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ONTOLOGY REPORT - ANNOTATIONS

Term:urea cycle
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Accession:GO:0000050 term browser browse the term
Definition:The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
Synonyms:exact_synonym: ornithine cycle;   urea biosynthesis;   urea biosynthetic process
 alt_id: GO:0006594;   GO:0006871
 xref: Wikipedia:Urea_cycle


show annotations for term's descendants           Sort by:
urea cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 involved_in IDA
IEA		 GO_REF:0000041 UniProt
RGD		 PMID:4062872 GO_REF:0000041, RGD:2300098 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Arg2 arginase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378 		JBrowse link
G Asl argininosuccinate lyase involved_in IDA
NAS
IEA		 GO_REF:0000041 UniProt
RGD		 PMID:4062872 PMID:2789519 GO_REF:0000041, RGD:2300098, RGD:632221 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662 		JBrowse link
G Ass1 argininosuccinate synthase 1 involved_in IDA
IEA
IMP
IBA
ISO		 GO_REF:0000041
PMID:19491403
PMID:21873635
(PMID:18473344), (PMID:27287393), (PMID:7977368), (PMID:8792870)		 UniProt
RGD		 PMID:7977368 PMID:8792870 PMID:18473344 PMID:27287393 PMID:4062872 More... GO_REF:0000041, RGD:2300098, RGD:12859071, RGD:13792537 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha acts_upstream_of_or_within ISO (MGI:3712404|PMID:17213233) RGD PMID:17213233 MGI:3712404 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 IDA RGD PMID:4062872 PMID:3680220 RGD:2300098, RGD:1582379 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033 		JBrowse link
G Fh fumarate hydratase acts_upstream_of ISO
ISS		 (MGI:5496931|PMID:23643539)
GO_REF:0000024		 RGD
UniProt		 PMID:23643539 GO_REF:0000024 MGI:5496931 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G Htt huntingtin acts_upstream_of_or_within ISO MGI:2177757 (MGI:3712404|PMID:17213233) RGD PMID:17213233 MGI:3712404 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070 		JBrowse link
G Otc ornithine transcarbamylase involved_in IDA
IEA
ISO		 GO_REF:0000041
(PMID:2556444)		 UniProt
RGD		 PMID:2556444 PMID:4062872 PMID:3680220 GO_REF:0000041, RGD:2300098, RGD:1582379 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19746
    metabolic process 12044
      small molecule metabolic process 1892
        urea metabolic process 10
          urea cycle 9
Path 2
Term Annotations click to browse term
  biological_process 19746
    metabolic process 12044
      cellular metabolic process 9531
        cellular biosynthetic process 5800
          cellular nitrogen compound biosynthetic process 5173
            amide biosynthetic process 1364
              urea cycle 9
paths to the root