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ONTOLOGY REPORT - ANNOTATIONS


Term:urea cycle
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Accession:GO:0000050 term browser browse the term
Definition:The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
Synonyms:exact_synonym: ornithine cycle;   urea biosynthesis;   urea biosynthetic process
 alt_id: GO:0006594;   GO:0006871
 xref: Wikipedia:Urea_cycle



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urea cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase, liver involved_in ISO RGD
MGI
PMID:4062872 GO_REF:0000096 MGI:4417868 RGD:2300098 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382
JBrowse link
G Arg2 arginase type II acts_upstream_of_or_within IEA UniProt GO_REF:0000043 MGI:1354194 NCBI chr12:79,177,562...79,203,075
Ensembl chr12:79,177,551...79,203,075
JBrowse link
G Asl argininosuccinate lyase involved_in ISO RGD
MGI
PMID:4062872 GO_REF:0000096 MGI:4417868 RGD:2300098 NCBI chr 5:130,040,099...130,053,222
Ensembl chr 5:130,040,099...130,058,088
JBrowse link
G Ass1 argininosuccinate synthetase 1 involved_in ISO
IBA
(MGI:6201960|PMID:21873635) RGD
MGI
GO_Central
PMID:4062872 PMID:21873635 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 MGI:6201960 RGD:2300098 NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha acts_upstream_of_or_within IDA (MGI:3712404|PMID:17213233) MGI PMID:17213233 MGI:3712404 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353
JBrowse link
G Cps1 carbamoyl-phosphate synthetase 1 acts_upstream_of_or_within
involved_in
IC
ISO
(MGI:1328875|PMID:9862865) MGI
RGD
PMID:3680220 PMID:4062872 PMID:9862865 GO_REF:0000096 MGI:1328875 MGI:4417868 RGD:1582379 RGD:2300098 NCBI chr 1:67,151,294...67,270,426
Ensembl chr 1:67,162,185...67,270,418
JBrowse link
G Fh1 fumarate hydratase 1 acts_upstream_of IMP (MGI:5496931|PMID:23643539) UniProt PMID:23643539 MGI:5496931 NCBI chr 1:175,428,944...175,453,201
Ensembl chr 1:175,427,940...175,453,201
JBrowse link
G Htt huntingtin acts_upstream_of_or_within IMP (MGI:3712404|PMID:17213233) MGI PMID:17213233 MGI:3712404 NCBI chr 5:34,919,084...35,069,878
Ensembl chr 5:34,919,084...35,069,878
JBrowse link
G Nags N-acetylglutamate synthase acts_upstream_of_or_within IEA UniProt GO_REF:0000043 MGI:1354194 NCBI chr11:102,036,339...102,040,354
Ensembl chr11:102,036,339...102,040,303
JBrowse link
G Otc ornithine transcarbamylase involved_in ISO RGD
MGI
PMID:3680220 PMID:4062872 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1582379 RGD:2300098 NCBI chr  X:10,118,584...10,187,275
Ensembl chr  X:10,118,544...10,187,263
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28558
    metabolic process 10986
      small molecule metabolic process 1865
        urea metabolic process 12
          urea cycle 10
Path 2
Term Annotations click to browse term
  biological_process 28558
    metabolic process 10986
      cellular metabolic process 9649
        cellular biosynthetic process 7700
          cellular nitrogen compound biosynthetic process 4526
            amide biosynthetic process 953
              urea cycle 10
paths to the root