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ONTOLOGY REPORT - ANNOTATIONS


Term:sulfur amino acid metabolic process
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Accession:GO:0000096 term browser browse the term
Definition:The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.
Synonyms:exact_synonym: sulfur amino acid metabolism;   sulphur amino acid metabolic process;   sulphur amino acid metabolism


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cysteine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase ISO MGI:MGI:1857139 (MGI:MGI:3044255|PMID:15030387)
(PMID:24416422)
RGD PMID:15030387, PMID:24416422 MGI:MGI:3044255 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Cth cystathionine gamma-lyase IDA
IEA
ISS
ISO
GO_REF:0000041
GO_REF:0000024
(PMID:10212249)
UniProt
RGD
PMID:10212249, PMID:9359866 GO_REF:0000024, GO_REF:0000041, RGD:1359024 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO (MGI:MGI:5294309|PMID:12468440) RGD PMID:12468440 MGI:MGI:5294309 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G LOC103691744 cystathionine gamma-lyase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:264,747,068...264,765,112
Ensembl chr 2:264,746,485...264,765,085
JBrowse link
cysteine biosynthetic process from serine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase TAS RGD PMID:9359866 RGD:1359024 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
cysteine biosynthetic process via cystathionine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Cth cystathionine gamma-lyase ISO
IBA
(PMID:19428278)
PMID:21873635
RGD PMID:19428278, PMID:21873635 RGD:13792537 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
cysteine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdo1 cysteine dioxygenase type 1 TAS RGD PMID:2334417 RGD:68765 NCBI chr18:40,702,027...40,716,901
Ensembl chr18:40,701,984...40,716,686
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit ISO
ISS
(PMID:2294991)
GO_REF:0000024
RGD
UniProt
PMID:2294991 GO_REF:0000024 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit ISO MGI:MGI:2447852 (MGI:MGI:2447526|PMID:12384496) RGD PMID:12384496 MGI:MGI:2447526 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
homocysteine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blmh bleomycin hydrolase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:63,197,367...63,240,447
Ensembl chr10:63,197,364...63,240,332
JBrowse link
G Cbs cystathionine beta synthase ISS
ISO
GO_REF:0000024
(PMID:18776696), (PMID:24416422)
UniProt
RGD
PMID:18776696, PMID:24416422 GO_REF:0000024 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO (PMID:11466310) RGD PMID:11466310 NCBI chr 1:37,743,089...37,774,485
Ensembl chr 1:37,743,147...37,774,015
JBrowse link
homocysteine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase TAS
IBA
ISO
IDA
PMID:21873635
MGI:MGI:1857139 (MGI:MGI:1888627|PMID:10953023), (MGI:MGI:1890086|PMID:10993757), (MGI:MGI:3039983|PMID:15131763), (MGI:MGI:3510570|PMID:15555590), (MGI:MGI:3611588|PMID:15916860), (MGI:MGI:3656462|PMID:15622513), (MGI:MGI:3663564|PMID:16226235), (MGI:MGI:3798351|PMID:18541157), (MGI:MGI:71081|PMID:7878023)
(PMID:19010420), (PMID:20031578), (PMID:23981774)
RGD PMID:7878023, PMID:10953023, PMID:10993757, PMID:15131763, PMID:15555590, PMID:15622513, PMID:15916860, PMID:16226235, PMID:18541157, PMID:19010420, PMID:20031578, PMID:23981774, PMID:12198128, PMID:21873635, PMID:9359866 MGI:MGI:1888627, MGI:MGI:1890086, MGI:MGI:3039983, MGI:MGI:3510570, MGI:MGI:3611588, MGI:MGI:3656462, MGI:MGI:3663564, MGI:MGI:3798351, MGI:MGI:71081, RGD:634704, RGD:13792537, RGD:1359024 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274
JBrowse link
G Cth cystathionine gamma-lyase IDA RGD PMID:9359866 RGD:1359024 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Dpep1 dipeptidase 1 ISO
ISS
(PMID:20031578)
GO_REF:0000024
RGD
UniProt
PMID:20031578 GO_REF:0000024 NCBI chr19:55,973,447...55,998,830
Ensembl chr19:55,982,740...55,998,208
JBrowse link
G Mmut methylmalonyl-CoA mutase ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 9:23,323,934...23,352,144
Ensembl chr 9:23,323,936...23,352,668
JBrowse link
G Mthfr methylenetetrahydrofolate reductase IEP
ISO
(PMID:20031578) RGD PMID:20031578, PMID:18726220 RGD:2317121 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IDA
IMP
RGD PMID:11730351, PMID:21121936 RGD:1601423, RGD:7207080 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO
IBA
(MGI:MGI:3710265|PMID:17369066)
PMID:21873635
RGD PMID:17369066, PMID:21873635 MGI:MGI:3710265, RGD:13792537 NCBI chr 1:37,743,089...37,774,485
Ensembl chr 1:37,743,147...37,774,015
JBrowse link
G Nox4 NADPH oxidase 4 ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
L-cysteine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase ISO (PMID:18492492) RGD PMID:18492492 NCBI chr 9:100,281,339...100,291,292
Ensembl chr 9:100,281,339...100,291,291
JBrowse link
G Cbs cystathionine beta synthase ISO (PMID:15520012) RGD PMID:15520012 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Cdo1 cysteine dioxygenase type 1 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:16611641, PMID:21873635 RGD:2301357, RGD:13792537 NCBI chr18:40,702,027...40,716,901
Ensembl chr18:40,701,984...40,716,686
JBrowse link
L-cysteine catabolic process to hypotaurine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csad cysteine sulfinic acid decarboxylase IDA PMID:9635011 UniProt PMID:9635011 RGD:13800536 NCBI chr 7:143,781,520...143,810,880
Ensembl chr 7:143,781,702...143,793,970
JBrowse link
L-cysteine catabolic process to taurine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csad cysteine sulfinic acid decarboxylase IDA PMID:9635011 UniProt PMID:9635011 RGD:13800536 NCBI chr 7:143,781,520...143,810,880
Ensembl chr 7:143,781,702...143,793,970
JBrowse link
L-cysteine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdo1 cysteine dioxygenase type 1 NAS RGD PMID:8973325 RGD:632438 NCBI chr18:40,702,027...40,716,901
Ensembl chr18:40,701,984...40,716,686
JBrowse link
L-methionine salvage term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhmt betaine-homocysteine S-methyltransferase ISO
IEA
(PMID:18230605)
GO_REF:0000107
RGD
Ensembl
PMID:18230605 GO_REF:0000107 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G Bhmt2 betaine-homocysteine S-methyltransferase 2 ISO
IEA
(PMID:18230605)
GO_REF:0000107
RGD
Ensembl
PMID:18230605 GO_REF:0000107 NCBI chr 2:23,272,320...23,289,266
Ensembl chr 2:23,272,328...23,289,266
JBrowse link
L-methionine salvage from methylthioadenosine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 IEA
ISS
ISO
GO_REF:0000041
GO_REF:0000024
(PMID:15938715)
UniProt
RGD
PMID:15938715 GO_REF:0000024, GO_REF:0000041 NCBI chr 6:47,940,211...47,947,173
Ensembl chr 6:47,940,183...47,947,230
JBrowse link
G Apip APAF1 interacting protein IEA
IBA
ISO
GO_REF:0000041
PMID:21873635
(PMID:22837397), (PMID:23285211)
UniProt
RGD
PMID:22837397, PMID:23285211, PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 3:92,969,128...92,998,104
Ensembl chr 3:92,969,141...92,995,483
JBrowse link
G Enoph1 enolase-phosphatase 1 IEA
IBA
ISS
ISO
GO_REF:0000041
PMID:21873635
GO_REF:0000024
(PMID:15843022)
UniProt
RGD
PMID:15843022, PMID:21873635 GO_REF:0000024, GO_REF:0000041, RGD:13792537 NCBI chr14:11,172,359...11,198,799
Ensembl chr14:11,172,362...11,198,194
JBrowse link
G Mri1 methylthioribose-1-phosphate isomerase 1 IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr19:25,360,299...25,366,283
Ensembl chr19:25,360,164...25,366,806
JBrowse link
G Mtap methylthioadenosine phosphorylase IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 5:107,711,077...107,777,530
Ensembl chr 5:107,711,077...107,777,530
JBrowse link
L-methionine salvage from S-adenosylmethionine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apip APAF1 interacting protein IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:92,969,128...92,998,104
Ensembl chr 3:92,969,141...92,995,483
JBrowse link
G Enoph1 enolase-phosphatase 1 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr14:11,172,359...11,198,799
Ensembl chr14:11,172,362...11,198,194
JBrowse link
G Mri1 methylthioribose-1-phosphate isomerase 1 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr19:25,360,299...25,366,283
Ensembl chr19:25,360,164...25,366,806
JBrowse link
methionine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhmt betaine-homocysteine S-methyltransferase IDA
ISO
(MGI:MGI:3510291|PMID:15217352) RGD PMID:15217352, PMID:15845641 MGI:MGI:3510291, RGD:1359026 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO (PMID:25633902) RGD PMID:25633902 NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr14:18,640,274...18,721,298
Ensembl chr14:18,640,277...18,720,357
JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO
IBA
MGI:MGI:2385823 (MGI:MGI:3510291|PMID:15217352)
PMID:21873635
RGD PMID:15217352, PMID:21873635 MGI:MGI:3510291, RGD:13792537 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IDA
IEA
ISO
GO_REF:0000107
(PMID:23825108)
MGI:MGI:2180496 (MGI:MGI:1930456|PMID:11158293)
Ensembl
RGD
PMID:11158293, PMID:23825108, PMID:15845641, PMID:11730351 GO_REF:0000107, MGI:MGI:1930456, RGD:1359026, RGD:1601423 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO
IBA
(PMID:11466310)
PMID:21873635
(MGI:MGI:3710265|PMID:17369066)
RGD PMID:11466310, PMID:17369066, PMID:21873635 MGI:MGI:3710265, RGD:13792537 NCBI chr 1:37,743,089...37,774,485
Ensembl chr 1:37,743,147...37,774,015
JBrowse link
methionine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mat1a methionine adenosyltransferase 1A IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:10677294)
Ensembl
UniProt
RGD
PMID:10677294 GO_REF:0000024, GO_REF:0000107 NCBI chr16:18,690,649...18,709,135
Ensembl chr16:18,690,246...18,709,133
JBrowse link
methionine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:47,940,211...47,947,173
Ensembl chr 6:47,940,183...47,947,230
JBrowse link
G Gnmt glycine N-methyltransferase ISO MGI:MGI:3842652 (MGI:MGI:3842675|PMID:17937387) RGD PMID:17937387 MGI:MGI:3842675 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO (MGI:MGI:5621260|PMID:23190757) RGD PMID:23190757 MGI:MGI:5621260 NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO UniProtKB:P53128 (PMID:10551815) RGD PMID:10551815 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IMP RGD PMID:21121936 RGD:7207080 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
positive regulation of homocysteine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase IMP RGD PMID:15779086 RGD:2289784 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
prenylcysteine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcyox1 prenylcysteine oxidase 1 ISO MGI:MGI:2449567 (MGI:MGI:2388263|PMID:12151402) RGD PMID:12151402 MGI:MGI:2388263 NCBI chr 4:118,187,133...118,198,029
Ensembl chr 4:118,187,134...118,198,029
JBrowse link
G Pcyox1l prenylcysteine oxidase 1 like IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr18:57,021,081...57,031,552
Ensembl chr18:57,021,083...57,031,459
JBrowse link
regulation of cysteine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc7a11 solute carrier family 7 member 11 ISO MGI:MGI:3608695 (MGI:MGI:3710059|PMID:17200146) RGD PMID:17200146 MGI:MGI:3710059 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
regulation of sulfur amino acid metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO
IEA
MGI:MGI:1856211 (MGI:MGI:60450|PMID:1485534)
GO_REF:0000107
RGD
Ensembl
PMID:1485534 GO_REF:0000107, MGI:MGI:60450 NCBI chr19:25,453,236...25,749,550
Ensembl chr19:25,526,751...25,749,550
JBrowse link
transsulfuration term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:16636197, PMID:21873635 RGD:1600624, RGD:13792537 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Cth cystathionine gamma-lyase TAS
IBA
IEA
ISO
PMID:21873635
GO_REF:0000002
(PMID:19428278)
InterPro
RGD
PMID:19428278, PMID:15347670, PMID:21873635 GO_REF:0000002, RGD:1600762, RGD:13792537 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G LOC103691744 cystathionine gamma-lyase IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:264,747,068...264,765,112
Ensembl chr 2:264,746,485...264,765,085
JBrowse link
G Mpst mercaptopyruvate sulfurtransferase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:17130129, PMID:21873635 RGD:9685559, RGD:13792537 NCBI chr 7:119,626,636...119,631,317
Ensembl chr 7:119,626,637...119,631,425
JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO (MGI:MGI:5621260|PMID:23190757) RGD PMID:23190757 MGI:MGI:5621260 NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
JBrowse link
G Tst thiosulfate sulfurtransferase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:119,616,323...119,623,072
Ensembl chr 7:119,616,324...119,623,072
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      primary metabolic process 10901
        cellular amino acid metabolic process 274
          sulfur amino acid metabolic process 35
            cysteine metabolic process + 13
            ergothioneine metabolic process + 0
            homocysteine metabolic process + 15
            homomethionine metabolic process + 0
            methionine metabolic process + 14
            negative regulation of sulfur amino acid metabolic process + 0
            positive regulation of sulfur amino acid metabolic process + 1
            prenylcysteine metabolic process + 2
            regulation of sulfur amino acid metabolic process + 3
            sulfur amino acid biosynthetic process + 16
            sulfur amino acid catabolic process + 9
Path 2
Term Annotations click to browse term
  biological_process 20017
    cellular process 18791
      cellular metabolic process 11064
        organic acid metabolic process 1089
          oxoacid metabolic process 1060
            carboxylic acid metabolic process 1004
              cellular amino acid metabolic process 274
                sulfur amino acid metabolic process 35
                  cysteine metabolic process + 13
                  ergothioneine metabolic process + 0
                  homocysteine metabolic process + 15
                  homomethionine metabolic process + 0
                  methionine metabolic process + 14
                  negative regulation of sulfur amino acid metabolic process + 0
                  positive regulation of sulfur amino acid metabolic process + 1
                  prenylcysteine metabolic process + 2
                  regulation of sulfur amino acid metabolic process + 3
                  sulfur amino acid biosynthetic process + 16
                  sulfur amino acid catabolic process + 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.