Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


Term:nuclear exosome (RNase complex)
go back to main search page
Accession:GO:0000176 term browser browse the term
Definition:A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Synonyms:exact_synonym: eukaryotic exosome multienzyme ribonuclease complex;   nuclear exosome (ribonuclease complex);   nuclear exosome multienzyme ribonuclease complex

show annotations for term's descendants       view all columns           Sort by:
nuclear exosome (RNase complex) term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07064102.1 RGD:13792537
G AABR07064998.2 RGD:13792537
G AABR07065012.1 RGD:13792537
G AABR07065013.1 RGD:13792537
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease JBrowse link 15 83,466,330 83,494,107 RGD:1624291
G Exosc1 exosome component 1 JBrowse link 1 261,169,798 261,179,865 RGD:13792537
G Exosc10 exosome component 10 JBrowse link 5 165,374,964 165,398,195 RGD:1624291
G Exosc2 exosome component 2 JBrowse link 3 10,151,734 10,161,997 RGD:1624291
G Exosc3 exosome component 3 JBrowse link 5 60,866,498 60,871,734 RGD:1624291
G Exosc4 exosome component 4 JBrowse link 7 117,390,302 117,393,044 RGD:13792537
G Exosc5 exosome component 5 JBrowse link 1 82,452,104 82,461,607 RGD:13792537
G Exosc6 exosome component 6 JBrowse link 19 43,190,879 43,193,164 RGD:13792537
G Exosc7 exosome component 7 JBrowse link 8 132,204,628 132,229,968 RGD:13792537
G Exosc8 exosome component 8 JBrowse link 2 143,925,643 143,932,240 RGD:13792537
G Exosc9 exosome component 9 JBrowse link 2 123,264,679 123,275,623 RGD:1624291
G Mphosph6 M phase phosphoprotein 6 JBrowse link 19 50,357,314 50,367,137 RGD:1624291
G Mtrex Mtr4 exosome RNA helicase JBrowse link 2 44,726,716 44,787,013 RGD:1624291
G Nvl nuclear VCP-like JBrowse link 13 99,410,026 99,468,783 RGD:1624291
G Wdr74 WD repeat domain 74 JBrowse link 1 224,933,906 224,938,659 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19951
    intracellular 13934
      exosome (RNase complex) 28
        nuclear exosome (RNase complex) 19
          nucleolar exosome (RNase complex) 0
Path 2
Term Annotations click to browse term
  cellular_component 19951
    cellular anatomical entity 19598
      organelle 12670
        intracellular organelle 12137
          intracellular membrane-bounded organelle 10066
            nucleus 6843
              nuclear lumen 4008
                nuclear exosome (RNase complex) 19
                  nucleolar exosome (RNase complex) 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.