349,025
Ensembl chr16:66,319,466...66,349,023
JBrowse link
G Dnm1l dynamin 1-like involved_in IMP
ISO
(PMID:19279012) RGD PMID:19279012 PMID:17443673 RGD:12738363 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Fis1 fission, mitochondrial 1 involved_in IMP
ISS
ISO
GO_REF:0000024
(PMID:23283981)
UniProt
RGD
PMID:23283981 PMID:17443673 PMID:15979461 GO_REF:0000024, RGD:12738363, RGD:12738370 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Kdr kinase insert domain receptor acts_upstream_of_or_within
involved_in
ISO
IEA
UniProtKB:P07585 (PMID:23798385)
GO_REF:0000107
RGD
Ensembl
PMID:23798385 GO_REF:0000107 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Marchf5 membrane associated ring-CH-type finger 5 involved_in ISO (PMID:20103533) RGD PMID:20103533 NCBI chr 1:234,931,137...234,953,849
Ensembl chr 1:234,931,271...234,952,632
JBrowse link
G Mcu mitochondrial calcium uniporter involved_in ISO (PMID:28388446) RGD PMID:28388446 NCBI chr20:27,417,529...27,580,110
Ensembl chr20:27,417,526...27,580,110
JBrowse link
G Mff mitochondrial fission factor involved_in IMP
IEA
ISS
IBA
ISO
GO_REF:0000104
GO_REF:0000024
PMID:21873635
(PMID:23283981), (PMID:23530241)
UniProt
RGD
PMID:23283981 PMID:23530241 PMID:23867156 PMID:21873635 GO_REF:0000024 GO_REF:0000104, RGD:12879458, RGD:13792537 NCBI chr 9:84,007,798...84,036,039
Ensembl chr 9:84,007,798...84,036,039
JBrowse link
G Mief1 mitochondrial elongation factor 1 involved_in ISO
IBA
ISS
(PMID:23283981), (PMID:23530241)
(MGI:5508698|PMID:23283981)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:23283981 PMID:23530241 PMID:21873635 GO_REF:0000024 MGI:5508698, RGD:13792537 NCBI chr 7:111,786,630...111,802,220
Ensembl chr 7:111,786,709...111,802,220
JBrowse link
G Mief2 mitochondrial elongation factor 2 involved_in IBA
ISO
PMID:21873635
(MGI:5508698|PMID:23283981)
(PMID:23283981), (PMID:23530241)
RGD PMID:23283981 PMID:23530241 PMID:21873635 MGI:5508698, RGD:13792537 NCBI chr10:45,408,055...45,414,144
Ensembl chr10:45,408,082...45,414,144
JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO (PMID:19407830) RGD PMID:19407830 NCBI chr 5:150,652,812...150,661,863
Ensembl chr 5:150,652,812...150,661,863
JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:46,409,324...46,416,410
Ensembl chr12:46,409,369...46,416,420
JBrowse link
G Pink1 PTEN induced kinase 1 involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:21613270 PMID:21873635 RGD:12903967, RGD:13792537 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISS GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Rala RAS like proto-oncogene A involved_in ISO
ISS
(PMID:21822277)
GO_REF:0000024
RGD
UniProt
PMID:21822277 GO_REF:0000024 NCBI chr17:47,092,139...47,145,192
Ensembl chr17:47,092,207...47,144,063
JBrowse link
G Ralbp1 ralA binding protein 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:21822277)
UniProt
RGD
PMID:21822277 GO_REF:0000024 NCBI chr 9:105,456,425...105,492,711
Ensembl chr 9:105,456,425...105,492,707
JBrowse link
G Spire1 spire-type actin nucleation factor 1 involved_in ISO (PMID:26305500)
(MGI:5698602|PMID:26305500)
RGD PMID:26305500 MGI:5698602 NCBI chr18:61,041,290...61,171,670
Ensembl chr18:61,041,290...61,171,899
JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO (PMID:26618722) RGD PMID:26618722 NCBI chr19:21,765,771...21,801,620
Ensembl chr19:21,765,749...21,801,618
JBrowse link
regulation of mitochondrial fission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyrib CYFIP related Rac1 interactor B involved_in ISO (PMID:29059164)
(MGI:6383355|PMID:29059164)
RGD PMID:29059164 MGI:6383355 NCBI chr 7:95,633,876...95,760,588
Ensembl chr 7:95,633,876...95,697,686
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) IMP RGD PMID:16120318 RGD:2316230 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link
G Inf2 inverted formin 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:23349293)
GO_REF:0000107
RGD
Ensembl
PMID:23349293 GO_REF:0000107 NCBI chr 6:131,649,162...131,675,944
Ensembl chr 6:131,649,211...131,675,941
JBrowse link
G Marchf5 membrane associated ring-CH-type finger 5 involved_in ISO (PMID:16874301), (PMID:17606867) RGD PMID:16874301 PMID:17606867 NCBI chr 1:234,931,137...234,953,849
Ensembl chr 1:234,931,271...234,952,632
JBrowse link
G Myo19 myosin XIX involved_in ISO (PMID:25447992) RGD PMID:25447992 NCBI chr10:69,753,082...69,782,450
Ensembl chr10:69,753,068...69,782,450
JBrowse link
G Stat2 signal transducer and activator of transcription 2 involved_in ISO (PMID:26122121) RGD PMID:26122121 NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967
JBrowse link
G Tmem135 transmembrane protein 135 involved_in ISS
ISO
GO_REF:0000024
(MGI:5811545|PMID:27863209)
UniProt
RGD
PMID:27863209 GO_REF:0000024 MGI:5811545 NCBI chr 1:143,006,343...143,279,824
Ensembl chr 1:143,006,344...143,221,171
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19512
    cellular process 18319
      cellular component organization or biogenesis 6656
        cellular component organization 6418
          organelle organization 3941
            organelle fission 510
              mitochondrial fission 45
                establishment of protein localization to mitochondrial membrane involved in mitochondrial fission 2
                mitochondrial membrane fission 2
                negative regulation of mitochondrial fission 8
                positive regulation of mitochondrial fission 21
                regulation of mitochondrial fission + 33
paths to the root