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ONTOLOGY REPORT - ANNOTATIONS


Term:sulfur amino acid metabolic process
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Accession:GO:0000096 term browser browse the term
Definition:The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.
Synonyms:exact_synonym: sulfur amino acid metabolism;   sulphur amino acid metabolic process;   sulphur amino acid metabolism


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cysteine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:24416422)
PMID:21873635
MGI:1857139 (MGI:3044255|PMID:15030387)
RGD PMID:15030387 PMID:24416422, PMID:21873635 MGI:3044255, RGD:13792537 NCBI chr20:9,708,089...9,732,623 JBrowse link
G Cth cystathionine gamma-lyase involved_in IDA
ISS
ISO
IEA
GO_REF:0000024
(PMID:10212249)
GO_REF:0000041
UniProt
RGD
PMID:10212249, PMID:9359866 GO_REF:0000024 GO_REF:0000041, RGD:1359024 NCBI chr 2:246,975,888...247,002,234 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in ISO (MGI:5294309|PMID:12468440) RGD PMID:12468440 MGI:5294309 NCBI chr20:13,074,695...13,104,095 JBrowse link
cysteine biosynthetic process from serine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase TAS RGD PMID:9359866 RGD:1359024 NCBI chr20:9,708,089...9,732,623 JBrowse link
cysteine biosynthetic process via cystathionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:9,708,089...9,732,623 JBrowse link
G Cth cystathionine gamma-lyase involved_in IBA
ISO
PMID:21873635
(PMID:19428278)
RGD PMID:19428278, PMID:21873635 RGD:13792537 NCBI chr 2:246,975,888...247,002,234 JBrowse link
cysteine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdo1 cysteine dioxygenase type 1 TAS RGD PMID:2334417 RGD:68765 NCBI chr18:39,432,473...39,447,253 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit involved_in ISS
ISO
GO_REF:0000024
(PMID:2294991)
UniProt
RGD
PMID:2294991 GO_REF:0000024 NCBI chr 8:78,629,899...78,668,547 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit acts_upstream_of_or_within ISO MGI:2447852 (MGI:2447526|PMID:12384496) RGD PMID:12384496 MGI:2447526 NCBI chr 2:210,347,482...210,367,537 JBrowse link
homocysteine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blmh bleomycin hydrolase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:61,772,112...61,815,212 JBrowse link
G Cbs cystathionine beta synthase involved_in ISO
ISS
(PMID:18776696), (PMID:24416422)
GO_REF:0000024
RGD
UniProt
PMID:18776696 PMID:24416422 GO_REF:0000024 NCBI chr20:9,708,089...9,732,623 JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO (PMID:11466310) RGD PMID:11466310 NCBI chr 1:34,866,991...34,899,425 JBrowse link
homocysteine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase acts_upstream_of_or_within
involved_in
TAS
ISO
IDA
MGI:1857139 (MGI:1888627|PMID:10953023), (MGI:1890086|PMID:10993757), (MGI:3039983|PMID:15131763), (MGI:3510570|PMID:15555590), (MGI:3611588|PMID:15916860), (MGI:3656462|PMID:15622513), (MGI:3663564|PMID:16226235), (MGI:3798351|PMID:18541157), (MGI:71081|PMID:7878023)
(PMID:19010420), (PMID:20031578), (PMID:23981774)
RGD PMID:7878023 PMID:10953023 PMID:10993757 PMID:15131763 PMID:15555590 PMID:15622513 PMID:15916860 PMID:16226235 PMID:18541157 PMID:19010420 PMID:20031578 PMID:23981774, PMID:12198128, PMID:9359866 MGI:1888627 MGI:1890086 MGI:3039983 MGI:3510570 MGI:3611588 MGI:3656462 MGI:3663564 MGI:3798351 MGI:71081, RGD:634704, RGD:1359024 NCBI chr20:9,708,089...9,732,623 JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 involved_in ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 9:68,614,153...68,737,037 JBrowse link
G Cth cystathionine gamma-lyase IDA RGD PMID:9359866 RGD:1359024 NCBI chr 2:246,975,888...247,002,234 JBrowse link
G Dpep1 dipeptidase 1 involved_in ISO
ISS
(PMID:20031578)
GO_REF:0000024
RGD
UniProt
PMID:20031578 GO_REF:0000024 NCBI chr19:51,209,831...51,237,004 JBrowse link
G Mmut methylmalonyl-CoA mutase involved_in ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 9:19,928,720...19,956,985 JBrowse link
G Mthfr methylenetetrahydrofolate reductase involved_in IEP
ISO
(PMID:20031578) RGD PMID:20031578, PMID:18726220 RGD:2317121 NCBI chr 5:158,465,248...158,484,999 JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IDA
IMP
RGD PMID:11730351, PMID:21121936 RGD:1601423, RGD:7207080 NCBI chr17:58,219,998...58,308,560 JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IBA
ISO
PMID:21873635
(MGI:3710265|PMID:17369066)
RGD PMID:17369066, PMID:21873635 MGI:3710265, RGD:13792537 NCBI chr 1:34,866,991...34,899,425 JBrowse link
G Nox4 NADPH oxidase 4 involved_in ISO (PMID:20031578) RGD PMID:20031578 NCBI chr 1:140,900,886...141,078,844 JBrowse link
L-cysteine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase involved_in ISO (PMID:18492492) RGD PMID:18492492 NCBI chr 9:93,675,384...93,685,337 JBrowse link
G Cbs cystathionine beta synthase involved_in ISO (PMID:15520012) RGD PMID:15520012 NCBI chr20:9,708,089...9,732,623 JBrowse link
G Cdo1 cysteine dioxygenase type 1 involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:16611641, PMID:21873635 RGD:2301357, RGD:13792537 NCBI chr18:39,432,473...39,447,253 JBrowse link
L-cysteine catabolic process to hypotaurine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csad cysteine sulfinic acid decarboxylase involved_in IDA PMID:9635011 UniProt PMID:9635011 RGD:13800536 NCBI chr 7:133,308,571...133,337,914 JBrowse link
L-cysteine catabolic process to taurine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csad cysteine sulfinic acid decarboxylase involved_in IDA PMID:9635011 UniProt PMID:9635011 RGD:13800536 NCBI chr 7:133,308,571...133,337,914 JBrowse link
L-cysteine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdo1 cysteine dioxygenase type 1 NAS RGD PMID:8973325 RGD:632438 NCBI chr18:39,432,473...39,447,253 JBrowse link
L-methionine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhmt betaine-homocysteine S-methyltransferase involved_in ISO
IEA
(PMID:18230605)
GO_REF:0000107
RGD
Ensembl
PMID:18230605 GO_REF:0000107 NCBI chr 2:24,859,871...24,879,449 JBrowse link
G Bhmt2 betaine-homocysteine S-methyltransferase 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:18230605)
Ensembl
RGD
PMID:18230605 GO_REF:0000107 NCBI chr 2:24,895,525...24,912,475 JBrowse link
L-methionine salvage from methylthioadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 involved_in IEA
ISS
ISO
GO_REF:0000041
GO_REF:0000024
(PMID:15938715)
UniProt
RGD
PMID:15938715 GO_REF:0000024 GO_REF:0000041 NCBI chr 6:45,306,885...45,313,847 JBrowse link
G Apip APAF1 interacting protein involved_in IEA
IBA
ISO
GO_REF:0000041
PMID:21873635
(PMID:22837397), (PMID:23285211)
UniProt
RGD
PMID:22837397 PMID:23285211, PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 3:89,431,973...89,457,999 JBrowse link
G Enoph1 enolase-phosphatase 1 involved_in IEA
ISO
IBA
ISS
GO_REF:0000041
(PMID:15843022)
PMID:21873635
GO_REF:0000024
UniProt
RGD
PMID:15843022, PMID:21873635 GO_REF:0000024 GO_REF:0000041, RGD:13792537 NCBI chr14:9,531,336...9,557,797 JBrowse link
G Mri1 methylthioribose-1-phosphate isomerase 1 involved_in IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr19:23,907,335...23,913,320 JBrowse link
G Mtap methylthioadenosine phosphorylase involved_in IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 5:103,873,020...103,939,406 JBrowse link
L-methionine salvage from S-adenosylmethionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apip APAF1 interacting protein involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:89,431,973...89,457,999 JBrowse link
G Enoph1 enolase-phosphatase 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr14:9,531,336...9,557,797 JBrowse link
G Mri1 methylthioribose-1-phosphate isomerase 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr19:23,907,335...23,913,320 JBrowse link
methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhmt betaine-homocysteine S-methyltransferase acts_upstream_of_or_within IDA
ISO
(MGI:3510291|PMID:15217352) RGD PMID:15217352, PMID:15845641 MGI:3510291, RGD:1359026 NCBI chr 2:24,859,871...24,879,449 JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (PMID:25633902) RGD PMID:25633902 NCBI chr 6:94,977,862...95,045,375 JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr14:17,089,947...17,170,036 JBrowse link
G Mthfr methylenetetrahydrofolate reductase involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2385823 (MGI:3510291|PMID:15217352)
RGD PMID:15217352, PMID:21873635 MGI:3510291, RGD:13792537 NCBI chr 5:158,465,248...158,484,999 JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase acts_upstream_of_or_within
involved_in
IDA
ISO
IEA
MGI:2180496 (MGI:1930456|PMID:11158293)
GO_REF:0000107
(PMID:23825108)
RGD
Ensembl
PMID:11158293 PMID:23825108, PMID:15845641, PMID:11730351 GO_REF:0000107 MGI:1930456, RGD:1359026, RGD:1601423 NCBI chr17:58,219,998...58,308,560 JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO
IBA
(PMID:11466310)
(MGI:3710265|PMID:17369066)
PMID:21873635
RGD PMID:11466310 PMID:17369066, PMID:21873635 MGI:3710265, RGD:13792537 NCBI chr 1:34,866,991...34,899,425 JBrowse link
methionine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mat1a methionine adenosyltransferase 1A involved_in ISO
IEA
ISS
(PMID:10677294)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:10677294 GO_REF:0000024 GO_REF:0000107 NCBI chr16:16,983,084...17,001,284 JBrowse link
methionine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:45,306,885...45,313,847 JBrowse link
G Gnmt glycine N-methyltransferase acts_upstream_of_or_within ISO MGI:3842652 (MGI:3842675|PMID:17937387) RGD PMID:17937387 MGI:3842675 NCBI chr 9:14,254,675...14,258,028 JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (MGI:5621260|PMID:23190757) RGD PMID:23190757 MGI:5621260 NCBI chr 6:94,977,862...95,045,375 JBrowse link
G Mthfr methylenetetrahydrofolate reductase involved_in ISO UniProtKB:P53128 (PMID:10551815) RGD PMID:10551815 NCBI chr 5:158,465,248...158,484,999 JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IMP RGD PMID:21121936 RGD:7207080 NCBI chr17:58,219,998...58,308,560 JBrowse link
positive regulation of homocysteine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase IMP RGD PMID:15779086 RGD:2289784 NCBI chr11:82,568,052...82,587,642 JBrowse link
regulation of cysteine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO MGI:3608695 (MGI:3710059|PMID:17200146) RGD PMID:17200146 MGI:3710059 NCBI chr 2:134,382,002...134,517,622 JBrowse link
regulation of sulfur amino acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:1856211 (MGI:60450|PMID:1485534) RGD PMID:1485534 MGI:60450 NCBI chr19:23,520,741...23,819,971 JBrowse link
transsulfuration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase IDA RGD PMID:16636197 RGD:1600624 NCBI chr20:9,708,089...9,732,623 JBrowse link
G Cth cystathionine gamma-lyase involved_in TAS
IEA
IBA
ISO
GO_REF:0000002
PMID:21873635
(PMID:19428278)
InterPro
RGD
PMID:19428278, PMID:15347670, PMID:21873635 GO_REF:0000002, RGD:1600762, RGD:13792537 NCBI chr 2:246,975,888...247,002,234 JBrowse link
G Mpst mercaptopyruvate sulfurtransferase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:17130129, PMID:21873635 RGD:9685559, RGD:13792537 NCBI chr 7:109,955,581...109,963,155 JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (MGI:5621260|PMID:23190757) RGD PMID:23190757 MGI:5621260 NCBI chr 6:94,977,862...95,045,375 JBrowse link
G Tst thiosulfate sulfurtransferase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:109,948,061...109,955,378 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      cellular metabolic process 10753
        organic acid metabolic process 1010
          sulfur amino acid metabolic process 32
            cysteine metabolic process + 12
            ergothioneine metabolic process + 0
            homocysteine metabolic process + 14
            methionine metabolic process + 14
            negative regulation of sulfur amino acid metabolic process + 0
            positive regulation of sulfur amino acid metabolic process + 1
            regulation of sulfur amino acid metabolic process + 3
            sulfur amino acid biosynthetic process + 15
            sulfur amino acid catabolic process + 7
paths to the root