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ONTOLOGY REPORT - ANNOTATIONS

Term:exosome (RNase complex)
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Accession:GO:0000178 term browser browse the term
Definition:A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Comment:Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
Synonyms:exact_synonym: exosome (ribonucleasease complex);   exosome multienzyme ribonuclease complex


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exosome (RNase complex) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1d C1D nuclear receptor corepressor part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:91,660,951...91,673,177
Ensembl chr14:91,660,989...91,672,852 		JBrowse link
G Exosc1 exosome component 1 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr 1:240,734,777...240,745,431
Ensembl chr 1:240,734,773...240,745,438 		JBrowse link
G Exosc10 exosome component 10 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr 5:158,995,313...159,018,940
Ensembl chr 5:158,995,313...159,018,940 		JBrowse link
G Exosc2 exosome component 2 part_of ISO (PMID:12419256), (PMID:20531389) RGD PMID:12419256 PMID:20531389 NCBI chr 3:14,962,930...14,973,645
Ensembl chr 3:14,962,917...14,973,575 		JBrowse link
G Exosc3 exosome component 3 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060 		JBrowse link
G Exosc4 exosome component 4 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573 		JBrowse link
G Exosc5 exosome component 5 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265 		JBrowse link
G Exosc6 exosome component 6 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515 		JBrowse link
G Exosc7 exosome component 7 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr 8:122,773,607...122,798,943
Ensembl chr 8:122,773,591...122,799,270 		JBrowse link
G Exosc8 exosome component 8 part_of ISO (PMID:20531389) RGD PMID:20531389 NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928 		JBrowse link
G Exosc9 exosome component 9 part_of ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000002
(PMID:20531389)		 UniProt
InterPro
RGD		 PMID:20531389 GO_REF:0000002 GO_REF:0000024 NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051 		JBrowse link
G Mphosph6 M phase phosphoprotein 6 part_of
located_in		 ISO (PMID:20531389)
(PMID:11719186)		 RGD PMID:11719186 PMID:20531389 NCBI chr19:45,860,152...45,870,117
Ensembl chr19:45,860,154...45,870,170 		JBrowse link
G Mtrex Mtr4 exosome RNA helicase located_in ISO (PMID:11719186) RGD PMID:11719186 NCBI chr 2:44,500,326...44,560,624
Ensembl chr 2:44,461,444...44,560,627 		JBrowse link
G Zfc3h1 zinc finger, C3H1-type containing part_of ISO
IBA		 (PMID:27871484)
GO_REF:0000033		 RGD
GO_Central		 PMID:27871484 GO_REF:0000033 NCBI chr 7:51,008,251...51,064,666
Ensembl chr 7:51,007,984...51,064,661 		JBrowse link
G Zfp36 zinc finger protein 36 part_of
NOT|located_in		 IEA
ISS
ISO		 GO_REF:0000043
GO_REF:0000024
(PMID:11719186)		 UniProt
RGD		 PMID:11719186 GO_REF:0000024 GO_REF:0000043 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564 		JBrowse link
cytoplasmic exosome (RNase complex) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carhsp1 calcium regulated heat stable protein 1 part_of
located_in		 ISO
ISS		 (MGI:5320273|PMID:21078874)
GO_REF:0000024		 RGD
UniProt		 PMID:21078874 GO_REF:0000024 MGI:5320273 NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019 		JBrowse link
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642 		JBrowse link
G Dis3l DIS3-like exosome 3'-5' exoribonuclease part_of ISO
IBA
ISS		 (PMID:20531386), (PMID:20531389)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:20531386 PMID:20531389 GO_REF:0000024 GO_REF:0000033 NCBI chr 8:64,803,925...64,840,306
Ensembl chr 8:64,803,927...64,840,165 		JBrowse link
G Exosc2 exosome component 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:14,962,930...14,973,645
Ensembl chr 3:14,962,917...14,973,575 		JBrowse link
G Exosc3 exosome component 3 part_of ISO
IBA		 (PMID:11110791)
GO_REF:0000033		 RGD
GO_Central		 PMID:11110791 GO_REF:0000033 NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060 		JBrowse link
G Exosc4 exosome component 4 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573 		JBrowse link
G Exosc5 exosome component 5 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265 		JBrowse link
G Exosc6 exosome component 6 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515 		JBrowse link
G Exosc7 exosome component 7 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:122,773,607...122,798,943
Ensembl chr 8:122,773,591...122,799,270 		JBrowse link
G Exosc8 exosome component 8 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928 		JBrowse link
G Exosc9 exosome component 9 part_of IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051 		JBrowse link
G Gtpbp1 GTP binding protein 1 part_of IDA PMID:21515746 UniProt PMID:21515746 RGD:8553842 NCBI chr 7:111,248,254...111,272,705
Ensembl chr 7:111,248,254...111,272,705 		JBrowse link
mitochondrial degradosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 part_of ISO (PMID:19509288), (PMID:29967381) RGD PMID:19509288 PMID:29967381 NCBI chr14:102,877,553...102,908,696
Ensembl chr14:102,877,553...102,908,696 		JBrowse link
G Supv3l1 Suv3 like RNA helicase part_of ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:19509288), (PMID:29967381)
GO_REF:0000107
GO_REF:0000033		 UniProt
RGD
Ensembl
GO_Central		 PMID:19509288 PMID:29967381 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr20:30,378,542...30,399,076
Ensembl chr20:30,378,550...30,399,054 		JBrowse link
nuclear exosome (RNase complex) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease part_of ISO
IBA		 (PMID:20531386)
GO_REF:0000033		 RGD
GO_Central		 PMID:20531386 GO_REF:0000033 NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642 		JBrowse link
G Exosc1 exosome component 1 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:240,734,777...240,745,431
Ensembl chr 1:240,734,773...240,745,438 		JBrowse link
G Exosc10 exosome component 10 part_of ISO
IBA
IEA		 (PMID:26166824)
GO_REF:0000033
GO_REF:0000118
GO_REF:0000002		 RGD
GO_Central
TreeGrafter
InterPro		 PMID:26166824 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:158,995,313...159,018,940
Ensembl chr 5:158,995,313...159,018,940 		JBrowse link
G Exosc2 exosome component 2 part_of ISO
IBA		 (PMID:26166824)
GO_REF:0000033		 RGD
GO_Central		 PMID:26166824 GO_REF:0000033 NCBI chr 3:14,962,930...14,973,645
Ensembl chr 3:14,962,917...14,973,575 		JBrowse link
G Exosc3 exosome component 3 part_of ISO
IBA		 (PMID:11110791)
GO_REF:0000033		 RGD
GO_Central		 PMID:11110791 GO_REF:0000033 NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060 		JBrowse link
G Exosc4 exosome component 4 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573 		JBrowse link
G Exosc5 exosome component 5 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265 		JBrowse link
G Exosc6 exosome component 6 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515 		JBrowse link
G Exosc7 exosome component 7 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:122,773,607...122,798,943
Ensembl chr 8:122,773,591...122,799,270 		JBrowse link
G Exosc8 exosome component 8 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928 		JBrowse link
G Exosc9 exosome component 9 part_of ISO
IBA
IEA		 (PMID:22791713)
GO_REF:0000033
GO_REF:0000118		 RGD
GO_Central
TreeGrafter		 PMID:22791713 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051 		JBrowse link
G Mphosph6 M phase phosphoprotein 6 located_in ISO (PMID:26166824) RGD PMID:26166824 NCBI chr19:45,860,152...45,870,117
Ensembl chr19:45,860,154...45,870,170 		JBrowse link
G Mtrex Mtr4 exosome RNA helicase located_in ISO (PMID:26166824) RGD PMID:26166824 NCBI chr 2:44,500,326...44,560,624
Ensembl chr 2:44,461,444...44,560,627 		JBrowse link
G Nvl nuclear VCP-like located_in ISO (PMID:26166824) RGD PMID:26166824 NCBI chr13:92,851,023...92,906,749
Ensembl chr13:92,853,650...92,906,049 		JBrowse link
G Wdr74 WD repeat domain 74 located_in ISO (PMID:26456651) RGD PMID:26456651 NCBI chr 1:205,631,769...205,636,558
Ensembl chr 1:205,631,824...205,636,563 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21392
    cellular anatomical entity 21234
      intracellular anatomical structure 15673
        exosome (RNase complex) 23
          cytoplasmic exosome (RNase complex) + 14
          nuclear exosome (RNase complex) + 15
Path 2
Term Annotations click to browse term
  cellular_component 21392
    protein-containing complex 6987
      catalytic complex 1938
        exoribonuclease complex 24
          exosome (RNase complex) 23
            cytoplasmic exosome (RNase complex) + 14
            nuclear exosome (RNase complex) + 15
paths to the root