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Term:nuclear exosome (RNase complex)
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Accession:GO:0000176 term browser browse the term
Definition:A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Synonyms:exact_synonym: eukaryotic exosome multienzyme ribonuclease complex;   nuclear exosome (ribonuclease complex);   nuclear exosome multienzyme ribonuclease complex

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nuclear exosome (RNase complex) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease JBrowse link 14 99,076,634 99,099,780 RGD:2290270
G Exosc1 exosome component 1 JBrowse link 19 41,922,978 41,933,423 RGD:2290270
G Exosc10 exosome component 10 JBrowse link 4 148,558,419 148,582,401 RGD:2290270
G Exosc2 exosome component 2 JBrowse link 2 31,670,715 31,681,352 RGD:2290270
G Exosc3 exosome component 3 JBrowse link 4 45,316,613 45,320,616 RGD:2290270
G Exosc4 exosome component 4 JBrowse link 15 76,327,397 76,330,670 RGD:2290270
G Exosc5 exosome component 5 JBrowse link 7 25,659,153 25,668,032 RGD:2290270
G Exosc6 exosome component 6 JBrowse link 8 111,056,339 111,057,664 RGD:2290270
G Exosc7 exosome component 7 JBrowse link 9 123,113,231 123,136,129 RGD:2290270
G Exosc8 exosome component 8 JBrowse link 3 54,728,679 54,735,364 RGD:2290270
G Exosc9 exosome component 9 JBrowse link 3 36,552,606 36,565,727 RGD:2290270
G Mphosph6 M phase phosphoprotein 6 JBrowse link 8 117,791,637 117,801,974 RGD:2290270
G Mtrex Mtr4 exosome RNA helicase JBrowse link 13 112,867,780 112,927,380 RGD:2290270
G Nvl nuclear VCP-like JBrowse link 1 181,087,138 181,144,214 RGD:2290270
G Wdr74 WD repeat domain 74 JBrowse link 19 8,735,795 8,740,624 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 23072
    intracellular 13867
      exosome (RNase complex) 24
        nuclear exosome (RNase complex) 15
          nucleolar exosome (RNase complex) 0
Path 2
Term Annotations click to browse term
  cellular_component 23072
    cellular anatomical entity 18765
      organelle 12507
        intracellular organelle 12146
          intracellular membrane-bounded organelle 10489
            nucleus 6974
              nuclear lumen 3956
                nuclear exosome (RNase complex) 15
                  nucleolar exosome (RNase complex) 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.