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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA replication checkpoint signaling
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Accession:GO:0000076 term browser browse the term
Definition:A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
Synonyms:exact_synonym: DNA replication checkpoint;   signal transduction involved in DNA replication checkpoint
 alt_id: GO:0072437



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DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in IBA
ISO
PMID:21873635
(MGI:2388867|PMID:12192004)
(PMID:14672932)
RGD PMID:12192004 PMID:14672932 PMID:21873635 MGI:2388867, RGD:13792537 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659
JBrowse link
G Clspn claspin acts_upstream_of_or_within ISO (PMID:12766152) RGD PMID:12766152 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034
JBrowse link
G Dna2 DNA replication helicase/nuclease 2 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:22570476)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:22570476 GO_REF:0000024 GO_REF:0000107 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319
JBrowse link
G Rad9a RAD9 checkpoint clamp component A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608
JBrowse link
G Rad9b RAD9 checkpoint clamp component B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:34,217,868...34,248,380
Ensembl chr12:34,218,024...34,248,372
JBrowse link
G Slc25a16 solute carrier family 25 member 16 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,661,158...25,717,558
Ensembl chr20:25,662,055...25,716,319
JBrowse link
G Timeless timeless circadian regulator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:654,804...678,769
Ensembl chr 7:654,822...678,738
JBrowse link
G Tipin timeless interacting protein involved_in ISO
ISS
IEA
IBA
(PMID:17102137)
GO_REF:0000024
GO_REF:0000104
PMID:21873635
RGD
UniProt
PMID:17102137 PMID:21873635 GO_REF:0000024 GO_REF:0000104, RGD:13792537 NCBI chr 8:64,780,741...64,801,355
Ensembl chr 8:64,780,828...64,801,352
JBrowse link
G Tipinl1 TIMELESS interacting protein like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:113,542,841...113,544,022
Ensembl chr 9:113,543,173...113,605,998
JBrowse link
mitotic DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07049960.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Cdc6 cell division cycle 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
JBrowse link
G Clspn claspin involved_in ISO
IBA
(PMID:16885022)
PMID:21873635
RGD PMID:16885022 PMID:21873635 RGD:13792537 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034
JBrowse link
G Hus1 HUS1 checkpoint clamp component involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442
JBrowse link
G LOC103690165 checkpoint protein HUS1B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Nae1 NEDD8 activating enzyme E1 subunit 1 involved_in ISO
IEA
(PMID:10722740)
GO_REF:0000107
RGD
Ensembl
PMID:10722740 GO_REF:0000107 NCBI chr19:446,015...472,145
Ensembl chr19:446,000...472,371
JBrowse link
G Orc1 origin recognition complex, subunit 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375
JBrowse link
G Rad17 RAD17 checkpoint clamp loader component involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072
JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:133,597,618...133,639,513
Ensembl chr 1:133,597,716...133,639,523
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
JBrowse link
G Zfp830 zinc finger protein 830 involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:4950701|PMID:21191184)
PMID:21873635
UniProt
RGD
PMID:21191184 PMID:21873635 GO_REF:0000024 MGI:4950701, RGD:13792537 NCBI chr10:67,701,340...67,702,804
Ensembl chr10:67,701,073...67,704,523
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19834
    cellular process 18637
      signal transduction 6997
        intracellular signal transduction 2658
          cell cycle checkpoint signaling 174
            DNA integrity checkpoint signaling 125
              DNA replication checkpoint signaling 19
                meiotic G2/MI DNA replication checkpoint signaling 0
                mitotic DNA replication checkpoint signaling 11
Path 2
Term Annotations click to browse term
  biological_process 19834
    biological regulation 13775
      regulation of biological process 13033
        regulation of cellular process 12501
          regulation of cell cycle 1077
            regulation of cell cycle process 704
              negative regulation of cell cycle process 290
                negative regulation of cell cycle phase transition 242
                  cell cycle checkpoint signaling 174
                    DNA integrity checkpoint signaling 125
                      DNA replication checkpoint signaling 19
                        meiotic G2/MI DNA replication checkpoint signaling 0
                        mitotic DNA replication checkpoint signaling 11
paths to the root