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ONTOLOGY REPORT - ANNOTATIONS


Term:urea cycle
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Accession:GO:0000050 term browser browse the term
Definition:The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.
Synonyms:exact_synonym: ornithine cycle;   urea biosynthesis;   urea biosynthetic process
 alt_id: GO:0006594;   GO:0006871
 xref: Wikipedia:Urea_cycle


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urea cycle term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 IDA
IEA
GO_REF:0000041 UniProt PMID:4062872 GO_REF:0000041, RGD:2300098 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arg2 arginase 2 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Asl argininosuccinate lyase NAS
IDA
IEA
GO_REF:0000041 UniProt PMID:2789519, PMID:4062872 GO_REF:0000041, RGD:632221, RGD:2300098 NCBI chr12:30,160,922...30,178,348
Ensembl chr12:30,165,694...30,178,341
JBrowse link
G Ass1 argininosuccinate synthase 1 IDA
IBA
ISO
IMP
IEA
PMID:21873635
(PMID:18473344), (PMID:27287393), (PMID:7977368), (PMID:8792870)
PMID:19491403
GO_REF:0000041
RGD
UniProt
PMID:7977368, PMID:8792870, PMID:18473344, PMID:27287393, PMID:4062872, PMID:21873635, PMID:19491403 GO_REF:0000041, RGD:2300098, RGD:13792537, RGD:12859071 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha ISO
IEA
(MGI:MGI:3712404|PMID:17213233)
GO_REF:0000107
RGD
Ensembl
PMID:17213233 GO_REF:0000107, MGI:MGI:3712404 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 IDA RGD PMID:3680220, PMID:4062872 RGD:1582379, RGD:2300098 NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274
JBrowse link
G Fh fumarate hydratase ISS
ISO
GO_REF:0000024
(MGI:MGI:5496931|PMID:23643539)
UniProt
RGD
PMID:23643539 GO_REF:0000024, MGI:MGI:5496931 NCBI chr13:93,651,486...93,677,371
Ensembl chr13:93,651,484...93,677,377
JBrowse link
G Htt huntingtin ISO MGI:MGI:2177757 (MGI:MGI:3712404|PMID:17213233) RGD PMID:17213233 MGI:MGI:3712404 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Otc ornithine carbamoyltransferase IDA
ISO
IEA
(PMID:2556444)
GO_REF:0000041
RGD
UniProt
PMID:2556444, PMID:3680220, PMID:4062872 GO_REF:0000041, RGD:1582379, RGD:2300098 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      small molecule metabolic process 1874
        urea metabolic process 10
          urea cycle 9
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      nitrogen compound metabolic process 10390
        cellular nitrogen compound metabolic process 6696
          cellular amide metabolic process 1533
            urea metabolic process 10
              urea cycle 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.