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ONTOLOGY REPORT - ANNOTATIONS


Term:G2/M transition of mitotic cell cycle
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Accession:GO:0000086 term browser browse the term
Definition:The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
Synonyms:exact_synonym: mitotic G2/M transition


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G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB1 ATP binding cassette subfamily B member 1 JBrowse link 7 79,497,536 79,706,277 RGD:9068941
G ARPP19 cAMP regulated phosphoprotein 19 JBrowse link 15 31,488,156 31,510,404 RGD:9068941
G BIRC5 baculoviral IAP repeat containing 5 JBrowse link 17 72,292,332 72,303,493 RGD:9068941
G BRSK1 BR serine/threonine kinase 1 JBrowse link 19 52,326,538 52,355,060 RGD:9068941
G BRSK2 BR serine/threonine kinase 2 JBrowse link 11 1,424,873 1,495,630 RGD:9068941
G CALM1 calmodulin 1 JBrowse link 14 71,015,099 71,026,322 RGD:9068941
G CALM2 calmodulin 2 JBrowse link 2A 47,274,722 47,290,861 RGD:9068941
G CALM3 calmodulin 3 JBrowse link 19 43,593,069 43,602,550 RGD:9068941
G CCNA2 cyclin A2 JBrowse link 4 114,016,917 114,024,816 RGD:9068941
G CCNY cyclin Y JBrowse link 10 35,458,092 35,698,142 RGD:9068941
G CDC25C cell division cycle 25C JBrowse link 5 133,663,210 133,717,974 RGD:9068941
G CDK14 cyclin dependent kinase 14 JBrowse link 7 82,609,791 83,216,851 RGD:9068941
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 36,241,405 36,250,032 RGD:9068941
G CDKN2B cyclin dependent kinase inhibitor 2B JBrowse link 9 21,838,902 21,845,355 RGD:9068941
G CHEK1 checkpoint kinase 1 JBrowse link 11 120,446,352 120,478,207 RGD:9068941
G CHEK2 checkpoint kinase 2 JBrowse link 22 9,757,038 9,811,171 RGD:9068941
G CIT citron rho-interacting serine/threonine kinase JBrowse link 12 117,264,627 117,456,069 RGD:9068941
G FBXL15 F-box and leucine rich repeat protein 15 JBrowse link 10 99,022,732 99,026,623 RGD:9068941
G FBXL7 F-box and leucine rich repeat protein 7 JBrowse link 5 15,804,479 16,237,326 RGD:9068941
G FOXM1 forkhead box M1 JBrowse link 12 2,978,400 2,999,077 RGD:9068941
G GADD45A growth arrest and DNA damage inducible alpha JBrowse link 1 66,925,063 66,928,222 RGD:9068941
G KAT14 lysine acetyltransferase 14 JBrowse link 20 18,106,400 18,152,231 RGD:9068941
G KDM8 lysine demethylase 8 RGD:9068941
G LATS1 large tumor suppressor kinase 1 JBrowse link 6 147,476,913 147,533,491 RGD:9068941
G MASTL microtubule associated serine/threonine kinase like JBrowse link 10 27,264,475 27,296,085 RGD:9068941
G NES nestin JBrowse link 1 132,012,273 132,020,907 RGD:9068941
G PLCB1 phospholipase C beta 1 JBrowse link 20 8,106,665 8,858,572 RGD:9068941
G PLK1 polo like kinase 1 JBrowse link 16 14,420,972 14,432,821 RGD:9068941
G PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D JBrowse link 17 54,698,338 54,761,889 RGD:9068941
G SKP2 S-phase kinase associated protein 2 JBrowse link 5 74,179,608 74,211,563 RGD:9068941
G TAF2 TATA-box binding protein associated factor 2 JBrowse link 8 116,421,520 116,523,138 RGD:9068941
G TPD52L1 TPD52 like 1 JBrowse link 6 122,943,780 123,053,201 RGD:9068941
G USH1C USH1 protein network component harmonin JBrowse link 11 17,548,501 17,598,923 RGD:9068941
G WNT10B Wnt family member 10B JBrowse link 12 39,771,163 39,785,411 RGD:9068941
mitotic cytokinesis checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CHMP4C charged multivesicular body protein 4C JBrowse link 8 78,259,783 78,286,807 RGD:9068941
G VPS4A vacuolar protein sorting 4 homolog A JBrowse link 16 49,685,827 49,699,542 RGD:9068941
G ZFYVE19 zinc finger FYVE-type containing 19 JBrowse link 15 19,747,606 19,755,185 RGD:9068941
mitotic DNA replication checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CLSPN claspin JBrowse link 1 34,991,082 35,040,515 RGD:9068941
G NAE1 NEDD8 activating enzyme E1 subunit 1 JBrowse link 16 47,119,548 47,147,679 RGD:9068941
G ZNF830 zinc finger protein 830 JBrowse link 17 21,823,998 21,825,632 RGD:9068941
mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BLM BLM RecQ like helicase JBrowse link 15 69,407,248 69,508,070 RGD:9068941
G BRSK1 BR serine/threonine kinase 1 JBrowse link 19 52,326,538 52,355,060 RGD:9068941
G C10H10orf90 chromosome 10 C10orf90 homolog JBrowse link 10 122,987,122 123,243,653 RGD:9068941
G CCNG1 cyclin G1 JBrowse link 5 158,814,563 158,822,019 RGD:9068941
G CDK1 cyclin dependent kinase 1 JBrowse link 10 57,314,692 57,331,261 RGD:9068941
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 JBrowse link 17 9,556,313 9,567,099 RGD:9068941
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 36,241,405 36,250,032 RGD:9068941
G CLSPN claspin JBrowse link 1 34,991,082 35,040,515 RGD:9068941
G DONSON DNA replication fork stabilization factor DONSON JBrowse link 21 19,944,692 19,956,140 RGD:9068941
G FOXN3 forkhead box N3 JBrowse link 14 69,778,191 70,238,813 RGD:9068941
G FOXO4 forkhead box O4 JBrowse link X 60,364,466 60,372,147 RGD:9068941
G HMGA2 high mobility group AT-hook 2 JBrowse link 12 22,954,946 23,096,623 RGD:9068941
G IER3 immediate early response 3 JBrowse link 6 30,488,162 30,489,784 RGD:9068941
G MBD4 methyl-CpG binding domain 4, DNA glycosylase JBrowse link 3 126,489,125 126,498,034 RGD:9068941
G MRE11 MRE11 homolog, double strand break repair nuclease JBrowse link 11 89,418,537 89,500,705 RGD:9068941
G MRNIP MRN complex interacting protein JBrowse link 5 174,989,967 175,020,550 RGD:9068941
G NBN nibrin JBrowse link 8 86,622,797 86,674,202 RGD:9068941
G NOP53 NOP53 ribosome biogenesis factor JBrowse link 19 44,739,739 44,751,303 RGD:9068941
G SYF2 SYF2 pre-mRNA splicing factor JBrowse link 1 24,422,931 24,432,870 RGD:9068941
G TAOK1 TAO kinase 1 JBrowse link 17 27,222,725 27,385,713 RGD:9068941
G TAOK2 TAO kinase 2 RGD:9068941
G TAOK3 TAO kinase 3 JBrowse link 12 115,730,619 115,954,149 RGD:9068941
G TRIM39 tripartite motif containing 39 JBrowse link 6 30,104,381 30,121,649 RGD:9068941
mitotic G2/M transition checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BRCA1 BRCA1 DNA repair associated JBrowse link 17 14,197,946 14,279,064 RGD:9068941
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 JBrowse link 17 9,556,313 9,567,099 RGD:9068941
negative regulation of G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CHEK1 checkpoint kinase 1 JBrowse link 11 120,446,352 120,478,207 RGD:9068941
G FHL1 four and a half LIM domains 1 JBrowse link X 125,270,340 125,334,961 RGD:9068941
G GPR132 G protein-coupled receptor 132 JBrowse link 14 85,697,589 85,716,764 RGD:9068941
G PINX1 PIN2 (TERF1) interacting telomerase inhibitor 1 JBrowse link 8 8,366,819 8,443,359 RGD:9068941
G RAD21 RAD21 cohesin complex component JBrowse link 8 113,520,456 113,549,339 RGD:9068941
G RFPL1 ret finger protein like 1 JBrowse link 22 10,485,218 10,488,052 RGD:9068941
G USP47 ubiquitin specific peptidase 47 JBrowse link 11 12,009,770 12,127,425 RGD:9068941
positive regulation of G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APP amyloid beta precursor protein JBrowse link 21 12,324,455 12,608,594 RGD:9068941
G BRD4 bromodomain containing 4 JBrowse link 19 14,768,239 14,805,770 RGD:9068941
G CAMK2D calcium/calmodulin dependent protein kinase II delta JBrowse link 4 105,957,773 106,271,887 RGD:9068941
G CCNB1 cyclin B1 JBrowse link 5 44,826,103 44,836,832 RGD:9068941
G CCND1 cyclin D1 JBrowse link 11 64,737,006 64,750,353 RGD:9068941
G CDC7 cell division cycle 7 JBrowse link 1 94,158,628 94,183,537 RGD:9068941
G CDK1 cyclin dependent kinase 1 JBrowse link 10 57,314,692 57,331,261 RGD:9068941
G CDK4 cyclin dependent kinase 4 JBrowse link 12 31,174,446 31,178,597 RGD:9068941
G DBF4B DBF4 zinc finger B JBrowse link 17 12,571,265 12,616,105 RGD:9068941
G DTL denticleless E3 ubiquitin protein ligase homolog JBrowse link 1 187,603,600 187,672,006 RGD:9068941
G FBXO5 F-box protein 5 JBrowse link 6 150,793,020 150,806,008 RGD:9068941
G HSPA2 heat shock protein family A (Hsp70) member 2 JBrowse link 14 45,124,326 45,127,105 RGD:9068941
G MECP2 methyl-CpG binding protein 2 JBrowse link X 143,571,864 143,647,192 RGD:9068941
G MTA3 metastasis associated 1 family member 3 JBrowse link 2A 42,593,721 42,847,045 RGD:9068941
G PBX1 PBX homeobox 1 JBrowse link 1 139,985,392 140,311,845 RGD:9068941
G RAB11A RAB11A, member RAS oncogene family JBrowse link 15 44,810,880 44,833,438 RGD:9068941
G RAD51B RAD51 paralog B JBrowse link 14 48,399,345 49,314,577 RGD:9068941
G RAD51C RAD51 paralog C JBrowse link 17 52,769,446 52,808,467 RGD:9068941
G RCC2 regulator of chromosome condensation 2 JBrowse link 1 16,353,770 16,386,810 RGD:9068941
G SIN3A SIN3 transcription regulator family member A JBrowse link 15 54,285,587 54,371,376 RGD:9068941
G SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 JBrowse link 7 142,825,864 142,864,159 RGD:9068941
G STOX1 storkhead box 1 JBrowse link 10 65,304,649 65,359,501 RGD:9068941
G VPS4B vacuolar protein sorting 4 homolog B JBrowse link 18 56,749,439 56,782,660 RGD:9068941
G WNT10B Wnt family member 10B JBrowse link 12 39,771,163 39,785,411 RGD:9068941
positive regulation of transcription involved in G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ESRRB estrogen related receptor beta JBrowse link 14 56,868,361 57,060,552 RGD:9068941
regulation of G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CDKN2A cyclin dependent kinase inhibitor 2A JBrowse link 9 21,803,862 21,831,322 RGD:9068941
G CENPF centromere protein F JBrowse link 1 190,170,414 190,231,478 RGD:9068941
G CTC1 CST telomere replication complex component 1 JBrowse link 17 43,410,385 43,433,784 RGD:9068941
G HACD1 3-hydroxyacyl-CoA dehydratase 1 JBrowse link 10 17,911,158 17,940,075 RGD:9068941
G KCNH5 potassium voltage-gated channel subfamily H member 5 JBrowse link 14 43,297,114 43,633,275 RGD:9068941
G KIF14 kinesin family member 14 JBrowse link 1 176,156,870 176,223,093 RGD:9068941
G PKIA cAMP-dependent protein kinase inhibitor alpha JBrowse link 8 75,046,316 75,136,264 RGD:9068941
G PRKCQ protein kinase C theta JBrowse link 10 6,458,138 6,610,781 RGD:9068941
G RNASEH2B ribonuclease H2 subunit B JBrowse link 13 32,047,830 32,108,573 RGD:9068941
regulation of signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RINT1 RAD50 interactor 1 JBrowse link 7 97,522,208 97,567,897 RGD:9068941
regulation of transcription involved in G2/M transition of mitotic cell cycle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BACH1 BTB domain and CNC homolog 1 JBrowse link 21 15,738,343 16,036,760 RGD:9068941
signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATM ATM serine/threonine kinase JBrowse link 11 103,109,979 103,256,405 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12489
    cellular process 11599
      cell cycle process 996
        cell cycle phase transition 362
          mitotic cell cycle phase transition 322
            G2/M transition of mitotic cell cycle 102
              negative regulation of G2/M transition of mitotic cell cycle + 38
              positive regulation of G2/M transition of mitotic cell cycle + 24
              regulation of G2/M transition of mitotic cell cycle + 70
              regulation of transcription involved in G2/M transition of mitotic cell cycle + 2
Path 2
Term Annotations click to browse term
  biological_process 12489
    cellular process 11599
      cell cycle 1245
        cell cycle process 996
          cell cycle phase transition 362
            mitotic cell cycle phase transition 322
              G2/M transition of mitotic cell cycle 102
                negative regulation of G2/M transition of mitotic cell cycle + 38
                positive regulation of G2/M transition of mitotic cell cycle + 24
                regulation of G2/M transition of mitotic cell cycle + 70
                regulation of transcription involved in G2/M transition of mitotic cell cycle + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.