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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of CD4-positive, alpha-beta T cell activation
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Accession:GO:2000516 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation.


show annotations for term's descendants           Sort by:
positive regulation of CD4-positive, alpha-beta T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) involved_in ISO (PMID:16818763) RGD PMID:16818763 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO (PMID:15265931) RGD PMID:15265931 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:15265931) RGD PMID:15265931 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
CD4-positive, alpha-beta T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 Cd81 molecule involved_in ISO
IEA
ISS		 (PMID:22307619)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:22307619 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:20639485) RGD PMID:20639485 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
negative regulation of CD4-positive, alpha-beta T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd160 CD160 molecule involved_in ISO (PMID:18193050) RGD PMID:18193050 NCBI chr 2:184,340,820...184,383,421
Ensembl chr 2:184,340,599...184,375,834 		JBrowse link
positive regulation of CD4-positive, alpha-beta T cell costimulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:20639485) RGD PMID:20639485 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
positive regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd83 CD83 molecule acts_upstream_of_or_within ISO MGI:3055293 (PMID:15322158) RGD PMID:15322158 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:17028180) RGD PMID:17028180 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISS
ISO		 GO_REF:0000024
(PMID:19015308)		 UniProt
RGD		 PMID:19015308 GO_REF:0000024 NCBI chr 7:134,577,470...134,622,928
Ensembl chr 7:134,577,482...134,622,934 		JBrowse link
G Sash3 SAM and SH3 domain containing 3 acts_upstream_of_or_within ISO MGI:3716944 (PMID:16227612) RGD PMID:16227612 NCBI chr  X:127,326,815...127,341,521
Ensembl chr  X:127,326,859...127,341,519 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:24880459)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:24880459 GO_REF:0000024 GO_REF:0000107 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:20639485) RGD PMID:20639485 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (PMID:24880459) RGD PMID:24880459 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
positive regulation of CD4-positive, alpha-beta T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Card11 caspase recruitment domain family, member 11 acts_upstream_of_or_within ISO MGI:3039682 (PMID:12867038) RGD PMID:12867038 NCBI chr12:13,621,140...13,758,115
Ensembl chr12:13,621,087...13,758,112 		JBrowse link
G Cd24 CD24 molecule acts_upstream_of_or_within ISO MGI:2179996 (PMID:15314074), (PMID:8125140) RGD PMID:8125140 PMID:15314074 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Cd28 Cd28 molecule acts_upstream_of_or_within ISO MGI:1857150 (PMID:14973438), (PMID:8125140), (PMID:9368605) RGD PMID:8125140 PMID:9368605 PMID:14973438 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex acts_upstream_of_or_within ISO (PMID:11894097), (PMID:14973438), (PMID:8125140) RGD PMID:8125140 PMID:11894097 PMID:14973438 NCBI chr 8:45,303,848...45,315,005
Ensembl chr 8:45,303,852...45,315,022 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) involved_in ISO (PMID:16818763) RGD PMID:16818763 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cd81 Cd81 molecule involved_in ISO
ISS
IEA		 (PMID:22307619)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:22307619 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660 		JBrowse link
G Irgm immunity-related GTPase M involved_in ISS
ISO		 GO_REF:0000024
(PMID:18806793)		 UniProt
RGD		 PMID:18806793 GO_REF:0000024 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:16116184) RGD PMID:16116184 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Prkcq protein kinase C, theta involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2664379 (PMID:12867038)		 Ensembl
RGD		 PMID:12867038 GO_REF:0000107 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2446070|MGI:2660793 (PMID:11894097), (PMID:11894098) RGD PMID:11894097 PMID:11894098 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in ISO
IEA		 (PMID:17164348)
GO_REF:0000107		 RGD
Ensembl		 PMID:17164348 GO_REF:0000107 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:9973465)		 Ensembl
RGD		 PMID:9973465 GO_REF:0000107 NCBI chr13:77,248,687...77,252,343
Ensembl chr13:77,248,717...77,252,329 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:1857034|MGI:2654936|MGI:3696705 (PMID:12612578), (PMID:16275384), (PMID:16301745), (PMID:18573908) RGD PMID:12612578 PMID:16275384 PMID:16301745 PMID:18573908 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:15778366 RGD:2303772 NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of_or_within ISO MGI:1857455 (PMID:16227984) RGD PMID:16227984 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Klhl25 kelch-like family member 25 involved_in ISO
ISS		 (PMID:34491895)
GO_REF:0000024		 RGD
UniProt		 PMID:34491895 GO_REF:0000024 NCBI chr 1:129,724,894...129,750,142
Ensembl chr 1:129,722,026...129,750,227 		JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO (PMID:28467828) RGD PMID:28467828 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:28467828) RGD PMID:28467828 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:17008549)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:17008549 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) RGD PMID:15845453 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308 		JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within ISO MGI:105367|MGI:2182089 (PMID:16424184) RGD PMID:16424184 NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2446070 (PMID:11894097) RGD PMID:11894097 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:12242343) RGD PMID:12242343 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr18:58,942,282...58,996,318
Ensembl chr18:58,942,299...58,994,260 		JBrowse link
G Mir326 microRNA 326 acts_upstream_of_or_within ISO (PMID:19838199) RGD PMID:19838199 NCBI chr 1:153,854,029...153,854,123
Ensembl chr 1:153,854,029...153,854,123 		JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (PMID:25282160) RGD PMID:25282160 NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (PMID:26098997) RGD PMID:26098997 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:28262505)		 UniProt
RGD		 PMID:28262505 GO_REF:0000024 NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (PMID:28262505) RGD PMID:28262505 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:28262505) RGD PMID:28262505 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in IBA
ISO		 GO_REF:0000033
(PMID:19501566)		 GO_Central
RGD		 PMID:19501566 GO_REF:0000033 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:36171294)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:36171294 GO_REF:0000024 GO_REF:0000107 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
positive regulation of T-helper 2 cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcq protein kinase C, theta involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:15263025)		 UniProt
Ensembl
RGD		 PMID:15263025 GO_REF:0000024 GO_REF:0000107 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:12496423) RGD PMID:12496423 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in IEA
ISO		 GO_REF:0000107
(PMID:12829194)		 Ensembl
RGD		 PMID:12829194 GO_REF:0000107 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:96109 (PMID:16424184) RGD PMID:16424184 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (PMID:12594267) RGD PMID:12594267 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (PMID:26098997) RGD PMID:26098997 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Prkcz protein kinase C, zeta involved_in ISS
ISO		 GO_REF:0000024
(PMID:15987782)		 UniProt
RGD		 PMID:15987782 GO_REF:0000024 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Rara retinoic acid receptor, alpha involved_in ISO (PMID:18416830) RGD PMID:18416830 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (PMID:18354165) RGD PMID:18354165 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shb SH2 domain containing adaptor protein B acts_upstream_of_or_within ISO MGI:3721903 (PMID:24645804) RGD PMID:24645804 NCBI chr 5:59,678,066...59,785,443
Ensembl chr 5:59,678,216...59,785,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    immune system process 3008
      leukocyte activation 1056
        lymphocyte activation 856
          T cell activation 607
            alpha-beta T cell activation 210
              CD4-positive, alpha-beta T cell activation 141
                positive regulation of CD4-positive, alpha-beta T cell activation 46
                  CD4-positive, alpha-beta T cell costimulation + 3
                  positive regulation of CD4-positive, alpha-beta T cell costimulation 1
                  positive regulation of CD4-positive, alpha-beta T cell differentiation + 35
                  positive regulation of CD4-positive, alpha-beta T cell proliferation 12
                  positive regulation of T-helper 1 cell activation 0
                  positive regulation of T-helper 2 cell activation 2
Path 2
Term Annotations click to browse term
  biological_process 20069
    biological regulation 13554
      regulation of biological process 13131
        regulation of cellular process 12768
          regulation of cell activation 660
            regulation of leukocyte activation 604
              regulation of lymphocyte activation 520
                regulation of T cell activation 382
                  regulation of alpha-beta T cell activation 129
                    positive regulation of alpha-beta T cell activation 76
                      positive regulation of CD4-positive, alpha-beta T cell activation 46
                        CD4-positive, alpha-beta T cell costimulation + 3
                        positive regulation of CD4-positive, alpha-beta T cell costimulation 1
                        positive regulation of CD4-positive, alpha-beta T cell differentiation + 35
                        positive regulation of CD4-positive, alpha-beta T cell proliferation 12
                        positive regulation of T-helper 1 cell activation 0
                        positive regulation of T-helper 2 cell activation 2
paths to the root