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ONTOLOGY REPORT - ANNOTATIONS


Term:rRNA (adenine-N6,N6-)-dimethyltransferase activity
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Accession:GO:0000179 term browser browse the term
Definition:Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor.
Synonyms:exact_synonym: 18S rRNA dimethylase activity;   S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity;   dimethyladenosine transferase activity
 alt_id: GO:0043790
 xref: reactome:R-HSA-6790994 "DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851";   reactome:R-HSA-6793066 "TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937"


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rRNA (adenine-N6,N6-)-dimethyltransferase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dimt1 DIMT1 rRNA methyltransferase and ribosome maturation factor ISO
IBA
(PMID:25851604)
PMID:21873635
RGD PMID:25851604, PMID:21873635 RGD:13792537 NCBI chr 2:38,120,562...38,144,871
Ensembl chr 2:38,120,592...38,144,327
JBrowse link
G Tfb1m transcription factor B1, mitochondrial IEA
IBA
ISO
GO_REF:0000104
PMID:21873635
(PMID:12496758), (PMID:23303773)
UniProt
RGD
PMID:12496758 PMID:23303773, PMID:21873635 GO_REF:0000104, RGD:13792537 NCBI chr 1:44,433,116...44,474,674
Ensembl chr 1:44,433,116...44,474,674
JBrowse link
G Tfb2m transcription factor B2, mitochondrial IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:97,820,493...97,838,275
Ensembl chr13:97,820,493...97,838,228
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20485
    catalytic activity 6060
      transferase activity 2357
        transferase activity, transferring one-carbon groups 220
          methyltransferase activity 210
            N-methyltransferase activity 103
              rRNA (adenine-N6,N6-)-dimethyltransferase activity 3
                16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity 0
                18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity 0
Path 2
Term Annotations click to browse term
  molecular_function 20485
    catalytic activity 6060
      transferase activity 2357
        transferase activity, transferring one-carbon groups 220
          methyltransferase activity 210
            S-adenosylmethionine-dependent methyltransferase activity 162
              rRNA methyltransferase activity 21
                rRNA (adenine) methyltransferase activity 7
                  rRNA (adenine-N6,N6-)-dimethyltransferase activity 3
                    16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity 0
                    18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity 0
paths to the root