ONTOLOGY REPORT - ANNOTATIONS
Term: urea cycle
Accession: GO:0000050
browse the term
Definition: The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
Synonyms: exact_synonym: ornithine cycle; urea biosynthesis; urea biosynthetic process
alt_id: GO:0006594; GO:0006871
xref: Wikipedia:Urea_cycle
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Arg1
arginase, liver
involved_in
ISO
RGD MGI
PMID:4062872
GO_REF:0000096 MGI:4417868 RGD:2300098
NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382
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Arg2
arginase type II
acts_upstream_of_or_within
IEA
UniProt
GO_REF:0000043 MGI:1354194
NCBI chr12:79,177,562...79,203,075
Ensembl chr12:79,177,551...79,203,075
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Asl
argininosuccinate lyase
involved_in
ISO
RGD MGI
PMID:4062872
GO_REF:0000096 MGI:4417868 RGD:2300098
NCBI chr 5:130,040,099...130,053,222
Ensembl chr 5:130,040,099...130,058,088
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Ass1
argininosuccinate synthetase 1
involved_in
ISO IBA
(MGI:6201960|PMID:21873635)
RGD MGI GO_Central
PMID:4062872 PMID:21873635
GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 MGI:6201960 RGD:2300098
NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684
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Cebpa
CCAAT/enhancer binding protein alpha
acts_upstream_of_or_within
IDA
(MGI:3712404|PMID:17213233)
MGI
PMID:17213233
MGI:3712404
NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353
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Cps1
carbamoyl-phosphate synthetase 1
acts_upstream_of_or_within involved_in
IC ISO
(MGI:1328875|PMID:9862865)
MGI RGD
PMID:3680220 PMID:4062872 PMID:9862865
GO_REF:0000096 MGI:1328875 MGI:4417868 RGD:1582379 RGD:2300098
NCBI chr 1:67,151,294...67,270,426
Ensembl chr 1:67,162,185...67,270,418
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Fh1
fumarate hydratase 1
acts_upstream_of
IMP
(MGI:5496931|PMID:23643539)
UniProt
PMID:23643539
MGI:5496931
NCBI chr 1:175,428,944...175,453,201
Ensembl chr 1:175,427,940...175,453,201
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Htt
huntingtin
acts_upstream_of_or_within
IMP
(MGI:3712404|PMID:17213233)
MGI
PMID:17213233
MGI:3712404
NCBI chr 5:34,919,084...35,069,878
Ensembl chr 5:34,919,084...35,069,878
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Nags
N-acetylglutamate synthase
acts_upstream_of_or_within
IEA
UniProt
GO_REF:0000043 MGI:1354194
NCBI chr11:102,036,339...102,040,354
Ensembl chr11:102,036,339...102,040,303
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Otc
ornithine transcarbamylase
involved_in
ISO
RGD MGI
PMID:3680220 PMID:4062872
GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1582379 RGD:2300098
NCBI chr X:10,118,584...10,187,275
Ensembl chr X:10,118,544...10,187,263
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