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ONTOLOGY REPORT - ANNOTATIONS

Term:lanosterol synthase activity
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Accession:GO:0000250 term browser browse the term
Definition:Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.
Synonyms:exact_synonym: OSC
 broad_synonym: 2,3-oxidosqualene sterol cyclase activity;   squalene epoxidase-cyclase activity
 related_synonym: (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming);   2,3-epoxysqualene lanosterol cyclase activity;   2,3-oxidosqualene-lanosterol cyclase activity;   oxidosqualene--lanosterol cyclase activity;   squalene 2,3-epoxide:lanosterol cyclase activity;   squalene-2,3-oxide-lanosterol cyclase activity
 xref: EC:5.4.99.7;   KEGG_REACTION:R03199;   MetaCyc:LANOSTEROL-SYNTHASE-RXN;   RHEA:14621;   reactome:R-HSA-191366 "Squalene 2,3-epoxide cyclizes, forming lanosterol"


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lanosterol synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lss lanosterol synthase enables IMP
IDA
IEA
ISO
IBA		 GO_REF:0000107
UniProtKB:P38604 (PMID:26200341), (PMID:7639730)
PMID:7568116
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:7639730 PMID:26200341 PMID:7568116 PMID:1429550 PMID:7568116 GO_REF:0000033 GO_REF:0000107, RGD:728996, RGD:2316919, RGD:728996 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
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  molecular_function 20626
    catalytic activity 6028
      isomerase activity 212
        intramolecular transferase activity 32
          oxidosqualene cyclase activity 1
            lanosterol synthase activity 1
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