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ONTOLOGY REPORT - ANNOTATIONS

Term:mitochondrial genome maintenance
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Accession:GO:0000002 term browser browse the term
Definition:The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.


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mitochondrial genome maintenance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt3 AKT serine/threonine kinase 3 involved_in ISO
IEA		 (PMID:18524868)
GO_REF:0000107		 RGD
Ensembl		 PMID:18524868 GO_REF:0000107 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Mef2a myocyte enhancer factor 2a involved_in IEA
ISO		 GO_REF:0000107
(MGI:2429350|PMID:12379849)		 Ensembl
RGD		 PMID:12379849 GO_REF:0000107 MGI:2429350 NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948 		JBrowse link
G Mgme1 mitochondrial genome maintenance exonuclease 1 involved_in ISO (PMID:23313956) RGD PMID:23313956 NCBI chr 3:131,640,770...131,649,933
Ensembl chr 3:131,640,944...131,649,932 		JBrowse link
G Mpv17 mitochondrial inner membrane protein MPV17 involved_in ISO (PMID:16582910) RGD PMID:16582910 NCBI chr 6:25,221,668...25,236,241
Ensembl chr 6:25,222,896...25,236,244 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in ISS
ISO		 GO_REF:0000024
(PMID:18158317)		 UniProt
RGD		 PMID:18158317 GO_REF:0000024 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Pif1 PIF1 5'-to-3' DNA helicase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 8:66,110,641...66,120,202
Ensembl chr 8:66,111,072...66,120,200 		JBrowse link
G Slc25a33 solute carrier family 25 member 33 involved_in ISO (PMID:25320081) RGD PMID:25320081 NCBI chr 5:160,195,040...160,219,961
Ensembl chr 5:160,195,042...160,219,961 		JBrowse link
G Slc25a36 solute carrier family 25 member 36 involved_in ISO
IBA		 (PMID:25320081)
PMID:21873635		 RGD PMID:25320081 PMID:21873635 RGD:13792537 NCBI chr 8:97,659,848...97,693,735
Ensembl chr 8:97,662,127...97,693,703 		JBrowse link
G Slc25a36l1 solute carrier family 25 (pyrimidine nucleotide carrier ), member 36-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:32,941,523...32,943,368
Ensembl chr19:32,942,127...32,943,222 		JBrowse link
G Tymp thymidine phosphorylase involved_in ISO (PMID:9924029) RGD PMID:9924029 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874 		JBrowse link
mitochondrial DNA catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endog endonuclease G involved_in ISO (PMID:29719607) RGD PMID:29719607 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H acts_upstream_of_or_within ISO (MGI:6304909|PMID:30705315) RGD PMID:30705315 MGI:6304909 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 acts_upstream_of_or_within ISO (PMID:25378300) RGD PMID:25378300 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit acts_upstream_of_or_within ISO MGI:5470227 (MGI:5465384|PMID:23197651) RGD PMID:23197651 MGI:5465384 NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008 		JBrowse link
G Sesn2 sestrin 2 acts_upstream_of_or_within ISO MGI:3587950 (MGI:5444071|PMID:22958918) RGD PMID:22958918 MGI:5444071 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Tk2 thymidine kinase 2 acts_upstream_of_or_within ISO MGI:3808750 (MGI:3807446|PMID:18467430) RGD PMID:18467430 MGI:3807446 NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924 		JBrowse link
G Top3a DNA topoisomerase III alpha involved_in ISO (PMID:29290614) RGD PMID:29290614 NCBI chr10:45,419,219...45,457,356
Ensembl chr10:45,419,217...45,457,559 		JBrowse link
mitochondrial DNA repair term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chchd4 coiled-coil-helix-coiled-coil-helix domain containing 4 acts_upstream_of_or_within ISO (MGI:5516376|PMID:24101517) RGD PMID:24101517 MGI:5516376 NCBI chr 4:123,968,264...123,977,398
Ensembl chr 4:123,968,265...123,977,414 		JBrowse link
G Dna2 DNA replication helicase/nuclease 2 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Lig3 DNA ligase 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:21390132)
(MGI:4943977|PMID:21390132), (MGI:4943978|PMID:21390131)		 RGD PMID:21390131 PMID:21390132 MGI:4943977 MGI:4943978 NCBI chr10:67,717,796...67,741,141
Ensembl chr10:67,717,812...67,798,414 		JBrowse link
G Mgme1 mitochondrial genome maintenance exonuclease 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:131,640,770...131,649,933
Ensembl chr 3:131,640,944...131,649,932 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 acts_upstream_of_or_within ISO (PMID:25378300) RGD PMID:25378300 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Primpol primase and DNA directed polymerase involved_in ISO (MGI:6393030|PMID:29073063) RGD PMID:29073063 MGI:6393030 NCBI chr16:45,681,252...45,715,758
Ensembl chr16:45,681,326...45,715,565 		JBrowse link
G Slc25a16 solute carrier family 25 member 16 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,661,158...25,717,558
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO MGI:3528279 (MGI:5516376|PMID:24101517) RGD PMID:24101517 MGI:5516376 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dna2 DNA replication helicase/nuclease 2 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 acts_upstream_of_or_within ISO MGI:2182091|MGI:3040717 (MGI:3612004|PMID:16327803) RGD PMID:16327803 MGI:3612004 NCBI chr10:10,855,510...10,880,175
Ensembl chr10:10,854,732...10,880,161 		JBrowse link
G Mgme1 mitochondrial genome maintenance exonuclease 1 involved_in ISO
IBA		 (PMID:23313956)
PMID:21873635		 RGD PMID:23313956 PMID:21873635 RGD:13792537 NCBI chr 3:131,640,770...131,649,933
Ensembl chr 3:131,640,944...131,649,932 		JBrowse link
G Polg DNA polymerase gamma, catalytic subunit involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(PMID:19837034), (PMID:26554610)
MGI:3584444 (MGI:3583846|PMID:15888483)		 RGD PMID:15888483 PMID:19837034 PMID:26554610 PMID:21873635 MGI:3583846, RGD:13792537 NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567 		JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit involved_in ISO
IBA		 (PMID:19837034)
PMID:21873635		 RGD PMID:19837034 PMID:21873635 RGD:13792537 NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008 		JBrowse link
G Primpol primase and DNA directed polymerase involved_in ISO
IBA		 (PMID:24207056)
(MGI:5527006|PMID:24207056)
PMID:21873635		 RGD PMID:24207056 PMID:21873635 MGI:5527006, RGD:13792537 NCBI chr16:45,681,252...45,715,758
Ensembl chr16:45,681,326...45,715,565 		JBrowse link
G Rnaseh1 ribonuclease H1 acts_upstream_of_or_within ISO MGI:2655784 (MGI:2655010|PMID:12667461) RGD PMID:12667461 MGI:2655010 NCBI chr 6:45,282,849...45,292,258
Ensembl chr 6:45,282,854...45,292,236 		JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 involved_in ISO (PMID:17486094)
(MGI:3714223|PMID:17486094)		 RGD PMID:17486094 MGI:3714223 NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B acts_upstream_of_or_within
involved_in		 ISO MGI:2672883 (MGI:3714223|PMID:17486094)
(PMID:17486094)		 RGD PMID:17486094 MGI:3714223 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G Slc25a16 solute carrier family 25 member 16 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,661,158...25,717,558
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Ssbp1 single stranded DNA binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135 		JBrowse link
G Tefm transcription elongation factor, mitochondrial NOT|involved_in ISO (PMID:21278163) RGD PMID:21278163 NCBI chr10:65,119,657...65,124,233
Ensembl chr10:65,119,659...65,124,486 		JBrowse link
G Tk2 thymidine kinase 2 acts_upstream_of_or_within ISO MGI:3802583 (MGI:3801405|PMID:18434326) RGD PMID:18434326 MGI:3801405 NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924 		JBrowse link
G Twnk twinkle mtDNA helicase involved_in IBA
ISO		 PMID:21873635
(MGI:3826298|PMID:18971204)
(PMID:18971204)		 RGD PMID:18971204 PMID:21873635 MGI:3826298, RGD:13792537 NCBI chr 1:243,867,568...243,874,802
Ensembl chr 1:243,868,330...243,874,802 		JBrowse link
negative regulation of mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flcn folliculin involved_in ISO (MGI:5463828|PMID:23150719) RGD PMID:23150719 MGI:5463828 NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769 		JBrowse link
negative regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg7 autophagy related 7 IMP RGD PMID:23800874 RGD:11557986 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Lig3 DNA ligase 3 involved_in ISO (PMID:21878356) RGD PMID:21878356 NCBI chr10:67,717,796...67,741,141
Ensembl chr10:67,717,812...67,798,414 		JBrowse link
positive regulation of mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppargc1a PPARG coactivator 1 alpha involved_in ISO (MGI:5463828|PMID:23150719) RGD PMID:23150719 MGI:5463828 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
positive regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endog endonuclease G involved_in ISO (PMID:29719607) RGD PMID:29719607 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Ssbp1 single stranded DNA binding protein 1 involved_in ISO
ISS		 (PMID:31550240)
GO_REF:0000024		 RGD
UniProt		 PMID:31550240 GO_REF:0000024 NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135 		JBrowse link
regulation of mitochondrial DNA metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpv17 mitochondrial inner membrane protein MPV17 involved_in ISO
ISS		 (PMID:26760297)
(MGI:5776643|PMID:26760297)
GO_REF:0000024		 RGD
UniProt		 PMID:26760297 GO_REF:0000024 MGI:5776643 NCBI chr 6:25,221,668...25,236,241
Ensembl chr 6:25,222,896...25,236,244 		JBrowse link
G Stox1 storkhead box 1 involved_in ISO (PMID:24738702) RGD PMID:24738702 NCBI chr20:30,598,656...30,666,371
Ensembl chr20:30,598,168...30,666,939 		JBrowse link
regulation of mitochondrial DNA replication term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mettl4 methyltransferase 4, N6-adenosine involved_in ISO (PMID:32183942) RGD PMID:32183942 NCBI chr 9:111,440,976...111,523,871
Ensembl chr 9:111,441,027...111,464,749 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19738
    cellular process 17330
      cellular component organization or biogenesis 6793
        cellular component organization 6548
          organelle organization 3613
            mitochondrion organization 609
              mitochondrial genome maintenance 36
                mitochondrial DNA metabolic process + 28
paths to the root