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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA replication checkpoint signaling
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Accession:GO:0000076 term browser browse the term
Definition:A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
Synonyms:exact_synonym: DNA replication checkpoint;   signal transduction involved in DNA replication checkpoint
 alt_id: GO:0072437



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DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in ISO
IBA
(PMID:14672932)
(PMID:12192004)
GO_REF:0000033
RGD
GO_Central
PMID:12192004 PMID:14672932 GO_REF:0000033 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659
JBrowse link
G Clspn claspin acts_upstream_of_or_within ISO (PMID:12766152)
(PMID:16123041)
RGD PMID:12766152 PMID:16123041 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034
JBrowse link
G Dna2 DNA replication helicase/nuclease 2 involved_in ISS
IEA
GO_REF:0000024
GO_REF:0000107
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319
JBrowse link
G LOC120094818 TIMELESS-interacting protein-like involved_in IBA
IEA
GO_REF:0000033
GO_REF:0000104
GO_Central
UniProt
GO_REF:0000033 GO_REF:0000104 NCBI chr 9:113,693,252...113,694,434
Ensembl chr 8:64,780,828...64,801,352
JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:21482717)
UniProt
RGD
PMID:21482717 GO_REF:0000024 NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240
JBrowse link
G Rad9a RAD9 checkpoint clamp component A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608
JBrowse link
G Rad9b RAD9 checkpoint clamp component B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:34,217,868...34,248,380
Ensembl chr12:34,218,024...34,248,372
JBrowse link
G Timeless timeless circadian regulator involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:654,804...678,769
Ensembl chr 7:654,822...678,738
JBrowse link
G Tipin timeless interacting protein involved_in ISO
IBA
ISS
IEA
(PMID:17102137)
GO_REF:0000033
GO_REF:0000024
GO_REF:0000104
RGD
GO_Central
UniProt
PMID:17102137 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr 8:64,780,813...64,801,358
Ensembl chr 8:64,780,828...64,801,352
JBrowse link
G Tipinl1 TIMELESS interacting protein like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:113,542,841...113,544,022
Ensembl chr 9:113,543,173...113,605,998
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 involved_in ISO (PMID:21482717), (PMID:21777809) RGD PMID:21482717 PMID:21777809 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
JBrowse link
mitotic DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc6 cell division cycle 6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
JBrowse link
G Clspn claspin involved_in ISO
IBA
(PMID:16885022)
GO_REF:0000033
RGD
GO_Central
PMID:16885022 GO_REF:0000033 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034
JBrowse link
G Donson DNA replication fork stabilization factor DONSON involved_in ISO (PMID:28191891) RGD PMID:28191891 NCBI chr11:30,919,834...30,933,150
Ensembl chr11:30,923,239...30,932,889
JBrowse link
G Hus1 HUS1 checkpoint clamp component involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442
JBrowse link
G Nae1 NEDD8 activating enzyme E1 subunit 1 involved_in ISO
IEA
(PMID:10722740)
GO_REF:0000107
RGD
Ensembl
PMID:10722740 GO_REF:0000107 NCBI chr19:446,015...472,145
Ensembl chr19:446,000...472,371
JBrowse link
G Orc1 origin recognition complex, subunit 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375
JBrowse link
G Rad17 RAD17 checkpoint clamp loader component involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072
JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:133,597,618...133,639,513
Ensembl chr 1:133,597,716...133,639,523
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
JBrowse link
G Zfp830 zinc finger protein 830 involved_in ISS
IBA
ISO
GO_REF:0000024
GO_REF:0000033
(PMID:21191184)
UniProt
GO_Central
RGD
PMID:21191184 GO_REF:0000024 GO_REF:0000033 NCBI chr10:67,701,340...67,702,804
Ensembl chr10:67,701,073...67,704,523
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20217
    cellular process 19275
      signal transduction 7197
        intracellular signal transduction 3076
          cell cycle checkpoint signaling 188
            DNA integrity checkpoint signaling 133
              DNA replication checkpoint signaling 19
                meiotic G2/MI DNA replication checkpoint signaling 0
                mitotic DNA replication checkpoint signaling 10
Path 2
Term Annotations click to browse term
  biological_process 20217
    biological regulation 13615
      regulation of biological process 13195
        negative regulation of biological process 5779
          negative regulation of cellular process 5538
            negative regulation of cell cycle 403
              negative regulation of cell cycle process 316
                negative regulation of cell cycle phase transition 266
                  cell cycle checkpoint signaling 188
                    DNA integrity checkpoint signaling 133
                      DNA replication checkpoint signaling 19
                        meiotic G2/MI DNA replication checkpoint signaling 0
                        mitotic DNA replication checkpoint signaling 10
paths to the root