C-4 methylsterol oxidase activity - Ontology Report

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Term:	C-4 methylsterol oxidase activity	go back to main search page
Accession:	GO:0000254	browse the term
Definition:	Catalysis of the reaction: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H+ + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O.
Synonyms:	exact_synonym:	4-methylsterol oxidase activity
	related_synonym:	methylsterol hydroxylase activity; methylsterol monooxygenase activity
	xref:	EC:1.14.18.9; MetaCyc:RXN-13188; RHEA:55220; reactome:R-HSA-194641 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol"; reactome:R-HSA-194669 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol"

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Rat (3) Mouse (3) Human (3) Chinchilla (0) Bonobo (0) Dog (5) Squirrel (0) Pig (3) Green Monkey (0) Naked Mole-rat (0) All
Genes (3)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ch25h

cholesterol 25-hydroxylase

enables

GO_REF:0000033

GO_REF:0000033

NCBI chr 1:241,428,048...241,429,366
Ensembl chr 1:232,014,880...232,016,195

fatty acid hydroxylase domain containing 2

enables

GO_REF:0000033

GO_REF:0000033

NCBI chr10:42,747,323...42,772,156
Ensembl chr10:42,246,868...42,271,871

methylsterol monooxygenase 1

enables

GO_REF:0000033
GO_REF:0000003
GO_REF:0000116

GO_REF:0000003 GO_REF:0000033 GO_REF:0000116

NCBI chr16:29,747,113...29,764,360
Ensembl chr16:24,980,697...24,998,016

Term paths to the root

Path 1
Term	Annotations
molecular_function	21100
catalytic activity	6213
oxidoreductase activity	868
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	244
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	9
C-4 methylsterol oxidase activity	3

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