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ONTOLOGY REPORT - ANNOTATIONS

Term:C-4 methylsterol oxidase activity
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Accession:GO:0000254 term browser browse the term
Definition:Catalysis of the reaction: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H+ + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O.
Comment:Note that zymosterol is cholesta-8,24-dien-3-ol.
Synonyms:exact_synonym: 4-methylsterol oxidase activity
 related_synonym: methylsterol hydroxylase activity;   methylsterol monooxygenase activity
 xref: EC:1.14.18.9;   MetaCyc:RXN-13188;   RHEA:55220;   reactome:R-HSA-194641 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol";   reactome:R-HSA-194669 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol"


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C-4 methylsterol oxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ch25h cholesterol 25-hydroxylase enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195 		JBrowse link
G Faxdc2 fatty acid hydroxylase domain containing 2 enables IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr10:42,245,808...42,271,679
Ensembl chr10:42,246,868...42,271,871 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Sc5d sterol-C5-desaturase enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273 		JBrowse link
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