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ONTOLOGY REPORT - ANNOTATIONS

Term:rRNA (adenine-N6,N6-)-dimethyltransferase activity
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Accession:GO:0000179 term browser browse the term
Definition:Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor.
Synonyms:exact_synonym: 18S rRNA dimethylase activity;   S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity;   dimethyladenosine transferase activity
 alt_id: GO:0043790
 xref: reactome:R-HSA-6790994 "DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851";   reactome:R-HSA-6793066 "TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937"

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rRNA (adenine-N6,N6-)-dimethyltransferase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dimt1 DIMT1 rRNA methyltransferase and ribosome maturation factor ISO (PMID:25851604) UniProtKB PMID:25851604 NCBI chrNW_004936480:6,311,389...6,323,156 JBrowse link
G Tfb1m transcription factor B1, mitochondrial ISO (PMID:12496758), (PMID:23303773) Reactome PMID:12496758 PMID:23303773 NCBI chrNW_004936489:7,464,550...7,510,108 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14104
    catalytic activity 3558
      transferase activity 1572
        transferase activity, transferring one-carbon groups 153
          methyltransferase activity 145
            N-methyltransferase activity 79
              rRNA (adenine-N6,N6-)-dimethyltransferase activity 2
                16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity 0
                18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity 0
Path 2
Term Annotations click to browse term
  molecular_function 14104
    catalytic activity 3558
      transferase activity 1572
        transferase activity, transferring one-carbon groups 153
          methyltransferase activity 145
            S-adenosylmethionine-dependent methyltransferase activity 126
              rRNA methyltransferase activity 13
                rRNA (adenine) methyltransferase activity 5
                  rRNA (adenine-N6,N6-)-dimethyltransferase activity 2
                    16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity 0
                    18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity 0
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